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1. 发明申请

US20060085340A1 Methods and systems for managing consumer transactional accounts 有权
标题翻译：管理消费者交易账户的方法和系统
公开(公告)号：US20060085340A1
公开(公告)日：2006-04-20
申请号：US11169526
申请日：2005-06-29
申请人： Kevin Hung , Susan Moon , Eric Yellin , Alice Yu
发明人： Kevin Hung , Susan Moon , Eric Yellin , Alice Yu
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q20/10 , G06Q20/102 , G06Q20/108 , G06Q30/04
摘要： Computer-implemented methods and systems for managing consumer transactional accounts provides a temporary line of credit with an installment option that a consumer can use for specific occasions or life events. The account remains open for only a limited period of time during which interest does not accrue. Thereafter, the account automatically expires, interest begins to accrue on the amount charged on the account, and an invoice is sent to the consumer with a number of payment options.
摘要翻译：用于管理消费者交易账户的计算机实现的方法和系统为消费者可以用于特定场合或生活事件的分期付款选项提供临时信用额度。该帐户只有在不产生利息的有限期间内才开放。此后，帐户自动到期，利息开始累积在帐户上的金额，发票将发送给具有多个付款方式的消费者。

2. 发明申请

US20060129454A1 Methods and systems for implementing a group buy 审中-公开
标题翻译：实施小组购买的方法和系统
公开(公告)号：US20060129454A1
公开(公告)日：2006-06-15
申请号：US11205825
申请日：2005-08-17
申请人： Susan Moon , Eric Yellin , Alice Yu , Kevin Hung , Evan Minskoff , B. Ballman
发明人： Susan Moon , Eric Yellin , Alice Yu , Kevin Hung , Evan Minskoff , B. Ballman
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0255 , G06Q30/06 , G06Q30/0601
摘要： Methods and systems for utilizing consumer transaction data to target and aggregate consumers for a group purchase involve maintaining a database storing transaction data consisting at least in part of data related to product purchase transactions for a plurality of consumers and analyzing the data related to product purchase transactions to identify members of a group of said plurality of consumers with a purchase history indicative of a preference for purchasing products in at least one pre-defined category of products. Based on such “data mining”, each member of the identified group of consumers is provided an offer to participate in a group purchase in which each member of the group who accepts the offer agrees to purchase a pre-designated product within the at least one category of products, and a purchase of a quantity of the pre-designated product from a vendor is negotiated at a discounted price based at least on part on an aggregation of purchasing power of the members of the group who accept the offer to participate in the group purchase.
摘要翻译：用于利用消费者交易数据来定价和聚集消费者进行组购买的方法和系统包括维护数据库，存储至少部分由多个消费者的产品购买交易相关数据组成的数据，并分析与产品购买交易有关的数据以具有指示在至少一个预定义类别的产品中购买产品的偏好的购买历史来识别一组所述多个消费者的成员。基于这样的“数据挖掘”，所识别的消费群体的每个成员被提供参与群组购买的提议，其中接受该优惠的组的每个成员同意在至少一个内部购买预先指定的产品至少部分地基于接受要约参与的组的成员的购买力的集合，以折扣价格协商商品类别和从供应商购买一定数量的预先指定的产品。团购。

