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1. 发明申请

US20120130227A1 System and Method for Assessing Response to Chemotherapy Using Magnetic Resonance Elastography 有权
标题翻译：使用磁共振弹性成像评估化疗反应的系统和方法
公开(公告)号：US20120130227A1
公开(公告)日：2012-05-24
申请号：US13301300
申请日：2011-11-21
申请人： Kiaran P. McGee , Richard L. Ehman , Stephen M. Ansell , Yogesh K. Mariappan , Jun Chen
发明人： Kiaran P. McGee , Richard L. Ehman , Stephen M. Ansell , Yogesh K. Mariappan , Jun Chen
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/0051
摘要： A system and method for determining a response of a tumor following a chemotherapy process includes the use of a magnetic resonance elastography (MRE) driver and a magnetic resonance imaging (MRI) system. The method includes controlling the MRE driver and the MRI system to acquire raw MRE data from the tumor, inverting the raw MRE data to produce an elastogram of the tumor, and determining a response of the tumor to the chemotherapy process from the elastogram.
摘要翻译：用于确定化疗后肿瘤反应的系统和方法包括使用磁共振弹性成像（MRE）驱动器和磁共振成像（MRI）系统。该方法包括控制MRE驱动器和MRI系统从肿瘤获取原始MRE数据，反转原始MRE数据以产生肿瘤的弹性图，并从弹性图确定肿瘤对化疗过程的反应。

2. 发明授权

US09750426B2 System and method for assessing response to chemotherapy using magnetic resonance elastography 有权
公开(公告)号：US09750426B2
公开(公告)日：2017-09-05
申请号：US13301300
申请日：2011-11-21
申请人： Kiaran P McGee , Richard L Ehman , Stephen M Ansell , Yogesh K Mariappan , Jun Chen
发明人： Kiaran P McGee , Richard L Ehman , Stephen M Ansell , Yogesh K Mariappan , Jun Chen
IPC分类号： A61B5/055 , A61B5/00
CPC分类号： A61B5/055 , A61B5/0051
摘要： A system and method for determining a response of a tumor following a chemotherapy process includes the use of a magnetic resonance elastography (MRE) driver and a magnetic resonance imaging (MRI) system. The method includes controlling the MRE driver and the MRI system to acquire raw MRE data from the tumor, inverting the raw MRE data to produce an elastogram of the tumor, and determining a response of the tumor to the chemotherapy process from the elastogram.

3. 发明申请

US20140073906A1 Passive Acoustic Driver for Magnetic Resonance Elastography 审中-公开
标题翻译：磁共振弹性成像的被动声驱动器
公开(公告)号：US20140073906A1
公开(公告)日：2014-03-13
申请号：US14082587
申请日：2013-11-18
申请人： Richard L. Ehman , Phillip J. Rossman , Jun Chen
发明人： Richard L. Ehman , Phillip J. Rossman , Jun Chen
IPC分类号： G01R33/563 , A61B5/055 , G01R33/48 , A61B8/08 , A61B8/00
CPC分类号： G01R33/56358 , A61B5/0051 , A61B5/055 , A61B8/4236 , A61B8/485 , G01R33/28 , G01R33/4814
摘要： An acoustic driver system for use in applying an oscillating stress to a subject undergoing a magnetic resonance elastography (MRE) examination includes a flexible passive driver located in the bore of the magnet and in contact with the subject. A remotely located active driver is acoustically coupled to the passive driver and produces acoustic energy in response to an applied current. The passive driver produces shear waves in response to the acoustic energy and are directed into the body of the subject undergoing the MRE examination.
摘要翻译：用于向经历磁共振弹性成像（MRE）检查的对象施加振荡应力的声学驱动器系统包括位于磁体的孔中并与对象接触的柔性被动驱动器。远程定位的有源驱动器与无源驱动器声学耦合，并响应于所施加的电流产生声能。被动驱动器响应于声能产生剪切波，并被引导到经历MRE检查的对象的身体中。

