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1. 发明授权

US08807801B2 Two-photon endoscopic scanning assembly for inflammatory disease detection 有权
标题翻译：双光子内窥镜扫描装置用于炎性疾病检测
公开(公告)号：US08807801B2
公开(公告)日：2014-08-19
申请号：US13356286
申请日：2012-01-23
申请人： Kenn Oldham , Thomas D. Wang , Zhongyao Liu , Jing Yong Ye
发明人： Kenn Oldham , Thomas D. Wang , Zhongyao Liu , Jing Yong Ye
IPC分类号： F21V17/02 , A61B1/06
CPC分类号： G01N21/6486 , A61B1/0011 , A61B1/00172 , A61B1/233 , A61B1/2733 , G01N33/4833
摘要： An endoscopic imaging device is described that achieves longitudinal axis (z-axis) scanning into a tissue or sample, using a piezoelectric microactuator. In some configurations, additional lateral (xy-plane) scanning is also achieved, to allow for the creation of full three-dimensional imaging, ex vivo or in vivo. The techniques may be used to image and diagnosis allergic rhinitis and eosinophilic esophagitis in tissue.
摘要翻译：描述了使用压电微致动器实现对组织或样品的纵轴（z轴）扫描的内窥镜成像装置。在一些配置中，还实现了另外的横向（xy平面）扫描，以允许在离体或体内产生完整的三维成像。该技术可用于成像和诊断组织中的过敏性鼻炎和嗜酸粒细胞性食管炎。

2. 发明申请

US20120270256A1 Two-Photon Endoscopic Scanning Assembly for Inflammatory Disease Detection 有权
标题翻译：用于炎症疾病检测的双光子内窥镜扫描组件
公开(公告)号：US20120270256A1
公开(公告)日：2012-10-25
申请号：US13356286
申请日：2012-01-23
申请人： Kenn Oldham , Thomas D. Wang , Zhongyao Liu , Jing Yong Ye
发明人： Kenn Oldham , Thomas D. Wang , Zhongyao Liu , Jing Yong Ye
IPC分类号： F21V14/06 , G01N21/64
CPC分类号： G01N21/6486 , A61B1/0011 , A61B1/00172 , A61B1/233 , A61B1/2733 , G01N33/4833
摘要： An endscopic imaging device is described that achieves longitudinal axis (z-axis) scanning into a tissue or sample, using a piezoelectric microactuator. In some configurations, additional lateral (xy-plane) scanning is also achieved, to allow for the creation of full three-dimensional imaging, ex vivo or in vivo. The techniques may be used to image and diagnosis allergic rhinitis and eosinophilic esophagitis in tissue.
摘要翻译：描述了使用压电微致动器实现对组织或样品的纵轴（z轴）扫描的内窥镜成像装置。在一些配置中，还实现了另外的横向（xy平面）扫描，以允许在离体或体内产生完整的三维成像。该技术可用于成像和诊断组织中的过敏性鼻炎和嗜酸粒细胞性食管炎。

3. 发明申请

US20180192887A1 Thermochromic Optical Waveguide Temperature Sensors 审中-公开
公开(公告)号：US20180192887A1
公开(公告)日：2018-07-12
申请号：US15869365
申请日：2018-01-12
申请人： Jing Yong Ye , Corinne Nawn
发明人： Jing Yong Ye , Corinne Nawn
IPC分类号： A61B5/01 , G01K13/00
CPC分类号： A61B5/015 , A61B5/0075 , A61B5/0084 , A61B5/01 , G01K11/165 , G01K11/3206 , G01K13/002
摘要： In one embodiment, a temperature sensor includes an optical waveguide having a distal tip and a thermochromic sensing element mounted to the distal tip of the optical waveguide, wherein light transmitted through the optical waveguide to the distal tip is reflected back from the thermochromic sensing element and wherein the reflected light provides an indication of a local temperature at a location of the thermochromic sensing element.

4. 发明授权

US07474919B2 Laser-based method and system for enhancing optical breakdown 有权
标题翻译：用于增强光学击穿的基于激光的方法和系统
公开(公告)号：US07474919B2
公开(公告)日：2009-01-06
申请号：US10637343
申请日：2003-08-08
申请人： Jing Yong Ye , Theodore B. Norris , James R. Baker, Jr. , Lajos P. Balogh
发明人： Jing Yong Ye , Theodore B. Norris , James R. Baker, Jr. , Lajos P. Balogh
IPC分类号： A61N1/30
CPC分类号： B82Y15/00 , A61B5/0095 , A61B8/481 , G01N21/718 , G01N29/2418 , G01N2291/02433 , G01N2291/02475 , G01N2291/02491
摘要： An additive, preferably in the form of metal nanoparticles or nanodomains, greatly improves a laser-based method and system for inducing optical breakdown. The use of ultrashort laser pulses to induce laser-induced breakdown (LIB) in metal nanoparticles or nanocomposites makes it possible to reduce significantly the threshold laser energy required for LIB. Such nanoscale (submicron) metallic particles allows one to control the LIB process. The nanoparticles can be synthesized so as to target specific biological structures or tissues (dendrimer nanoparticles are one system for which this has been demonstrated). This opens up the possibility of performing LIB for targeted cancer treatment or microsurgery.
摘要翻译：优选以金属纳米颗粒或纳米域的形式的添加剂大大改进了用于诱导光学击穿的基于激光的方法和系统。使用超短激光脉冲来诱导金属纳米颗粒或纳米复合材料中的激光诱发击穿（LIB）使得可以显着降低LIB所需的阈值激光能量。这种纳米尺度（亚微米）金属颗粒允许控制LIB工艺。可以合成纳米颗粒以靶向特定的生物结构或组织（树状聚合物纳米颗粒是已经证明其的一个体系）。这开辟了进行靶向癌症治疗或显微手术的LIB的可能性。

