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1. 发明授权

US08688221B2 Collecting posture and activity information to evaluate therapy 有权
标题翻译：收集姿势和活动信息以评估治疗
公开(公告)号：US08688221B2
公开(公告)日：2014-04-01
申请号：US13401348
申请日：2012-02-21
申请人： Keith A. Miesel , Kenneth T. Heruth , Gregory F. Molnar
发明人： Keith A. Miesel , Kenneth T. Heruth , Gregory F. Molnar
IPC分类号： A61N1/36
CPC分类号： A61B5/103 , A61B5/0205 , A61B5/1116 , A61B5/4082 , A61B5/4094 , A61B5/6804 , A61B5/6825 , A61B5/686 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36071 , A61N1/36082 , A61N1/36585 , A61N1/37235 , G06F19/00
摘要： A medical device, programmer, or other computing device may determine values of one or more activity and, in some embodiments, posture metrics for each therapy parameter set used by the medical device to deliver therapy. The metric values for a parameter set are determined based on signals generated by the sensors when that therapy parameter set was in use. Activity metric values may be associated with a postural category in addition to a therapy parameter set, and may indicate the duration and intensity of activity within one or more postural categories resulting from delivery of therapy according to a therapy parameter set. A posture metric for a therapy parameter set may indicate the fraction of time spent by the patient in various postures when the medical device used a therapy parameter set. The metric values may be used to evaluate the efficacy of the therapy parameter sets.
摘要翻译：医疗设备，程序员或其他计算设备可以确定一个或多个活动的值，并且在一些实施例中，确定由医疗设备用于递送治疗的每个治疗参数集的姿势度量。当参数组被使用时，基于由传感器产生的信号来确定参数集的度量值。除了治疗参数集之外，活动度量值可以与姿势类别相关联，并且可以指示根据治疗参数集合递送治疗产生的一个或多个姿势类别内的活动的持续时间和强度。用于治疗参数组的姿势度量可以指示当医疗装置使用治疗参数集时患者在各种姿势中花费的时间的分数。度量值可用于评估治疗参数组的功效。

2. 发明授权

US08337431B2 Collecting activity and sleep quality information via a medical device 有权
标题翻译：通过医疗设备收集活动和睡眠质量信息
公开(公告)号：US08337431B2
公开(公告)日：2012-12-25
申请号：US12351414
申请日：2009-01-09
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61B5/103 , A61B5/117
CPC分类号： A61B5/1116 , A61B5/1118 , A61B5/4519 , A61B5/4815 , A61B5/6826 , A61B5/686 , A61N1/36135 , A61N1/36542
摘要： A device, such as an implantable medical device (IMD) or a programming device, determines when a patient is attempting to sleep. When the device determines that the patient is attempting to sleep, the device determines values for one or more metrics that indicate the quality of a patient's sleep based on at least one physiological parameter of the patient. When the device determines that the patient is not attempting to sleep, the device periodically determines activity levels of the patient. Activity metric values may be determined based on the determined activity levels. A clinician may use sleep quality information and patient activity information presented by a programming device to, for example, evaluate the effectiveness of therapy delivered to the patient by the medical device.
摘要翻译：诸如可植入医疗装置（IMD）或编程装置之类的装置确定患者何时试图睡觉。当设备确定患者正在尝试睡眠时，设备基于患者的至少一个生理参数来确定指示患者睡眠质量的一个或多个度量的值。当设备确定患者没有尝试睡眠时，设备周期性地确定患者的活动水平。活动度量值可以基于确定的活动水平来确定。临床医生可以使用由编程设备呈现的睡眠质量信息和患者活动信息，以例如评估由医疗设备递送给患者的治疗的有效性。

