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1. 发明授权

US5672694A .beta.-sarcoglycan nucleic acid sequence, and nucleic acid probes 失效
标题翻译： β-聚糖核酸序列和核酸探针
公开(公告)号：US5672694A
公开(公告)日：1997-09-30
申请号：US547182
申请日：1995-10-24
申请人： Kevin P. Campbell , Leland Lim , Franck Duclos , Yoshihide Sunada , Jacques S. Beckmann , Odile Broux , Fernando M. S. Tome , Michel Fardeau , Charles E. Jackson
发明人： Kevin P. Campbell , Leland Lim , Franck Duclos , Yoshihide Sunada , Jacques S. Beckmann , Odile Broux , Fernando M. S. Tome , Michel Fardeau , Charles E. Jackson
IPC分类号： A61K39/00 , C07K14/47 , C12Q1/68 , C07H19/00 , C07H21/02 , C07H21/04
CPC分类号： C07K14/4707 , C12Q1/6883 , A61K39/00 , C12Q2600/156 , C12Q2600/172
摘要： Disclosed herein is a substantially pure nucleic acid sequence encoding a mammalian 43 kDa non-dystrophin component (.beta.-sarcoglycan) of the dystrophin-glycoprotein complex. Also disclosed are immunogenic peptides which, when used to immunize a mammal, stimulate the production of antibodies which bind specifically to the .beta.-sarcoglycan. Mutations in the .beta.-sarcoglycan gene which are associated with autosomal recessive limb-girdle muscular dystrophy are also disclosed. The identification of such mutations enables the design of nucleic acid probes which hybridize specifically to a mutant form of .beta.-sarcoglycan, or the complement thereof, but not to the DNA of the wild-type form of the gene (or the complement thereof), under stringent hybridization conditions. Such probes are useful, for example, in connection with the diagnosis of autosomal recessive limb-girdle muscular dystrophy. In addition, the identification of such mutations enables the diagnosis of autosomal recessive limb-girdle muscular dystrophy through the use of direct DNA sequencing techniques.
摘要翻译：本文公开了编码肌营养不良蛋白 - 糖蛋白复合物的哺乳动物43kDa非肌营养不良蛋白成分（β-卡非糖）的基本上纯的核酸序列。还公开了免疫原性肽，其当用于免疫哺乳动物时，刺激特异性结合β-糖聚糖的抗体的产生。还公开了与常染色体隐性遗传性肢体肌营养不良症相关的β - 肌凝蛋白基因的突变。这种突变的鉴定使得能够设计与β-丝裂核糖苷或其补体的突变形式特异性杂交的核酸探针，而不与野生型形式的基因（或其补体）的DNA杂交，在严格的杂交条件下。这样的探针可用于例如与常染色体隐性性腰带肌营养不良症的诊断有关。此外，通过使用直接DNA测序技术，鉴定这种突变能够诊断常染色体隐性的腰带肌营养不良症。

2. 发明授权

US07691250B2 Membrane-mediated electropolishing with topographically patterned membranes 失效
标题翻译：膜介导的电抛光与地形图案膜
公开(公告)号：US07691250B2
公开(公告)日：2010-04-06
申请号：US11413367
申请日：2006-04-28
申请人： Stephen Mazur , Charles E. Jackson , Gary W. Foggin
发明人： Stephen Mazur , Charles E. Jackson , Gary W. Foggin
IPC分类号： B23H3/00 , C25D17/00 , C25B9/08
CPC分类号： B23H5/08 , C25F3/00 , C25F3/02 , C25F7/00 , H01L21/32115 , H01L21/32125 , H01L21/7684
摘要： This invention provides membrane-mediated electropolishing (MMEP) processes for polishing and/or planarizing metal work pieces using topographically patterned membranes. The processes can be used for both pure metals and alloys, and provide advantages over conventional electropolishing processes and known MMEP processes using smooth membranes. This invention also provides a cathode half-cell and an apparatus useful in membrane-mediated electropolishing processes. The invention also provides processes for electroengraving and electromachining topographic patterns, holes and/or grooves into the surface of a metal work piece.
摘要翻译：本发明提供了膜介导的电解抛光（MMEP）工艺，用于使用拓扑图案化的膜抛光和/或平面化金属工件。这些方法可用于纯金属和合金，并且比使用平滑膜的常规电解抛光方法和已知的MMEP方法提供优点。本发明还提供了阴极半电池和用于膜介导的电解抛光方法的装置。本发明还提供了将金属工件的表面电雕刻和电加工地形图案，孔和/或凹槽的方法。

