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1. 发明申请

US20110129522A1 TRANSDERMAL SYSTEM FOR EXTENDED DELIVERY OF INCRETINS AND INCRETN MIMETIC PEPTIDES 审中-公开
标题翻译：用于延长递送和增加化学纤维素的变态系统
公开(公告)号：US20110129522A1
公开(公告)日：2011-06-02
申请号：US13054908
申请日：2009-07-21
申请人： Keren Mevorat-Kaplan , Galit Levin , Hagit Sacks , Meir Stern
发明人： Keren Mevorat-Kaplan , Galit Levin , Hagit Sacks , Meir Stern
IPC分类号： A61K38/26 , A61K38/22 , A61K9/70 , A61P3/04 , A61P3/10
CPC分类号： A61K9/7084 , A61K38/2278
摘要： A transdermal patch formulation of a viscous liquid that includes an active agent of incretin or incretin mimetic peptide, a stabilizer, a buffer, a water soluble thickening agent, and a pharmaceutically acceptable carrier. Also, a patch adapted for transdermal delivery of the active agent and having a drug reservoir compartment of the transdermal patch formulation and a system for facilitating transdermal delivery of the active agent through the skin of a subject. The system includes the patch and an apparatus capable of generating a plurality of micro-channels in an area on the subject's skin. The patch and apparatus are used in methods of treatment for reducing blood glucose level, lowering plasma glucagon levels, reducing food intake, or reducing gastric motility in a subject in need of the same by extending the release of the incretin or incretin mimetic peptide in the subject.
摘要翻译：粘性液体的透皮贴剂制剂，其包含肠降血糖素或模拟肽肠降胆固醇的活性剂，稳定剂，缓冲液，水溶性增稠剂和药学上可接受的载体。而且，适于透皮递送活性剂并具有透皮贴剂制剂的药物储存室的贴剂以及促进活性剂通过受试者皮肤透皮递送的系统。该系统包括贴片和能够在受试者皮肤上的区域中产生多个微通道的装置。贴剂和装置用于治疗方法中，以降低血糖水平，降低血浆胰高血糖素水平，降低食物摄入量，或减少需要相同受试者的胃动力，从而延长肠内营养素或肠促胰岛素素模型肽的释放学科。

2. 发明申请

US20110150976A1 TRANSDERMAL DELIVERY OF OLIGOSACCHARIDES 审中-公开
标题翻译：低密度脂蛋白的转运
公开(公告)号：US20110150976A1
公开(公告)日：2011-06-23
申请号：US13061466
申请日：2009-09-10
申请人： Galit Levin , Hagit Sacks , Meir Stern , Galit Mazooz
发明人： Galit Levin , Hagit Sacks , Meir Stern , Galit Mazooz
IPC分类号： A61K31/727 , A61K31/715 , A61K9/70 , A61P7/02 , A61M37/00
CPC分类号： A61K9/0021 , A61K9/0014 , A61K9/7023 , A61K9/7084 , A61K31/702
摘要： The present invention relates to a system for facilitating transdermal delivery of oligosaccharides, The system includes an apparatus that generates micro-channels in the skin of a subject and a skin patch. The patch includes a pharmaceutical composition containing an active agent of an oligosaccharide. Particularly, the oligosaccharide has 5 to 20 monosaccharide units, such as a pentasaccharide, which exerts anticoagulant activity. The system is capable of delivering the oligosaccharides into the blood circulation for treating thromboembolic diseases.
摘要翻译：本发明涉及促进寡糖透皮递送的系统。该系统包括在受试者的皮肤和皮肤贴片中产生微通道的装置。贴剂包括含有寡糖活性剂的药物组合物。特别地，寡糖具有5〜20个具有抗凝血活性的单糖，例如五糖。该系统能够将低聚糖输送到血液循环中用于治疗血栓栓塞性疾病。

3. 发明申请

US20080274166A1 Patch for Transdermal Drug Delivery 审中-公开
标题翻译：透皮给药补片
公开(公告)号：US20080274166A1
公开(公告)日：2008-11-06
申请号：US11915831
申请日：2006-06-11
申请人： Hagit Sacks , Meir Stern , Galit Levin , Bar El Yossi , Giora Arbel
发明人： Hagit Sacks , Meir Stern , Galit Levin , Bar El Yossi , Giora Arbel
IPC分类号： A61K9/70 , A61P43/00
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7084
摘要： Apparatus is provided including a transdermal drug delivery patch product (10, 100), which includes a patch (20, 120), which includes a drug; and protective packaging, adapted to store the patch (20, 120), and to allow the drug to dry while the patch (20, 120) is stored in the protective packaging. Other embodiments are also described.
摘要翻译：提供了包括透皮药物递送贴片产品（10,100）的装置，其包括贴剂（20,120），其包括药物; 和保护性包装，其适于储存所述贴片（20,120），并且当所述贴片（20,120）存储在所述保护性包装中时允许所述药物干燥。还描述了其它实施例。

