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1. 发明授权

US08853204B2 Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the RSV fusion protein 有权
标题翻译：药物组合物，其包含苯并二氮杂衍生物和RSV融合蛋白的抑制剂
公开(公告)号：US08853204B2
公开(公告)日：2014-10-07
申请号：US10593666
申请日：2005-03-18
申请人： Kenneth Powell , Richard Kelsey , Malcolm Carter , Dagmar Alber , Lara Wilson , Elisa Henderson , Phil Chambers , Debra Taylor , Stan Tyms , Verity Dowdell
发明人： Kenneth Powell , Richard Kelsey , Malcolm Carter , Dagmar Alber , Lara Wilson , Elisa Henderson , Phil Chambers , Debra Taylor , Stan Tyms , Verity Dowdell
IPC分类号： A01N43/62 , A61K31/55 , A01N43/52 , A61K31/415 , C07D243/24 , C07D235/04 , A61K45/06 , A61K31/5513
CPC分类号： A61K45/06 , A61K31/5513 , A61K2300/00
摘要： A pharmaceutical composition which comprises a pharmaceutically acceptable carrier or diluent and: (a) an inhibitor of the RSV fusion protein; and (b) a benzodiazepine derivative capable of inhibiting RSV replication is found to be highly active against RSV.
摘要翻译：一种药物组合物，其包含药学上可接受的载体或稀释剂，和：（a）RSV融合蛋白的抑制剂; 发现能够抑制RSV复制的苯并二氮杂衍生物对RSV具有高度活性。

2. 发明申请

US20070185096A1 Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the rsv fusion protein 审中-公开
标题翻译：药物组合物，其包含苯并二氮杂衍生物和rsv融合蛋白的抑制剂
公开(公告)号：US20070185096A1
公开(公告)日：2007-08-09
申请号：US10593382
申请日：2005-03-18
申请人： Kenneth Powell , Richard Kelsey , Malcolm Carter , Verity Dowdell , Dagmar Alber , Elisa Henderson
发明人： Kenneth Powell , Richard Kelsey , Malcolm Carter , Verity Dowdell , Dagmar Alber , Elisa Henderson
IPC分类号： A61K31/55
CPC分类号： A61K45/06 , A61K31/5513 , A61K2300/00
摘要： A pharmaceutical composition which comprises a pharmaceutically acceptable carrier or diluent and: (a) an inhibitor of the RSV fusion protein; and (b) a benzodiazepine derivative capable of inhibiting RSV replication is found to be highly active against RSV.
摘要翻译：一种药物组合物，其包含药学上可接受的载体或稀释剂，和：（a）RSV融合蛋白的抑制剂; 发现能够抑制RSV复制的苯并二氮杂衍生物对RSV具有高度活性。

3. 发明申请

US20070142403A1 Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the rsv fusion protein 有权
公开(公告)号：US20070142403A1
公开(公告)日：2007-06-21
申请号：US10593666
申请日：2005-03-18
申请人： Kenneth Powell , Richard Kelsey , Malcolm Carter , Dagmar Alber , Lara Wilson , Elisa Henderson , Phil Chambers , Debra Taylor , Stan Tyms , Verity Dowdell
发明人： Kenneth Powell , Richard Kelsey , Malcolm Carter , Dagmar Alber , Lara Wilson , Elisa Henderson , Phil Chambers , Debra Taylor , Stan Tyms , Verity Dowdell
IPC分类号： A01N43/90
CPC分类号： A61K45/06 , A61K31/5513 , A61K2300/00
摘要： A pharmaceutical composition which comprises a pharmaceutically acceptable carrier or diluent and: (a) an inhibitor of the RSV fusion protein; and (b) a benzodiazepine derivative capable of inhibiting RSV replication is found to be highly active against RSV.

