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1. 发明授权

US08538120B2 System for targeting cells or other materials 有权
标题翻译：用于靶向细胞或其他材料的系统
公开(公告)号：US08538120B2
公开(公告)日：2013-09-17
申请号：US13114982
申请日：2011-05-24
申请人： Kenneth Edward Salsman , Ulrich Boettiger , Dmitry Bakin , Curtis W. Stith
发明人： Kenneth Edward Salsman , Ulrich Boettiger , Dmitry Bakin , Curtis W. Stith
IPC分类号： G06K9/00
CPC分类号： G01N15/1012 , G01N15/1434 , G01N15/1459 , G01N15/1463 , G01N2015/1025 , G01N2015/1443
摘要： An image sensor integrated circuit may contain image sensor pixels. A channel containing a fluid with particles such as cells may be formed on top of the image sensor. Some of the image sensor pixels may form a calibration sensor and some of the image sensor pixels may form an imager. As the fluid and particles flow through the channel at a flow rate, the calibration sensor may measures the flow rate and illumination intensity in the channel. Based on calibration data such as measured flow rate and measured illumination intensity, adjustments may be made to ensure that the imager acquires satisfactory image data. The adjustments may include flow rate adjustments, image acquisition data rate adjustments, and illumination adjustments. A processing unit in the channel may contain a laser or other component to destroy selected cells. A flared region in the channel may be used as a chromatograph.
摘要翻译：图像传感器集成电路可以包含图像传感器像素。可以在图像传感器的顶部上形成包含诸如细胞等颗粒的流体的通道。一些图像传感器像素可以形成校准传感器，并且一些图像传感器像素可以形成成像器。当流体和颗粒以流速流过通道时，校准传感器可以测量通道中的流量和照射强度。基于诸如测量流量和测量的照射强度的校准数据，可以进行调整以确保成像器获得令人满意的图像数据。调整可以包括流量调整，图像采集数据速率调整和照明调整。通道中的处理单元可以包含用于摧毁所选择的单元的激光器或其他组件。通道中的扩口区域可用作色谱仪。

2. 发明申请

US20120326256A1 SPECTRALLY TUNED PLASMONIC LIGHT COLLECTORS 有权
公开(公告)号：US20120326256A1
公开(公告)日：2012-12-27
申请号：US13365067
申请日：2012-02-02
申请人： Kenneth Edward Salsman , Ulrich Boettiger , Dmitry Bakin , Curtis W. Stith
发明人： Kenneth Edward Salsman , Ulrich Boettiger , Dmitry Bakin , Curtis W. Stith
IPC分类号： H01L31/0232
CPC分类号： H01L27/14625 , H01L27/14603
摘要： Electronic devices may be provided with imaging modules that include plasmonic light collectors. Plasmonic light collectors may be configured to exploit an interaction between incoming light and plasmons in the plasmonic light collector to alter the path of the incoming light. Plasmonic light collectors may include one or more spectrally tuned plasmonic image pixels configured to preferentially trap light of a given frequency. Spectrally tuned plasmonic image pixels may include plasmonic structures formed form a patterned metal layer over doped silicon layers. Doped silicon layers may be interposed between plasmonic structures and a reflective layer. Plasmonic image pixels may be used to absorb and detect as much as, or more than, ninety percent of incident light at wavelengths ranging from the infrared to the ultraviolet. Plasmonic image pixels that capture light of different colors may be arranged in patterned arrays to form imager modules or imaging spectrometers for optofluidic microscopes.
摘要翻译：电子设备可以设置有包括等离子体激光收集器的成像模块。等离子体光收集器可以被配置为利用等离子体光收集器中的入射光和等离子体激元之间的相互作用来改变入射光的路径。等离子体光收集器可以包括被配置为优先捕获给定频率的光的一个或多个频谱调谐等离子体像图像。光谱调谐等离子体激元图像像素可以包括由掺杂硅层上的图案化金属层形成的等离子体结构。掺杂的硅层可以介于等离子体激元结构和反射层之间。等离子体像图像可用于吸收和检测多达或多于百分之九十的入射光，其范围从红外至紫外。捕获不同颜色的光的等离子体像图像可以以图案化阵列布置以形成用于光流体显微镜的成像器模块或成像光谱仪。

