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1. 发明申请

US20130289471A1 GAS BASED WOUND AND TISSUE THERAPEUTICS 审中-公开
标题翻译：基于气体和组织治疗
公开(公告)号：US20130289471A1
公开(公告)日：2013-10-31
申请号：US13886832
申请日：2013-05-03
申请人： Kevin R. Ward , Robert Diegelmann , Bruce Spiess , Gary S Huvard , Gurbhagat S Sandhu , Gary Bowlin , Chris Stern
发明人： Kevin R. Ward , Robert Diegelmann , Bruce Spiess , Gary S Huvard , Gurbhagat S Sandhu , Gary Bowlin , Chris Stern
IPC分类号： A61L15/20 , A61L15/44
CPC分类号： A61L15/20 , A61F13/00063 , A61F13/069 , A61F2013/00153 , A61F2013/00157 , A61F2013/0017 , A61F2013/00246 , A61F2013/00285 , A61F2013/00468 , A61F2013/00519 , A61F2013/00646 , A61F2013/00906 , A61F2013/00919 , A61K9/1271 , A61K33/00 , A61L15/44 , A61L2300/11 , A61L2300/114 , A61L2300/608
摘要： This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perfluorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue.
摘要翻译：本发明提供包括隔室和包含氧气和其它治疗气体储存形式和全氟化碳的层的制品和绷带。本发明还提供了将氧气和其它治疗气体输送到受试者组织中的方法，包括向组织施用包含全氟化碳和氧气或治疗气体储存形式的组合物，从而将氧气或治疗气体输送到组织。

2. 发明申请

US20090202617A1 Gas based wound and tissue therapeutics 审中-公开
标题翻译：基于气体的伤口和组织治疗
公开(公告)号：US20090202617A1
公开(公告)日：2009-08-13
申请号：US12378460
申请日：2009-02-13
申请人： Kevin R. Ward , Robert Diegelmann , Bruce Spiess , Gary S. Huvard , Gurbhagat S. Sandhu , Gary Bowlin , Chris Stern
发明人： Kevin R. Ward , Robert Diegelmann , Bruce Spiess , Gary S. Huvard , Gurbhagat S. Sandhu , Gary Bowlin , Chris Stern
IPC分类号： A61L15/16 , A61K33/40 , A61K33/00 , A61K33/04 , A61K9/20 , A61K38/44 , A61P17/00 , A61P17/02
CPC分类号： A61L15/20 , A61F13/00063 , A61F13/069 , A61F2013/00153 , A61F2013/00157 , A61F2013/0017 , A61F2013/00246 , A61F2013/00285 , A61F2013/00468 , A61F2013/00519 , A61F2013/00646 , A61F2013/00906 , A61F2013/00919 , A61K9/1271 , A61K33/00 , A61L15/44 , A61L2300/11 , A61L2300/114 , A61L2300/608
摘要： This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perfluorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue.
摘要翻译：本发明提供包括隔室和包含氧气和其它治疗气体储存形式和全氟化碳的层的制品和绷带。本发明还提供了将氧气和其它治疗气体输送到受试者组织中的方法，包括向组织施用包含全氟化碳和氧气或治疗气体储存形式的组合物，从而将氧气或治疗气体输送到组织。

3. 发明申请

US20120184898A1 GAS BASED WOUND AND TISSUE THERAPEUTICS 审中-公开
标题翻译：基于气体和组织治疗
公开(公告)号：US20120184898A1
公开(公告)日：2012-07-19
申请号：US13433120
申请日：2012-03-28
申请人： Kevin R. Ward , Robert Diegelmann , Bruce Spiess , Gary S. Huvard , Gurbhagat S. Sandhu , Gary Bowlin , Chris Stern
发明人： Kevin R. Ward , Robert Diegelmann , Bruce Spiess , Gary S. Huvard , Gurbhagat S. Sandhu , Gary Bowlin , Chris Stern
IPC分类号： A61M37/00
CPC分类号： A61L15/20 , A61F13/00063 , A61F13/069 , A61F2013/00153 , A61F2013/00157 , A61F2013/0017 , A61F2013/00246 , A61F2013/00285 , A61F2013/00468 , A61F2013/00519 , A61F2013/00646 , A61F2013/00906 , A61F2013/00919 , A61K9/1271 , A61K33/00 , A61L15/44 , A61L2300/11 , A61L2300/114 , A61L2300/608
摘要： This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perfluorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue.
摘要翻译：本发明提供包括隔室和包含氧气和其它治疗气体储存形式和全氟化碳的层的制品和绷带。本发明还提供了将氧气和其它治疗气体输送到受试者组织中的方法，包括向组织施用包含全氟化碳和氧气或治疗气体储存形式的组合物，从而将氧气或治疗气体输送到组织。