4. 发明申请

US20070203454A1 Patch-Like Infusion Device 有权
标题翻译：补片式输液器
公开(公告)号：US20070203454A1
公开(公告)日：2007-08-30
申请号：US11739784
申请日：2007-04-25
申请人： Charles Shermer , Kenneth Powell , Alexander Lastovich , P. Kinsey , Chad Smutney , John Polidoro , Ed Browka , Carl Sahi , James Fentress , David Chapin , Daniel Stipe , Jeff Moss , Melody Kuroda
发明人： Charles Shermer , Kenneth Powell , Alexander Lastovich , P. Kinsey , Chad Smutney , John Polidoro , Ed Browka , Carl Sahi , James Fentress , David Chapin , Daniel Stipe , Jeff Moss , Melody Kuroda
IPC分类号： A61M5/20
CPC分类号： A61M5/148 , A61M5/142 , A61M5/14248 , A61M5/145 , A61M2005/14252 , A61M2005/1426 , A61M2005/14268 , A61M2005/14506
摘要： A system and method for a patch-like, self-contained substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir subassembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. Simple removal of an interlock allows a disk, or Belleville spring assembly to apply an essentially even and constant pressure to the contents of the fluid reservoir assembly, and allows the device to then be attached to a skin surface via an adhesive contact surface. A push button activation assembly is provided which can then be used to release and seat one or more spring-loaded patient needles into the skin surface, and establish a fluid communication path between the patient needles and the pressurized fluid reservoir contents thereby delivering an infusion into the skin.
摘要翻译：一种用于贴片状独立物质输注装置的系统和方法，其提供一个或多个基本上隐藏的患者针头，所述患者针头可与流体储存器子组件流体连通，所述流体储存器子组件包括与非结合使用的刚性囊部分，可扩张的膀胱膜，例如金属化膜。互锁的简单去除允许盘或贝氏弹簧组件对流体储存器组件的内容物施加基本均匀且恒定的压力，并且允许该装置经由粘合剂接触表面附接到皮肤表面。提供按钮激活组件，其可以用于将一个或多个弹簧加载的患者针头释放并安置到皮肤表面中，并且在患者针和加压流体储存器内容物之间建立流体连通路径，从而将输注输送到皮。

5. 发明申请

US20060137297A1 Method for filling a container having at least one flexible component 有权
公开(公告)号：US20060137297A1
公开(公告)日：2006-06-29
申请号：US11359351
申请日：2006-02-22
申请人： Kenneth Powell , Carl Sahi , Charles Shermer , John Polidoro , Chad Smutney
发明人： Kenneth Powell , Carl Sahi , Charles Shermer , John Polidoro , Chad Smutney
IPC分类号： B65B31/04 , A61B19/02
CPC分类号： B65B31/02 , A61J1/10 , A61J1/20 , A61J3/002 , B65B3/003
摘要： Methods for filling and sealing containers having one or more flexible sides. Non-standard containers for holding fluid are releasably supported during the filling and sealing process. Both the interior and exterior of the filled container are subjected to an environment of reduced pressure to minimize the headspace and sealed.

6. 发明申请

US20060106346A1 Reconstituting infusion device 有权
公开(公告)号：US20060106346A1
公开(公告)日：2006-05-18
申请号：US11222204
申请日：2005-09-08
申请人： Vincent Sullivan , Ge Jiang , Matthew Ferriter , Kenneth Powell , P. Kinsey , Carl Sahi , John Polidoro
发明人： Vincent Sullivan , Ge Jiang , Matthew Ferriter , Kenneth Powell , P. Kinsey , Carl Sahi , John Polidoro
IPC分类号： A61M37/00 , A61M5/20
CPC分类号： A61M5/145 , A61M5/1407 , A61M5/1409 , A61M5/14248 , A61M5/14566 , A61M5/14586 , A61M2005/14256
摘要： A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.

7. 发明申请

US20070156086A1 MULTI-STAGE FLUID DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：多级流体输送装置及方法
公开(公告)号：US20070156086A1
公开(公告)日：2007-07-05
申请号：US11684837
申请日：2007-03-12
申请人： James Fentress , Kenneth Powell
发明人： James Fentress , Kenneth Powell
IPC分类号： A61M5/14
CPC分类号： A61M5/145 , A61M5/148 , A61M5/16827 , A61M2005/14506
摘要： A fluid delivery device for delivering a substance to a patient by way of infusion delivers the preparation at a rate of flow which varies in steps from a substantially constant higher rate, to a stepped-down substantially constant lower rate or rates. The delivery device includes one or more reservoirs, and one or more Belleville springs for applying generally constant pressures to the substance contained in the reservoirs. Each reservoir will have a different constant pressure applied in a mid-range of operation. The reservoirs can be interconnected to each other and to an infusion device in a number of arrangements, including various manifolds and flow restrictors, such that the rate of flow is controlled in steps in accordance with the pressures applied by the springs of the plurality of reservoirs.
摘要翻译：用于通过输液将物质递送到患者的流体递送装置以从基本上恒定的较高速率到逐步降低的基本上恒定的较低速率或速率的逐步变化的速率递送制剂。输送装置包括一个或多个储存器，以及一个或多个用于对容纳在储存器中的物质施加一般恒定压力的贝氏弹簧。每个储存器将在中等范围的操作中施加不同的恒定压力。储存器可以以包括各种歧管和限流器的多种布置的方式彼此互连并连接到输注装置，使得流速根据由多个储存器的弹簧施加的压力而逐步地控制。