4. 发明授权

US08016810B2 Transdermal delivery system for cosmetic agents 有权
标题翻译：化妆品的透皮递送系统
公开(公告)号：US08016810B2
公开(公告)日：2011-09-13
申请号：US10561933
申请日：2004-06-23
申请人： Galit Levin , Hagit Sacks , Sergey Rudaev
发明人： Galit Levin , Hagit Sacks , Sergey Rudaev
IPC分类号： A61M31/00
CPC分类号： A61N1/327 , A61B18/14 , A61B2017/00765 , A61K8/347 , A61K8/368 , A61K8/4953 , A61N1/0424 , A61Q19/02 , A61Q19/06 , A61Q19/08
摘要： An intradermal or transdermal delivery system for topical administration of cosmetic agents, particularly water-soluble, poorly water-soluble, or water-insoluble cosmetic agents, in conjunction with an apparatus that generates micro-channels in the skin of a subject, is useful in treating skin conditions such as cellulite, hyper-pigmentation, skin aging, and acne.
摘要翻译：用于局部施用化妆品，特别是水溶性，水溶性差或水不溶性的化妆品的皮内或透皮递送系统与在受试者的皮肤中产生微通道的装置结合使用可用于治疗皮肤病，如脂肪团，色素沉着过度，皮肤老化和痤疮。

5. 发明申请

US20070287949A1 Transdermal System for Sustained Delivery of Polypeptides 审中-公开
标题翻译：用于持续递送多肽的透皮系统
公开(公告)号：US20070287949A1
公开(公告)日：2007-12-13
申请号：US10580875
申请日：2007-03-15
申请人： Galit Levin , Hagit Sacks
发明人： Galit Levin , Hagit Sacks
IPC分类号： A61K38/02 , A61K38/28 , A61K38/39 , A61K9/14 , A61N1/00 , A61N1/30 , A61P17/00 , C07K14/62 , C07K14/78 , C07K2/00
CPC分类号： A61N1/30 , A61B18/14 , A61B2017/00765 , A61B2018/00452 , A61K9/7007 , A61K9/7084 , A61K38/27 , A61K38/28 , A61N1/044 , A61N1/0448 , A61N1/325
摘要： A transdermal system for sustained delivery of high molecular weight hydrophilic drugs, especially peptide-, polypeptide- or protein-drugs, and methods of use thereof, are provided. The system includes an apparatus that generates micro-channels in the skin of a subject in combination with a transdermal patch comprising at least one drug reservoir layer comprising a polymeric matrix and a therapeutic or immunogenic peptide, polypeptide, or protein. The system provides sustained delivery of therapeutic or immunogenic agents, thereby achieving sustained therapeutic blood concentrations of these agents.
摘要翻译：提供用于持续递送高分子量亲水药物，特别是肽，多肽或蛋白质药物的透皮系统及其使用方法。该系统包括在包含至少一个包含聚合物基质和治疗性或免疫原性肽，多肽或蛋白质的药物储存层的透皮贴剂的情况下在受试者皮肤中产生微通道的装置。该系统提供治疗性或免疫原性药物的持续递送，从而实现这些药剂的持续治疗血液浓度。

6. 发明申请

US20070270732A1 Transdermal Delivery System for Cosmetic Agents 有权
标题翻译：化妆品的透皮递送系统
公开(公告)号：US20070270732A1
公开(公告)日：2007-11-22
申请号：US10561933
申请日：2004-06-23
申请人： Galit Levin , Hagit Sacks , Sergey Rudaev
发明人： Galit Levin , Hagit Sacks , Sergey Rudaev
IPC分类号： A61N1/30 , A61F13/00
CPC分类号： A61N1/327 , A61B18/14 , A61B2017/00765 , A61K8/347 , A61K8/368 , A61K8/4953 , A61N1/0424 , A61Q19/02 , A61Q19/06 , A61Q19/08
摘要： An intradermal or transdermal delivery system for topical administration of cosmetic agents, particularly water-soluble, poorly water-soluble, or water-insoluble cosmetic agents, in conjunction with an apparatus that generates micro-channels in the skin of a subject, is useful in treating skin conditions such as cellulite, hyper-pigmentation, skin aging, and acne.
摘要翻译：用于局部施用化妆品，特别是水溶性，水溶性差或水不溶性的化妆品的皮内或透皮递送系统与在受试者的皮肤中产生微通道的装置结合使用可用于治疗皮肤病，如脂肪团，色素沉着过度，皮肤老化和痤疮。

