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1. 发明授权

US4044003A Process for preparing 1,4-benzodiazepines 失效
标题翻译：制备1,4-苯并二氮杂卓的方法
公开(公告)号：US4044003A
公开(公告)日：1977-08-23
申请号：US598621
申请日：1975-07-24
申请人： Kikuo Ishizumi , Kazuo Mori , Tadashi Okamoto , Takeshi Akase , Takahiro Izumi , Mitsuhiro Akatsu , Yoshiharu Kume , Shigeho Inaba , Hisao Yamamoto
发明人： Kikuo Ishizumi , Kazuo Mori , Tadashi Okamoto , Takeshi Akase , Takahiro Izumi , Mitsuhiro Akatsu , Yoshiharu Kume , Shigeho Inaba , Hisao Yamamoto
IPC分类号： C07D243/16
CPC分类号： C07D243/16
摘要： 1,4-Benzodiazepine derivatives of the formula, ##STR1## wherein R.sub.1 is hydrogen, a lower alkyl, a haloalkyl, a cycloalkylalkyl, an alkoxyalkyl, an acyloxyalkyl, an alkylthioalkyl, an alkylaminoalkyl, a dialkylaminoalkyl, a hydroxyalkyl, carbamoyl, or an N-alkylcarbamoyl; R.sub.2 is hydrogen or a lower alkyl; X is hydrogen, a halogen, nitro, or trifluoromethyl; A is a group of the formula, ##STR2## (wherein Y and Z each represent hydrogen, a halogen, a lower alkyl, or nitro) and a salt thereof, are prepared by reacting a 1,4-benzodiazepin-2-one compound of the formula, ##STR3## wherein R.sub.1, R.sub.2, X, Y and Z are the same as defined above, with diborane in an inert solvent.
摘要翻译：其中R1是氢，低级烷基，卤代烷基，环烷基烷基，烷氧基烷基，酰氧基烷基，烷基硫代烷基，烷基氨基烷基，二烷基氨基烷基，羟基烷基，氨基甲酰基或 N-烷基氨基甲酰基; R2是氢或低级烷基; X是氢，卤素，硝基或三氟甲基; A是通过使1,4-苯并二氮杂-2-酮化合物（其中Y和Z各自表示氢，卤素，低级烷基或硝基）及其盐的式其中R1，R2，X，Y和Z与上述定义相同，与乙硼烷在惰性溶剂中反应。

2. 发明授权

US4079053A Benzodiazepine derivatives 失效
标题翻译：苯并二氮杂衍生物
公开(公告)号：US4079053A
公开(公告)日：1978-03-14
申请号：US710665
申请日：1976-08-02
申请人： Hisao Yamamoto , Shigeho Inaba , Toshiyuki Hirohashi , Michihiro Yamamoto , Kikuo Ishizumi , Mitsuhiro Akatsu , Isamu Maruyama , Kazuo Mori , Yoshiharu Kume , Takahiro Izumi
发明人： Hisao Yamamoto , Shigeho Inaba , Toshiyuki Hirohashi , Michihiro Yamamoto , Kikuo Ishizumi , Mitsuhiro Akatsu , Isamu Maruyama , Kazuo Mori , Yoshiharu Kume , Takahiro Izumi
IPC分类号： A61K31/55 , C07D243/24 , C07D401/04
CPC分类号： C07D243/24 , A61K31/55 , C07D243/26 , C07D243/28 , C07D243/30 , C07D243/36 , C07D401/04
摘要： Novel 1-substituted benzodiazepine derivatives and salt thereof having the formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a lower alkoxy group or a trifluoromethyl group; R.sub.2 is a pyridyl group or a group of the formula ##STR2## wherein R.sub.5 and R.sub.6 represent individually a hydrogen atom, a halogen atom, a lower alkyl group or a trifluoromethyl group); R.sub.3 is a hydrogen atom or a lower alkyl group; R.sub.4 is a lower alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl group; m is 1 or 2; and n is an integer of 1 to 4, and a process for preparation thereof and pharmaceutical use of the same.The benzodiazepine derivatives are effective as tranquillizers, muscle-relaxants and hypnotics.
摘要翻译：新颖的1-取代苯并二氮杂衍生物及其盐，具有下式：其中R 1是氢原子，卤原子，硝基，氰基，低级烷氧基或三氟甲基; R2是吡啶基或式的基团，其中R5和R6分别表示氢原子，卤素原子，低级烷基或三氟甲基）。 R3是氢原子或低级烷基; R4是低级烷基，环烷基，环烷基烷基，芳基或芳烷基; m为1或2; n为1〜4的整数，其制备方法和药物用途。