3. 发明申请

US20060129471A1 Methods and systems for managing financial accounts 审中-公开
标题翻译：管理财务账目的方法和系统
公开(公告)号：US20060129471A1
公开(公告)日：2006-06-15
申请号：US11186278
申请日：2005-07-21
申请人： Susan Moon , B. Ballman , Evan Minskoff , Alice Yu , Kevin Hung
发明人： Susan Moon , B. Ballman , Evan Minskoff , Alice Yu , Kevin Hung
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q40/00
摘要： Computer-implemented methods and systems for managing a special-purpose financial account involve establishing the account by a financial institution for a consumer relating to at least one consumer-designated future purchase for a pre-determined purchase price. Thereafter, contributions to a principal balance of the account are received and interest is accrued on the principal balance by the financial institution until the principal balance and accrued interest reaches a consumer-designated target amount, at which time, the principal balance and accrued interest are disposed of according to pre-defined parameters that can involve forfeiture of the accrued interest, depending on the consumer's actions.
摘要翻译：用于管理专用金融账户的计算机实现的方法和系统涉及由金融机构为消费者建立与至少一个消费者指定的未来购买预定购买价格的消费者的账户。此后，收到对该账户本金余额的会费，并由金融机构在本金余额上计提利息，直至本金余额和应计利息达到消费者指定的目标金额，此时本金余额和应计利息为根据预先定义的参数进行处置，这些参数可能涉及到没收应计利息，具体取决于消费者的行为。

4. 发明授权

US09255130B2 Puf-A and related compounds for treatment of retinopathies and sight-threatening ophthalmologic disorders 有权
标题翻译： Puf-A和相关化合物用于治疗视网膜病变和眼睛威胁眼科疾病
公开(公告)号：US09255130B2
公开(公告)日：2016-02-09
申请号：US13056975
申请日：2009-07-29
申请人： John Yu , Alice Yu , Ming-Wei Kuo , Jui-Chin Chang
发明人： John Yu , Alice Yu , Ming-Wei Kuo , Jui-Chin Chang
IPC分类号： A61K48/00 , C07K14/47 , C07K16/18 , C12N15/113 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/4747 , A61K48/005 , C07K16/18 , C12N15/113 , C12N2799/025 , C12Q1/6876 , G01N33/6854
摘要： Methods and compositions for treating retinal diseases comprising therapeutic amounts of a compound selected from a normal Puf-A gene product, an active polypeptide fragment thereof, an analog thereof or a peptidomimetic thereof. Vectors, including AAV vectors comprising the therapeutic compound are provided. Puf-A compositions suitable for subretinal, intravitreal, topical, subconjunctival, retrobulbar, periocular, suprachoroidal, or intraocular administration are provided. Methods for screening siRNA, RNAi and shRNA, small molecules and monoclonal antibodies that inhibit Puf-A target activity and reduce apoptosis are provided.
摘要翻译：用于治疗视网膜疾病的方法和组合物包括治疗量的选自正常Puf-A基因产物，其活性多肽片段，其类似物或肽模拟物的化合物。提供载体，包括包含治疗化合物的AAV载体。提供适用于视网膜下，玻璃体内，局部，结膜下结膜，球后，眼周，脉络膜或眼内给药的Puf-A组合物。提供了筛选siRNA，RNAi和shRNA，抑制Puf-A靶活性和减少细胞凋亡的小分子和单克隆抗体的方法。

5. 发明申请

US20090060949A1 Flu vaccines and methods of use thereof 有权
标题翻译：流感疫苗及其使用方法
公开(公告)号：US20090060949A1
公开(公告)日：2009-03-05
申请号：US12011032
申请日：2008-01-23
申请人： David D. Ho , Yaoxing Huang , Ming Wei Chen , Rachel T.J. Cheng , Chi-Huey Wong , Alice Yu
发明人： David D. Ho , Yaoxing Huang , Ming Wei Chen , Rachel T.J. Cheng , Chi-Huey Wong , Alice Yu
IPC分类号： A61K39/145 , C07H21/04 , C07K14/00 , C07K16/08 , A61P37/04 , C12N15/09 , C12N15/64 , A61K31/711
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K2039/53 , A61K2039/58 , C12N2760/16122 , C12N2760/16134
摘要： This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection.
摘要翻译：本公开特别涉及多核苷酸，多肽，载体，细胞和包含其的组合物，以及它们在影响病毒发病机理中的用途，特别是针对流感病毒感染的用途。

