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1. 发明授权

US07498415B2 Recombinant antibody against human insulin-like growth factor 有权
标题翻译：针对人胰岛素样生长因子的重组抗体
公开(公告)号：US07498415B2
公开(公告)日：2009-03-03
申请号：US10573378
申请日：2004-09-24
申请人： Kenya Shitara , Kazuyasu Nakamura , Yuji Ohki
发明人： Kenya Shitara , Kazuyasu Nakamura , Yuji Ohki
IPC分类号： C07K16/00 , C07K16/28
CPC分类号： C07K16/2896 , C07K2317/73
摘要： It is demanded that pharmaceutical agents for therapeutic treatment of diseases such as cancer, acromegaly and diabetic complications, of which IGF is involved in the progress of the conditions.The present invention provides a recombinant antibody or an antibody fragment thereof which specifically binds to human insulin-like growth factor-I (hereinafter referred to as hIGF-I) and human insulin-like growth factor-II (hereinafter referred to as hIGF-II) to inhibit the biological activities of human IGF-I and human IGF-II, a transformant producing the antibody or the antibody fragment thereof, a process for producing the antibody or the antibody fragment thereof, and a medicament comprising the antibody or the antibody fragment thereof as the active ingredient therein.
摘要翻译：要求用于治疗治疗诸如癌症，肢端肥大症和糖尿病并发症的药剂，其中IGF涉及条件的进展。本发明提供与人胰岛素样生长因子-1（以下称为hIGF-1）和人胰岛素样生长因子-II（以下称为hIGF-II）特异性结合的重组抗体或其抗体片段）抑制人IGF-I和人IGF-II的生物活性，产生抗体或其抗体片段的转化体，制备抗体或其抗体片段的方法，以及包含抗体或抗体片段的药物作为其中的活性成分。

2. 发明授权

US07438911B2 Antibody against human insulin-like growth factor 有权
标题翻译：抗人类胰岛素样生长因子的抗体
公开(公告)号：US07438911B2
公开(公告)日：2008-10-21
申请号：US10513148
申请日：2003-04-30
申请人： Kenya Shitara , Kazuyasu Nakamura , Akiko Furuya , Rinpei Niwa , Yuji Ohki , Nobuo Hanai
发明人： Kenya Shitara , Kazuyasu Nakamura , Akiko Furuya , Rinpei Niwa , Yuji Ohki , Nobuo Hanai
IPC分类号： A61K39/395 , G01N33/53 , C12N5/06 , C12N15/00 , C12P21/08 , C07K16/22
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present invention provides antibodies which have the ability to specifically bind to human IGF-I and IGF-II to thereby inhibit the functions of human IGF-I and IGF-II and have binding activity with a binding constant of 5×109 M−1 or more measured with a biosensor BIACORE. In addition, the present invention provides diagnostics, preventives and remedies for an hIGF-mediated disease and a disease showing pathological progressing due to abnormally promoted hIGF production, which use said antibodies.
摘要翻译：为了有效治疗诸如hIGF参与的癌症的疾病，期望开发出与hIGF-1和hIGF-II两者强烈结合并抑制其功能和这些抗体片段的抗体。本发明提供具有特异性结合人IGF-I和IGF-II从而抑制人IGF-I和IGF-II的功能并具有结合常数为5×10 9的结合活性的抗体，或者用生物传感器BIACORE测量的更高/更高。此外，本发明提供了hIGF介导的疾病的诊断，预防措施和补救措施以及由于异常促进的hIGF产生导致使用所述抗体的病理进展的疾病。

3. 发明申请

US20060263362A1 Cancer metastasis inhibitor 审中-公开
标题翻译：癌转移抑制剂
公开(公告)号：US20060263362A1
公开(公告)日：2006-11-23
申请号：US10568714
申请日：2004-08-20
申请人： Atsushi Ochiai , Kenya Shitara , Kazuyasu Nakamura , Yuji Ohki
发明人： Atsushi Ochiai , Kenya Shitara , Kazuyasu Nakamura , Yuji Ohki
IPC分类号： A61K39/395
CPC分类号： A61K31/00
摘要： An object of the present invention is to provide a cancer metastasis inhibitor or, more particularly, a useful pharmaceutical composition for treating of bone metastasis and liver metastasis. In accordance with the invention, a cancer metastasis inhibitor comprising a substance inhibiting the activity of IGF (insulin-like growth factor)-I and IGF-II is an active ingredient is provided. The inhibitor can significantly suppress the metastasis of cancer.
摘要翻译：本发明的目的是提供一种癌症转移抑制剂，更具体地，提供一种治疗骨转移和肝转移的有用的药物组合物。根据本发明，提供了包含抑制IGF（胰岛素样生长因子）-I和IGF-II的活性的物质的癌症转移抑制剂是活性成分。抑制剂可显着抑制癌症转移。