3. 发明授权

US08335568B2 Controlling therapy based on sleep quality 有权
标题翻译：基于睡眠质量控制治疗
公开(公告)号：US08335568B2
公开(公告)日：2012-12-18
申请号：US12544727
申请日：2009-08-20
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61N1/18
CPC分类号： A61M5/14276 , A61B5/02 , A61B5/04 , A61B5/4815 , A61M5/1723 , A61M2230/06 , A61M2230/63 , A61N1/36071 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/36557
摘要： A medical device, such as an implantable medical device (IMD), determines values for one or more metrics that indicate the quality of a patient's sleep, and controls delivery of a therapy based on the sleep quality metric values. For example, the medical device may compare a sleep quality metric value with one or more threshold values, and adjust the therapy based on the comparison. In some embodiments, the medical device adjusts the intensity of therapy based on the comparison, e.g., increases the therapy intensity when the comparison indicates that the patient's sleep quality is poor. In some embodiments, the medical device automatically selects one of a plurality of therapy parameter set available for use in delivering therapy based on a comparison sleep quality metric values associated with respective therapy parameter sets within the plurality of available therapy parameter sets.
摘要翻译：诸如可植入医疗装置（IMD）的医疗设备确定指示患者睡眠质量的一个或多个指标的值，并且基于睡眠质量量度值控制治疗的递送。例如，医疗设备可以将睡眠质量度量值与一个或多个阈值进行比较，并且基于比较来调整治疗。在一些实施例中，医疗装置基于比较来调整治疗的强度，例如当比较表明患者的睡眠质量差时，增加治疗强度。在一些实施例中，医疗设备基于与多个可用治疗参数组内的各个治疗参数组相关联的比较睡眠质量量度值，自动选择可用于递送治疗的多个治疗参数集中的一个。

4. 发明授权

US07792583B2 Collecting posture information to evaluate therapy 有权
标题翻译：收集姿势信息以评估治疗
公开(公告)号：US07792583B2
公开(公告)日：2010-09-07
申请号：US11691391
申请日：2007-03-26
申请人： Keith A. Miesel , Kenneth T. Heruth
发明人： Keith A. Miesel , Kenneth T. Heruth
IPC分类号： A61N1/36
CPC分类号： A61B5/4848 , A61B5/103 , A61B5/1116 , A61B5/4082 , A61B5/6825 , A61B5/686 , A61M5/14276 , A61N1/0531 , A61N1/0534 , A61N1/36071 , A61N1/36082 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36557 , A61N1/37235
摘要： A medical device delivers a therapy to a patient. Posture events are identified, e.g., a posture of the patient is periodically determined and/or posture transitions by the patient are identified, and each determined posture event is associated with a current therapy parameter set. A value of at least one posture metric is determined for each of a plurality of therapy parameter sets based on the posture events associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more posture metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of posture metrics, the list may be ordered according to the one of the posture metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。识别姿势事件，例如，周期性地确定患者的姿势和/或患者的姿势转换，并且每个确定的姿势事件与当前治疗参数组相关联。基于与该治疗参数组相关联的姿势事件，为多个治疗参数组中的每一个确定至少一个姿势度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。可以根据一个或多个姿势度量值对列表进行排序，以帮助评估治疗参数组。在针对多个姿势度量确定值的情况下，可以根据用户选择的姿势度量中的一个排序列表。

5. 发明授权

US07717848B2 Collecting sleep quality information via a medical device 有权
标题翻译：通过医疗设备收集睡眠质量信息
公开(公告)号：US07717848B2
公开(公告)日：2010-05-18
申请号：US10826925
申请日：2004-04-15
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61B5/00 , A61B5/02 , A61B5/08 , A61N1/00
CPC分类号： A61N1/36139 , A61B3/113 , A61B5/01 , A61B5/0402 , A61B5/0476 , A61B5/1116 , A61B5/1118 , A61B5/4815 , A61B5/6826 , A61B5/686 , A61M5/14276 , A61M5/1723 , A61N1/36071 , A61N1/36078 , A61N1/36135 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/3702 , A61N1/37247
摘要： At least one of a medical device, such as an implantable medical device, and a programming device determines values for one or more metrics that indicate the quality of a patient's sleep. Sleep efficiency, sleep latency, and time spent in deeper sleep states are example sleep quality metrics for which values may be determined. In some embodiments, determined sleep quality metric values are associated with a current therapy parameter set. In some embodiments, a programming device presents sleep quality information to a user based on determined sleep quality metric values values. A clinician, for example, may use the sleep quality information presented by the programming device to evaluate the effectiveness of therapy delivered to the patient by the medical device, to adjust the therapy delivered by the medical device, or to prescribe a therapy not delivered by the medical device in order to improve the quality of the patient's sleep.
摘要翻译：诸如可植入医疗设备的医疗设备和编程设备中的至少一个确定了指示患者睡眠质量的一个或多个度量的值。睡眠效率，睡眠延迟和在更深的睡眠状态中花费的时间是可以确定值的示例性睡眠质量度量。在一些实施例中，确定的睡眠质量度量值与当前治疗参数组相关联。在一些实施例中，编程设备基于确定的睡眠质量度量值值向用户呈现睡眠质量信息。例如，临床医生可以使用编程设备呈现的睡眠质量信息来评估由医疗设备递送给患者的治疗的有效性，以调整由医疗设备递送的治疗，或者开出不由医疗器械为了提高病人的睡眠质量。