6. 发明申请

US20080260774A1 Alpha-galactosyl ceramide analogs and their use as immunotherapies 审中-公开
标题翻译： α-半乳糖基神经酰胺类似物及其作为免疫治疗的用途
公开(公告)号：US20080260774A1
公开(公告)日：2008-10-23
申请号：US12082751
申请日：2008-04-14
申请人： Chi-Huey Wong , Alice Yu , Ya-Jen Chang
发明人： Chi-Huey Wong , Alice Yu , Ya-Jen Chang
IPC分类号： A61K39/00 , A61K31/35 , C07D315/00 , A61P37/00
CPC分类号： C07H15/26 , A61K8/68 , A61K2800/91 , A61Q17/005 , C07H15/06 , C07H15/18
摘要： The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1: wherein, n is 0 to 25; X is selected from O and S; R1 is selected from H, CH3, and phenyl, where phenyl is optionally substituted with H, OH, OCH3, F, CF3, phenyl, phenyl-F, C1-C6 alkyl, or C2-C6 branched alkyl; R2 is selected from OH and H; R3 is selected from C1-C15 alkyl, and phenyl, where phenyl is optionally substituted with H, OH, OCH3, F, CF3, phenyl, C1-C6 alkyl, or C2-C6 branched alkyl; R4 is selected from OH, OSO3H, OSO3Na, and OSO3K; and R5 is selected from CH2OH and CO2H; or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.
摘要翻译：本公开涉及合成的α-半乳糖神经酰胺（α-GalCer）类似物，以及它们作为免疫治疗的用途。一方面，在受试者中激活细胞因子应答的方法包括向受试者施用有效量的化合物，其中所述受试者具有包括细胞群的适应性免疫系统，所述群体包括至少一种淋巴细胞，并且在至少一种抗原呈递细胞，并且其中所述化合物由式1的结构表示：其中n为0至25; X选自O和S; R 1选自H，CH 3和苯基，其中苯基任选被H，OH，OCH 3，F，CF 苯基，苯基-F，C 1 -C 6烷基或C 2 -C 6亚烷基 >支链烷基; R 2选自OH和H; R 3选自C 1 -C 15烷基和苯基，其中苯基任选被H，OH，OCH 3取代， 3，F，CF 3，苯基，C 1 -C 6烷基或C 2 H 2 -C 6 -C 6支链烷基; R 4选自OH，OSO 3 H，OSO 3 Na和OSO 3 K; 和R 5选自CH 2 OH和CO 2 H; 或其药学上可接受的盐; 在化合物和抗原呈递细胞之间形成复合物，其中复合物的形成导致淋巴细胞上受体的活化; 并激活淋巴细胞以产生细胞因子反应。

7. 发明申请

US20100041740A1 FLU VACCINES AND METHODS OF USE THEREOF 有权
标题翻译：流感疫苗及其使用方法
公开(公告)号：US20100041740A1
公开(公告)日：2010-02-18
申请号：US12417556
申请日：2009-04-02
申请人： Chi-Huey Wong , David D. Ho , Yaoxing Huang , Ting-Jen R. Cheng , Ming Wei Chen , Alice Yu
发明人： Chi-Huey Wong , David D. Ho , Yaoxing Huang , Ting-Jen R. Cheng , Ming Wei Chen , Alice Yu
IPC分类号： A61K31/7088 , C07H21/04 , C07K16/00 , C12N15/63
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/505 , A61K2039/53 , A61K2039/58 , A61K2039/70 , C07K14/005 , C07K16/1018 , C07K2317/76 , C12N2760/16122 , C12N2760/16134
摘要： This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection.
摘要翻译：本公开特别涉及多核苷酸，多肽，载体，细胞和包含其的组合物，以及它们在影响病毒发病机理中的用途，特别是针对流感病毒感染的用途。

