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1. 发明申请

US20110160830A1 IMPLANTABLE LEADS WITH AN AXIAL REINFORCEMENT MEMBER 审中-公开
标题翻译：具有轴向加固构件的可伸缩导轨
公开(公告)号：US20110160830A1
公开(公告)日：2011-06-30
申请号：US12953094
申请日：2010-11-23
申请人： Kimberly A. Morris , Eduardo Carlo Lopez , Andrew De Kock , Joel Grover , Joshua Haarer , Timothy R. Jackson , Ronald W. Kunkel , David R. Wulfman
发明人： Kimberly A. Morris , Eduardo Carlo Lopez , Andrew De Kock , Joel Grover , Joshua Haarer , Timothy R. Jackson , Ronald W. Kunkel , David R. Wulfman
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： Implantable electrical leads including an axial reinforcement member are disclosed. In some embodiments, an implantable electrical lead can have a body, one or more electrodes, a cable conductor, a conductor coil, and a reinforcement member. A cable conductor can be disposed within the body and is configured to convey electrical signals between the proximal region and the distal region of the lead. The reinforcement member may be coupled to or integrally formed within the lead body and is configured to limit elongation of the lead body in response to a tensile force.
摘要翻译：公开了包括轴向加强构件的可植入电引线。在一些实施例中，可植入电引线可以具有主体，一个或多个电极，电缆导体，导体线圈和加强构件。电缆导体可以设置在主体内并且构造成在导线的近端区域和远端区域之间传送电信号。加强构件可以联接到引线本体内或整体地形成在引线主体内，并且被配置为限制引线本体响应于拉伸力的伸长。

2. 发明授权

US08666512B2 Implantable medical device lead including inner coil reverse-wound relative to shocking coil 有权
标题翻译：可植入医疗器械引线，包括相对于震动线圈反绕的内线圈
公开(公告)号：US08666512B2
公开(公告)日：2014-03-04
申请号：US13620934
申请日：2012-09-15
申请人： Joseph Walker , David R. Wulfman , Devon N. Arnholt
发明人： Joseph Walker , David R. Wulfman , Devon N. Arnholt
IPC分类号： A61N1/39
CPC分类号： A61N1/0563 , A61N1/086
摘要： A medical device lead includes a proximal connector configured to couple the lead to a pulse generator and an insulative lead body extending distally from the proximal connector. The lead also includes an inner conductor and one or more cable conductors coupled to the proximal connector at a proximal end and extending through the lead body. The lead further includes one or more defibrillation coil electrodes coupled to a distal end of the one or more cable conductors. The one or more defibrillation coil electrodes are disposed around and electrically isolated from the inner conductor. The one or more defibrillation coil electrodes have a first winding direction and the inner conductor has a second winding direction opposite the first winding direction.
摘要翻译：医疗器械引线包括被配置为将引线耦合到脉冲发生器的近端连接器和从近端连接器向远侧延伸的绝缘引线体。引线还包括内导体和一个或多个电缆导体，其在近端处连接到近端连接器并且延伸穿过引线体。引线还包括耦合到一个或多个电缆导体的远端的一个或多个除颤线圈电极。一个或多个除颤线圈电极设置在内部导体周围并与内部导体电绝缘。一个或多个除颤线圈电极具有第一卷绕方向，并且内部导体具有与第一卷绕方向相反的第二卷绕方向。

3. 发明授权

US08594792B2 Implantable lead and coronary venous pressure sensor apparatus and method 有权
标题翻译：植入式铅和冠状静脉压力传感器的设备及方法
公开(公告)号：US08594792B2
公开(公告)日：2013-11-26
申请号：US13690068
申请日：2012-11-30
申请人： Lili Liu , Mohan Krishnan , Bruce A Tockman , David R. Wulfman
发明人： Lili Liu , Mohan Krishnan , Bruce A Tockman , David R. Wulfman
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61M25/0041 , A61M2025/0002 , A61M2205/3344 , A61N1/056 , A61N1/3627 , A61N1/36585 , A61N2001/0585
摘要： A cardiac rhythm management system comprises a medical electrical lead, a pressure sensing element, and an implantable pulse generator. The lead is sized to be advanced through the right atrium and coronary sinus into a coronary vein adjacent to the left ventricle. The lead includes an opening intermediate its proximal and distal ends, and a lumen extending longitudinally within the body in communication with the opening. The pressure sensing element is movably disposed in lead lumen and is dimensioned to extend through the opening in the lead, and includes a flexible, elongated conductive member having a distal end, and a pressure transducer coupled to the distal end of the conductive member. The pulse generator is configured to receive cardiac rhythm signals from the electrode and fluid pressure signals from the pressure transducer.
摘要翻译：心律管理系统包括医疗电引线，压力感测元件和可植入脉冲发生器。铅的大小可以通过右心房和冠状窦进入与左心室相邻的冠状静脉。引线包括在其近端和远端之间的开口，以及在主体内与开口连通的纵向延伸的内腔。压力感测元件可移动地设置在引导腔中，并且其尺寸设计成延伸穿过引线中的开口，并且包括具有远端的柔性细长导电构件和耦合到导电构件的远端的压力传感器。脉冲发生器被配置为从电极接收心律信号和来自压力传感器的流体压力信号。

