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1. 发明授权

US07692856B2 Focus error detecting optical system for a microscope 有权
标题翻译：用于显微镜的聚焦误差检测光学系统
公开(公告)号：US07692856B2
公开(公告)日：2010-04-06
申请号：US11730438
申请日：2007-04-02
申请人： Kenta Mikuriya , Takayuki Kei , Yasunori Yokoyama , Naomichi Chida , Yoshiaki Naganuma
发明人： Kenta Mikuriya , Takayuki Kei , Yasunori Yokoyama , Naomichi Chida , Yoshiaki Naganuma
IPC分类号： G02B21/00
CPC分类号： G02B21/245
摘要： A focus error detecting optical system has an optical parameter which makes a focus lock-in range by a focus error signal be a value capable of detecting focus on a front surface of a cover glass and focus on a back surface thereof separately. A control section, based on the focus error signal obtained by the focus error detecting optical system, brings a focal point of an observational optical system to a focus position. Further, focus error detecting optical systems include optical units each having an optical parameter corresponding to a numerical aperture of respective objective lenses. A control section selects the optical unit of the focus error detecting optical system corresponding to the objective lens in use. The control section, using a focus error signal obtained by the selected focus error detecting optical system, brings a focal point of an observational optical system to a focus position.
摘要翻译：聚焦误差检测光学系统具有通过聚焦误差信号使焦点锁定范围成为能够检测聚焦在盖玻璃的前表面并分别聚焦在其背面上的值的光学参数。基于由聚焦误差检测光学系统获得的聚焦误差信号的控制部分将观察光学系统的焦点带到聚焦位置。此外，聚焦误差检测光学系统包括各自具有对应于各个物镜的数值孔径的光学参数的光学单元。控制部选择与使用中的物镜对应的聚焦误差检测光学系统的光学单元。使用由所选择的聚焦误差检测光学系统获得的聚焦误差信号的控制部分将观察光学系统的焦点带到聚焦位置。

2. 发明申请

US20070236687A1 Microscope 有权
标题翻译：显微镜
公开(公告)号：US20070236687A1
公开(公告)日：2007-10-11
申请号：US11730438
申请日：2007-04-02
申请人： Kenta Mikuriya , Takayuki Kei , Yasunori Yokoyama , Naomichi Chida , Yoshiaki Naganuma
发明人： Kenta Mikuriya , Takayuki Kei , Yasunori Yokoyama , Naomichi Chida , Yoshiaki Naganuma
IPC分类号： G01B11/26
CPC分类号： G02B21/245
摘要： A focus error detecting optical system has an optical parameter which makes a focus lock-in range by a focus error signal be a value capable of detecting focus on a front surface of a cover glass and focus on aback surface thereof separately. A control section, based on the focus error signal obtained by the focus error detecting optical system, brings a focal point of an observational optical system to a focus position. Further, focus error detecting optical systems include optical units each having an optical parameter corresponding to a numerical aperture of respective objective lenses. A control section selects the optical unit of the focus error detecting optical system corresponding to the objective lens in use. The control section, using a focus error signal obtained by the selected focus error detecting optical system, brings a focal point of an observational optical system to a focus position.
摘要翻译：聚焦误差检测光学系统具有通过聚焦误差信号使聚焦锁定范围成为能够检测聚焦在盖玻璃前表面上并分别聚焦在其表面上的光学参数的光学参数。基于由聚焦误差检测光学系统获得的聚焦误差信号的控制部分将观察光学系统的焦点带到聚焦位置。此外，聚焦误差检测光学系统包括各自具有对应于各个物镜的数值孔径的光学参数的光学单元。控制部选择与使用中的物镜对应的聚焦误差检测光学系统的光学单元。使用由所选择的聚焦误差检测光学系统获得的聚焦误差信号的控制部分将观察光学系统的焦点带到聚焦位置。

3. 发明授权

US07400446B2 Confocal microscope 失效
标题翻译：共焦显微镜
公开(公告)号：US07400446B2
公开(公告)日：2008-07-15
申请号：US11362228
申请日：2006-02-27
申请人： Kenta Mikuriya , Takashi Yoshida , Takayuki Kei
发明人： Kenta Mikuriya , Takashi Yoshida , Takayuki Kei
IPC分类号： G02B21/06
CPC分类号： G02B21/004 , G02B21/0044 , G02B21/0076
摘要： A confocal microscope uses fluorescent or reflected light obtained by irradiating a plurality of beam spots to a sample so as to observe the sample. The confocal microscope has a phase modulator element which modulates phase of laser light to form the beam spots, a liquid crystal element which forms a plurality of pinholes through which only the fluorescent or the reflected light is transmitted, and a control section which controls the phase modulator element and the liquid crystal element.
摘要翻译：共焦显微镜使用通过对样品照射多个束斑而获得的荧光或反射光，以观察样品。共聚焦显微镜具有调制激光相位以形成光束斑的相位调制元件，形成仅透过荧光或反射光的多个针孔的液晶元件和控制相位的控制部调制元件和液晶元件。