4. 发明申请

US20120259201A1 System and Method for Inertial Magnetic Resonance Elastography Driver for Use With Interventional Medical Device 有权
标题翻译：用于介入医疗器械的惯性磁共振弹性成像驱动器的系统和方法
公开(公告)号：US20120259201A1
公开(公告)日：2012-10-11
申请号：US13435657
申请日：2012-03-30
申请人： Jun Chen , David A. Woodrum , Kevin J. Glaser , Richard L. Ehman , Phillip J. Rossman
发明人： Jun Chen , David A. Woodrum , Kevin J. Glaser , Richard L. Ehman , Phillip J. Rossman
IPC分类号： A61B5/055 , A61M25/08 , A61M25/095 , A61N5/067
CPC分类号： A61B5/055 , A61B5/0051 , A61B18/22 , A61B2018/00577 , G01R33/285 , G01R33/56358
摘要： A system and method for performing a magnetic resonance elastography (MRE) procedure using an MRI system to monitor operation of a medical device performing a medical procedure. The driver system includes a housing, a port located in the housing and connected to a driving power, and an inertial driver moved within the housing by the driving power. A passage is formed in the housing and extends from a first opening in the housing, through the inertial driver, and to a second opening in the housing. The inertial driver receives a medical device extending through the passage and engages the medical device to impart oscillatory motion thereto as the inertial driver is moved by the driving power. The imparted oscillatory motion travels along the medical device as a waveguide to deliver the oscillatory motion to tissue receiving the medical procedure to perform the MRE procedure.
摘要翻译：一种使用MRI系统执行磁共振弹性成像（MRE）程序以监测执行医疗程序的医疗装置的操作的系统和方法。驱动器系统包括壳体，位于壳体中并连接到驱动力的端口，以及通过驱动力在壳体内移动的惯性驾驶员。通道形成在壳体中并且从壳体中的第一开口穿过惯性驱动器延伸到壳体中的第二开口。惯性驾驶员接收通过通道延伸的医疗装置，并且当惯性驾驶员被驱动力移动时，该医疗装置接合医疗装置以给予振荡运动。所施加的振荡运动沿着医疗装置作为波导传播，以将振荡运动传递到接收医疗过程的组织以执行MRE过程。

5. 发明申请

US20140114177A1 SYSTEM AND METHOD FOR MAGNETIC RESONANCE ELASTOGRAPHY OF THE BREAST 审中-公开
标题翻译：乳腺磁共振成像系统及方法
公开(公告)号：US20140114177A1
公开(公告)日：2014-04-24
申请号：US14112324
申请日：2012-04-17
申请人： Jun Chen , Kevin J. Glaser , Richard L. Ehman , Jennifer L. Kugel
发明人： Jun Chen , Kevin J. Glaser , Richard L. Ehman , Jennifer L. Kugel
IPC分类号： G01R33/563 , A61B5/055
CPC分类号： A61B5/0555 , A61B5/0051 , A61B5/055 , A61B5/4312 , G01R33/56358
摘要： A system and method for performing magnetic resonance elastography (MRE] of a patient's breasts is provided. An MRE driver configured to be placed on the sternum of the patient is used to impart mechanical energy to the sternum, which in turn generates shear waves in at least one of the patient's breasts. Such a driver is amenable to use with standard breast radio frequency (RF] coils without the need for modification of the existing breast RF coil hardware.
摘要翻译：提供了一种用于执行患者乳房的磁共振弹性成像（MRE）的系统和方法，被配置为放置在患者胸骨上的MRE驱动器用于向胸骨施加机械能，这又产生剪切波至少一个患者的乳房，这样的司机适合与标准的乳房射频（RF）线圈一起使用，而不需要修改现有的乳房RF线圈硬件。