4. 发明申请

US20130131765A1 FIBROUS MATRIX COATING MATERIALS 审中-公开
标题翻译：纤维基质涂料
公开(公告)号：US20130131765A1
公开(公告)日：2013-05-23
申请号：US13680590
申请日：2012-11-19
申请人： Jeannette C. Polkinghorne , Devon N. Arnholt , James P. Rohl , Brian L. Schmidt , Jan Seppala , Richard L. Tadsen , Patrick Willoughby , Steve Zhang , Shrojalkumar Desai , Joseph T. Delaney, JR. , David R. Wulfman
发明人： Jeannette C. Polkinghorne , Devon N. Arnholt , James P. Rohl , Brian L. Schmidt , Jan Seppala , Richard L. Tadsen , Patrick Willoughby , Steve Zhang , Shrojalkumar Desai , Joseph T. Delaney, JR. , David R. Wulfman
IPC分类号： A61N1/04
CPC分类号： A61N1/04 , A61L29/085 , A61L29/14 , A61L2400/12 , A61N1/05 , C08L75/04
摘要： A medical electrical lead may include an insulative lead body, a conductor disposed within the insulative lead body, an electrode disposed on the insulative lead body and in electrical contact with the conductor and a fibrous matrix disposed at least partially over the electrode. The fibrous matrix may be formed from a polyisobutylene urethane, urea or urethane/urea copolymer.
摘要翻译：医疗电引线可以包括绝缘引线体，布置在绝缘引线体内的导体，设置在绝缘引线体上并与导体电接触的电极和至少部分地布置在电极上的纤维基质。纤维基质可以由聚异丁烯氨基甲酸酯，脲或氨基甲酸酯/脲共聚物形成。

5. 发明申请

US20130116764A1 IMPLANTABLE MEDICAL DEVICE LEAD INCLUDING INNER COIL REVERSE-WOUND RELATIVE TO SHOCKING COIL 有权
标题翻译：可植入医疗器械引线，包括内圈绕线圈相对于震动线圈
公开(公告)号：US20130116764A1
公开(公告)日：2013-05-09
申请号：US13620934
申请日：2012-09-15
申请人： Joseph Walker , David R. Wulfman , Devon N. Arnholt
发明人： Joseph Walker , David R. Wulfman , Devon N. Arnholt
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/086
摘要： A medical device lead includes a proximal connector configured to couple the lead to a pulse generator and an insulative lead body extending distally from the proximal connector. The lead also includes an inner conductor and one or more cable conductors coupled to the proximal connector at a proximal end and extending through the lead body. The lead further includes one or more defibrillation coil electrodes coupled to a distal end of the one or more cable conductors. The one or more defibrillation coil electrodes are disposed around and electrically isolated from the inner conductor. The one or more defibrillation coil electrodes have a first winding direction and the inner conductor has a second winding direction opposite the first winding direction.
摘要翻译：医疗器械引线包括被配置为将引线耦合到脉冲发生器的近端连接器和从近端连接器向远侧延伸的绝缘引线体。引线还包括内导体和一个或多个电缆导体，其在近端处连接到近端连接器并且延伸穿过引线体。引线还包括耦合到一个或多个电缆导体的远端的一个或多个除颤线圈电极。一个或多个除颤线圈电极设置在内部导体周围并与内部导体电绝缘。一个或多个除颤线圈电极具有第一卷绕方向，并且内部导体具有与第一卷绕方向相反的第二卷绕方向。