4. 发明授权

US06982824B2 Three-dimensional confocal microscope system 失效
标题翻译：三维共焦显微镜系统
公开(公告)号：US06982824B2
公开(公告)日：2006-01-03
申请号：US10800754
申请日：2004-03-16
申请人： Takayuki Kei , Kenji Hachiya , Kenta Mikuriya
发明人： Takayuki Kei , Kenji Hachiya , Kenta Mikuriya
IPC分类号： G02B21/00
CPC分类号： G02B21/0024
摘要： The present invention is characterized in that it is possible to provide a three-dimensional confocal microscope system configured so that an objective lens can be scanned in the optical-axis direction using an actuator to obtain sliced confocal images of a sample, wherein the actuator is driven using a scanning waveform signal, which is triangular or step-like and has been corrected so that acceleration is kept virtually constant at discontinuous points of change in the scanning waveform signal, thereby consistently providing sliced confocal images of the sample.
摘要翻译：本发明的特征在于，可以提供一种三维共聚焦显微镜系统，其被配置为使得可以使用致动器在光轴方向上扫描物镜，以获得样品的切片共聚焦图像，其中致动器是使用三角形或阶梯状的扫描波形信号进行驱动，并且已被校正，使得加速度在扫描波形信号的不连续点处几乎保持不变，从而一致地提供样品的切片共聚焦图像。

5. 发明申请

US20060044648A1 THREE-DIMENSIONAL CONFOCAL MICROSCOPE 失效
标题翻译：三维共焦显微镜
公开(公告)号：US20060044648A1
公开(公告)日：2006-03-02
申请号：US10929554
申请日：2004-08-31
申请人： Takashi Akiyama , Takayuki Kei , Kenta Mikuriya
发明人： Takashi Akiyama , Takayuki Kei , Kenta Mikuriya
IPC分类号： G02B21/00
CPC分类号： G02B3/14 , G02B21/006 , G02B21/0084 , G02B26/005
摘要： This invention realizes a three-dimensional confocal microscope in which mechanical vibrations do not occur in the scanning unit for scanning in the direction of optical axis, and in which scanning in the direction of optical axis can be carried out at a high speed. This invention has the following features. In the confocal microscope having a confocal scanner attached to an optical microscope and constructed to enable acquisition of an image of a sample as a confocal image by the confocal scanner, a variable-focus lens of surface tension control type having no moving part is uses as the field lens.
摘要翻译：本发明实现了三维共聚焦显微镜，其中在扫描单元中不会在光轴方向上进行机械振动，并且可以高速地进行光轴方向的扫描。本发明具有以下特征。在具有附着到光学显微镜并被构造为能够通过共聚焦扫描仪获取样品的图像作为共焦图像的共聚焦扫描器的共聚焦显微镜中，具有无移动部分的表面张力控制型变焦聚焦透镜用作现场镜头。

6. 发明授权

US07002737B1 Three-dimensional confocal microscope 失效
标题翻译：三维共聚焦显微镜
公开(公告)号：US07002737B1
公开(公告)日：2006-02-21
申请号：US10929554
申请日：2004-08-31
申请人： Takashi Akiyama , Takayuki Kei , Kenta Mikuriya
发明人： Takashi Akiyama , Takayuki Kei , Kenta Mikuriya
IPC分类号： G02B21/00
CPC分类号： G02B3/14 , G02B21/006 , G02B21/0084 , G02B26/005
摘要： This invention realizes a three-dimensional confocal microscope in which mechanical vibrations do not occur in the scanning unit for scanning in the direction of optical axis, and in which scanning in the direction of optical axis can be carried out at a high speed. This invention has the following features. In the confocal microscope having a confocal scanner attached to an optical microscope and constructed to enable acquisition of an image of a sample as a confocal image by the confocal scanner, a variable-focus lens of surface tension control type having no moving part is uses as the field lens.
摘要翻译：本发明实现了三维共聚焦显微镜，其中在扫描单元中不会在光轴方向上进行机械振动，并且可以高速地进行光轴方向的扫描。本发明具有以下特征。在具有附着到光学显微镜并被构造为能够通过共聚焦扫描仪获取样品的图像作为共焦图像的共聚焦扫描器的共聚焦显微镜中，具有无移动部分的表面张力控制型变焦聚焦透镜用作现场镜头。

