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1. 发明授权

US07543468B2 Locking device and method for unlocking the locking device 有权
标题翻译：用于解锁锁定装置的锁定装置和方法
公开(公告)号：US07543468B2
公开(公告)日：2009-06-09
申请号：US12036442
申请日：2008-02-25
申请人： Kevin Houlihan , Patrick E. Wind , Michael Gallo
发明人： Kevin Houlihan , Patrick E. Wind , Michael Gallo
IPC分类号： E05B63/00 , E05B65/06
CPC分类号： E05B65/025 , E05B1/0053 , E05B63/0065 , E05C9/026 , Y10T70/5124 , Y10T70/5345 , Y10T70/5363 , Y10T70/8459
摘要： A locking device and a method for unlocking the locking device are provided. The locking device includes a stationary plug having a first aperture extending therein configured to receive a key. The stationary plug further includes an outer surface, an inner surface defined by the first aperture, and at least a second aperture extending from the outer surface to the inner surface. The locking device further includes a housing having an outer wall disposed around at least a portion of the stationary plug. The outer wall has at least a third aperture extending therethrough. The locking device further includes a bolt member operably coupled to the outer wall of the housing. The locking device further includes a locking mechanism disposed in the third aperture of the housing and extending into the second aperture of the stationary plug. The locking mechanism is configured to allow rotation of the housing about the stationary plug when the key is inserted into the first aperture. The housing is configured to rotate from a first operational position to a second operational position in response to a force being applied to the bolt member.
摘要翻译：提供了锁定装置和用于解锁锁定装置的方法。锁定装置包括具有在其中延伸的第一孔的固定塞，其构造成接收钥匙。固定塞还包括外表面，由第一孔限定的内表面和至少一个从外表面延伸到内表面的第二孔。锁定装置还包括具有围绕固定塞的至少一部分设置的外壁的壳体。外壁具有至少延伸穿过其中的第三孔。锁定装置还包括可操作地联接到壳体的外壁的螺栓构件。锁定装置还包括设置在壳体的第三孔中并延伸到固定塞的第二孔中的锁定机构。锁定机构构造成当钥匙插入第一孔口时允许壳体围绕固定塞旋转。壳体构造成响应于施加到螺栓构件的力而从第一操作位置旋转到第二操作位置。

2. 发明申请

US20080141739A1 LOCKING DEVICE AND METHOD FOR UNLOCKING THE LOCKING DEVICE 有权
标题翻译：用于解锁锁定装置的锁定装置和方法
公开(公告)号：US20080141739A1
公开(公告)日：2008-06-19
申请号：US12036442
申请日：2008-02-25
申请人： Kevin Houlihan , Patrick E. Wind , Michael Gallo
发明人： Kevin Houlihan , Patrick E. Wind , Michael Gallo
IPC分类号： E05B63/00 , E05B65/06
CPC分类号： E05B65/025 , E05B1/0053 , E05B63/0065 , E05C9/026 , Y10T70/5124 , Y10T70/5345 , Y10T70/5363 , Y10T70/8459
摘要： A locking device and a method for unlocking the locking device are provided. The locking device includes a stationary plug having a first aperture extending therein configured to receive a key. The stationary plug further includes an outer surface, an inner surface defined by the first aperture, and at least a second aperture extending from the outer surface to the inner surface. The locking device further includes a housing having an outer wall disposed around at least a portion of the stationary plug. The outer wall has at least a third aperture extending therethrough. The locking device further includes a bolt member operably coupled to the outer wall of the housing. The locking device further includes a locking mechanism disposed in the third aperture of the housing and extending into the second aperture of the stationary plug. The locking mechanism is configured to allow rotation of the housing about the stationary plug when the key is inserted into the first aperture. The housing is configured to rotate from a first operational position to a second operational position in response to a force being applied to the bolt member.
摘要翻译：提供了锁定装置和用于解锁锁定装置的方法。锁定装置包括具有在其中延伸的第一孔的固定塞，其构造成接收钥匙。固定塞还包括外表面，由第一孔限定的内表面和至少一个从外表面延伸到内表面的第二孔。锁定装置还包括具有围绕固定塞的至少一部分设置的外壁的壳体。外壁具有至少延伸穿过其中的第三孔。锁定装置还包括可操作地联接到壳体的外壁的螺栓构件。锁定装置还包括设置在壳体的第三孔中并延伸到固定塞的第二孔中的锁定机构。锁定机构构造成当钥匙插入第一孔口时允许壳体围绕固定塞旋转。壳体构造成响应于施加到螺栓构件的力而从第一操作位置旋转到第二操作位置。

