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1. 发明授权

US5155125A Method of treating gastrointestinal ulcers with spiro hydantoins 失效
标题翻译：用SPIRO HYDANTOINS治疗胃肠综合征的方法
公开(公告)号：US5155125A
公开(公告)日：1992-10-13
申请号：US600872
申请日：1990-10-22
申请人： Kiichi Sawai , Masayasu Kurono , Kazumasa Nakano , Makoto Sato , Noboru Kuboyama , Takashi Ito , Yoshiya Kondo
发明人： Kiichi Sawai , Masayasu Kurono , Kazumasa Nakano , Makoto Sato , Noboru Kuboyama , Takashi Ito , Yoshiya Kondo
IPC分类号： A61K9/00 , A61K9/06 , A61K9/107 , A61K31/00 , A61K31/415 , A61K31/425 , A61K31/50 , A61K45/00 , A61P17/00 , A61P43/00
CPC分类号： A61K31/50 , A61K31/00 , A61K31/415 , A61K31/425 , Y10S514/926
摘要： A therapeutic preparation for ulcers contains as a primary ingredient a compound having an aldose reductase inhibitory activity and can accelerate dermal metabolism. That compound may be d-6-fluoro-2,3-dihydro-2',5'-dioxo-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2-carboxyamide, d-2-chloromethyl-6-fluoro-2,3-dihydro-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione and d-2-bromomethyl-6-fluoro-2,3-dihydro-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione.

2. 发明申请

US20110012276A1 Method For Manufacturing Molded Article With Core 审中-公开
标题翻译：用核心制造成型品的方法
公开(公告)号：US20110012276A1
公开(公告)日：2011-01-20
申请号：US12823137
申请日：2010-06-25
申请人： Yuichi Ozeki , Yoshiya Kondo , Yukinao Watanabe
发明人： Yuichi Ozeki , Yoshiya Kondo , Yukinao Watanabe
IPC分类号： B29C43/20
CPC分类号： A61J3/06 , A61J3/10 , A61K9/2054 , A61K9/2081 , A61K9/2095 , B30B11/02 , B30B11/08 , B30B11/34 , B60R13/0206 , B60R13/0212 , Y10T428/29
摘要： A method for manufacturing molded articles with cores uses a compression molding apparatus that includes upper and lower punches that have a double structure comprising a central punch and an outer punch that surrounds the periphery of the central punch. The central punch and the outer punch are movable and capable either of moving together or sliding with respect to one another. Molding materials are supplied for a core and an outer layer. The molding materials are compressed by the punches to form molded articles that include the core. The method may be executed in a rotary compression molding machine.
摘要翻译：用于制造具有芯的模塑制品的方法使用压缩成型装置，该压缩成型装置包括具有双重结构的上冲头和下冲头，该冲头具有围绕中心冲头的周边的中心冲头和外冲头。中心冲头和外冲头是可移动的并且能够相互移动在一起或滑动。为核心和外层提供成型材料。成型材料通过冲头压缩以形成包括芯的模制品。该方法可以在旋转压缩成型机中执行。

3. 发明授权

US07811488B2 Method for manufacturing molded article with core 有权
标题翻译：具有芯的模制品的制造方法
公开(公告)号：US07811488B2
公开(公告)日：2010-10-12
申请号：US10317360
申请日：2002-12-12
申请人： Yuichi Ozeki , Yoshiya Kondo , Yukinao Watanabe
发明人： Yuichi Ozeki , Yoshiya Kondo , Yukinao Watanabe
IPC分类号： A61J3/00 , A61J3/06 , A61J3/10 , A61K9/20 , A61K9/28 , B30B11/02 , B30B11/08 , B30B15/30 , B30B11/00
CPC分类号： A61J3/06 , A61J3/10 , A61K9/2054 , A61K9/2081 , A61K9/2095 , B30B11/02 , B30B11/08 , B30B11/34 , B60R13/0206 , B60R13/0212 , Y10T428/29
摘要： A method for manufacturing a molded article with at one or more cores uses compression molding apparatus that includes upper and lower punches that have a double structure comprising a central punch and an outer punch that surrounds the periphery of the central punch. The central punch and the outer punch are capable of independent sliding motions and compressing operations. Molding materials are supplied for a core and an outer layer respectively. The molding materials are compressed by the punches to form molded articles that include the core. The method may be executed in a rotary compression molding machine.
摘要翻译：用于制造具有一个或多个芯体的模制品的方法使用压缩成型装置，其包括具有双重结构的上冲头和下冲头，所述双冲程包括围绕中心冲头的周边的中心冲头和外冲头。中心冲头和外冲头能够独立的滑动运动和压缩操作。为核心和外层分别提供成型材料。成型材料通过冲头压缩以形成包括芯的模制品。该方法可以在旋转压缩成型机中执行。