5. 发明授权

US07362500B2 Double-clad fiber scanning microscope 有权
标题翻译：双包层光纤扫描显微镜
公开(公告)号：US07362500B2
公开(公告)日：2008-04-22
申请号：US10556620
申请日：2004-05-28
申请人： Jing Yong Ye , Theodore B. Norris
发明人： Jing Yong Ye , Theodore B. Norris
IPC分类号： G02B21/00 , G02B21/06
CPC分类号： G02B6/02366 , G01N21/6458 , G01N2021/6484 , G01N2021/656 , G02B6/02042 , G02B6/02342 , G02B6/03622 , G02B6/04 , G02B6/32 , G02B21/0024 , G02B21/0076
摘要： A scanning microscope having a laser outputting an excitation laser beam and a fiber member having a first core and a second core. The second core is generally disposed within the first core and is operable to receive the excitation laser beam from the laser and transmit the excitation laser beam to a sample to be tested. A moveable stage supports an end of the fiber member and/or a sample to be tested and is operable to move the end of the fiber member and the sample to be tested relative to each other.
摘要翻译：一种具有输出激发激光束的激光和具有第一芯和第二芯的光纤部件的扫描显微镜。第二芯通常设置在第一芯内，并且可操作以从激光器接收激发激光束并将激发激光束传输到待测样品。可移动台支撑纤维构件和/或待测试样品的端部并且可操作以相对于彼此移动待测试的纤维构件和样品的端部。

6. 发明授权

US07277169B2 Whole spectrum fluorescence detection with ultrafast white light excitation 有权
标题翻译：全光谱荧光检测与超快白光激发
公开(公告)号：US07277169B2
公开(公告)日：2007-10-02
申请号：US11355387
申请日：2006-02-16
申请人： Jing Yong Ye , Theodore B. Norris , James R. Baker, Jr.
发明人： Jing Yong Ye , Theodore B. Norris , James R. Baker, Jr.
IPC分类号： G01N21/64
CPC分类号： G01J3/4406 , G01J3/10 , G01J3/2889 , G01N21/6408 , G01N21/6458
摘要： A fluorescence detection system for testing a sample having at least one fluorophore. The fluorescence detection system comprises a white light generation system outputting a white light pulse. The white light pulse has a first frequency range and a first time duration. The white light pulse excites the at least one fluorophore of the sample to emit a fluorescence. The fluorescence has a second frequency range and a second time duration, wherein the first time duration is less than the second time duration. A time-resolving detector receives the fluorescence and at least a portion of the white light pulse and separates the fluorescence from the portion of the white light pulse.
摘要翻译：一种用于测试具有至少一个荧光团的样品的荧光检测系统。荧光检测系统包括输出白光脉冲的白光发生系统。白光脉冲具有第一频率范围和第一持续时间。白光脉冲激发样品的至少一个荧光团以发射荧光。荧光具有第二频率范围和第二持续时间，其中第一持续时间小于第二持续时间。时间分辨检测器接收荧光和白光脉冲的至少一部分，并将荧光与白光脉冲的该部分分离。

7. 发明授权

US10157483B2 Backprojection approach for photoacoustic image reconstruction 有权
公开(公告)号：US10157483B2
公开(公告)日：2018-12-18
申请号：US14577960
申请日：2014-12-19
申请人： He Huang , Jing Yong Ye
发明人： He Huang , Jing Yong Ye
IPC分类号： A61B5/05 , G06T11/00 , A61B5/00
摘要： Various examples are provided for photoacoustic image reconstruction and processing utilizing a backprojection approach. In one example, among others, a method for producing an image with a photoacoustic imaging system includes scanning an object with a plurality of light beams, detecting a plurality of acoustic signals produced by the light beams, and generating a reconstructed image from the plurality of acoustic signals by filtered backprojection (FBP) that utilizes a weighted ramp filter. In another example, a system includes a plurality of acoustic detector units and a processing unit. The acoustic detector units can receive an acoustic wave and convert it to time dependent electrical signals. The processing unit can reconstruct an image of the subject from the time-dependent electrical signals by FBP that utilizes a weighted ramp filter. In another example, non-transitory computer readable medium stores a program that can cause a processing unit to reconstruct an image.