6. 发明申请

US20090299168A1 Passive Acoustic Driver For Magnetic Resonance Elastography 有权
标题翻译：用于磁共振弹性成像的被动声学驱动器
公开(公告)号：US20090299168A1
公开(公告)日：2009-12-03
申请号：US12418204
申请日：2009-04-03
申请人： Richard L. Ehman , Phillip J. Rossman , Jun Chen
发明人： Richard L. Ehman , Phillip J. Rossman , Jun Chen
IPC分类号： A61B5/055
CPC分类号： G01R33/56358 , A61B5/0051 , A61B5/055 , A61B8/4236 , A61B8/485 , G01R33/28 , G01R33/4814
摘要： An acoustic driver system for use in applying an oscillating stress to a subject undergoing a magnetic resonance elastography (MRE) examination includes a flexible passive driver located in the bore of the magnet and in contact with the subject. A remotely located active driver is acoustically coupled to the passive driver and produces acoustic energy in response to an applied current. The passive driver produces shear waves in response to the acoustic energy and are directed into the body of the subject undergoing the MRE examination.
摘要翻译：用于向经历磁共振弹性成像（MRE）检查的对象施加振荡应力的声学驱动器系统包括位于磁体的孔中并与对象接触的柔性被动驱动器。远程定位的有源驱动器与无源驱动器声学耦合，并响应于所施加的电流产生声能。被动驱动器响应于声能产生剪切波，并被引导到经历MRE检查的对象的身体中。

7. 发明授权

US09149204B2 Flexible passive acoustic driver for magnetic resonance elastography 有权
标题翻译：用于磁共振弹性成像的柔性无源声学驱动器
公开(公告)号：US09149204B2
公开(公告)日：2015-10-06
申请号：US13453681
申请日：2012-04-23
申请人： Richard L. Ehman , Jun Chen , Phillip J. Rossman
发明人： Richard L. Ehman , Jun Chen , Phillip J. Rossman
IPC分类号： A61B5/055 , A61B5/00 , A61B8/08
CPC分类号： A61B5/055 , A61B5/0051 , A61B8/485
摘要： A flexible passive acoustic driver for use in an acoustic driver system which applies an oscillating stress to a subject undergoing a magnetic resonance elastography (MRE) examination which includes receiving acoustic pressure waves from an active driver through a tube and imparts pressure waves to a subject of an imaging procedure. In one configuration, the passive driver includes a flexible bag that forms the walls of an acoustic cavity, and a structure filling material located inside the acoustic cavity provides support for the flexible bag. The flexible bag conforms to the shape of the subject and may be held in place by an elastic band. The passive driver can have an integrated or detachable non-active push-on compartment which is rigid or semi-flexible to improve the human-driver mechanical coupling and the driver energy efficiency of converting acoustic pressure to mechanical vibration applied to a subject.
摘要翻译：一种在声学驱动器系统中使用的灵活的无源声学驱动器，其向经历磁共振弹性成像（MRE）检查的对象施加振荡应力，该检查包括通过管接收来自主动驱动器的声压波并将压力波施加到成像过程。在一种配置中，被动驱动器包括形成声腔的壁的柔性袋，并且位于声腔内的结构填充材料为柔性袋提供支撑。柔性袋符合被检者的形状，可以通过弹性带保持在适当的位置。被动驱动器可以具有集成或可拆卸的非活动推动隔室，其是刚性或半柔性的，以改善人 - 驱动器机械耦合以及将声压转换为施加到对象的机械振动的驾驶员能量效率。

8. 发明授权

US09173589B2 System and method for inertial magnetic resonance elastography driver for use with interventional medical device 有权
标题翻译：用于介入医疗器械的惯性磁共振弹性成像驱动器的系统和方法
公开(公告)号：US09173589B2
公开(公告)日：2015-11-03
申请号：US13435657
申请日：2012-03-30
申请人： Jun Chen , David A. Woodrum , Kevin J. Glaser , Richard L. Ehman , Phillip J. Rossman
发明人： Jun Chen , David A. Woodrum , Kevin J. Glaser , Richard L. Ehman , Phillip J. Rossman
IPC分类号： A61B5/05 , A61B5/055 , G01R33/28 , G01R33/563 , A61B18/22 , A61B18/00
CPC分类号： A61B5/055 , A61B5/0051 , A61B18/22 , A61B2018/00577 , G01R33/285 , G01R33/56358
摘要： A system and method for performing a magnetic resonance elastography (MRE) procedure using an MRI system to monitor operation of a medical device performing a medical procedure. The driver system includes a housing, a port located in the housing and connected to a driving power, and an inertial driver moved within the housing by the driving power. A passage is formed in the housing and extends from a first opening in the housing, through the inertial driver, and to a second opening in the housing. The inertial driver receives a medical device extending through the passage and engages the medical device to impart oscillatory motion thereto as the inertial driver is moved by the driving power. The imparted oscillatory motion travels along the medical device as a waveguide to deliver the oscillatory motion to tissue receiving the medical procedure to perform the MRE procedure.
摘要翻译：一种使用MRI系统执行磁共振弹性成像（MRE）程序以监测执行医疗程序的医疗装置的操作的系统和方法。驱动器系统包括壳体，位于壳体中并连接到驱动力的端口，以及通过驱动力在壳体内移动的惯性驾驶员。通道形成在壳体中并且从壳体中的第一开口穿过惯性驱动器延伸到壳体中的第二开口。惯性驾驶员接收通过通道延伸的医疗装置，并且当惯性驾驶员被驱动力移动时，该医疗装置接合医疗装置以给予振荡运动。所施加的振荡运动沿着医疗装置作为波导传播，以将振荡运动传递到接收医疗过程的组织以执行MRE过程。

