专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110182905A1 MONOCLONAL ANTIBODIES THAT BIND TO HGM-CSF AND MEDICAL COMPOSITIONS COMPRISING SAME 有权
标题翻译：包含HGM-CSF的单克隆抗体和包含其的医药组合物
公开(公告)号：US20110182905A1
公开(公告)日：2011-07-28
申请号：US12681396
申请日：2008-11-12
申请人： Kenzo Takada , Kantou Nakajima , Barbara Kistler , John Park
发明人： Kenzo Takada , Kantou Nakajima , Barbara Kistler , John Park
IPC分类号： A61K39/395 , C12N15/63 , C12N5/10 , C12P21/08 , C07K16/24 , C07H21/00 , C07H21/04 , A61P11/00 , A61P11/06 , A61P19/02 , A61P17/06 , A61P35/02 , A61P25/00
CPC分类号： C07K16/243 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Disclosed herein are anti-hGM-CSF monoclonal antibodies and antigen-binding fragments of such antibodies, with improved neutralizing capacity to hGM-CSF activity. Pharmaceutical compositions comprising such an antibody or antigen-binding fragment are also provided. The present invention is useful for the treatment of various diseases that are associated with aberrant expression of hGM-CSF.
摘要翻译：本文公开了抗hGM-CSF单克隆抗体和这种抗体的抗原结合片段，具有改善的对hGM-CSF活性的中和能力。还提供了包含这种抗体或抗原结合片段的药物组合物。本发明可用于治疗与hGM-CSF的异常表达相关的各种疾病。

2. 发明授权

US08679502B2 Monoclonal antibodies that bind to HGM-CSF and medical compositions comprising same 有权
标题翻译：结合HGM-CSF的单克隆抗体和包含其的医药组合物
公开(公告)号：US08679502B2
公开(公告)日：2014-03-25
申请号：US12681396
申请日：2008-11-12
申请人： Kenzo Takada , Kantou Nakajima , Barbara Kistler , John Park
发明人： Kenzo Takada , Kantou Nakajima , Barbara Kistler , John Park
IPC分类号： A61K39/395 , C12N5/00 , C12N15/00 , C07K16/22 , C07H21/00
CPC分类号： C07K16/243 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Disclosed herein are anti-hGM-CSF monoclonal antibodies and antigen-binding fragments of such antibodies, with improved neutralizing capacity to hGM-CSF activity. Pharmaceutical compositions comprising such an antibody or antigen-binding fragment are also provided. The present invention is useful for the treatment of various diseases that are associated with aberrant expression of hGM-CSF.
摘要翻译：本文公开了抗hGM-CSF单克隆抗体和这种抗体的抗原结合片段，具有改善的对hGM-CSF活性的中和能力。还提供了包含这种抗体或抗原结合片段的药物组合物。本发明可用于治疗与hGM-CSF的异常表达相关的各种疾病。

3. 发明申请

US20090004198A1 Human monoclonal antibody binding to human cytomegalovirus and its antigen binding portion 审中-公开
标题翻译：人单克隆抗体结合人巨细胞病毒及其抗原结合部分
公开(公告)号：US20090004198A1
公开(公告)日：2009-01-01
申请号：US12228393
申请日：2008-08-12
申请人： Kantou Nakajima , Takeshi Matsumura , Uiko Kagaya
发明人： Kantou Nakajima , Takeshi Matsumura , Uiko Kagaya
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06 , C12N1/20 , C12N1/19 , A61P31/00
CPC分类号： C07K16/088 , A61K2039/505 , C07K2317/21 , C07K2317/76
摘要： The present invention aims to provide a human monoclonal antibody and an antigen binding portion of a human monoclonal antibody with higher affinity and neutralizing capacity to the human cytomegalovirus (HCMV), a virus which causes various diseases in situations where immunodeficiencies are present. The current invention provides an anti-human cytomegalovirus (HCMV) monoclonal antibody which is a human monoclonal antibody capable of binding to HCMV and neutralizing bioactivity of the HCMV, and which may be further characterized as possessing a light chain (L chain) comprising an amino acid sequence of SEQ ID. NO. 1, and has a heavy chain (H chain) comprising an amino acid sequence of SEQ ID NO. 2.
摘要翻译：本发明旨在提供人单克隆抗体和人单克隆抗体的抗原结合部分，其具有对存在免疫缺陷的情况下引起各种疾病的人巨细胞病毒（HCMV）的高亲和力和中和能力。本发明提供了抗人巨细胞病毒（HCMV）单克隆抗体，其是能够结合HCMV并中和HCMV的生物活性的人单克隆抗体，并且其可进一步表征为具有包含氨基的轻链（L链）酸序列。没有。 1，并且具有包含SEQ ID NO：1的氨基酸序列的重链（H链）。 2。