3. 发明授权

US07353673B2 Locking device and method for unlocking the locking device 有权
标题翻译：锁定装置和解锁锁定装置的方法
公开(公告)号：US07353673B2
公开(公告)日：2008-04-08
申请号：US11322171
申请日：2005-12-29
申请人： Kevin Houlihan , Patrick E. Wind , Michael Gallo
发明人： Kevin Houlihan , Patrick E. Wind , Michael Gallo
IPC分类号： E05B63/00 , E05B65/06
CPC分类号： E05B65/025 , E05B1/0053 , E05B63/0065 , E05C9/026 , Y10T70/5124 , Y10T70/5345 , Y10T70/5363 , Y10T70/8459
摘要： A locking device and a method for unlocking the locking device are provided. The locking device includes a stationary plug having a first aperture extending therein configured to receive a key. The stationary plug further includes an outer surface, an inner surface defined by the first aperture, and at least a second aperture extending from the outer surface to the inner surface. The locking device further includes a housing having an outer wall disposed around at least a portion of the stationary plug. The outer wall has at least a third aperture extending therethrough. The locking device further includes a bolt member operably coupled to the outer wall of the housing. The locking device further includes a locking mechanism disposed in the third aperture of the housing and extending into the second aperture of the stationary plug. The locking mechanism is configured to allow rotation of the housing about the stationary plug when the key is inserted into the first aperture. The housing is configured to rotate from a first operational position to a second operational position in response to a force being applied to the bolt member.
摘要翻译：提供了锁定装置和用于解锁锁定装置的方法。锁定装置包括具有在其中延伸的第一孔的固定塞，其构造成接收钥匙。固定塞还包括外表面，由第一孔限定的内表面和至少一个从外表面延伸到内表面的第二孔。锁定装置还包括具有围绕固定塞的至少一部分设置的外壁的壳体。外壁具有至少延伸穿过其中的第三孔。锁定装置还包括可操作地联接到壳体的外壁的螺栓构件。锁定装置还包括设置在壳体的第三孔中并延伸到固定塞的第二孔中的锁定机构。锁定机构构造成当钥匙插入第一孔口时允许壳体围绕固定塞旋转。壳体构造成响应于施加到螺栓构件的力而从第一操作位置旋转到第二操作位置。

4. 发明申请

US20060150693A1 Locking device and method for unlocking the locking device 有权
公开(公告)号：US20060150693A1
公开(公告)日：2006-07-13
申请号：US11322171
申请日：2005-12-29
申请人： Kevin Houlihan , Patrick Wind , Michael Gallo
发明人： Kevin Houlihan , Patrick Wind , Michael Gallo
IPC分类号： E05B65/06
CPC分类号： E05B65/025 , E05B1/0053 , E05B63/0065 , E05C9/026 , Y10T70/5124 , Y10T70/5345 , Y10T70/5363 , Y10T70/8459
摘要： A locking device and a method for unlocking the locking device are provided. The locking device includes a stationary plug having a first aperture extending therein configured to receive a key. The stationary plug further includes an outer surface, an inner surface defined by the first aperture, and at least a second aperture extending from the outer surface to the inner surface. The locking device further includes a housing having an outer wall disposed around at least a portion of the stationary plug. The outer wall has at least a third aperture extending therethrough. The locking device further includes a bolt member operably coupled to the outer wall of the housing. The locking device further includes a locking mechanism disposed in the third aperture of the housing and extending into the second aperture of the stationary plug. The locking mechanism is configured to allow rotation of the housing about the stationary plug when the key is inserted into the first aperture. The housing is configured to rotate from a first operational position to a second operational position in response to a force being applied to the bolt member.

5. 发明申请

US20080196460A1 INSERTABLE LOCK PLUG 审中-公开
公开(公告)号：US20080196460A1
公开(公告)日：2008-08-21
申请号：US11967192
申请日：2007-12-29
申请人： Kevin Houlihan , Michael Gallo
发明人： Kevin Houlihan , Michael Gallo
IPC分类号： E05B37/00 , E05B37/08
CPC分类号： E05B9/084 , E05B37/0034 , E05B37/08 , Y10T70/7147
摘要： A dial assembly for a master key controlled combination lock is disclosed herein, the dial assembly having: a dial having a front side, a back side and a gripping surface disposed therebetween, the front side having an opening therein; a key plug having a lock cylinder rotatably disposed therein, the lock cylinder having a key hole end and a lever end, the lock cylinder being configured to receive a master key having a particular key code sequence in the key hole end, the key plug being configured to be installed within the dial through the opening of the dial and the lever end is configured to actuate a combination lock; and a cover plate for securing the key plug in the dial, the cover plate having a face portion and an engagement portion, the face portion having an aperture extending therethrough, the aperture being configured to rotatably receive the keyhole end of the lock cylinder therein and the engagement portion is configured to secure the face portion in the opening of the dial when the cover plate is secured to the dial by inserting the engagement portion of the cover plate in the opening until the engagement portion engages the dial.
摘要翻译：本文公开了一种用于主钥匙控制的组合锁的拨盘组件，所述拨盘组件具有：具有前侧，后侧和设置在其间的抓握表面的表盘，前侧在其中具有开口; 具有可旋转地设置在其中的锁芯的钥匙塞，所述锁芯具有钥匙孔端和杠杆端，所述锁芯被配置为在所述钥匙孔端部接收具有特定钥匙代码序列的主钥匙，所述钥匙塞被配置为通过所述表盘的开口安装在所述表盘内，并且所述杠杆端构造成致动组合锁; 以及用于将所述键插头固定在所述表盘中的盖板，所述盖板具有面部和接合部，所述面部具有延伸穿过所述孔的所述孔，所述孔构造成可旋转地将所述锁芯的锁眼端部容纳在其中，接合部被构造成通过将盖板的接合部分插入开口中而将盖板固定到表盘上来将面部部分固定在表盘的开口中，直到接合部分接合表盘。