6. 发明授权

US08126569B2 Compression control lead anchoring device 有权
标题翻译：压缩控制引导锚定装置
公开(公告)号：US08126569B2
公开(公告)日：2012-02-28
申请号：US12265285
申请日：2008-11-05
申请人： Adam J. Rivard , Kevin E. Verzal , David A. Durand , David R. Wulfman
发明人： Adam J. Rivard , Kevin E. Verzal , David A. Durand , David R. Wulfman
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N2001/0582
摘要： An implanted medical system includes a medical lead, an anchoring device and at least one suture secured circumferentially about the anchoring device to cause compression of the anchoring device on the medical lead. In particular, the anchoring device is received coaxially over the medical lead and includes an elastomeric sleeve and a compression governor. The elastomeric sleeve has a substantially elongate, hollow, and tubular body. The compression governor is substantially more rigid than the elastomeric sleeve and is coaxially secured to the elastomeric sleeve. The compression governor defines an inner bore having an effective diameter and is adapted to limit compression at a pre-selected minimum effective diameter to limit compressive forces exerted on the lead by the anchoring device.
摘要翻译：植入式医疗系统包括医疗引线，锚定装置和围绕锚定装置周向固定的至少一个缝合线，以将锚定装置压缩在医疗引线上。特别地，锚定装置被同轴地接纳在医疗引线上并且包括弹性体套筒和压缩调节器。弹性体套筒具有基本上细长的中空管状体。压缩调节器基本上比弹性体套筒更刚性，并且同轴地固定到弹性体套筒上。压缩调速器限定具有有效直径的内孔，并且适于以预选的最小有效直径限制压缩，以限制由锚定装置施加在引线上的压缩力。

7. 发明申请

US20090088811A1 IMPLANTABLE LEAD WITH AN ELECTROSTIMULATION CAPACITOR 有权
标题翻译：具有电化学电容器的可植入引线
公开(公告)号：US20090088811A1
公开(公告)日：2009-04-02
申请号：US12233333
申请日：2008-09-18
申请人： David R. Wulfman
发明人： David R. Wulfman
IPC分类号： A61N1/362 , A61N1/05
CPC分类号： A61N1/056 , A61N1/0563 , A61N1/37205 , A61N1/375
摘要： One example includes an implantable lead with an elongate lead body including a proximal portion and a distal portion. The lead includes a coupler configured to be coupled to an implantable medical device, a conductor, extending through the coupler, a first electrode, and a first electrostimulation capacitor located at the distal portion of the lead body, the first electrostimulation capacitor including a capacitance value that is large enough to store an electrostimulation charge of an electrostimulation energy that is large enough to perform electrostimulation of tissue. The lead includes a first switch located at the distal portion of the lead body and coupled to the conductor, the first switch configured to selectively couple the first electrostimulation capacitor to the first electrode during a stimulating state and to selectively couple the first electrostimulation capacitor to the conductor during a charging state.
摘要翻译：一个示例包括具有包括近端部分和远端部分的细长引线主体的可植入引线。引线包括被配置为耦合到可植入医疗器件的耦合器，延伸穿过耦合器的导体，第一电极和位于引线本体的远端部分的第一电刺激电容器，所述第一电刺激电容器包括电容值其足够大以存储足够大的电刺激能量的电刺激电荷以进行组织的电刺激。引线包括位于引线主体的远端部分并且耦合到导体的第一开关，第一开关被配置为在刺激状态期间将第一电刺激电容器选择性地耦合到第一电极，并且选择性地将第一电刺激电容器耦合到导体在充电状态。

8. 发明授权

US08914130B2 Implantable lead with in-lead switching electronics 有权
标题翻译：带有引线开关电子元件的可植入引线
公开(公告)号：US08914130B2
公开(公告)日：2014-12-16
申请号：US12233345
申请日：2008-09-18
申请人： David R. Wulfman
发明人： David R. Wulfman
IPC分类号： A61N1/05 , A61N1/375 , A61N1/372
CPC分类号： A61N1/056 , A61N1/0563 , A61N1/37205 , A61N1/375
摘要： One example includes an implantable lead including an elongate lead body which includes a proximal portion and a distal portion. In the example, the lead includes a coupler configured to couple to an implantable medical device. The lead includes a first conductor, coupled to the coupler, and extending away from the coupler at least partially through the lead. The lead includes a first electrode, located on the lead away from the coupler and a first switch, located on the lead away from the coupler, the first switch configured to control conductivity between the conductor and the electrode. The lead also includes a first controller circuit, coupled to the conductor and including a first multiplexer circuit configured to multiplex over the conductor a first signal and a second signal, the first controller circuit configured to control the first switch based at least on the first signal.
摘要翻译：一个示例包括可植入引线，其包括细长引线体，其包括近端部分和远端部分。在该示例中，引线包括被配置为耦合到可植入医疗装置的耦合器。引线包括耦合到耦合器的第一导体，并且至少部分地穿过引线远离耦合器延伸。引线包括位于远离耦合器的引线上的第一电极和位于远离耦合器的引线上的第一开关，第一开关被配置为控制导体和电极之间的导电性。引线还包括耦合到导体的第一控制器电路，并且包括配置为在导体上复用第一信号和第二信号的第一多路复用器电路，第一控制器电路被配置为至少基于第一信号来控制第一开关。