6. 发明申请

US20090270942A1 COLLECTING ACTIVITY INFORMATION TO EVALUATE THERAPY 有权
标题翻译：收集活动信息以评估治疗
公开(公告)号：US20090270942A1
公开(公告)日：2009-10-29
申请号：US12498928
申请日：2009-07-07
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61N1/36
CPC分类号： A61M5/1723 , A61B5/0031 , A61B5/02055 , A61B5/0476 , A61B5/0488 , A61B5/1118 , A61B5/1455 , A61B5/6814 , A61B5/6826 , A61B5/6831 , A61B5/6838 , A61B2562/0219 , A61M5/14276 , A61N1/36071 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/36557
摘要： A medical device delivers a therapy to a patient. The medical device may periodically determine an activity level of the patient, and associate each determined activity level with a current therapy parameter set. A value of at least one activity metric is determined for each of a plurality of therapy parameter sets based on the activity levels associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more activity metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of activity metrics, the list may be ordered according to the one of the activity metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。医疗设备可以周期性地确定患者的活动水平，并将每个确定的活动水平与当前治疗参数组相关联。基于与该治疗参数组相关联的活动水平，为多个治疗参数组中的每一个确定至少一个活动度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。该列表可以根据一个或多个活动度量值来排序以帮助评估治疗参数集。在确定多个活动度量的值的情况下，可以根据用户选择的活动度量中的一个排序列表。

7. 发明授权

US07590455B2 Controlling therapy based on sleep quality 有权
标题翻译：基于睡眠质量控制治疗
公开(公告)号：US07590455B2
公开(公告)日：2009-09-15
申请号：US11081155
申请日：2005-03-16
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61N1/18
CPC分类号： A61M5/14276 , A61B5/02 , A61B5/04 , A61B5/4815 , A61M5/1723 , A61M2230/06 , A61M2230/63 , A61N1/36071 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/36557
摘要： A medical device, such as an implantable medical device (IMD), determines values for one or more metrics that indicate the quality of a patient's sleep, and controls delivery of a therapy based on the sleep quality metric values. For example, the medical device may compare a sleep quality metric value with one or more threshold values, and adjust the therapy based on the comparison. In some embodiments, the medical device adjusts the intensity of therapy based on the comparison, e.g., increases the therapy intensity when the comparison indicates that the patient's sleep quality is poor. In some embodiments, the medical device automatically selects one of a plurality of therapy parameter set available for use in delivering therapy based on a comparison sleep quality metric values associated with respective therapy parameter sets within the plurality of available therapy parameter sets.
摘要翻译：诸如可植入医疗装置（IMD）的医疗设备确定指示患者睡眠质量的一个或多个指标的值，并且基于睡眠质量量度值控制治疗的递送。例如，医疗设备可以将睡眠质量度量值与一个或多个阈值进行比较，并且基于比较来调整治疗。在一些实施例中，医疗装置基于比较来调整治疗的强度，例如当比较表明患者的睡眠质量差时，增加治疗强度。在一些实施例中，医疗设备基于与多个可用治疗参数组内的各个治疗参数组相关联的比较睡眠质量量度值，自动选择可用于递送治疗的多个治疗参数集中的一个。