6. 发明申请

US20130236931A1 SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS AND OTHER PROTEINS 审中-公开
标题翻译：免疫球蛋白和其他蛋白质的序列多样性生成
公开(公告)号：US20130236931A1
公开(公告)日：2013-09-12
申请号：US13765484
申请日：2013-02-12
申请人： Michael Gallo , Jaspal Singh Kang , Craig Robin Pigott
发明人： Michael Gallo , Jaspal Singh Kang , Craig Robin Pigott
IPC分类号： C12P21/00
CPC分类号： C12P21/00 , C07K16/00 , C07K2317/56 , C12N15/102 , C12N15/113 , C12N2310/14
摘要： An in vitro system for generating sequence, and thus structural, diversity in proteins is described. The system can be constructed using appropriately selected nucleic acid molecules that encode regions of a selected protein or proteins and recombination signal sequences (RSS). The selected protein(s) can be, for example, immunoglobulin (Ig) V, D, J and/or C regions, regions of a non-immunoglobulin (non-Ig) protein, or a combination of Ig regions and non-Ig regions. Assembly of such appropriately selected components and their introduction into suitable recombination-competent host cells allows for recombination between the RSS sequences and introduction of sequence and structural diversity into the protein(s).
摘要翻译：描述了用于产生序列的体外系统，因此蛋白质的结构多样性。可以使用适当选择的编码所选蛋白质或蛋白质区域的重组信号序列（RSS）的核酸分子来构建该系统。所选择的蛋白可以是例如免疫球蛋白（Ig）V，D，J和/或C区，非免疫球蛋白（非Ig）蛋白的区域，或Ig区和非Ig的组合地区。组装这些适当选择的组分并将其引入合适的可重组的宿主细胞中允许RSS序列之间的重组，并将序列和结构多样性引入到蛋白质中。

7. 发明申请

US20050100546A1 Human monoclonal antibodies to epidermal growth factor receptor 审中-公开
标题翻译：人表皮生长因子受体单克隆抗体
公开(公告)号：US20050100546A1
公开(公告)日：2005-05-12
申请号：US11021795
申请日：2004-12-22
申请人： Aya Jakobovits , Xiao-Dong Yang , Michael Gallo , Xiao-Chi Jia
发明人： Aya Jakobovits , Xiao-Dong Yang , Michael Gallo , Xiao-Chi Jia
IPC分类号： A61K38/00 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2863 , A61K38/00 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/77
摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided. Also provided in accordance with the invention are antibodies that possess one or more of the following functional characteristics: (i) inhibit tyrosine phosphorylation of EGF-r, (ii) do not inhibit EGF-r internalization, (ii) inhibit EGF-r degradation, (iii) inhibition of EGF induced EGF-r degradation, (iv) protect threonine phosphorylation of EGF-r, (v) protect threonine phosphorylation of other molecules, particularly a 62 KD molecule identified by immunoprecipitation, and (vi) inhibit vascular endothelial cell growth factor signal by tumor cells by greater than 50% and endothelial cells by greater than 40% relative to control.
摘要翻译：根据本发明，提供了针对人表皮生长因子受体（EGF-r）的完全人单克隆抗体。提供了含有重链和轻链免疫球蛋白分子的Nuclotide序列编码和氨基酸序列，特别是对应于CDR1至CDR3的连续重链和轻链序列的序列。还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤。根据本发明还提供了具有一个或多个以下功能特征的抗体：（i）抑制EGF-r的酪氨酸磷酸化，（ii）不抑制EGF-r内化，（ii）抑制EGF-r降解，（iii）抑制EGF诱导的EGF-r降解，（iv）保护EGF-r的苏氨酸磷酸化，（v）保护其他分子，特别是通过免疫沉淀鉴定的62KD分子的苏氨酸磷酸化，和（vi）抑制血管内皮肿瘤细胞的细胞生长因子信号大于50％，内皮细胞相对于对照组大于40％。