3. 发明授权

US4010154A Benzodiazepinones 失效
标题翻译：苯并二氮杂
公开(公告)号：US4010154A
公开(公告)日：1977-03-01
申请号：US497936
申请日：1974-08-16
申请人： Hisao Yamamoto , Shigeho Inaba , Toshiyuki Hirohashi , Michihiro Yamamoto , Kikuo Ishizumi , Mitsuhiro Akatsu , Isamu Maruyama , Kazuo Mori , Yoshiharu Kume , Takahiro Izumi
发明人： Hisao Yamamoto , Shigeho Inaba , Toshiyuki Hirohashi , Michihiro Yamamoto , Kikuo Ishizumi , Mitsuhiro Akatsu , Isamu Maruyama , Kazuo Mori , Yoshiharu Kume , Takahiro Izumi
IPC分类号： A61K31/55 , C07D243/24 , C07D401/04 , C07D243/20
CPC分类号： C07D243/24 , A61K31/55 , C07D243/26 , C07D243/28 , C07D243/30 , C07D243/36 , C07D401/04
摘要： Novel 1-substituted benzodiazepine derivatives and salt thereof having the formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a lower alkoxy group or a trifluoromethyl group; R.sub.2 is a pyridyl group or a group of the formula ##STR2## wherein R.sub.5 and R.sub.6 represent individually a hydrogen atom, a halogen atom, a lower alkyl group or a trifluoromethyl group); R.sub.3 is a hydrogen atom or a lower alkyl group; R.sub.4 is a lower alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl group; m is 1 or 2; and n is an integer of 1 to 4, and a process for preparation thereof and pharmaceutical use of the same.
摘要翻译：新颖的1-取代苯并二氮杂衍生物及其盐，具有下式：其中R 1是氢原子，卤原子，硝基，氰基，低级烷氧基或三氟甲基; R2是吡啶基或式的基团，其中R5和R6分别表示氢原子，卤素原子，低级烷基或三氟甲基）。 R3是氢原子或低级烷基; R4是低级烷基，环烷基，环烷基烷基，芳基或芳烷基; m为1或2; n为1〜4的整数，其制备方法和药物用途。

4. 发明授权

US3989829A 1,4-Benzodiazepines 失效
标题翻译： 1,4-苯并二氮杂
公开(公告)号：US3989829A
公开(公告)日：1976-11-02
申请号：US594771
申请日：1975-07-10
申请人： Hisao Yamamoto , Shigeho Inaba , Toshiyuki Hirohashi , Michihiro Yamamoto , Kikuo Ishizumi , Mitsuhiro Akatsu , Isamu Maruyama , Yoshiharu Kume , Kazuo Mori , Takahiro Izumi
发明人： Hisao Yamamoto , Shigeho Inaba , Toshiyuki Hirohashi , Michihiro Yamamoto , Kikuo Ishizumi , Mitsuhiro Akatsu , Isamu Maruyama , Yoshiharu Kume , Kazuo Mori , Takahiro Izumi
IPC分类号： A61K31/395 , A61K31/55 , C07D243/14 , C07D243/24 , C07D243/30 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/06
CPC分类号： C07D243/24 , A61K31/395 , A61K31/55 , C07D243/14 , C07D243/30 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/06
摘要： Benzodiazepine derivatives of the formula, ##SPC1##Wherein R.sub.1 is a C.sub.2-4 alkenyl group, R.sub.2 is a halogen atom and R.sub.3 is a hydrogen or halogen atom, which are useful as minor tranquilizer and anticonvulsant. These compounds are prepared by reacting a compound of the formula, ##SPC2##Wherein R.sub.1, R.sub.2, and R.sub.3 are as defined above, with a compound of the formula, ##EQU1## wherein X is an oxygen or sulfur atom.
摘要翻译：下式的苯并二氮杂衍生物，其中R 1为C 2-4链烯基，R 2为卤素原子，R 3为氢或卤素原子，其可用作较小的镇静剂和抗惊厥药。这些化合物通过使下式的化合物，即WHEREIN R 1，R 2和R 3如上所定义的化合物与下式化合物O CH 2 -CONGOR | X NH-C ANGLE O反应而制备，其中X是氧或硫原子。