3. 发明授权

US08779483B2 Spectrally tuned plasmonic light collectors 有权
标题翻译：光谱调谐等离子体光收发器
公开(公告)号：US08779483B2
公开(公告)日：2014-07-15
申请号：US13365067
申请日：2012-02-02
申请人： Kenneth Edward Salsman , Ulrich Boettiger , Dmitry Bakin , Curtis W. Stith
发明人： Kenneth Edward Salsman , Ulrich Boettiger , Dmitry Bakin , Curtis W. Stith
IPC分类号： H01L31/02 , H01L27/146
CPC分类号： H01L27/14625 , H01L27/14603
摘要： Electronic devices may be provided with imaging modules that include plasmonic light collectors. Plasmonic light collectors may be configured to exploit an interaction between incoming light and plasmons in the plasmonic light collector to alter the path of the incoming light. Plasmonic light collectors may include one or more spectrally tuned plasmonic image pixels configured to preferentially trap light of a given frequency. Spectrally tuned plasmonic image pixels may include plasmonic structures formed form a patterned metal layer over doped silicon layers. Doped silicon layers may be interposed between plasmonic structures and a reflective layer. Plasmonic image pixels may be used to absorb and detect as much as, or more than, ninety percent of incident light at wavelengths ranging from the infrared to the ultraviolet. Plasmonic image pixels that capture light of different colors may be arranged in patterned arrays to form imager modules or imaging spectrometers for optofluidic microscopes.
摘要翻译：电子设备可以设置有包括等离子体激光收集器的成像模块。等离子体光收集器可以被配置为利用等离子体光收集器中的入射光和等离子体激元之间的相互作用来改变入射光的路径。等离子体光收集器可以包括被配置为优先捕获给定频率的光的一个或多个频谱调谐等离子体像图像。光谱调谐等离子体激元图像像素可以包括由掺杂硅层上的图案化金属层形成的等离子体结构。掺杂的硅层可以介于等离子体激元结构和反射层之间。等离子体像图像可用于吸收和检测多达或多于百分之九十的入射光，其范围从红外至紫外。捕获不同颜色的光的等离子体像图像可以以图案化阵列布置以形成用于光流体显微镜的成像器模块或成像光谱仪。

4. 发明申请

US20120044339A1 OPTO-FLUIDIC MICROSCOPE SYSTEM WITH EVALUATION CHAMBERS 审中-公开
公开(公告)号：US20120044339A1
公开(公告)日：2012-02-23
申请号：US13114980
申请日：2011-05-24
申请人： Curtis W. Stith , Dmitry Bakin , Ulrich Boettiger , Kenneth Edward Salsman
发明人： Curtis W. Stith , Dmitry Bakin , Ulrich Boettiger , Kenneth Edward Salsman
IPC分类号： H04N7/18
CPC分类号： G01N21/6458 , B01L3/502715
摘要： An image sensor integrated circuit may contain image sensor pixels. A channel containing a fluid with particles such as cells may be formed on top of the image sensor. The image sensor pixels may form light sensors and imagers. The imagers may gather images of the cells or other particles as the fluid passes over the imagers. The channel may have multiple branches. Gating structures and other fluid control structures may control the flow of fluid through the channel branches. Portions of the channel may be used to form chambers. The chambers may each be provided with one or more light sensors, light sources, and color filters to alter the color of illumination form a light source, one or more reactants such as dyes, antigens, and antibodies, and heaters. The branches may route the fluid to respective chambers each of which has a different set of capabilities.
摘要翻译：图像传感器集成电路可以包含图像传感器像素。可以在图像传感器的顶部上形成包含诸如细胞等颗粒的流体的通道。图像传感器像素可以形成光传感器和成像器。当流体通过成像器时，成像器可以收集细胞或其他颗粒的图像。频道可能有多个分支。浇口结构和其他流体控制结构可以控制通过通道分支的流体的流动。可以使用通道的一部分来形成室。每个室可以各自设置有一个或多个光传感器，光源和滤色器，以改变来自光源的照明的颜色，一种或多种反应物，例如染料，抗原和抗体，以及加热器。分支可以将流体路由到各自具有不同能力集合的室。

5. 发明申请

US20120045103A1 SYSTEM FOR TARGETING CELLS OR OTHER MATERIALS 有权
标题翻译：靶向细胞或其他材料的系统
公开(公告)号：US20120045103A1
公开(公告)日：2012-02-23
申请号：US13114982
申请日：2011-05-24
申请人： Kenneth Edward Salsman , Ulrich Boettiger , Dmitry Bakin , Curtis W. Stith
发明人： Kenneth Edward Salsman , Ulrich Boettiger , Dmitry Bakin , Curtis W. Stith
IPC分类号： G06K9/00 , H04N7/18
CPC分类号： G01N15/1012 , G01N15/1434 , G01N15/1459 , G01N15/1463 , G01N2015/1025 , G01N2015/1443
摘要： An image sensor integrated circuit may contain image sensor pixels. A channel containing a fluid with particles such as cells may be formed on top of the image sensor. Some of the image sensor pixels may form a calibration sensor and some of the image sensor pixels may form an imager. As the fluid and particles flow through the channel at a flow rate, the calibration sensor may measures the flow rate and illumination intensity in the channel. Based on calibration data such as measured flow rate and measured illumination intensity, adjustments may be made to ensure that the imager acquires satisfactory image data. The adjustments may include flow rate adjustments, image acquisition data rate adjustments, and illumination adjustments. A processing unit in the channel may contain a laser or other component to destroy selected cells. A flared region in the channel may be used as a chromatograph.
摘要翻译：图像传感器集成电路可以包含图像传感器像素。可以在图像传感器的顶部上形成包含诸如细胞等颗粒的流体的通道。一些图像传感器像素可以形成校准传感器，并且一些图像传感器像素可以形成成像器。当流体和颗粒以流速流过通道时，校准传感器可以测量通道中的流量和照射强度。基于诸如测量流量和测量的照射强度的校准数据，可以进行调整以确保成像器获得令人满意的图像数据。调整可以包括流量调整，图像采集数据速率调整和照明调整。通道中的处理单元可以包含用于摧毁所选择的单元的激光器或其他组件。通道中的扩口区域可用作色谱仪。