8. 发明申请

US20080214442A1 Anti-Viral Effect of an Extract of Ganoderma Lucidum 审中-公开
标题翻译：灵芝提取物的抗病毒作用
公开(公告)号：US20080214442A1
公开(公告)日：2008-09-04
申请号：US11859729
申请日：2007-09-21
申请人： Alice Yu , Chi-Huey Wong , Jia Tsrong Jan , Y.-S. Edmond Cheng
发明人： Alice Yu , Chi-Huey Wong , Jia Tsrong Jan , Y.-S. Edmond Cheng
IPC分类号： A61K38/16 , C07K14/00 , A61P31/12
CPC分类号： C07K2/00 , A61K36/074 , A61K38/00
摘要： Compositions and methods for the treatment viral infections in organisms, particularly flu virus. The methods and compositions of the disclosure involve the administration to mammals and immune cells of a fucose-containing glycoprotein fraction from Reishi. An extract of G. lucidum induces immune responses that are shown to induce increase survivability in mice injected with lethal does of influenza virus. The effect is increased when the G. lucidum extract is dosed prior to injection of the lethal dose of influenza virus.
摘要翻译：用于治疗生物体中的病毒感染的组合物和方法，特别是流感病毒。本公开的方法和组合物涉及向来自Reishi的含岩藻糖的糖蛋白部分的哺乳动物和免疫细胞施用。灵芝的提取物诱导免疫应答，显示其在注射致死性流感病毒的小鼠中诱导增加的存活能力。当在注射致死剂量的流感病毒之前配制灵芝提取物时，效果增加。

9. 发明申请

US20130202678A1 PUF-A AND RELATED COMPOUNDS FOR TREATMENT OF RETINOPATHIES AND SIGHT-THREATENING OPHTHALMOLOGIC DISORDERS 有权
标题翻译： PUF-A及相关化合物治疗复发性眼病和视力障碍性眼病
公开(公告)号：US20130202678A1
公开(公告)日：2013-08-08
申请号：US13056975
申请日：2008-07-29
申请人： John Yu , Alice Yu , Ming-Wei Kuo , Jui-Chin Chang
发明人： John Yu , Alice Yu , Ming-Wei Kuo , Jui-Chin Chang
IPC分类号： C07K14/47 , G01N33/68 , C12Q1/68 , C12N15/113 , C07K16/18
CPC分类号： C07K14/4747 , A61K48/005 , C07K16/18 , C12N15/113 , C12N2799/025 , C12Q1/6876 , G01N33/6854
摘要： Methods and compositions for treating retinal diseases comprising therapeutic amounts of a compound selected from a normal Puf-A gene product, an active polypeptide fragment thereof, an analog thereof or a peptidomimetic thereof. Vectors, including AAV vectors comprising the therapeutic compound are provided. Puf-A compositions suitable for subretinal, intravitreal, topical, subconjunctival, retrobulbar, periocular, suprachoroidal, or intraocular administration are provided. Methods for screening siRNA, RNAi and shRNA, small molecules and monoclonal antibodies that inhibit Puf-A target activity and reduce apoptosis are provided.
摘要翻译：用于治疗视网膜疾病的方法和组合物包括治疗量的选自正常Puf-A基因产物，其活性多肽片段，其类似物或肽模拟物的化合物。提供载体，包括包含治疗化合物的AAV载体。提供适用于视网膜下，玻璃体内，局部，结膜下结膜，球后，眼周，脉络膜或眼内给药的Puf-A组合物。提供了筛选siRNA，RNAi和shRNA，抑制Puf-A靶活性和减少细胞凋亡的小分子和单克隆抗体的方法。

10. 发明授权

US08030029B2 Flu vaccines and methods of use thereof 有权
公开(公告)号：US08030029B2
公开(公告)日：2011-10-04
申请号：US12011032
申请日：2008-01-23
申请人： David D. Ho , Yaoxing Huang , Ming Wei Chen , Rachel TJ Cheng , Chi-Huey Wong , Alice Yu
发明人： David D. Ho , Yaoxing Huang , Ming Wei Chen , Rachel TJ Cheng , Chi-Huey Wong , Alice Yu
IPC分类号： C12N15/44 , A61K48/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K2039/53 , A61K2039/58 , C12N2760/16122 , C12N2760/16134
摘要： This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection.

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