5. 发明授权

US08247082B2 Aluminum alloy brazing sheet 有权
标题翻译：铝合金钎焊板
公开(公告)号：US08247082B2
公开(公告)日：2012-08-21
申请号：US13037543
申请日：2011-03-01
申请人： Toshiki Ueda , Shimpei Kimura , Takahiro Izumi
发明人： Toshiki Ueda , Shimpei Kimura , Takahiro Izumi
IPC分类号： B32B15/20 , F28F21/08
CPC分类号： B23K35/0266 , B23K35/0238 , B23K35/286 , B32B15/016 , C22C21/00 , C22C21/02 , C22C21/14 , C22F1/04 , C22F1/043 , C22F1/057 , F28D1/05316 , F28F9/001 , F28F9/18 , F28F21/089 , Y10T428/12764
摘要： There is provided an aluminum alloy brazing sheet having an improved brazability than in the related art while keeping the post-braze strength, workability, corrosion resistance, and the like at respective prescribed or higher levels. An aluminum alloy brazing sheet has a two-layered structure in which on one side of a core material, a brazing material is provided. The core material contains Si: 0.6 to 1.0 mass %, Cu: 0.6 to 1.0 mass %, Mn: 0.7 to 1.8 mass %, Mg: 0.1 to 0.7 mass %, and Ti: 0.06 to 0.20 mass %, and the balance including Al and inevitable impurities. The brazing material includes an aluminum alloy containing Si: 3.0 to 12.0 mass %, the gage of the aluminum alloy brazing sheet is 0.6 to 1.4 mm, and the area ratio of a {001} plane in the core material surface is 0.3 or more.
摘要翻译：提供了一种铝合金钎焊片，其具有比现有技术更好的钎焊性，同时保持钎焊强度，加工性，耐腐蚀性等在规定或更高的水平。铝合金钎焊片具有其中在芯材的一侧上设置钎焊材料的双层结构。芯材含有Si：0.6〜1.0质量％，Cu：0.6〜1.0质量％，Mn：0.7〜1.8质量％，Mg：0.1〜0.7质量％，Ti：0.06〜0.20质量％，余量：Al 和不可避免的杂质。钎焊材料包括含有Si：3.0〜12.0质量％的铝合金，铝合金钎焊片的规定为0.6〜1.4mm，芯材表面中的{001}面的面积比为0.3以上。

6. 发明授权

US08247084B2 Aluminum alloy brazing sheet 有权
标题翻译：铝合金钎焊板
公开(公告)号：US08247084B2
公开(公告)日：2012-08-21
申请号：US13099695
申请日：2011-05-03
申请人： Shimpei Kimura , Toshiki Ueda , Takahiro Izumi
发明人： Shimpei Kimura , Toshiki Ueda , Takahiro Izumi
IPC分类号： B32B15/20 , F28F21/08
CPC分类号： C22C21/00 , B23K35/28 , B23K35/286 , B32B15/016 , C22C21/10 , C22C21/14 , C22F1/04 , C22F1/043 , C22F1/047 , C22F1/053 , C22F1/057 , F28F21/089 , Y10T428/12076 , Y10T428/12764
摘要： An aluminum alloy brazing sheet includes a core material containing Si, Cu and Mn by a predetermined amount, the balance being Al and inevitable impurities, a sacrificial anode material disposed on one face side of the core material and containing Si, Zn and Mg by a predetermined amount, the balance being Al and inevitable impurities, and a brazing filler material disposed on the other face side of the core material and formed of an aluminum alloy, and the area fraction of Zn—Mg-based intermetallic compounds with 2.0 μm or above particle size on the surface of the sacrificial anode material may be 1.0% or below. Or otherwise, in the aluminum alloy brazing sheet, the number density of Al—Cu-based intermetallic compounds with 0.5 μm or above particle size inside the core material may be 1.0 piece/μm2 or below.
摘要翻译：铝合金钎焊片包括含有预定量的Si，Cu和Mn的芯材，余量为Al和不可避免的杂质，牺牲阳极材料设置在芯材的一个正面，并含有Si，Zn和Mg 预定量，余量为Al和不可避免的杂质，以及设置在芯材的另一个面上并由铝合金形成的钎料，以及2.0μm以上的Zn-Mg系金属间化合物的面积率牺牲阳极材料的表面上的粒径可以为1.0％以下。否则，在铝合金钎焊片中，核心材料内部具有0.5μm以上粒径的Al-Cu系金属间化合物的数密度可以为1.0片/μm2以下。