8. 发明申请

US20060197004A1 METHOD AND APPARATUS FOR MANUFACTURING A DEVICE 审中-公开
标题翻译：用于制造装置的方法和装置
公开(公告)号：US20060197004A1
公开(公告)日：2006-09-07
申请号：US11419298
申请日：2006-05-19
申请人： Kenneth Powell , Larry Monahan , Burton Sage
发明人： Kenneth Powell , Larry Monahan , Burton Sage
IPC分类号： B29C33/42
CPC分类号： B29C33/405 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , B29C33/424 , B29C45/372 , B29C2045/0094 , B29K2883/00 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C1/00111 , B81C2201/034
摘要： A device, preferably a micro-device, is molded from a plastic material by injection molding, compression molding or embossing. A microabrader can be molded having microneedles for abrading the stratum corneum of the skin to form an abraded site in the tissue for enhancing drug delivery. The micro-device is molded using a mold assembly having a silicon molding surface. The silicon molding surface can include a recess corresponding to the desired shape and length of the microneedles. The silicon molding surface enables micron and submicron size features to be molded from polymeric materials without the polymeric material adhering to the mold surface. Micro-devices having molded features having micron and submicron dimensions can be rapidly produced without the use of a release agent.
摘要翻译：一种装置，优选一种微型装置，通过注塑，压塑或压花由塑料材料模制。微型造型机可以模制成具有用于研磨皮肤角质层的微针，以在组织中形成用于增强药物递送的磨损部位。使用具有硅模制表面的模具组件来模制微型装置。硅成型表面可以包括对应于所需形状和长度的微针的凹部。硅成型表面使得微米和亚微米尺寸的特征能够由聚合物材料模制而不会使聚合材料粘附到模具表面。具有微米和亚微米尺寸的模制特征的微型装置可以在不使用脱模剂的情况下快速生产。

9. 发明申请

US20110270222A1 Injection Pen For Intradermal Medication Injection 有权
标题翻译：注射用于注射内皮注射液
公开(公告)号：US20110270222A1
公开(公告)日：2011-11-03
申请号：US13127451
申请日：2009-11-06
申请人： Min Wei , Ying Xu , James Bates , Kenneth Powell
发明人： Min Wei , Ying Xu , James Bates , Kenneth Powell
IPC分类号： A61M5/31
CPC分类号： A61M5/31585 , A61M5/24 , A61M5/31535 , A61M5/31543 , A61M5/31551 , A61M5/31555 , A61M5/31558 , A61M5/31563 , A61M5/31575 , A61M2005/2407 , A61M2005/2488 , A61M2005/3152
摘要： A pen body assembly (100) for a drug delivery pen includes a pen body (101) and a dose setting body (111) movably connected to the pen body (101). A knob (109) is connected to the dose setting body (111) for moving the dose setting body (111) relative to the pen body (111). One of the pen body (101) and the dose setting body (111) has a thread groove (107) having a varied pitch disposed thereon and the other one has a protrusion (105) engaging the thread groove (107).
摘要翻译：用于药物输送笔的笔体组件（100）包括可移动地连接到笔体（101）的笔体（101）和剂量设定体（111）。一个把手（109）连接到剂量设定体（111）上，用于相对于笔体（111）移动剂量设定体（111）。笔体（101）和剂量设定体（111）中的一个具有设置在其上的具有变化间距的螺纹槽（107），另一个具有与螺纹槽（107）接合的突起（105）。

10. 发明申请

US20070095424A1 Retainer for filling a container having at least one flexible component 审中-公开
标题翻译：用于填充具有至少一个柔性部件的容器的保持器
公开(公告)号：US20070095424A1
公开(公告)日：2007-05-03
申请号：US11557798
申请日：2006-11-08
申请人： Kenneth Powell , Carl Sahi , Charles Shermer , John Polidoro , Chad Smutney
发明人： Kenneth Powell , Carl Sahi , Charles Shermer , John Polidoro , Chad Smutney
IPC分类号： B65B3/16
CPC分类号： B65B31/02 , A61J1/10 , A61J1/20 , A61J3/002 , B65B3/003
摘要： A retainer for filling and sealing containers having one or more flexible sides which has features for filling semi-flexible containers is disclosed. Non-standard containers for holding fluid are releasably supported during the filling and sealing process. Both the interior and exterior of the filled container are subjected to an environment of reduced pressure to minimize the headspace and sealed.
摘要翻译：公开了一种用于填充和密封具有一个或多个具有用于填充半柔性容器的特征的柔性侧面的容器的保持器。用于保持流体的非标准容器在填充和密封过程中可释放地支撑。填充容器的内部和外部均经受减压环境以使顶部空间最小化并密封。

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