4. 发明授权

US07132072B2 Method for producing multi-cored molded article 有权
标题翻译：多芯成型品的制造方法
公开(公告)号：US07132072B2
公开(公告)日：2006-11-07
申请号：US10490880
申请日：2002-09-24
申请人： Yuichi Ozeki , Yoshiya Kondo , Yukinao Watanabe
发明人： Yuichi Ozeki , Yoshiya Kondo , Yukinao Watanabe
IPC分类号： B29C43/04
CPC分类号： B30B11/08 , A61J3/06 , A61J3/10 , A61K9/2072 , B30B11/34 , Y10T428/15 , Y10T428/239
摘要： To manufacture a multi-core press-coated molded product efficiently and in a single step from molding materials, namely, powder or granular particles, a punch has been devised that is characterized in that the punch, consists of a center punch whose tip portion is split into two or more parts, and an outer punch enclosing the outer perimeter of the center punch, and whose tip portion fills the gap at the tip portion of the center punch, with both the center and outer punches being slidable and manipulatable for compression operation the method of manufacturing a multi-core press-coated molded product using the punch of the invention as compression molding means for at least the upper punch and preferably for both the upper and lower punches, and a rotary compression molding machine therefore is also discribed. This has led to the successful manufacture of a multi-core press-coated molded product in which a plurality of cores are arranged horizontally relative to the pressure applied surface of the molded product and further located at specific positions. When provided with a score line, the multi-core press-coated molded product can be made into a dividable molded product.
摘要翻译：为了从模制材料即粉末或颗粒状颗粒中有效地和单步地制造多芯压制成型产品，已经设计出一种冲头，其特征在于冲头由中心冲头组成，中心冲头的顶端部分为分为两个或多个部件，以及包围中心冲头的外周边的外冲头，其顶部填充中心冲头的尖端部分处的间隙，中心冲头和外冲头都可滑动并可操作用于压缩操作因此，使用本发明的冲头制造多芯压制成形品的方法至少用于上冲头和上冲头以及上冲头和下冲头的压模机，因此也描述了旋转压缩成型机。这导致成功地制造多芯压制成型制品，其中多个芯相对于模制产品的施加压力的表面水平布置并且进一步位于特定位置。当设有刻痕线时，可以将多芯压制成型产品制成可分割的模制产品。