7. 发明授权

US08247083B2 Aluminium alloy brazing sheet 有权
标题翻译：铝合金钎焊板
公开(公告)号：US08247083B2
公开(公告)日：2012-08-21
申请号：US13099590
申请日：2011-05-03
申请人： Takahiro Izumi , Toshiki Ueda , Shimpei Kimura
发明人： Takahiro Izumi , Toshiki Ueda , Shimpei Kimura
IPC分类号： B32B15/20 , F28F21/08
CPC分类号： B23K35/286 , B23K35/0233 , B23K2101/14 , B32B15/016 , C22C21/00 , C22C21/02 , C22C21/04 , C22F1/043 , C22F1/053 , F28F21/089 , Y10T428/12028 , Y10T428/12764
摘要： To provide an aluminum alloy brazing sheet which can improve erosion resistance while maintaining post-braze strength, brazability, formability, corrosion resistance and other properties even when Mg is added to the core material. The aluminum alloy brazing sheet comprises an Al—Si-based or Al—Si—Zn-based filler material cladded on at least one side of a core material. The core material comprises Si: 0.3 to 1.0% by mass, Mn: 0.6 to 2.0% by mass, Cu: 0.3 to 1.0% by mass, Mg: 0.15 to 0.5% by mass, Ti: 0.05 to 0.25% by mass, with the remainder being Al and inevitable impurities, and has the density of an Mg—Si-based, Al—Mg—Cu-based, Al—Cu—Mg—Si-based intermetallic compound with a particle size smaller than 0.5 μm of 10000/mm2 or higher, or has the density of the Mg—Si-based, Al—Mg—Cu-based and Al—Cu—Mg—Si-based intermetallic compounds with a particle size of 1.0 μm or larger lower than 5000/mm2.
摘要翻译：提供即使将Mg添加到芯材中也能够保持钎焊后强度，钎焊性，成形性，耐腐蚀性等特性，能够提高耐侵蚀性的铝合金钎焊片。铝合金钎焊板包括包覆在芯材的至少一侧的Al-Si系或Al-Si-Zn系填料。芯材的Si：0.3〜1.0质量％，Mn：0.6〜2.0质量％，Cu：0.3〜1.0质量％，Mg：0.15〜0.5质量％，Ti：0.05〜0.25质量％其余为Al和不可避免的杂质，并且具有粒径小于0.5μm的Mg-Si系，Al-Mg-Cu系，Al-Cu-Mg-Si系金属间化合物的密度为10000 / 或者具有粒径为1.0μm以上且低于5000 / mm2的Mg-Si系，Al-Mg-Cu系和Al-Cu-Mg-Si系金属间化合物的密度。