4. 发明申请

US20060240015A1 Recombinant antibody against human insulin-like growth factor 有权
公开(公告)号：US20060240015A1
公开(公告)日：2006-10-26
申请号：US10573378
申请日：2004-09-24
申请人： Kenya Shitara , Kazuyasu Nakamura , Yuji Ohki
发明人： Kenya Shitara , Kazuyasu Nakamura , Yuji Ohki
IPC分类号： A61K39/395 , C07K16/26
CPC分类号： C07K16/2896 , C07K2317/73
摘要： It is demanded that pharmaceutical agents for therapeutic treatment of diseases such as cancer, acromegaly and diabetic complications, of which IGF is involved in the progress of the conditions. The present invention provides a recombinant antibody or an antibody fragment thereof which specifically binds to human insulin-like growth factor-I (hereinafter referred to as hIGF-I) and human insulin-like growth factor-II (hereinafter referred to as hIGF-II) to inhibit the biological activities of human IGF-I and human IGF-II, a transformant producing the antibody or the antibody fragment thereof, a process for producing the antibody or the antibody fragment thereof, and a medicament comprising the antibody or the antibody fragment thereof as the active ingredient therein.

5. 发明申请

US20060165695A1 Antibody against human insulin-like growth factor 有权
标题翻译：抗人类胰岛素样生长因子的抗体
公开(公告)号：US20060165695A1
公开(公告)日：2006-07-27
申请号：US10513148
申请日：2003-04-30
申请人： Kenya Shitara , Kazuyasu Nakamura , Akiko Furuya , Rinpei Niwa , Yuji Ohki
发明人： Kenya Shitara , Kazuyasu Nakamura , Akiko Furuya , Rinpei Niwa , Yuji Ohki
IPC分类号： A61K39/395 , G01N33/53 , C07H21/04 , C12P21/06 , C07K16/22 , C12N5/06
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present invention provides antibodies which have the ability to specifically bind to human IGF-I and IGF-II to thereby inhibit the functions of human IGF-I and IGF-II and have binding activity with a binding constant of 5×109 M−1 or more measured with a biosensor BIACORE. In addition, the present invention provides diagnostics, preventives and remedies for an hIGF-mediated disease and a disease showing pathological progressing due to abnormally promoted hIGF production, which use said antibodies.
摘要翻译：为了有效治疗诸如hIGF参与的癌症的疾病，期望开发出与hIGF-1和hIGF-II两者强烈结合并抑制其功能和这些抗体片段的抗体。本发明提供具有特异性结合人IGF-I和IGF-II从而抑制人IGF-I和IGF-II的功能并具有结合常数为5×10 9的结合活性的抗体，或者用生物传感器BIACORE测量的更高/更高。此外，本发明提供了hIGF介导的疾病的诊断，预防措施和补救措施以及由于异常促进的hIGF产生导致使用所述抗体的病理进展的疾病。

6. 发明授权

US08093362B2 Anti-PERP recombinant antibody 有权
标题翻译：抗PERP重组抗体
公开(公告)号：US08093362B2
公开(公告)日：2012-01-10
申请号：US11634209
申请日：2006-12-06
申请人： Atsushi Ochiai , Emi Hosaka , Kazuyasu Nakamura , Akiko Furuya , Yuji Ohki
发明人： Atsushi Ochiai , Emi Hosaka , Kazuyasu Nakamura , Akiko Furuya , Yuji Ohki
IPC分类号： C07K16/00 , C12P21/08 , C12P21/04 , A61K39/395 , A61K39/00
CPC分类号： C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732
摘要： An antibody which binds to a polypeptide encoded by human PERP (p53 apoptosis effector related to PMP-22) gene which is considered to be related to incidence of cancer or the like is desired. The present invention provides a gene recombinant antibody which has no consensus sequence of an N-linked sugar chain in a variable region, specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by the PERP gene and binds to the extracellular region. The antibody is useful for treatment of various diseases expressing a polypeptide encoded by the PERP gene.
摘要翻译：需要与被认为与癌症等发生相关的人PERP（PMP-22）相关的p53凋亡效应基因编码的多肽结合的抗体。本发明提供了在可变区中不具有N-连接糖链的共有序列的基因重组抗体，特异性地识别由PERP基因编码的多肽的细胞外区域的三维结构并结合到细胞外区域。该抗体可用于治疗表达由PERP基因编码的多肽的各种疾病。