9. 发明授权

US08406898B2 Implantable lead with an electrostimulation capacitor 有权
标题翻译：具有电刺激电容器的可植入引线
公开(公告)号：US08406898B2
公开(公告)日：2013-03-26
申请号：US12233333
申请日：2008-09-18
申请人： David R. Wulfman
发明人： David R. Wulfman
IPC分类号： A61N1/08
CPC分类号： A61N1/056 , A61N1/0563 , A61N1/37205 , A61N1/375
摘要： One example includes an implantable lead with an elongate lead body including a proximal portion and a distal portion. The lead includes a coupler configured to be coupled to an implantable medical device, a conductor, extending through the coupler, a first electrode, and a first electrostimulation capacitor located at the distal portion of the lead body, the first electrostimulation capacitor including a capacitance value that is large enough to store an electrostimulation charge of an electrostimulation energy that is large enough to perform electrostimulation of tissue. The lead includes a first switch located at the distal portion of the lead body and coupled to the conductor, the first switch configured to selectively couple the first electrostimulation capacitor to the first electrode during a stimulating state and to selectively couple the first electrostimulation capacitor to the conductor during a charging state.
摘要翻译：一个示例包括具有包括近端部分和远端部分的细长引线主体的可植入引线。引线包括被配置为耦合到可植入医疗器件的耦合器，延伸穿过耦合器的导体，第一电极和位于引线本体的远端部分的第一电刺激电容器，所述第一电刺激电容器包括电容值其足够大以存储足够大的电刺激能量的电刺激电荷以进行组织的电刺激。引线包括位于引线主体的远端部分并且耦合到导体的第一开关，第一开关被配置为在刺激状态期间将第一电刺激电容器选择性地耦合到第一电极，并且选择性地将第一电刺激电容器耦合到导体在充电状态。

10. 发明授权

US08340767B2 Implantable lead and coronary venous pressure sensor apparatus and method 有权
标题翻译：植入式铅和冠状静脉压力传感器的设备及方法
公开(公告)号：US08340767B2
公开(公告)日：2012-12-25
申请号：US12539832
申请日：2009-08-12
申请人： Lili Liu , Mohan Krishnan , Bruce A. Tockman , David R. Wulfman
发明人： Lili Liu , Mohan Krishnan , Bruce A. Tockman , David R. Wulfman
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61M25/0041 , A61M2025/0002 , A61M2205/3344 , A61N1/056 , A61N1/3627 , A61N1/36585 , A61N2001/0585
摘要： A cardiac rhythm management system comprises a medical electrical lead, a pressure sensing element, and an implantable pulse generator. The lead is sized to be advanced through the right atrium and coronary sinus into a coronary vein adjacent to the left ventricle. The lead includes an opening intermediate its proximal and distal ends, and a lumen extending longitudinally within the body in communication with the opening. The pressure sensing element is movably disposed in lead lumen and is dimensioned to extend through the opening in the lead, and includes a flexible, elongated conductive member having a distal end, and a pressure transducer coupled to the distal end of the conductive member. The pulse generator is configured to receive cardiac rhythm signals from the electrode and fluid pressure signals from the pressure transducer.
摘要翻译：心律管理系统包括医疗电引线，压力感测元件和可植入脉冲发生器。铅的大小可以通过右心房和冠状窦进入与左心室相邻的冠状静脉。引线包括在其近端和远端之间的开口，以及在主体内与开口连通的纵向延伸的内腔。压力感测元件可移动地设置在引导腔中，并且其尺寸设计成延伸穿过引线中的开口，并且包括具有远端的柔性细长导电构件和耦合到导电构件的远端的压力传感器。脉冲发生器被配置为从电极接收心律信号和来自压力传感器的流体压力信号。

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