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1. 发明授权

US08492150B2 Engineered cell growth on polymeric films and biotechnological applications thereof 失效
标题翻译：聚合物膜上的工程化细胞生长及其生物技术应用
公开(公告)号：US08492150B2
公开(公告)日：2013-07-23
申请号：US12223560
申请日：2007-02-05
申请人： Kevin Kit Parker , Adam W. Feinberg , George M. Whitesides , Sergey S. Shevkoplyas , Alexander Feigel
发明人： Kevin Kit Parker , Adam W. Feinberg , George M. Whitesides , Sergey S. Shevkoplyas , Alexander Feigel
IPC分类号： C12N5/07
CPC分类号： G01N33/5061 , C12N5/0062 , C12N5/0657 , C12N2533/30 , C12N2533/52 , C12N2539/10 , G01N2500/10
摘要： A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.
摘要翻译：独立的薄膜由包括涂覆有牺牲聚合物层的基层的结构制成，牺牲聚合物层又被柔性聚合物层涂覆。然后将细胞接种到柔性聚合物层上并进行培养以形成组织。然后将柔性聚合物层从基底层释放出来，以产生包含柔性聚合物层上的组织的自立薄膜。在一个实施方案中，细胞是肌细胞，其可被致动以推动或置换自立膜。在另一个实施方案中，自立膜用于治疗受损的人体组织。

2. 发明申请

US20090317852A1 Engineered Cell Growth on Polymeric Films and Biotechnological Applications Thereof 失效
标题翻译：聚合物膜上的工程化细胞生长及其生物技术应用
公开(公告)号：US20090317852A1
公开(公告)日：2009-12-24
申请号：US12223560
申请日：2007-02-05
申请人： Kevin Kit Parker , Adam W. Feinberg , George M. Whitesides , Sergey S. Shevkoplyas , Alexander Feigel
发明人： Kevin Kit Parker , Adam W. Feinberg , George M. Whitesides , Sergey S. Shevkoplyas , Alexander Feigel
IPC分类号： C12Q1/02 , C12N5/06
CPC分类号： G01N33/5061 , C12N5/0062 , C12N5/0657 , C12N2533/30 , C12N2533/52 , C12N2539/10 , G01N2500/10
摘要： A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.
摘要翻译：独立的薄膜由包括涂覆有牺牲聚合物层的基层的结构制成，牺牲聚合物层又被柔性聚合物层涂覆。然后将细胞接种到柔性聚合物层上并进行培养以形成组织。然后将柔性聚合物层从基底层释放出来，以产生包含柔性聚合物层上的组织的自立薄膜。在一个实施方案中，细胞是肌细胞，其可被致动以推动或置换自立膜。在另一个实施方案中，自立膜用于治疗受损的人体组织。

3. 发明授权

US09409265B2 Three dimensional assembly of diamagnetic materials using magnetic levitation 有权
标题翻译：使用磁悬浮的抗磁材料三维组装
公开(公告)号：US09409265B2
公开(公告)日：2016-08-09
申请号：US13994595
申请日：2011-12-20
申请人： George M. Whitesides , Filip Ilievski , Audrey Ellerbee , Sergey S. Shevkoplyas , Katherine A. Mirica
发明人： George M. Whitesides , Filip Ilievski , Audrey Ellerbee , Sergey S. Shevkoplyas , Katherine A. Mirica
IPC分类号： C30B30/04 , B23P19/04 , B03C1/01 , B03C1/28 , B81C3/00
CPC分类号： B23P19/04 , B03C1/01 , B03C1/288 , B03C2201/18 , B81C3/005 , B81C2203/054 , B81C2203/057 , B81C2203/058 , C30B30/04 , Y10S117/901 , Y10T29/49826
摘要： The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.
摘要翻译：描述了使用悬浮在含有顺磁阳离子的溶液中的反磁性颗粒组装三维结构的能力。这种分离装置的主要优点是：（i）它是一种不需要电力的简单装置（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）组装的结构可以在固定结构之后从顺磁溶液中除去以进一步处理; iii）装配快速; 和iv）它是小，便携式。