4. 发明授权

US08497408B2 Treatment for high pressure bleeding 有权
标题翻译：治疗高压出血
公开(公告)号：US08497408B2
公开(公告)日：2013-07-30
申请号：US11855205
申请日：2007-09-14
申请人： Gary Wnek , Marcus E. Carr, Jr. , Gary Bowlin , Kelman I. Cohen , Kevin R. Ward , Wayne Barbee , Rao Ivatury
发明人： Gary Wnek , Marcus E. Carr, Jr. , Gary Bowlin , Kelman I. Cohen , Kevin R. Ward , Wayne Barbee , Rao Ivatury
IPC分类号： A61F13/00
CPC分类号： A61L26/0061 , A61B17/0057 , A61B17/122 , A61B17/132 , A61B2017/00659 , A61F13/0269 , A61K9/0048 , A61L15/22 , A61L24/106 , A61L24/108 , A61L2400/04
摘要： High-pressure bleeding wounds (and other bleeding wounds) may be treated by applying direct pressure directly in the bleeding wound, such as by applying a back pressure in a confined space around and in the wound. Certain substances and articles may be inserted into the wound, and the wound may be enclosed with that substance or article (such as a hemostatic substance, which may be polymeric), by swelling on contact with molecules (such as water molecules in the blood) encountered in the wound, generates the desired pressure to stop or at least reduce the bleeding without the detrimental effects of a tourniquet. Clot-inducing substances may be introduced into the wound contemporaneously with direct pressure application directly in the wound. Compressible and non-compressible wounds are treated. Treatment stops bleeding without producing pressure injury or ischemic damage. Medical devices using this technology are provided, including removable, biodegradable, medic-administrable devices.
摘要翻译：可以通过直接对出血伤口施加直接压力来治疗高压出血性伤口（和其他出血性伤口），例如通过在围绕和缠绕的受限空间中施加背压。某些物质和制品可以插入到伤口中，并且伤口可以与该物质或制品（例如可以是聚合物的止血物质）一起被封闭，通过与分子（例如血液中的水分子）接触而膨胀，在伤口中遇到，产生所需的停止压力或至少减少出血，而不会有止血带的不利影响。可以直接在伤口中直接施加压力诱导物质同时引入伤口。可压缩和不可压缩的伤口被处理。治疗停止出血而不产生压力损伤或缺血性损伤。提供使用此技术的医疗设备，包括可拆卸，可生物降解的医疗管理设备。

5. 发明申请

US20120221025A1 ELECTROSPUN NERVE GUIDES FOR NERVE REGENERATION DESIGNED TO MODULATE NERVE ARCHITECTURE 有权
标题翻译：用于神经再生的ELECTROSPUN神经指南设计用于调节神经结构
公开(公告)号：US20120221025A1
公开(公告)日：2012-08-30
申请号：US13394415
申请日：2010-09-14
申请人： David Simpson , Gary Bowlin , Raymond Colello , Woon Chow , Balendu Shekhar Jha
发明人： David Simpson , Gary Bowlin , Raymond Colello , Woon Chow , Balendu Shekhar Jha
IPC分类号： A61F2/02 , B29C35/16
CPC分类号： A61L27/18 , A61B17/1128 , A61F2/02 , A61L2430/32 , C08L67/04
摘要： Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.
摘要翻译：提供由高度排列的电纺纤维的三维（3D）阵列形成的神经引导件。电纺纤维被定向成平行于引导件的长轴线，并且叠置的光纤阵列之间的间隙和细长空间提供用于定向轴突生长的通道。在一些实施例中，神经导向器还包括诸如生长因子的有益物质的高精度梯度，其有助于神经再生和沿着引导物的生长。