7. 发明申请

US20050012989A1 Three-dimensional confocal microscope system 失效
标题翻译：三维共焦显微镜系统
公开(公告)号：US20050012989A1
公开(公告)日：2005-01-20
申请号：US10800754
申请日：2004-03-16
申请人： Takayuki Kei , Kenji Hachiya , Kenta Mikuriya
发明人： Takayuki Kei , Kenji Hachiya , Kenta Mikuriya
IPC分类号： G02B21/00
CPC分类号： G02B21/0024
摘要： The present invention is characterized in that it is possible to provide a three-dimensional confocal microscope system configured so that an objective lens can be scanned in the optical-axis direction using an actuator to obtain sliced confocal images of a sample, wherein the actuator is driven using a scanning waveform signal, which is triangular or step-like and has been corrected so that acceleration is kept virtually constant at discontinuous points of change in the scanning waveform signal, thereby consistently providing sliced confocal images of the sample.
摘要翻译：本发明的特征在于，可以提供一种三维共聚焦显微镜系统，其被配置为使得可以使用致动器在光轴方向上扫描物镜，以获得样品的切片共聚焦图像，其中致动器是使用三角形或阶梯状的扫描波形信号进行驱动，并且已被校正，使得加速度在扫描波形信号的不连续点处几乎保持不变，从而一致地提供样品的切片共聚焦图像。

8. 发明申请

US20060209399A1 Confocal microscope 失效
标题翻译：共焦显微镜
公开(公告)号：US20060209399A1
公开(公告)日：2006-09-21
申请号：US11362228
申请日：2006-02-27
申请人： Kenta Mikuriya , Takashi Yoshida , Takayuki Kei
发明人： Kenta Mikuriya , Takashi Yoshida , Takayuki Kei
IPC分类号： G02B21/06
CPC分类号： G02B21/004 , G02B21/0044 , G02B21/0076
摘要： A confocal microscope uses fluorescent or reflected light obtained by irradiating a plurality of beam spots to a sample so as to observe the sample. The confocal microscope has a phase modulator element which modulates phase of laser light to form the beam spots, a liquid crystal element which forms a plurality of pinholes through which only the fluorescent or the reflected light is transmitted, and a control section which controls the phase modulator element and the liquid crystal element.
摘要翻译：共焦显微镜使用通过对样品照射多个束斑而获得的荧光或反射光，以观察样品。共聚焦显微镜具有调制激光相位以形成光束斑的相位调制元件，形成仅透过荧光或反射光的多个针孔的液晶元件和控制相位的控制部调制元件和液晶元件。

9. 发明申请

US20060050375A1 Confocal microscope 审中-公开
标题翻译：共焦显微镜
公开(公告)号：US20060050375A1
公开(公告)日：2006-03-09
申请号：US11210656
申请日：2005-08-25
申请人： Kenta Mikuriya , Takayuki Kei , Takashi Yoshida
发明人： Kenta Mikuriya , Takayuki Kei , Takashi Yoshida
IPC分类号： G02B21/06
CPC分类号： G02B21/0076 , G02B21/0044 , G02B21/0064
摘要： A confocal microscope for performing an observation of a sample using a confocal image, the confocal microscope comprises a microscope, a confocal scanner of a Nipkow disk type, and a laser beam output section which is connected to the microscope and outputs a first laser beam for applying photic stimulation on the sample.
摘要翻译：共焦显微镜用于使用共聚焦图像进行样品的观察，共聚焦显微镜包括显微镜，Nipkow盘型的共聚焦扫描仪和激光束输出部分，其连接到显微镜并输出第一激光束对样品施加光刺激。

10. 发明授权

US5428475A Confocal optical scanner 失效
标题翻译：共焦光学扫描仪
公开(公告)号：US5428475A
公开(公告)日：1995-06-27
申请号：US942156
申请日：1992-09-08
申请人： Takeo Tanaami , Kenta Mikuriya
发明人： Takeo Tanaami , Kenta Mikuriya
IPC分类号： G02B3/00 , G02B3/08 , G02B21/00 , G02B26/02
CPC分类号： G02B3/0056 , G02B21/0044 , G02B21/0064 , G02B3/08 , G02B3/0006
摘要： A confocal optical scanner which realizes optical scanning without nonuniformity of brightness at the inside and outside periperies of the pinhole disk by arraying the pinholes along spiral tracks at the same pitch; which allows adjustment of decentering to be readily performed by disposing pinholes so that stripes do not occur even when decentering is large; which allows more incident light to be collected at the pinholes through a plurality of collector elements by disposing the pinholes at focal points of the collector elements; which improves luminous utilization efficacy by reducing the illumination area of light by adopting the collector elements to focus outside of the aperture pupil; which prevents decrease of confocal resolution due to pinhole diameter by causing the light reflected from the sample to not enter a collector disk; and which reduces stray light from the pinhole disk by covering non-collector portions of the collector disk with a shading film.
摘要翻译：一种共焦光学扫描仪，通过以相同的间距沿着螺旋轨道排列针孔，实现光学扫描，而不会在针孔盘的内侧和外侧的亮度不均匀; 这允许通过布置针孔来容易地进行偏心调节，使得即使在偏心较大时也不会发生条纹; 这允许通过将针孔设置在集电器元件的焦点处，通过多个收集器元件在针孔处收集更多的入射光; 通过采集收集器元件聚焦在孔径光瞳外部，通过减小光的照明面积来提高发光效率; 通过使得从样品反射的光不进入集电盘，防止由于针孔直径引起的共聚焦分辨率降低; 并且通过用遮光膜覆盖收集盘的非集电器部分来减少来自针孔盘的杂散光。

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