9. 发明授权

US08615285B2 Passive acoustic driver for magnetic resonance elastography 有权
标题翻译：用于磁共振弹性成像的无源声学驱动器
公开(公告)号：US08615285B2
公开(公告)日：2013-12-24
申请号：US12418204
申请日：2009-04-03
申请人： Richard L Ehman , Phillip J. Rossman , Jun Chen
发明人： Richard L Ehman , Phillip J. Rossman , Jun Chen
IPC分类号： A61B5/05
CPC分类号： G01R33/56358 , A61B5/0051 , A61B5/055 , A61B8/4236 , A61B8/485 , G01R33/28 , G01R33/4814
摘要： An acoustic driver system for use in applying an oscillating stress to a subject undergoing a magnetic resonance elastography (MRE) examination includes a flexible passive driver located in the bore of the magnet and in contact with the subject. A remotely located active driver is acoustically coupled to the passive driver and produces acoustic energy in response to an applied current. The passive driver produces shear waves in response to the acoustic energy and are directed into the body of the subject undergoing the MRE examination.
摘要翻译：用于向经历磁共振弹性成像（MRE）检查的对象施加振荡应力的声学驱动器系统包括位于磁体的孔中并与对象接触的柔性被动驱动器。远程定位的有源驱动器与无源驱动器声学耦合，并响应于所施加的电流产生声能。被动驱动器响应于声能产生剪切波，并被引导到经历MRE检查的对象的身体中。

10. 发明申请

US20120271150A1 Flexible Passive Acoustic Driver for Magnetic Resonance Elastography 有权
标题翻译：用于磁共振弹性的柔性无源声学驱动器
公开(公告)号：US20120271150A1
公开(公告)日：2012-10-25
申请号：US13453681
申请日：2012-04-23
申请人： Richard L. Ehman , Jun Chen , Phillip J. Rossman
发明人： Richard L. Ehman , Jun Chen , Phillip J. Rossman
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/0051 , A61B8/485
摘要： A flexible passive acoustic driver for use in an acoustic driver system which applies an oscillating stress to a subject undergoing a magnetic resonance elastography (MRE) examination which includes receiving acoustic pressure waves from an active driver through a tube and imparts pressure waves to a subject of an imaging procedure. In one configuration, the passive driver includes a flexible bag that forms the walls of an acoustic cavity, and a structure filling material located inside the acoustic cavity provides support for the flexible bag. The flexible bag conforms to the shape of the subject and may be held in place by an elastic band. The passive driver can have an integrated or detachable non-active push-on compartment which is rigid or semi-flexible to improve the human-driver mechanical coupling and the driver energy efficiency of converting acoustic pressure to mechanical vibration applied to a subject.
摘要翻译：一种在声学驱动器系统中使用的灵活的无源声学驱动器，其向经历磁共振弹性成像（MRE）检查的对象施加振荡应力，该检查包括通过管接收来自主动驱动器的声压波并将压力波施加到成像过程。在一种配置中，被动驱动器包括形成声腔的壁的柔性袋，并且位于声腔内的结构填充材料为柔性袋提供支撑。柔性袋符合被检者的形状，可以通过弹性带保持在适当的位置。被动驱动器可以具有集成或可拆卸的非活动推动隔室，其是刚性或半柔性的，以改善人 - 驱动器机械耦合以及将声压转换为施加到被摄体的机械振动的驱动能量效率。

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