6. 发明申请

US20080009898A1 TREATMENT FOR HIGH PRESSURE BLEEDING 有权
标题翻译：高压治疗
公开(公告)号：US20080009898A1
公开(公告)日：2008-01-10
申请号：US11855205
申请日：2007-09-14
申请人： Gary WNEK , Marcus Carr , Gary Bowlin , Kelman Cohen , Kevin Ward , Wayne Barbee , Rao Ivatury
发明人： Gary WNEK , Marcus Carr , Gary Bowlin , Kelman Cohen , Kevin Ward , Wayne Barbee , Rao Ivatury
IPC分类号： A61B17/12
CPC分类号： A61L26/0061 , A61B17/0057 , A61B17/122 , A61B17/132 , A61B2017/00659 , A61F13/0269 , A61K9/0048 , A61L15/22 , A61L24/106 , A61L24/108 , A61L2400/04
摘要： High-pressure bleeding wounds (and other bleeding wounds) may be treated by applying direct pressure directly in the bleeding wound, such as by applying a back pressure in a confined space around and in the wound. Certain substances and articles may be inserted into the wound, and the wound may be enclosed with that substance or article (such as a hemostatic substance, which may be polymeric), by swelling on contact with molecules (such as water molecules in the blood) encountered in the wound, generates the desired pressure to stop or at least reduce the bleeding without the detrimental effects of a tourniquet. Clot-inducing substances may be introduced into the wound contemporaneously with direct pressure application directly in the wound. Compressible and non-compressible wounds are treated. Treatment stops bleeding without producing pressure injury or ischemic damage. Medical devices using this technology are provided, including removable, biodegradable, medic-administrable devices.
摘要翻译：可以通过直接对出血伤口施加直接压力来治疗高压出血性伤口（和其他出血性伤口），例如通过在围绕和缠绕的受限空间中施加背压。某些物质和制品可以插入到伤口中，并且伤口可以与该物质或制品（例如可以是聚合物的止血物质）一起被封闭，通过与分子（例如血液中的水分子）接触而膨胀，在伤口中遇到，产生所需的停止压力或至少减少出血，而不会有止血带的不利影响。可以直接在伤口中直接施加压力诱导物质同时引入伤口。可压缩和不可压缩的伤口被处理。治疗停止出血而不产生压力损伤或缺血性损伤。提供使用此技术的医疗设备，包括可拆卸，可生物降解的医疗管理设备。

7. 发明申请

US20080038352A1 Electroprocessed Collagen and Tissue Engineering 审中-公开
标题翻译：电加工胶原和组织工程
公开(公告)号：US20080038352A1
公开(公告)日：2008-02-14
申请号：US11842748
申请日：2007-08-21
申请人： David Simpson , Gary Bowlin , Gary Wnek , Peter Stevens , Marcus Carr , Jamil Matthews , Saravanamoorthy Rajendran
发明人： David Simpson , Gary Bowlin , Gary Wnek , Peter Stevens , Marcus Carr , Jamil Matthews , Saravanamoorthy Rajendran
IPC分类号： A61K9/14 , A61K35/12 , A61P41/00
CPC分类号： B29C67/0007 , A61F2/08 , A61K38/00 , A61K2035/126 , A61L15/32 , A61L27/18 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/507 , A61L31/041 , A61L2430/30 , B29C41/006 , C07K14/78 , C12N5/0012 , C12N5/0068 , C12N2533/40 , C12N2533/54 , D01D5/0038 , D01F1/10 , D01F4/00 , Y10T428/298 , Y10T442/2525 , Y10T442/60 , Y10T442/614 , C08L67/04 , C08L89/00 , C08L89/06
摘要： The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.
摘要翻译：本发明涉及电加工胶原的形成和使用，包括用作细胞外基质，并与细胞一起用于形成工程化组织。工程组织可以包括可以植入受体的特定器官或组织的合成制造。电处理胶原蛋白也可以与其他分子组合，以将物质递送到电加工胶原的施用部位或植入。将胶原或胶原/细胞悬浮液电沉积在基质上以形成组织和器官。