8. 发明申请

US20120258495A1 SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS 有权
标题翻译：免疫球蛋白中的序列多样性生成
公开(公告)号：US20120258495A1
公开(公告)日：2012-10-11
申请号：US13205218
申请日：2011-08-08
申请人： Michael Gallo , Jaspal Singh Kang , Craig Robin Pigott
发明人： Michael Gallo , Jaspal Singh Kang , Craig Robin Pigott
IPC分类号： C12N5/10 , C12P21/00
CPC分类号： C07K16/00 , C07K2317/56 , C12N15/113 , C12N2310/14
摘要： Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations of immunoglobulin gene elements, including introduction of artificial diversity (D) segment genes and optimization of recombination signal sequence (RSS) efficiency, are disclosed.
摘要翻译：公开了用于在体外产生免疫球蛋白结构多样性的组合物和方法，特别是用于减少V区和J区段基因利用中的偏差，并且以不需要DJ重组在V-DJ之前产生免疫球蛋白VDJ重组事件重组。公开了选择免疫球蛋白基因元件的有利组合，包括引入人工多样性（D）片段基因和优化重组信号序列（RSS）效率。

9. 发明授权

US07982024B2 Antibodies to insulin-like growth factor I receptor 有权
标题翻译：胰岛素样生长因子I受体的抗体
公开(公告)号：US07982024B2
公开(公告)日：2011-07-19
申请号：US12756417
申请日：2010-04-08
申请人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose Ramon Corvalan , Michael Gallo
发明人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose Ramon Corvalan , Michael Gallo
IPC分类号： C07H21/04 , C12N15/00 , C12N5/07 , C12N5/16 , A61K39/395 , C07K16/00
CPC分类号： C07K16/2863 , A01K2217/05 , A61K31/138 , A61K31/513 , A61K31/517 , A61K31/704 , A61K39/39541 , A61K39/39558 , A61K48/00 , A61K2039/505 , C07K14/72 , C07K16/30 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N33/57492 , G01N2333/65 , G01N2333/71 , A61K2300/00
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的抗体及其抗原结合部分，其优选为人IGF-1R。本发明还涉及人抗IGF-1R抗体，包括嵌合，双特异性，衍生的单链抗体或融合蛋白的部分。本发明还涉及衍生自抗IGF-1R抗体和编码这种分子的核酸分子的分离的重链和轻链免疫球蛋白分子。本发明还涉及制备抗IGF-1R抗体的方法，包含这些抗体的药物组合物和使用抗体及其组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗IGF-1R抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的基因治疗方法和转基因动物。

10. 发明申请

US20080134735A1 APPARATUS AND METHOD FOR VENDING SECURELY STORED PRODUCTS TO CONSUMERS 有权
标题翻译：用于向消费者发放安全存储产品的装置和方法
公开(公告)号：US20080134735A1
公开(公告)日：2008-06-12
申请号：US11938002
申请日：2007-11-09
申请人： Michael Gallo , Steve Sanelli
发明人： Michael Gallo , Steve Sanelli
IPC分类号： E05B63/14
CPC分类号： E05B15/0046 , E05B13/004 , E05B15/101 , E05B35/12 , E05B47/023 , E05C3/24 , G07F7/0609 , Y10S70/62 , Y10S70/63 , Y10T70/625 , Y10T70/7441 , Y10T70/7768 , Y10T292/1047 , Y10T292/1062 , Y10T292/1078 , Y10T403/602
摘要： A lock mechanism is disclosed, the lock mechanism having a rotary latch configured for rotation between a locked position and an unlocked position, the rotary latch rotating in a first plane and the rotary latch is retained in the locked position after it has been rotated into the locked position from the unlocked position, the rotary latch being spring biased into the unlocked position by a biasing member; and a first lock mechanism for releasing the rotary latch from the locked position after actuation of the first lock mechanism, the biasing member rotating the rotary latch into the unlocked position, the rotary latch being capable of being manipulated back into the locked position from the unlocked position after release by the first locking mechanism and the first locking mechanism must be reset in order to once again release the rotary latch.
摘要翻译：公开了一种锁定机构，该锁定机构具有构造成在锁定位置和解锁位置之间旋转的旋转闩锁，所述旋转闩锁在第一平面中旋转，并且所述旋转闩锁在已经旋转到所述锁定位置之后被保持在所述锁定位置锁定位置从解锁位置，旋转闩锁通过偏置构件弹簧偏压到解锁位置; 以及第一锁定机构，用于在所述第一锁定机构致动之后将所述旋转闩锁从所述锁定位置释放，所述偏置构件将所述旋转闩锁旋转到所述解锁位置，所述旋转闩锁能够被解锁回锁定位置必须复位通过第一锁定机构释放的位置和第一锁定机构以再次释放旋转闩锁。

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