专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120264766A9 PSEUDOBASE BENZO[C]PHENANTRIDINES WITH IMPROVED EFFICACY, STABILITY AND SAFETY 有权
标题翻译： PSEUDOBASE BENZO [C]具有改善效率，稳定性和安全性的苯丙胺
公开(公告)号：US20120264766A9
公开(公告)日：2012-10-18
申请号：US12418823
申请日：2009-04-06
申请人： Kenneth Shaw , Mingbao Zhang , Amy F.T. Arnsten
发明人： Kenneth Shaw , Mingbao Zhang , Amy F.T. Arnsten
IPC分类号： A61K31/497 , A61K31/473 , A61P35/00 , A61K31/4355
CPC分类号： A61K31/4355 , A61K31/473 , A61K31/497
摘要： Pseudobase benzo[c]phenanthridines and the pharmaceutically acceptable salts thereof of Formula I are provided herein. The variables R, R1, R2, R3, and R4 are defined herein. Certain pseudobase benzo[c]phenanthridines provided herein act as prodrugs, targeting the parent benzo[c]phenanthridinium alkaloid to hydrophilic or hydrophobic regions in the body. Pharmaceutical compositions comprising a pseudobase benzo[c]phenanthridine and a carrier, excipient, or diluent are provided herein. Methods of treating or preventing microbial, fungal and or viral infections and methods of treating diseases and disorders responsive to protein kinase C modulation, topoisomerase I, and/or topoisomerase II modulation are also provided.
摘要翻译：本文提供了假碱性苯并[c]菲啶及其式I的药学上可接受的盐。变量R，R1，R2，R3和R4在本文中定义。本文提供的某些假碱性苯并[c]菲啶用作前药，将母体苯并[c]菲啶生物碱靶向体内的亲水或疏水区域。本文提供了包含假碱性苯并[c]菲啶和载体，赋形剂或稀释剂的药物组合物。还提供了治疗或预防微生物，真菌和/或病毒感染的方法以及治疗对蛋白激酶C调节，拓扑异构酶I和/或拓扑异构酶II调节的疾病和病症的方法。

2. 发明申请

US20100256164A1 PSEUDOBASE BENZO[C]PHENANTRIDINES WITH IMPROVED EFFICACY, STABILITY AND SAFETY 有权
标题翻译： PSEUDOBASE BENZO [C]具有改善效率，稳定性和安全性的苯丙胺
公开(公告)号：US20100256164A1
公开(公告)日：2010-10-07
申请号：US12418823
申请日：2009-04-06
申请人： Kenneth Shaw , Mingbao Zhang , Amy F.T. Arnsten
发明人： Kenneth Shaw , Mingbao Zhang , Amy F.T. Arnsten
IPC分类号： A61K31/497 , A61K31/4355 , A61K31/473 , A61P35/00
CPC分类号： A61K31/4355 , A61K31/473 , A61K31/497
摘要： Pseudobase benzo[c]phenanthridines and the pharmaceutically acceptable salts thereof of Formula I are provided herein. The variables R, R1, R2, R3, and R4 are defined herein. Certain pseudobase benzo[c]phenanthridines provided herein act as prodrugs, targeting the parent benzo[c]phenanthridinium alkaloid to hydrophilic or hydrophobic regions in the body. Pharmaceutical compositions comprising a pseudobase benzo[c]phenanthridine and a carrier, excipient, or diluent are provided herein. Methods of treating or preventing microbial, fungal and or viral infections and methods of treating diseases and disorders responsive to protein kinase C modulation, topoisomerase I, and/or topoisomerase II modulation are also provided.
摘要翻译：本文提供了假碱性苯并[c]菲啶及其式I的药学上可接受的盐。变量R，R1，R2，R3和R4在本文中定义。本文提供的某些假碱性苯并[c]菲啶用作前药，将母体苯并[c]菲啶生物碱靶向体内的亲水或疏水区域。本文提供了包含假碱性苯并[c]菲啶和载体，赋形剂或稀释剂的药物组合物。还提供了治疗或预防微生物，真菌和/或病毒感染的方法以及治疗对蛋白激酶C调节，拓扑异构酶I和/或拓扑异构酶II调节的疾病和病症的方法。

