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1. 发明申请

US20070030001A1 Resonant magnetometer device 有权
标题翻译：共振磁力计装置
公开(公告)号：US20070030001A1
公开(公告)日：2007-02-08
申请号：US10572379
申请日：2004-09-21
申请人： Kevin Brunson , David King
发明人： Kevin Brunson , David King
IPC分类号： G01R15/18 , G01R33/04 , G01R33/00
CPC分类号： G01R33/0283 , G01R33/0286
摘要： A resonant magnetometer (20) is described that comprises a substrate having an member (26) and means for passing an alternating current (AC) through said oscillatory member (26). The magnetometer is characterised in that driving means (46,48) are also provided to impart a magnetic field independent oscillatory force to said oscillatory member (26). A micro-electromechanical systems (MEMS) implementation of the magnetometer is described.
摘要翻译：描述了包括具有构件（26）的衬底和用于使交流（AC）通过所述振荡构件（26）的装置的谐振磁力计（20）。磁力计的特征在于，还提供驱动装置（46,48）以向所述振荡构件（26）施加与磁场无关的振荡力。描述了磁力计的微机电系统（MEMS）实现。

2. 发明申请

US20070096729A1 Combined magnetic field gradient and magnetic field strength sensor 失效
标题翻译：组合磁场梯度和磁场强度传感器
公开(公告)号：US20070096729A1
公开(公告)日：2007-05-03
申请号：US10581308
申请日：2004-12-16
申请人： Kevin Brunson , David King
发明人： Kevin Brunson , David King
IPC分类号： G01R33/02
CPC分类号： G01R33/0286 , G01R33/022 , G01R33/0283
摘要： A magnetic field sensor device (2) is described that comprises an oscillatory member (8) and current control means (6). The current control means (6) is arranged to pass an alternating current (AC) along at least first (10) and second (12) current paths provided through the oscillatory member (8) and is arranged to provide magnetic gradiometer mode operation (i.e. to measure magnetic field gradient) in which current flow through the first current path (10) is in substantially the opposite direction to current flow through the second current path (12). The current control means (6) can also prove magnetometer mode operation (i.e. to measure magnetic field strength). The magnetic field sensor (2) may be used in a compass.
摘要翻译：描述了包括振荡构件（8）和电流控制装置（6）的磁场传感器装置（2）。电流控制装置（6）被布置成沿着穿过振荡构件（8）提供的至少第一（10）和第二（12）电流路径传递交流电（AC），并且被布置成提供磁梯度计模式操作以测量磁场梯度），其中流过第一电流路径（10）的电流基本上与通过第二电流路径（12）的电流相反。电流控制装置（6）还可以证明磁力计模式操作（即测量磁场强度）。磁场传感器（2）可以用于罗盘。

3. 发明申请

US20050104675A1 Micro-electromechanical systems 失效
标题翻译：微机电系统
公开(公告)号：US20050104675A1
公开(公告)日：2005-05-19
申请号：US10507113
申请日：2003-03-19
申请人： Kevin Brunson , David Hamilton , David King , Mark McNie
发明人： Kevin Brunson , David Hamilton , David King , Mark McNie
IPC分类号： B81B5/00 , B81B7/02 , G01C19/5684 , H03B5/30
CPC分类号： G01C19/5684
摘要： A micro-electromechanical system (MEMS) comprises a substrate incorporating an oscillatory ring, forcing electrodes for driving the ring into resonance, and sensing electrodes providing an electrical output signal dependent on oscillation of the ring as a result of such forcing and any externally applied force. A positive feedback circuit is provided for feeding back a signal dependent on the output signal of the sensing electrodes to the forcing electrodes in order to sustain oscillation of the ring. The use of positive feedback to drive the forcing electrodes in order to sustain oscillation of the ring is highly advantageous in such an application since it produces a system which exhibits very low phase noise of a magnitude considerably less than the phase noise experienced in use of a phase-lock loop circuit to sustain oscillation.
摘要翻译：微机电系统（MEMS）包括：包含振荡环的衬底，迫使用于将环驱动到谐振中的电极;以及感测电极，其由于这种强制和任何外力施加的力而提供取决于环的振荡的电输出信号。提供正反馈电路，用于将取决于感测电极的输出信号的信号反馈到强制电极，以维持环的振荡。使用正反馈来驱动强制电极以维持环的振荡在这种应用中是非常有利的，因为它产生的系统显示出非常低的相位噪声，其幅度远远小于使用锁相环电路来维持振荡。

4. 发明授权

US10779515B1 Anchor device 有权
公开(公告)号：US10779515B1
公开(公告)日：2020-09-22
申请号：US16007159
申请日：2018-06-13
申请人： David King , Ray Stewart
发明人： David King , Ray Stewart
IPC分类号： A01K61/00 , A01K61/78 , F16B9/00 , A01K61/10
摘要： The present invention is an anchor for an artificial structure for attracting fish within a body of water. The structure is comprised of a base and has a central attachment post, a central column configured to secure to the attachment post, and a protective plate.