8. 发明申请

US20070225631A1 Sealants for Skin and Other Tissues 审中-公开
标题翻译：皮肤和其他组织的密封剂
公开(公告)号：US20070225631A1
公开(公告)日：2007-09-27
申请号：US10588344
申请日：2003-10-06
申请人： Gary Bowlin , David Simpson , Gary Wnek , Marcus Carr , Peter Stevens , Gary Cadd , I. Cohen
发明人： Gary Bowlin , David Simpson , Gary Wnek , Marcus Carr , Peter Stevens , Gary Cadd , I. Cohen
IPC分类号： A61F13/00 , A61K38/17 , C07K1/00
CPC分类号： A61L24/102 , A61F2/105 , A61F2013/00314 , A61F2013/00472 , A61K38/363 , A61K38/39 , A61L24/106 , C07K14/78 , Y10T428/298 , A61K2300/00
摘要： The present invention relates to sealants for skin and other tissues. The sealants include an electroprocessed material. The sealants may contain more than one electroprocessed materials and may contain additional substances. The invention further relates to methods of making and using such sealants.
摘要翻译：本发明涉及用于皮肤和其它组织的密封剂。密封剂包括电加工材料。密封剂可能含有多于一种的电处理材料，并且可能含有其他物质。本发明还涉及制造和使用这种密封剂的方法。

9. 发明授权

US09572909B2 Electrospun nerve guides for nerve regeneration designed to modulate nerve architecture 有权
标题翻译：用于神经再生的电极神经导管设计用于调节神经结构
公开(公告)号：US09572909B2
公开(公告)日：2017-02-21
申请号：US13394415
申请日：2010-09-14
申请人： David Simpson , Gary Bowlin , Raymond Colello , Woon Chow , Balendu Shekhar Jha
发明人： David Simpson , Gary Bowlin , Raymond Colello , Woon Chow , Balendu Shekhar Jha
IPC分类号： A61L27/18 , A61F2/02 , A61B17/11
CPC分类号： A61L27/18 , A61B17/1128 , A61F2/02 , A61L2430/32 , C08L67/04
摘要： Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.
摘要翻译：提供由高度排列的电纺纤维的三维（3D）阵列形成的神经引导件。电纺纤维被定向成平行于引导件的长轴线，并且叠置的光纤阵列之间的间隙和细长空间提供用于定向轴突生长的通道。在一些实施例中，神经导向器还包括诸如生长因子的有益物质的高精度梯度，其有助于神经再生和沿着引导物的生长。

10. 发明申请

US20050192622A1 Method of fusing electroprocessed matrices to a substrate 审中-公开
标题翻译：将电处理基质熔合到基底上的方法
公开(公告)号：US20050192622A1
公开(公告)日：2005-09-01
申请号：US11096482
申请日：2005-04-01
申请人： Gary Bowlin
发明人： Gary Bowlin
IPC分类号： A61F2/01 , A61M5/165 , A61M29/00
CPC分类号： A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61M5/165 , A61M25/09 , A61M2025/09183
摘要： An electroprocessed matrix of polymer, and specifically an electrospun matrix of fibers is attached to a substrate be using electroprocessing technique variations. First the electroprocessing equipment is configured to coat a substrate with a layer of electrosprayed droplets or wet, electrospun fibers, or a mixture thereof. The equipment is then modified to form an electrospun matrix of fibers onto the coated substrate.
摘要翻译：聚合物的电加工基质，特别是纤维的电纺丝基质，使用电加工技术的变化，附着在基材上。首先，电处理设备被配置为用电喷雾液滴层或湿电纺丝纤维或其混合物涂覆基底。然后对设备进行改性以在涂覆的基材上形成纤维的电纺丝基质。

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