8. 发明申请

US20090118599A1 COLLECTING ACTIVITY AND SLEEP QUALITY INFORMATION VIA A MEDICAL DEVICE 有权
标题翻译：通过医疗设备收集活动和睡眠质量信息
公开(公告)号：US20090118599A1
公开(公告)日：2009-05-07
申请号：US12351414
申请日：2009-01-09
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61B5/00 , A61N1/36 , A61M5/142
CPC分类号： A61B5/1116 , A61B5/1118 , A61B5/4519 , A61B5/4815 , A61B5/6826 , A61B5/686 , A61N1/36135 , A61N1/36542
摘要： A device, such as an implantable medical device (IMD) or a programming device, determines when a patient is attempting to sleep. When the device determines that the patient is attempting to sleep, the device determines values for one or more metrics that indicate the quality of a patient's sleep based on at least one physiological parameter of the patient. When the device determines that the patient is not attempting to sleep, the device periodically determines activity levels of the patient. Activity metric values may be determined based on the determined activity levels. A clinician may use sleep quality information and patient activity information presented by a programming device to, for example, evaluate the effectiveness of therapy delivered to the patient by the medical device.
摘要翻译：诸如可植入医疗装置（IMD）或编程装置之类的装置确定患者何时试图睡觉。当设备确定患者正在尝试睡眠时，设备基于患者的至少一个生理参数来确定指示患者睡眠质量的一个或多个度量的值。当设备确定患者没有尝试睡眠时，设备周期性地确定患者的活动水平。活动度量值可以基于所确定的活动水平来确定。临床医生可以使用由编程设备呈现的睡眠质量信息和患者活动信息，以例如评估由医疗设备递送给患者的治疗的有效性。

9. 发明申请

US20090036951A1 SENSITIVITY ANALYSIS FOR SELECTING THERAPY PARAMETER SETS 审中-公开
标题翻译：敏感性分析选择治疗参数集
公开(公告)号：US20090036951A1
公开(公告)日：2009-02-05
申请号：US12248609
申请日：2008-10-09
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61N1/36 , A61M37/00
CPC分类号： A61M5/14276 , A61B3/113 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/042 , A61B5/0488 , A61B5/11 , A61B5/1459 , A61B5/4815 , A61B5/4824 , A61B5/4839 , A61B8/06 , A61B8/12 , A61M5/1723 , A61M2230/06 , A61M2230/63 , A61N1/08 , A61N1/36071 , A61N1/36135 , A61N1/36146 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/37241
摘要： Techniques for controlling delivery of a therapy to a patient by a medical device, such as an implantable medical device (IMD), involve a sensitivity analysis of a performance metric. The performance metric may relate to efficacy or side effects of the therapy. For example, the performance metric may comprise a sleep quality metric, an activity level metric, a movement disorder metric for patients with Parkinson's disease, or the like. The sensitivity analysis identifies values of therapy parameters that defines a substantially maximum or minimum value of the performance metric. The identified therapy parameters are a baseline therapy parameter set, and a medical device may control delivery of the therapy based on the baseline therapy parameter set.
摘要翻译：用于通过医疗装置（例如可植入医疗装置（IMD））控制对患者的治疗递送的技术涉及对性能度量的灵敏度分析。性能指标可能与治疗的功效或副作用有关。例如，性能度量可以包括睡眠质量度量，活动水平度量，帕金森病患者的运动障碍度量等。灵敏度分析确定定义性能度量的基本上最大或最小值的治疗参数的值。所确定的治疗参数是基线治疗参数组，并且医疗装置可以基于基线治疗参数集来控制治疗的递送。

10. 发明授权

US07330760B2 Collecting posture information to evaluate therapy 有权
标题翻译：收集姿势信息以评估治疗
公开(公告)号：US07330760B2
公开(公告)日：2008-02-12
申请号：US10826926
申请日：2004-04-15
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61B5/103 , A61B5/1116 , A61M5/14276 , A61N1/02 , A61N1/36082 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36557
摘要： A medical device delivers a therapy to a patient. The medical device may identify posture events, e.g., periodically determine a posture of the patient and/or identify posture transitions by the patient, and associate each determined posture event with a current therapy parameter set. A value of at least one posture metric is determined for each of a plurality of therapy parameter sets based on the posture events associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more posture metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of posture metrics, the list may be ordered according to the one of the posture metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。医疗设备可以识别姿势事件，例如周期性地确定患者的姿势和/或识别患者的姿势转换，并且将每个确定的姿势事件与当前治疗参数组相关联。基于与该治疗参数组相关联的姿势事件，为多个治疗参数组中的每一个确定至少一个姿势度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。可以根据一个或多个姿势度量值对列表进行排序，以帮助评估治疗参数组。在针对多个姿势度量确定值的情况下，可以根据用户选择的姿势度量中的一个排序列表。

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