4. 发明申请

US20080317757A1 Human monoclonal antibody binding to hGM-CSF and its antigen binding portion 有权
标题翻译：与hGM-CSF结合的人单克隆抗体及其抗原结合部分
公开(公告)号：US20080317757A1
公开(公告)日：2008-12-25
申请号：US12149009
申请日：2008-04-24
申请人： Kantou Nakajima
发明人： Kantou Nakajima
IPC分类号： C07K16/26 , A61K39/395 , C12N15/13 , C12N5/10
CPC分类号： C07K16/243 , A61K2039/505 , C07K14/535 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： [Problems] The present invention aims to provide a human monoclonal antibody with higher affinity and neutralizing capacity to the hGM-CSF, whose overproduction causes various diseases.[Means for Solving Problems] An anti-hGM-CSF monoclonal antibody which is a human monoclonal antibody capable of binding to hGM-CSF and neutralizing bioactivity of the hGM-CSF, wherein the anti-hGM-CSF monoclonal antibody has a light chain (L chain) represented by an amino acid sequence of sequence number 1, and has a heavy chain (H chain) represented by an amino acid sequence of sequence number 2.
摘要翻译：本发明旨在提供对hGM-CSF具有更高亲和力和中和能力的人单克隆抗体，其过量产生引起各种疾病。解决问题的手段抗hGM-CSF单克隆抗体是能够结合hGM-CSF的人单克隆抗体并中和hGM-CSF的生物活性，其中抗hGM-CSF单克隆抗体具有轻链（ L链），具有由序列号2的氨基酸序列表示的重链（H链）。

5. 发明授权

US07935795B2 Human monoclonal antibody binding to hGM-CSF and its antigen binding portion 有权
标题翻译：与hGM-CSF结合的人单克隆抗体及其抗原结合部分
公开(公告)号：US07935795B2
公开(公告)日：2011-05-03
申请号：US12149009
申请日：2008-04-24
申请人： Kantou Nakajima
发明人： Kantou Nakajima
IPC分类号： C12P21/08
CPC分类号： C07K16/243 , A61K2039/505 , C07K14/535 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： The present invention provides a human monoclonal antibody, and antigen-binding portions thereof, capable of binding to human granulocyte-macrophage colony stimulating factor (hGM-CSF) and neutralizing the bioactivity of the hGM-CSF, wherein the anti-hGM-CSF monoclonal antibody has a light chain (L chain) including an amino acid sequence SEQ ID NO:1 and a heavy chain (H chain) including an amino acid sequence SEQ ID NO: 2. Also provided are human monoclonal anti-hGM-CSF antibodies, and antigen-binding portions thereof, characterized by complementarity determining regions (CDRs) or H chain and L chain variable regions related to SEQ ID NO:1 and SEQ ID NO:2. Antibodies, and antigen-binding portions thereof, of the invention are useful in the treatment of diseases associated with overproduction of hGM-CSF, including allergic disease, graft rejection and graft-versus-host disease (GVHD), and autoimmune diseases.
摘要翻译：本发明提供能够结合人粒细胞 - 巨噬细胞集落刺激因子（hGM-CSF）的人单克隆抗体及其抗原结合部分，并中和hGM-CSF的生物活性，其中抗hGM-CSF单克隆抗体抗体具有包含氨基酸序列SEQ ID NO：1的轻链（L链）和包含氨基酸序列SEQ ID NO：2的重链（H链）。还提供了人单克隆抗hGM-CSF抗体，和其抗原结合部分，其特征在于与SEQ ID NO：1和SEQ ID NO：2相关的互补决定区（CDR）或H链和L链可变区。本发明的抗体及其抗原结合部分可用于治疗与过量生产hGM-CSF相关的疾病，包括过敏性疾病，移植排斥反应和移植物抗宿主病（GVHD）和自身免疫性疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式