8. 发明申请

US20150178959A1 BACKPROJECTION APPROACH FOR PHOTOACOUSTIC IMAGE RECONSTRUCTION 审中-公开
标题翻译：背景图像重建方法
公开(公告)号：US20150178959A1
公开(公告)日：2015-06-25
申请号：US14577960
申请日：2014-12-19
申请人： He Huang , Jing Yong Ye
发明人： He Huang , Jing Yong Ye
IPC分类号： G06T11/00 , A61B5/00
CPC分类号： G06T11/006 , A61B5/0095 , G06T2211/421
摘要： Various examples are provided for photoacoustic image reconstruction and processing utilizing a backprojection approach. In one example, among others, a method for producing an image with a photoacoustic imaging system includes scanning an object with a plurality of light beams, detecting a plurality of acoustic signals produced by the light beams, and generating a reconstructed image from the plurality of acoustic signals by filtered backprojection (FBP) that utilizes a weighted ramp filter. In another example, a system includes a plurality of acoustic detector units and a processing unit. The acoustic detector units can receive an acoustic wave and convert it to time dependent electrical signals. The processing unit can reconstruct an image of the subject from the time-dependent electrical signals by FBP that utilizes a weighted ramp filter. In another example, non-transitory computer readable medium stores a program that can cause a processing unit to reconstruct an image.
摘要翻译：提供了利用反投影方法的光声图像重建和处理的各种示例。在一个示例中，除其他之外，用于产生具有光声成像系统的图像的方法包括用多个光束扫描对象，检测由光束产生的多个声信号，以及从多个光束生成重建图像通过使用加权斜坡滤波器的滤波反投影（FBP）的声信号。在另一示例中，系统包括多个声学检测器单元和处理单元。声学检测器单元可以接收声波并将其转换为与时间相关的电信号。处理单元可以通过利用加权斜坡滤波器的FBP从时间相关的电信号中重建被摄体的图像。在另一示例中，非暂时性计算机可读介质存储可使处理单元重构图像的程序。

9. 发明授权

US07639362B2 Photonic crystal sensor 失效
标题翻译：光子晶体传感器
公开(公告)号：US07639362B2
公开(公告)日：2009-12-29
申请号：US11881040
申请日：2007-07-25
申请人： Jing Yong Ye , Yunbo Guo , Theodore B. Norris , James R. Baker, Jr.
发明人： Jing Yong Ye , Yunbo Guo , Theodore B. Norris , James R. Baker, Jr.
IPC分类号： G01N21/55
CPC分类号： G01N21/648 , B82Y20/00 , G01N21/6408 , G01N21/7743 , G02B1/005
摘要： A photonic crystal sensor for outputting an output signal using a light source. The photonic crystal sensor includes a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface. An input light signal from the light source is inputted to the photonic crystal structure and defect member and is internally reflected to thereby output the output signal. Also, the output signal relates to a condition at the operative surface.
摘要翻译：一种用于使用光源输出输出信号的光子晶体传感器。光子晶体传感器包括光子晶体结构和邻近光子晶体结构设置的缺陷部件。缺陷构件限定了操作表面。来自光源的输入光信号被输入到光子晶体结构和缺陷部件，并被内反射，从而输出输出信号。另外，输出信号与操作面的状态有关。

10. 发明申请

US20080292555A1 Quantitative Two-Photon Flow Cytometry 有权
标题翻译：定量双光子流式细胞术
公开(公告)号：US20080292555A1
公开(公告)日：2008-11-27
申请号：US11662835
申请日：2005-09-16
申请人： Jing Yong Ye , Theodore B. Norris , Cheng F. Zhong , James R. Baker
发明人： Jing Yong Ye , Theodore B. Norris , Cheng F. Zhong , James R. Baker
IPC分类号： A61K49/00 , C12Q1/02 , A61B5/00
CPC分类号： G01N15/1459 , G01N15/1404 , G01N15/1484 , G01N2015/1075 , G01N2015/145 , G01N2015/1472 , G01N2015/1493
摘要： A method and apparatus of multi-dye analysis of particles using flow cytometer. The method includes dying particles to be detected using two or more dyes; urging the particles through a capillary in a non-uniform flow; exciting a first of the particles within the capillary using a multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a first output signal and a second output signal respectively; and detecting the first output signal and the second output signal. A second of the particles within the capillary being excited using the multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a third output signal and a forth output signal respectively. The method finally includes comparing a ratio of the first output signal and the second output signal to a ratio of the third output signal and the forth output signal to detect a desired change in the particles.
摘要翻译：使用流式细胞仪对颗粒进行多染色分析的方法和装置。该方法包括使用两种或更多种染料染色待检测的颗粒; 以不均匀的流动促使颗粒通过毛细管; 使用多光子激发激光束激发毛细管内的第一颗粒，使得两种或更多种染料各自发荧光，从而分别产生第一输出信号和第二输出信号; 以及检测第一输出信号和第二输出信号。使用多光子激发激光束激发毛细管内的第二颗粒，使得两种或更多种染料各自发出荧光，从而分别产生第三输出信号和第四输出信号。该方法最后包括将第一输出信号和第二输出信号的比率与第三输出信号和第四输出信号的比率进行比较，以检测颗粒中期望的变化。

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