7. 发明申请

US20060121104A1 Transdermal delivery system for dried particulate or lyophilized medications 有权
公开(公告)号：US20060121104A1
公开(公告)日：2006-06-08
申请号：US11327016
申请日：2006-01-05
申请人： Meir Stern , Galit Levin
发明人： Meir Stern , Galit Levin
IPC分类号： A61K9/70 , A61F13/00
CPC分类号： A61L15/44 , A61K9/0021 , A61K9/703 , A61L2300/252 , A61L2300/414 , A61L2300/43 , A61L2300/602 , A61M37/00 , A61N1/0416 , A61N1/0476 , A61N1/327
摘要： The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of an agent that generates hydrophilic micro-channels, and a patch comprising a therapeutically active agent. The present invention is useful for transdermal delivery of hydrophilic agents, particularly of high molecular weight proteins.

8. 发明授权

US07558625B2 Combined micro-channel generation and iontophoresis for transdermal delivery of pharmaceutical agents 有权
标题翻译：组合的微通道产生和离子电渗疗法用于药物的透皮递送
公开(公告)号：US07558625B2
公开(公告)日：2009-07-07
申请号：US11749814
申请日：2007-05-17
申请人： Galit Levin , Amikam Gershonowitz , Meir Stern , Amir Sherman
发明人： Galit Levin , Amikam Gershonowitz , Meir Stern , Amir Sherman
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： The present invention relates to methods of transdermal delivery of pharmaceutical agents. In particular, the present invention relates to a method for transdermal delivery by generating micro-channels on the skin of a subject and delivering iontophoretically a pharmaceutical agent through the micro-channels. The method provides synergistic transdermal delivery of such pharmaceutical agents.
摘要翻译：本发明涉及药剂的透皮递送方法。特别地，本发明涉及一种通过在受试者的皮肤上产生微通道并通过微通道离子电渗药物给药的透皮递送方法。该方法提供这种药剂的协同透皮递送。

9. 发明申请

US20090137480A1 TRANSDERMAL DELIVERY SYSTEM FOR DRIED PARTICULATE OR LYOPHILIZED MEDICATIONS 有权
标题翻译：用于干燥或延长使用的药物的透皮递送系统
公开(公告)号：US20090137480A1
公开(公告)日：2009-05-28
申请号：US12357283
申请日：2009-01-21
申请人： Meir Stern , Galit Levin
发明人： Meir Stern , Galit Levin
IPC分类号： A61K38/23 , A61P19/10
CPC分类号： A61K9/0021 , A61F2013/00646 , A61K9/703
摘要： The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of an agent that generates hydrophilic micro-channels, and a patch comprising a therapeutically active agent. The present invention is useful for transdermal delivery of hydrophilic agents, particularly of high molecular weight proteins.
摘要翻译：本发明提供了一种用于透皮递送干燥或冻干的药物组合物及其使用方法的系统。该系统包括用于促进产生亲水微通道的药剂的透皮递送的装置和包含治疗活性剂的贴剂。本发明可用于透皮递送亲水剂，特别是高分子量蛋白质。

10. 发明授权

US07383084B2 Transdermal delivery system for dried particulate or lyophilized medications 有权
公开(公告)号：US07383084B2
公开(公告)日：2008-06-03
申请号：US11390844
申请日：2006-03-27
申请人： Meir Stern , Galit Levin
发明人： Meir Stern , Galit Levin
IPC分类号： A61L15/16 , A61N1/30 , A61K38/28
CPC分类号： A61N1/327 , A61K9/0021 , A61K9/703 , A61K9/7084 , A61L15/44 , A61L2300/252 , A61L2300/414 , A61L2300/43 , A61L2300/602 , A61M37/00 , A61N1/042 , A61N1/0436
摘要： The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of an agent that generates hydrophilic micro-channels, and a patch comprising a therapeutically active agent. The present invention is useful for transdermal delivery of hydrophilic agents, particularly of high molecular weight proteins.

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