5. 发明申请

US20050202082A1 Press-coated molded article undergoing quick disintegration 审中-公开
标题翻译：压制成型制品经历快速分解
公开(公告)号：US20050202082A1
公开(公告)日：2005-09-15
申请号：US10491027
申请日：2002-09-27
申请人： Tsuneyuki Hibino , Yuichi Ozeki , Yoshiya Kondo , Yukinao Watanabe
发明人： Tsuneyuki Hibino , Yuichi Ozeki , Yoshiya Kondo , Yukinao Watanabe
IPC分类号： A61J3/10 , A61K9/00 , A61K9/20 , A61K9/24 , A61K9/28 , B30B11/08 , B30B11/34
CPC分类号： B30B11/08 , A61J3/10 , A61K9/0056 , A61K9/209 , A61K9/2095 , A61K9/2826 , A61K9/2866 , A61K9/2893 , B30B11/34 , B30B15/0082
摘要： A press-coated fast-dissolving/disintegrating molded product of the present invention is characterized in that the molded product comprises an inner core that contains ingredients rich in dissolubility or/and disintegrability and whose disintegration time is 1 minute or less and an outer layer that contains ingredients rich in moldability on the outside of the inner core and whose disintegration time is 1 minute or less and that the disintegration time of the entire molded product is 1 minute or less. Preferably, here, ingredients rich in dissolubility or/and disintegrability are further contained in the outer layer and dissolution/disintegration accelerants in the inner core. Thus, by allowing the molded product to have a double structure consisting of an outer layer and inner core and imparting moldability to the outer layer alone—the layer that requires strength—and excellent dissolubility/disintegrability to the inner core, the molded product has been perfected that offers an extremely fast dissolution/disintegration time with sufficient moldability. The present molded product can be readily manufactured by compression molding means having punches above and below a die, with at least the upper punch having a double structure consisting of a center punch and an outer punch enclosing the outer perimeter of the center punch and both the center and outer punches being slidable and manipulatable for compression operation.
摘要翻译：本发明的压制型快速溶解/崩解成型体的特征在于，成型体含有内芯，该内芯含有溶解性或/和崩解性优异且崩解时间为1分钟以下的成分，外层为在内芯的外侧含有成型性高的成分，其崩解时间为1分钟以下，整个成型品的崩解时间为1分钟以下。优选地，在内层中还含有富含溶解性或/和崩解性的组分，并且内核中的溶解/崩解促进剂。因此，通过使成型体具有由外层和内芯构成的双重结构，并且仅对外层赋予成形性 - 对于内芯需要强度和优异的溶解性/崩解性的层，成型体已经完美的提供极快的溶解/崩解时间，具有足够的成型性。本发明的模制产品可以容易地通过在模具上方和下方具有冲压件的压模装置制造，至少上冲头具有由中心冲头和外冲头组成的双重结构，该冲头包围中心冲头的外周边，中心和外部冲头可滑动和可操作用于压缩操作。

6. 发明申请

US20050013960A1 Multi-cored molded article, method of producing the same, and device for producing the same 有权
标题翻译：多芯成型品及其制造方法及其制造方法
公开(公告)号：US20050013960A1
公开(公告)日：2005-01-20
申请号：US10490880
申请日：2002-09-24
申请人： Yuichi Ozeki , Yoshiya Kondo , Yukinao Watanabe
发明人： Yuichi Ozeki , Yoshiya Kondo , Yukinao Watanabe
IPC分类号： A61J3/06 , A61J3/10 , A61K9/20 , B29C43/36 , B30B11/08 , B30B11/34 , G09F3/00
CPC分类号： B30B11/08 , A61J3/06 , A61J3/10 , A61K9/2072 , B30B11/34 , Y10T428/15 , Y10T428/239
摘要： To manufacture a multi-core press-coated molded product efficiently and in a single step from molding materials, namely, powder or granular particles, a punch has been devised that is characterized in that the punch, consists of a center punch whose tip portion is split into two or more parts, and an outer punch enclosing the outer perimeter of the center punch, and whose tip portion fills the gap at the tip portion of the center punch, with both the center and outer punches being slidable and manipulatable for compression operation. the method of manufacturing a multi-core press-coated molded product using the punch of the invention as compression molding means for at least the upper punch and preferably for both the upper and lower punches, and a rotary compression molding machine therefore is also discribed. This has led to the successful manufacture of a multi-core press-coated molded product in which a plurality of cores are arranged horizontally relative to the pressure applied surface of the molded product and further located at specific positions. When provided with a score line, the multi-core press-coated molded product can be made into a dividable molded product.
摘要翻译：为了从模制材料即粉末或颗粒状颗粒中有效地和单步地制造多芯压制成型产品，已经设计出一种冲头，其特征在于冲头由中心冲头组成，中心冲头的顶端部分为分为两个或多个部件，以及包围中心冲头的外周边的外冲头，其顶部填充中心冲头的尖端部分处的间隙，中心冲头和外冲头都可滑动并可操作用于压缩操作。因此，使用本发明的冲头制造多芯压制成形品的方法至少用于上冲头和上冲头以及上冲头和下冲头的压模机，因此也描述了旋转压缩成型机。这导致成功地制造多芯压制成型制品，其中多个芯相对于模制产品的施加压力的表面水平布置并且进一步位于特定位置。当设有刻痕线时，可以将多芯压制成型产品制成可分割的模制产品。

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