5. 发明授权

US10494671B2 Enzymatic ligation of nucleic acids 有权
公开(公告)号：US10494671B2
公开(公告)日：2019-12-03
申请号：US13980280
申请日：2012-01-17
申请人： Stephen Hendricks , David King
发明人： Stephen Hendricks , David King
IPC分类号： C12Q1/68 , C12Q1/6869 , C07H21/00 , C12Q1/6874 , A61J1/14 , B65D8/00 , B65B3/00 , B65B31/04 , A61J1/06 , C12N9/00 , C12Q1/6876 , A61M5/00 , B65B55/08 , B65B55/10 , A61M5/50
CPC分类号： C12Q1/6874 , A61J1/062 , A61J1/14 , B65B3/003 , B65B3/006 , B65B31/046 , B65D15/02 , C12N9/93 , C12Q1/6876 , A61J2200/76 , A61J2205/30 , A61M5/008 , A61M5/5086 , B65B55/08 , B65B55/10 , C12Q2600/16 , C12Y605/01001
摘要： Methods, assays, compositions and kits for the ligation of short polynucleotides are presented herein. The short polynucleotides are optionally no more than 7 nucleotides in length, and can be as short as 3 or 4 nucleotides in length. The ligation is optionally performed by CV ligase.

6. 发明申请

US20130202591A1 ANTIBODIES DIRECTED AGAINST IL-17 有权
标题翻译：针对IL-17的抗体
公开(公告)号：US20130202591A1
公开(公告)日：2013-08-08
申请号：US13814262
申请日：2011-08-02
申请人： Robert Horlick , David King , Peter Bowers , Jennifer Dalton , Betty Wu , Traci Roberts , Xue Zhang , Laurence Altobell, III
发明人： Robert Horlick , David King , Peter Bowers , Jennifer Dalton , Betty Wu , Traci Roberts , Xue Zhang , Laurence Altobell, III
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要： The disclosure relates to an isolated IL-17-binding agent which comprises an immunoglobulin heavy chain polypeptide comprising SEQ ID NO: 1 and optionally an immunoglobulin light chain polypeptide comprising SEQ ID NO: 23, except that one or more specific of residues of SEQ ID NO: 1 and SEQ ID NO: 23 are replaced with a different residue. The disclosure also provides vectors, compositions, and methods of using the IL-17-binding agent to treat an IL-17-mediated disease.
摘要翻译：本公开涉及分离的IL-17结合剂，其包含包含SEQ ID NO：1的免疫球蛋白重链多肽和任选的包含SEQ ID NO：23的免疫球蛋白轻链多肽，除了SEQ ID NO：23的一个或多个特异性残基 NO：1和SEQ ID NO：23被不同的残基取代。本公开还提供了使用IL-17结合剂治疗IL-17介导的疾病的载体，组合物和方法。

7. 发明授权

US08475797B2 Interferon alpha antibodies and their uses 有权
标题翻译：干扰素α抗体及其用途
公开(公告)号：US08475797B2
公开(公告)日：2013-07-02
申请号：US13211092
申请日：2011-08-16
申请人： Alison Witte , Denise Williams , Josphine M Cardelli , David King , David Passmore
发明人： Alison Witte , Denise Williams , Josphine M Cardelli , David King , David Passmore
IPC分类号： A61K39/395
CPC分类号： C07K16/249 , A61K51/1021 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76
摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
摘要翻译：本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性或IFNγ。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病本发明的抗体。

8. 发明授权

US08290147B2 Systems and methods for efficiently creating digests of digital data 有权
标题翻译：有效地创建数字数据摘要的系统和方法
公开(公告)号：US08290147B2
公开(公告)日：2012-10-16
申请号：US12609888
申请日：2009-10-30
申请人： Gerardo Orlando , David King , Mark Krumpoch
发明人： Gerardo Orlando , David King , Mark Krumpoch
IPC分类号： H04L9/28
CPC分类号： H04L9/0637 , H03M13/09 , H04L9/3236 , H04L2209/12
摘要： Systems and methods efficiently process digests, hashes or other results by performing multiplicative functions in parallel with each other. In various embodiments, successive processing stages are provided, with each stage performing parallel multiplicative functions and also combining input terms to reduce the total number of terms that remain to be processed. By progressively combining the active terms into a smaller number of terms for subsequent processing, the time needed to process a result can be significantly reduced.
摘要翻译：系统和方法通过彼此并行执行乘法函数来有效地处理摘要，散列或其他结果。在各种实施例中，提供了连续的处理阶段，每个阶段执行并行乘法函数，并且还组合输入项以减少待处理的项的总数。通过将活动术语逐渐组合成较少数量的术语以用于后续处理，可以显着减少处理结果所需的时间。

9. 外观设计

USD655752S1 Clip for a photo album 有权
标题翻译：剪辑一张相册
公开(公告)号：USD655752S1
公开(公告)日：2012-03-13
申请号：US29384871
申请日：2011-02-04
申请人： David King , David Harbinson
设计人： David King , David Harbinson

10. 外观设计

USD625471S1 Fish retention structure 有权
标题翻译：养鱼结构
公开(公告)号：USD625471S1
公开(公告)日：2010-10-12
申请号：US29316174
申请日：2009-08-31
申请人： David King
设计人： David King

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