8. 发明申请

US20110287276A1 ALUMINIUM ALLOY BRAZING SHEET 有权
标题翻译：铝合金烧结片
公开(公告)号：US20110287276A1
公开(公告)日：2011-11-24
申请号：US13099590
申请日：2011-05-03
申请人： Takahiro Izumi , Toshiki Ueda , Shimpei Kimura
发明人： Takahiro Izumi , Toshiki Ueda , Shimpei Kimura
IPC分类号： B22F7/02
CPC分类号： B23K35/286 , B23K35/0233 , B23K2101/14 , B32B15/016 , C22C21/00 , C22C21/02 , C22C21/04 , C22F1/043 , C22F1/053 , F28F21/089 , Y10T428/12028 , Y10T428/12764
摘要： To provide an aluminium alloy brazing sheet which can improve erosion resistance while maintaining post-braze strength, brazability, formability, corrosion resistance and other properties even when Mg is added to the core material. The aluminium alloy brazing sheet comprises an Al—Si-based or Al—Si—Zn-based filler material cladded on at least one side of a core material. The core material comprises Si: 0.3 to 1.0% by mass, Mn: 0.6 to 2.0% by mass, Cu: 0.3 to 1.0% by mass, Mg: 0.15 to 0.5% by mass, Ti: 0.05 to 0.25% by mass, with the remainder being Al and inevitable impurities, and has the density of an Mg—Si-based, Al—Mg—Cu-based, Al—Cu—Mg—Si-based intermetallic compound with a particle size smaller than 0.5 μm of 10000/mm2 or higher, or has the density of the Mg—Si-based, Al—Mg—Cu-based and Al—Cu—Mg—Si-based intermetallic compounds with a particle size of 1.0 μm or larger lower than 5000/mm2.
摘要翻译：提供即使将Mg添加到芯材中也能够保持钎焊后强度，钎焊性，成形性，耐腐蚀性等特性，能够提高耐侵蚀性的铝合金钎焊片。铝合金钎焊板包括包覆在芯材的至少一侧的Al-Si系或Al-Si-Zn系填料。芯材的Si：0.3〜1.0质量％，Mn：0.6〜2.0质量％，Cu：0.3〜1.0质量％，Mg：0.15〜0.5质量％，Ti：0.05〜0.25质量％其余为Al和不可避免的杂质，并且具有粒径小于0.5μm的Mg-Si系，Al-Mg-Cu系，Al-Cu-Mg-Si系金属间化合物的密度为10000 / 或者具有粒径为1.0μm以上且低于5000 / mm2的Mg-Si系，Al-Mg-Cu系和Al-Cu-Mg-Si系金属间化合物的密度。

9. 发明申请

US20110236717A1 ALUMINUM ALLOY BRAZING SHEET 有权
标题翻译：铝合金烧结片
公开(公告)号：US20110236717A1
公开(公告)日：2011-09-29
申请号：US13037543
申请日：2011-03-01
申请人： Toshiki UEDA , Shimpei Kimura , Takahiro Izumi
发明人： Toshiki UEDA , Shimpei Kimura , Takahiro Izumi
IPC分类号： B23K35/24 , B32B15/20
CPC分类号： B23K35/0266 , B23K35/0238 , B23K35/286 , B32B15/016 , C22C21/00 , C22C21/02 , C22C21/14 , C22F1/04 , C22F1/043 , C22F1/057 , F28D1/05316 , F28F9/001 , F28F9/18 , F28F21/089 , Y10T428/12764
摘要： There is provided an aluminum alloy brazing sheet having an improved brazability than in the related art while keeping the post-braze strength, workability, corrosion resistance, and the like at respective prescribed or higher levels. An aluminum alloy brazing sheet has a two-layered structure in which on one side of a core material, a brazing material is provided. The core material contains Si: 0.6 to 1.0 mass %, Cu: 0.6 to 1.0 mass %, Mn: 0.7 to 1.8 mass %, Mg: 0.1 to 0.7 mass %, and Ti: 0.06 to 0.20 mass %, and the balance including Al and inevitable impurities. The brazing material includes an aluminum alloy containing Si: 3.0 to 12.0 mass %, the gage of the aluminum alloy brazing sheet is 0.6 to 1.4 mm, and the area ratio of a {001} plane in the core material surface is 0.3 or more.
摘要翻译：提供了一种铝合金钎焊片，其具有比现有技术更好的钎焊性，同时保持钎焊强度，加工性，耐腐蚀性等在规定或更高的水平。铝合金钎焊片具有其中在芯材的一侧上设置钎焊材料的双层结构。芯材含有Si：0.6〜1.0质量％，Cu：0.6〜1.0质量％，Mn：0.7〜1.8质量％，Mg：0.1〜0.7质量％，Ti：0.06〜0.20质量％，余量：Al 和不可避免的杂质。钎焊材料包括含有Si：3.0〜12.0质量％的铝合金，铝合金钎焊片的规定为0.6〜1.4mm，芯材表面中的{001}面的面积比为0.3以上。

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