6. 发明申请

US20120044341A1 OPTOFLUIDIC MICROSCOPE SYSTEM-ON-CHIP 审中-公开
标题翻译： OPTOFLUIDIC微观系统芯片
公开(公告)号：US20120044341A1
公开(公告)日：2012-02-23
申请号：US13205340
申请日：2011-08-08
申请人： Curtis W. Stith , Kenneth Edward Salsman , Dmitry Bakin , Ulrich Boettiger
发明人： Curtis W. Stith , Kenneth Edward Salsman , Dmitry Bakin , Ulrich Boettiger
IPC分类号： H01L27/146 , H04N5/228 , H04N7/18 , H04N5/335
CPC分类号： G01N21/645 , B01L3/502715 , G01N21/6458 , G02B21/0004 , G02B21/16 , H01L27/14603 , H04N2005/2255
摘要： An integrated circuit may contain image sensor pixels. Channels containing a fluid with samples such as cells may be formed on top of the image sensor. Control circuitry may be formed on the integrated circuit. The image sensor pixels may form light sensors and imagers. Portions of the channel may have multiple chambers such as fluorescence detection chambers. Gating structures and other fluid control structures may control the flow of fluid through the channels and chambers. Portions of the channel may be used to form chambers. The chambers may each be provided with one or more light sensors, light sources, and color filters to alter the color of illumination form a light source, one or more reactants such as dyes, antigens, and antibodies, and heaters. The control circuitry may be configured to control the imagers, the gating structures, the fluid control structures, the light source, the heaters, etc.
摘要翻译：集成电路可以包含图像传感器像素。可以在图像传感器的顶部上形成包含诸如细胞样品的流体的通道。控制电路可以形成在集成电路上。图像传感器像素可以形成光传感器和成像器。通道的一部分可以具有多个室，例如荧光检测室。门控结构和其他流体控制结构可以控制通过通道和腔室的流体流动。可以使用通道的一部分来形成室。每个室可以各自设置有一个或多个光传感器，光源和滤色器，以改变来自光源的照明的颜色，一种或多种反应物，例如染料，抗原和抗体，以及加热器。控制电路可以被配置为控制成像器，门控结构，流体控制结构，光源，加热器等

7. 发明授权

US09093579B2 Dielectric barriers for pixel arrays 有权
标题翻译：像素阵列的介质阻挡层
公开(公告)号：US09093579B2
公开(公告)日：2015-07-28
申请号：US13294951
申请日：2011-11-11
申请人： Jeffrey Mackey , Ulrich Boettiger , Mattia Cichocki , Loriston Ford , Rick Holscher , Mitchell J. Mooney , Brian Vaartstra
发明人： Jeffrey Mackey , Ulrich Boettiger , Mattia Cichocki , Loriston Ford , Rick Holscher , Mitchell J. Mooney , Brian Vaartstra
IPC分类号： H01L31/0232 , H01L31/0216 , H01L27/144 , H01L27/146
CPC分类号： H01L31/02327 , H01L27/1446 , H01L27/14605 , H01L27/14621 , H01L27/14629 , H01L27/1464 , H01L27/14685 , H01L31/02162
摘要： Pixel arrays are provided for image sensors that have barriers between color filters in an array of color filters. Color filter barriers may be formed from a transparent or semi-transparent material. Color filter barriers may be formed from a low refractive index material. Color filters may be etched and color filter barrier material may be formed in the etched regions of the color filters. If desired, a layer of color filter barrier material may be etched to form open regions and color filter material may be formed in the open regions of the color filter barrier material. An image sensor may be a front-side illuminated image sensor or a back-side illuminated image sensor.
摘要翻译：像素阵列被提供用于在滤色器阵列中的滤色器之间具有屏障的图像传感器。滤色器屏障可以由透明或半透明材料形成。滤色器屏障可以由低折射率材料形成。可以蚀刻滤色器，并且可以在滤色器的蚀刻区域中形成滤色器阻挡材料。如果需要，可以蚀刻一层滤色器阻挡材料以形成开放区域，并且滤色器材料可以形成在滤色器阻挡材料的开放区域中。图像传感器可以是前侧照明图像传感器或背面照明图像传感器。