3. 发明授权

US5867806A System and method for performing inversion on LWD resistivity logs with enhanced resolution 失效
标题翻译：在LWD电阻率测井中进行反演的系统和方法，具有更高的分辨率
公开(公告)号：US5867806A
公开(公告)日：1999-02-02
申请号：US734772
申请日：1996-10-22
申请人： Robert W. Strickland , Gulamabbas A. Merchant , Charles E. Jackson , Herbert Max Joseph Illfelder
发明人： Robert W. Strickland , Gulamabbas A. Merchant , Charles E. Jackson , Herbert Max Joseph Illfelder
IPC分类号： G01V3/38 , G06F19/00
CPC分类号： G01V3/38
摘要： A system and method for performing inversion and for correcting for shoulder bed effect. The method enhances the resolution of wave propagation resistivity logs and corrects the logs for adjacent bed effects, whereby the resulting logs have a vertical response as good as wireline high-resolution induction logs. The method first performs logging while drilling on a formation to obtain LWD resistivity log data. The method then selects one or more control depths at one or more locations of each of a plurality of detected beds in the formation. The present invention includes a novel method for selecting bed boundaries from the log data, and the control depths are then determined based on the determined bed boundaries. The method then estimates the resistivity of each bed only at the selected control depths to produce an estimated resistivity of the beds. The method then computes a simulated log value at each control depth using a current estimate of the resistivity of the beds. The computed simulated log, is then compared to the actual log data at each control depth, and the resistivity of each bed is adjusted using the difference between the actual and simulated values at the control depths. The above method iteratively repeats a plurality of times until the simulated log substantially matches the actual log at the control depths.
摘要翻译：一种用于执行反转和校正肩部床效应的系统和方法。该方法提高了波传播电阻率测井的分辨率，并校正了相邻床效应的原木，从而得到的原木垂直响应与有线高分辨率感应测井一样好。该方法首先在地层上钻井时进行测井以获得LWD电阻率测井数据。然后，该方法在地层中的多个检测到的床中的每一个的一个或多个位置处选择一个或多个控制深度。本发明包括从日志数据中选择床边界的新方法，然后基于确定的床边界来确定控制深度。然后，该方法仅在所选择的控制深度处估计每个床的电阻率，以产生床的估计电阻率。然后，该方法使用当前对床的电阻率的估计来计算每个控制深度处的模拟对数值。然后将计算的模拟日志与每个控制深度的实际日志数据进行比较，并使用控制深度的实际值和模拟值之间的差值来调整每个床的电阻率。上述方法迭代重复多次，直到模拟日志与控制深度的实际日志基本匹配。

4. 发明授权

US4164269A Safety bracket for securing ladder in place 失效
标题翻译：安全支架用于将梯子固定到位
公开(公告)号：US4164269A
公开(公告)日：1979-08-14
申请号：US953962
申请日：1978-10-23
申请人： Charles E. Jackson
发明人： Charles E. Jackson
IPC分类号： E06C7/48
CPC分类号： E06C7/48
摘要： A safety bracket for securing a ladder in place against a building structure, the bracket having two extending arm members interconnected in crossing relation intermediate the respective ends thereof with each arm member being slidable with respect to the other. Each arm member includes an intermediate portion and two end portions pivotally joined to the intermediate portion, the two end portions of each arm member including, respectively, a hook shaped portion which may be hooked around an upright member of a ladder and an eyelet for receiving therethrough a projecting member secured to the building structure.
摘要翻译：一种用于将梯子固定在建筑结构上的安全支架，所述支架具有两个延伸的臂构件，所述两个延伸的臂构件在其相应端部之间的交叉关系中互相连接，每个臂构件可相对于另一个滑动。每个臂构件包括中间部分和两个枢转地连接到中间部分的端部，每个臂构件的两个端部分别包括钩状部分，该钩状部分可以钩在梯子的直立构件和孔眼上，用于接收通过其固定到建筑结构的突出构件。

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