4. 发明授权

US09551706B2 Density-based methods for separation of materials, monitoring of solid supported reactions and measuring densities of small liquid volumes and solids 有权
标题翻译：用于分离材料的基于密度的方法，监测固体支持的反应和测量小液体体积和固体的密度
公开(公告)号：US09551706B2
公开(公告)日：2017-01-24
申请号：US12666132
申请日：2008-06-30
申请人： Scott T. Phillips , George M. Whitesides , Katherine A. Mirica , Emanuel Carrilho , Andres W. Martinez , Sergey S. Shevkoplyas , Phillip W. Snyder , Raquel Perez-Castillejos , Malancha Gupta , Adam Winkleman , Katherine L. Gudiksen
发明人： Scott T. Phillips , George M. Whitesides , Katherine A. Mirica , Emanuel Carrilho , Andres W. Martinez , Sergey S. Shevkoplyas , Phillip W. Snyder , Raquel Perez-Castillejos , Malancha Gupta , Adam Winkleman , Katherine L. Gudiksen
IPC分类号： G01N33/553 , G01N33/543 , B01L3/00 , G01R33/12 , B01D35/06
CPC分类号： G01N33/5434 , B01L3/502761 , B01L3/502776 , B01L3/50825 , B01L2200/0652 , B01L2300/045 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , G01N33/54333 , G01R33/1269
摘要： The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.
摘要翻译：描述了使用非均匀磁场悬浮在含有顺磁性阳离子的溶液中的反磁性颗粒悬浮，分离和检测密度变化的能力。这种分离装置的主要优点是：i）不需要电力的简单装置（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）它与简单的光学检测（只要透明材料用于制造分离发生的容器/通道）兼容; iii）收集分离的颗粒进行进一步处理是简单的; iv）不需要对颗粒/材料进行磁性标记; 和v）它是小，便携。所提供的方法和试剂盒用于分离和收集不同密度的材料，用于检测感兴趣的分析物的诊断，固体支持的化学反应的监测和固体和液体混合物的密度的测定。

5. 发明授权

US08486833B2 Fabrication of conductive pathways, microcircuits and microstructures in microfluidic networks 有权
标题翻译：微流控网络中导电通路，微电路和微结构的制作
公开(公告)号：US08486833B2
公开(公告)日：2013-07-16
申请号：US11920483
申请日：2006-05-18
申请人： Derek A. Bruzewicz , Mila Boncheva-Bettex , George M. Whitesides , Adam Siegel , Douglas B. Weibel , Sergey S. Shevkoplyas , Andres Martinez
发明人： Derek A. Bruzewicz , Mila Boncheva-Bettex , George M. Whitesides , Adam Siegel , Douglas B. Weibel , Sergey S. Shevkoplyas , Andres Martinez
IPC分类号： H01L21/44 , H01L21/4763
CPC分类号： H05K3/101 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2400/0415 , B33Y80/00 , H05K1/0272 , H05K1/032 , H05K3/389 , H05K2201/0162 , H05K2201/0305 , H05K2203/128 , Y10T29/49117
摘要： Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as “microsolidic” devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.
摘要翻译：本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。在某些实施方案中，所形成的装置包括通过固化存在于一个或多个微流体通道中的液体金属形成的导电通路（以下称为“微溶体”装置）。在某些这样的器件中，其中可以在微流体结构中的区域之间形成和/或重组电连接; 在一些情况下，形成的器件/电路可以是柔性的和/或涉及柔性电气部件。在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。在某些这样的实施例中，所形成的导电路径可以位于结构的其它微流体通道附近，其携带流动的流体，使得导电路径可以产生与其相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。在某些实施方案中，所形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

6. 发明申请

US20110045577A1 Fabrication of conductive pathways, microcircuits and microstructures in microfluidic networks 有权
标题翻译：微流控网络中导电通路，微电路和微结构的制作
公开(公告)号：US20110045577A1
公开(公告)日：2011-02-24
申请号：US11920483
申请日：2006-05-18
申请人： Derek A. Bruzewicz , Mila Boncheva-Bettex , George M. Whitesides , Adam Siegel , Douglas B. Weibel , Sergey S. Shevkoplyas , Andres Martinez
发明人： Derek A. Bruzewicz , Mila Boncheva-Bettex , George M. Whitesides , Adam Siegel , Douglas B. Weibel , Sergey S. Shevkoplyas , Andres Martinez
IPC分类号： C12M1/00 , G01N33/00 , H01R43/00
CPC分类号： H05K3/101 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2400/0415 , B33Y80/00 , H05K1/0272 , H05K1/032 , H05K3/389 , H05K2201/0162 , H05K2201/0305 , H05K2203/128 , Y10T29/49117
摘要： Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as “microsolidic” devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.
摘要翻译：本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。在某些实施方案中，所形成的装置包括通过固化存在于一个或多个微流体通道中的液体金属形成的导电通路（以下称为“微溶体”装置）。在某些这样的器件中，其中可以在微流体结构中的区域之间形成和/或重组电连接; 在一些情况下，形成的器件/电路可以是柔性的和/或涉及柔性电气部件。在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。在某些这样的实施例中，所形成的导电路径可以位于结构的其它微流体通道附近，其携带流动的流体，使得导电路径可以产生与其相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。在某些实施方案中，所形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