8. 发明申请

US20120188421A1 IMAGING SYSTEMS WITH ARRAYS OF ALIGNED LENSES 有权
标题翻译：具有对准镜片阵列的成像系统
公开(公告)号：US20120188421A1
公开(公告)日：2012-07-26
申请号：US13053728
申请日：2011-03-22
申请人： Ulrich Boettiger
发明人： Ulrich Boettiger
IPC分类号： H04N5/335 , H01L31/18
CPC分类号： H04N5/2254
摘要： An imaging system may include an array of lenses, each of which is aligned over a respective one of a plurality of imaging pixels. The array of lenses may be formed in two layers. The first layer may include a first set of non-adjacent lenses and centering structures between the first lenses. The centering structures may be aligned with the first set of lenses as part of a mask design with a high level of accuracy. The second layer may include a second set of lenses, each of which is formed on a respective one of the centering structures. Forming the second set of lenses may include a reflow process in which surface tension forces center the second set of lenses on their respective centering structures, thereby aligning the second set of lenses with the first set of lenses with a high level of accuracy.
摘要翻译：成像系统可以包括透镜阵列，每个透镜阵列在多个成像像素中的相应一个上对准。透镜阵列可以形成为两层。第一层可以包括第一组非相邻透镜和第一透镜之间的定心结构。定心结构可以与第一组透镜对准，作为掩模设计的一部分，具有高精度。第二层可以包括第二组透镜，每个透镜形成在相应的定心结构之一上。形成第二组透镜可以包括回流工艺，其中表面张力将第二组透镜定位在它们各自的对中结构上，从而以高精度对准第二组透镜与第一组透镜。

9. 发明申请

US20120061787A1 LIQUID ELECTRICAL INTERCONNECT AND DEVICES USING SAME 有权
标题翻译：液体电气互连和使用相同的装置
公开(公告)号：US20120061787A1
公开(公告)日：2012-03-15
申请号：US13302907
申请日：2011-11-22
申请人： Rick Lake , Ulrich Boettiger , Shashikant Hegde , Jacques Duparre
发明人： Rick Lake , Ulrich Boettiger , Shashikant Hegde , Jacques Duparre
IPC分类号： H01L31/0232
CPC分类号： H01L24/16 , H01L21/76898 , H01L23/481 , H01L24/81 , H01L2224/13099 , H01L2224/16237 , H01L2224/81141 , H01L2224/81191 , H01L2224/83191 , H01L2924/00011 , H01L2924/00014 , H01L2924/01006 , H01L2924/01013 , H01L2924/01029 , H01L2924/01033 , H01L2924/01046 , H01L2924/01047 , H01L2924/01079 , H01L2924/014 , H01L2924/14 , H01L2924/1433 , H01L2924/1461 , H01L2924/351 , H05K3/32 , H05K3/4007 , H05K2201/09045 , H01L2924/00 , H01L2224/0401
摘要： Various embodiments include interconnects for semiconductor structures that can include a first conductive structure, a second conductive structure and a non-hardening liquid conductive material in contact with the first and second structure. Other embodiments include semiconductor components and imager devices using the interconnects. Further embodiments include methods of forming a semiconductor structure and focusing methods for an imager device.
摘要翻译：各种实施例包括用于半导体结构的互连，其可以包括与第一和第二结构接触的第一导电结构，第二导电结构和非硬化液体导电材料。其他实施例包括使用互连的半导体部件和成像器件。另外的实施例包括形成半导体结构的方法和用于成像器装置的聚焦方法。

10. 发明申请

US20090225435A1 GRADIENT INDEX MICROLENSES AND METHOD OF FORMATION 有权
标题翻译：梯度指数微生物和形成方法
公开(公告)号：US20090225435A1
公开(公告)日：2009-09-10
申请号：US12043838
申请日：2008-03-06
申请人： Ulrich Boettiger , Saijin Liu
发明人： Ulrich Boettiger , Saijin Liu
IPC分类号： G02B3/00 , B29D11/00
CPC分类号： G02B3/0018 , B29D11/00365 , G02B3/0087 , H01L27/14627 , H01L27/14685
摘要： A lens includes a gradient index of refraction and a curved shape. A method of making the lens includes forming a plurality of layers, forming a shaped resist on the plurality of layers, and etching the resist and the plurality of layers to transfer the shape of the resist into the plurality of layers.
摘要翻译：透镜包括梯度折射率和弯曲形状。制造透镜的方法包括形成多个层，在多个层上形成成形抗蚀剂，并蚀刻抗蚀剂和多个层，以将抗蚀剂的形状转移到多个层中。

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