3. 发明申请

US20090221610A1 Compositions and Methods for Treating Cognitive Disorders 审中-公开
标题翻译：治疗认知障碍的组合和方法
公开(公告)号：US20090221610A1
公开(公告)日：2009-09-03
申请号：US12086658
申请日：2007-01-31
申请人： Amy F.T. Arnsten , Min Wang , David A. McCormick , Brian P. Ramos
发明人： Amy F.T. Arnsten , Min Wang , David A. McCormick , Brian P. Ramos
IPC分类号： A61K31/44 , A61P25/00
CPC分类号： A61K31/505 , A61K31/155 , A61K45/06 , C07D239/48 , A61K2300/00
摘要： The present invention relates to the use of inhibitors or blockers of Ih (hyperpolarization-activated cationic current) channels in the treatment of cognitive disorders. In preferred aspects of the present invention, an effective amount of a compound is administered to a patient in need, wherein the compound has the chemical structure: Where R1 is H, or an optionally substituted C1-C3 alkyl, preferably a C2 alkyl (ethyl) group; R2 is an optionally substituted C1-C3 alkyl group, preferably a methyl group; R3 is H, an optionally substituted C1-C3 alkyl (preferably methyl), a halogen or 0(Ci-Ca) alkyl; R4 is an optionally substituted C1-C6 alkyl, C(O)—(C1-C5)alkyl, C(O)-aryl, C(O)O—(C1-C4)alkyl, C(O)O-aryl, or an optionally substituted heterocyclic, aryl or heteroaryl group; R4 is H or an optionally substituted C1-C6 (preferably a C1-C3) alkyl; R5, R6 and R7 are each independently H, halogen, an optionally substituted C1-C6 alkyl (preferably, an optionally substituted C1-C3 alkyl), 0-(C1-C3) alkyl, or an optionally substituted heterocyclic, aryl or heteroaryl group; Y− is an anion of a pharmaceutically acceptable salt (a physiologically acceptable anion, preferably a Cl−, Br−, I−, OAc−); or a solvate or polymorph thereof, optionally, in combination with guanfacine and/or chelerythrine, and a pharmaceutically acceptable carrier, additive or excipient to a patient in need of therapy.
摘要翻译：本发明涉及Ih（超极化 - 活化阳离子电流）通道抑制剂或阻断剂在治疗认知障碍中的用途。在本发明的优选方面，向有需要的患者施用有效量的化合物，其中所述化合物具有以下化学结构：其中R 1为H或任选取代的C 1 -C 3烷基，优选C 2烷基（乙基）组 R2是任选取代的C 1 -C 3烷基，优选甲基; R 3是H，任选取代的C 1 -C 3烷基（优选甲基），卤素或0（C 1 -C 6）烷基; R 4是任选取代的C 1 -C 6烷基，C（O） - （C 1 -C 5）烷基，C（O） - 芳基，C（O）O-（C 1 -C 4）烷基，C（O）或任选取代的杂环，芳基或杂芳基; R4是H或任选取代的C 1 -C 6（优选C 1 -C 3）烷基; R 5，R 6和R 7各自独立地为H，卤素，任选取代的C 1 -C 6烷基（优选任选取代的C 1 -C 3烷基），O-（C 1 -C 3）烷基或任选取代的杂环，芳基或杂芳基 ; Y-是药学上可接受的盐（生理上可接受的阴离子，优选Cl-，Br-，I-，OAc-）的阴离子; 或其溶剂化物或多晶型物，任选地与胍法和/或螯合菊酯组合，以及药物可接受的载体，添加剂或赋形剂给需要治疗的患者。

4. 发明申请

US20100222376A1 CHELERYTHRINE, ANALOGS THEREOF AND THEIR USE IN THE TREATMENT OF BIPOLAR DISORDER AND OTHER COGNITIVE DISORDERS 审中-公开
标题翻译： CHELERYTHRINE，其模拟及其在治疗双瘫病和其他认知障碍中的应用
公开(公告)号：US20100222376A1
公开(公告)日：2010-09-02
申请号：US12546737
申请日：2009-08-25
申请人： Amy F.T. Arnsten , Shari G. Birnbaum
发明人： Amy F.T. Arnsten , Shari G. Birnbaum
IPC分类号： A61K31/4355 , A61P25/00 , A61P25/22 , A61P25/18
CPC分类号： A61K31/4741 , A61K31/473
摘要： The present invention relates to the use of chelerythrine and chelerythrine analogs in pharmaceutical compositions for the treatment of prefrontal cortical cognitive disorders, including bipolar disorder, among others.
摘要翻译：本发明涉及螯合物和螯合物类似物在药物组合物中的用途，用于治疗前额叶皮层认知障碍，包括双相情感障碍等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式