7. 发明申请

US20100285606A1 DENSITY-BASED METHODS FOR SEPARATION OF MATERIALS, MONITORING OF SOLID SUPPORTED REACTIONS AND MEASURING DENSITIES OF SMALL LIQUID VOLUMES AND SOLIDS 有权
标题翻译：用于分离材料的基于密度的方法，监测固体支持反应和测量小液体和固体的浓度
公开(公告)号：US20100285606A1
公开(公告)日：2010-11-11
申请号：US12666132
申请日：2008-06-30
申请人： Scott T. Phillips , George M. Whitesides , Katherine A. Mirica , Emanuel Carrilho , Andres W. Martinez , Sergey S. Shevkoplyas , Phillip W. Snyder , Raquel Perez-Castillejos , Malancha Gupta , Adam Winkleman , Katherine L. Gudiksen
发明人： Scott T. Phillips , George M. Whitesides , Katherine A. Mirica , Emanuel Carrilho , Andres W. Martinez , Sergey S. Shevkoplyas , Phillip W. Snyder , Raquel Perez-Castillejos , Malancha Gupta , Adam Winkleman , Katherine L. Gudiksen
IPC分类号： G01N33/553 , G01N33/44 , G01N33/53 , G01N33/20 , G01N33/14
CPC分类号： G01N33/5434 , B01L3/502761 , B01L3/502776 , B01L3/50825 , B01L2200/0652 , B01L2300/045 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , G01N33/54333 , G01R33/1269
摘要： The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.
摘要翻译：描述了使用非均匀磁场悬浮在含有顺磁性阳离子的溶液中的反磁性颗粒悬浮，分离和检测密度变化的能力。这种分离装置的主要优点是：i）不需要电力的简单装置（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）它与简单的光学检测（只要透明材料用于制造分离发生的容器/通道）兼容; iii）收集分离的颗粒进行进一步处理是简单的; iv）不需要对颗粒/材料进行磁性标记; 和v）它是小，便携。所提供的方法和试剂盒用于分离和收集不同密度的材料，用于检测感兴趣的分析物的诊断，固体支持的化学反应的监测和固体和液体混合物的密度的测定。

8. 发明申请

US20170023556A1 Paper Based Diagnostic Test 审中-公开
标题翻译：纸基诊断测试
公开(公告)号：US20170023556A1
公开(公告)日：2017-01-26
申请号：US15215107
申请日：2016-07-20
申请人： Sergey S. Shevkoplyas , Xiaoxi Yang , Julie Kanter Washko , Nathaniel Zane Piety
发明人： Sergey S. Shevkoplyas , Xiaoxi Yang , Julie Kanter Washko , Nathaniel Zane Piety
IPC分类号： G01N33/52 , G01N30/92 , G01N33/86 , G01N33/80 , G01N33/66
CPC分类号： G01N33/523 , G01N30/90 , G01N30/92 , G01N33/526 , G01N33/66 , G01N33/80 , G01N33/86 , G01N2333/805
摘要： The present invention relates to simple, low-cost, rapid paper-based diagnostic devices and their methods of use.
摘要翻译：本发明涉及简单，低成本，快速的纸基诊断装置及其使用方法。

9. 发明申请

US20140123461A1 THREE DIMENSIONAL ASSEMBLY OF DIAMAGNETIC MATERIALS USING MAGNETIC LEVITATION 有权
标题翻译：使用磁力捕获的二维材料的三维装配
公开(公告)号：US20140123461A1
公开(公告)日：2014-05-08
申请号：US13994595
申请日：2011-12-20
申请人： George M. Whitesids , Filip Iievski , Audrey Ellerbee , Sergey S. Shevkoplyas , Katherine A. Mirica
发明人： George M. Whitesids , Filip Iievski , Audrey Ellerbee , Sergey S. Shevkoplyas , Katherine A. Mirica
IPC分类号： B23P19/04
CPC分类号： B23P19/04 , B03C1/01 , B03C1/288 , B03C2201/18 , B81C3/005 , B81C2203/054 , B81C2203/057 , B81C2203/058 , C30B30/04 , Y10S117/901 , Y10T29/49826
摘要： The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.
摘要翻译：描述了使用悬浮在含有顺磁阳离子的溶液中的反磁性颗粒组装三维结构的能力。这种分离装置的主要优点是：（i）它是一种不需要电力的简单装置（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）组装的结构可以在固定结构之后从顺磁溶液中除去以进一步处理; iii）装配快速; 和iv）它是小，便携式。

10. 发明申请

US20140295472A1 Paper Based Diagnostic Test 审中-公开
标题翻译：纸基诊断测试
公开(公告)号：US20140295472A1
公开(公告)日：2014-10-02
申请号：US14357074
申请日：2012-11-13
申请人： Sergey S. Shevkoplyas , Xiaoxi Yang , Julie Kanter Washko , Nathaniel Zane Piety
发明人： Sergey S. Shevkoplyas , Xiaoxi Yang , Julie Kanter Washko , Nathaniel Zane Piety
IPC分类号： G01N33/52 , G01N33/80
CPC分类号： G01N33/523 , G01N30/90 , G01N30/92 , G01N33/526 , G01N33/66 , G01N33/80 , G01N33/86 , G01N2333/805
摘要： A device utilizing agglutination and its method of use to diagnose diseases or conditions. The diagnostic device may comprise a substrate having pores, an agglutination zone, and a test readout zone wherein said agglutination zone is functionalized with an agglutinating agent to cause agglutination of the sample.
摘要翻译：利用凝集的装置及其诊断疾病或病症的方法。诊断装置可以包括具有孔的基底，凝集区和测试读出区，其中所述凝集区用凝集剂官能化以引起样品的凝集。

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