7. 发明申请

US20080267953A1 Anti-perp recombinant antibody 有权
标题翻译：抗重组抗体
公开(公告)号：US20080267953A1
公开(公告)日：2008-10-30
申请号：US11634209
申请日：2006-12-06
申请人： Atsushi Ochiai , Emi Hosaka , Kazuyasu Nakamura , Akiko Furuya , Yuji Ohki
发明人： Atsushi Ochiai , Emi Hosaka , Kazuyasu Nakamura , Akiko Furuya , Yuji Ohki
IPC分类号： A61K39/395 , C07K16/18 , C12P21/02 , A61P35/00 , C12N15/85 , C12N15/13 , C12N5/16
CPC分类号： C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732
摘要： An antibody which binds to a polypeptide encoded by human PERP (p53 apoptosis effector related to PMP-22) gene which is considered to be related to incidence of cancer or the like is desired. The present invention provides a gene recombinant antibody which has no consensus sequence of an N-linked sugar chain in a variable region, specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by the PERP gene and binds to the extracellular region. The antibody is useful for treatment of various diseases expressing a polypeptide encoded by the PERP gene.
摘要翻译：需要与被认为与癌症等发生相关的人PERP（PMP-22）相关的p53凋亡效应基因编码的多肽结合的抗体。本发明提供了在可变区中不具有N-连接糖链的共有序列的基因重组抗体，特异性地识别由PERP基因编码的多肽的细胞外区域的三维结构并结合到细胞外区域。该抗体可用于治疗表达由PERP基因编码的多肽的各种疾病。

8. 发明授权

US07626634B2 Camera stand with camera charging mechanism 有权
标题翻译：相机支架带相机充电机构
公开(公告)号：US07626634B2
公开(公告)日：2009-12-01
申请号：US10922277
申请日：2004-08-19
申请人： Yuji Ohki , Atsushi Shigemura , Masakazu Iwamoto , Shuji Shibuki
发明人： Yuji Ohki , Atsushi Shigemura , Masakazu Iwamoto , Shuji Shibuki
IPC分类号： H04N5/225
CPC分类号： H04N1/195 , F16M11/10 , F16M11/2021 , F16M11/38 , H04N2101/00
摘要： A camera stand comprising a foot that will be placed a surface, a support having opposite ends at one of which the support is supported rotatably on the foot and turnable between a lying position and an upstanding position, an arm mechanism capable of attaching a digital camera removably at one end thereto and supported rotatably at the other end to the other end of the support such that in use the arm mechanism is adjusted in angle to the support so as to allow the camera to pick up an image of a picture/document placed under the camera while in non-use the arm mechanism is received within the confine of the support, which is then folded on the foot.
摘要翻译：一种相机支架，包括将被放置在表面上的脚，支撑件具有相对的端部，其中一个支撑件可旋转地支撑在脚上，并且可在平躺位置和直立位置之间转动;臂机构，其能够附接数字照相机可拆卸地在一端向上并且可旋转地支撑在另一端到支撑件的另一端，使得在使用中臂臂机构被调整成与支撑件成一定角度，以便允许相机拾起放置的图片/文件的图像在照相机下，在不使用时，臂机构被容纳在支撑件的限制内，然后将其折叠在脚上。

9. 外观设计

USD554679S1 Digital camera 有权
公开(公告)号：USD554679S1
公开(公告)日：2007-11-06
申请号：US29260363
申请日：2006-05-24
申请人： Yosuke Nagayama , Yuji Ohki
设计人： Yosuke Nagayama , Yuji Ohki

10. 外观设计

USD367494S Electronic calculator having the functions of telephone book, address book, calendar, schedule book and memo book 失效
公开(公告)号：USD367494S
公开(公告)日：1996-02-27
申请号：US030526
申请日：1994-11-01
申请人： Yuji Ohki
设计人： Yuji Ohki

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