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    • 2. 发明授权
    • Humanized anti-human α9-integrin antibody
    • 人源化抗人α9整联蛋白抗体
    • US08603476B2
    • 2013-12-10
    • US12812341
    • 2009-01-09
    • Kenji UeharaHirofumi HiguchiToshihiro NakashimaDaisuke IshikawaNobuchika YamamotoHirotada FujitaFumihiko Sakai
    • Kenji UeharaHirofumi HiguchiToshihiro NakashimaDaisuke IshikawaNobuchika YamamotoHirotada FujitaFumihiko Sakai
    • A61K39/395
    • C07K16/2839C07K2317/24C07K2317/565C07K2317/76C07K2317/92C07K2317/94
    • The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
    • 本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体,即包含重链可变区的人源化抗人α9整联蛋白抗体,其包含 的SEQ ID NO:11所示的氨基酸序列和由SEQ ID NO:17所示的氨基酸序列组成的轻链可变区,含有重链可变区的人源化抗人α9整联蛋白抗体包含由 由SEQ ID NO:13所示的氨基酸序列和由SEQ ID NO:17所示的氨基酸序列组成的轻链可变区,含有重链可变区的人源化抗人α9整联蛋白抗体 由SEQ ID NO:15所示的氨基酸序列和由SEQ ID NO:9所示的氨基酸序列组成的轻链可变区,以及预防或治疗涉及 人类α9整联蛋白在发病机制中使用抗体。
    • 6. 发明授权
    • Aeration tine device
    • 曝气装置
    • US06945332B2
    • 2005-09-20
    • US10760578
    • 2004-01-20
    • Kenji Uehara
    • Kenji Uehara
    • A01B45/02
    • A01B45/023
    • A highly durable aeration tine device attached to a soil aerator has a tubular tine member extending cylindrically and a hard metal tip made of a hard metal material and typically made in a frustum shape of a cone, which is in an area contact with the tubular tine member between the surfaces of the tubular tine member and the hard metal tip. Each surface of the tubular tine member and the hard metal tip is extending in a plane perpendicular to the axial direction and can be fabricated easily, and the drive force provided from the soil aerator can be transmitted without loss.
    • 连接到土壤充气器的高度耐用的曝气装置具有圆柱形延伸的管状构件和由硬质金属材料制成的硬质金属尖端,并且通常制成锥形的锥体形状,其与管状尖端接触 管状构件的表面和硬质金属尖端之间的构件。 管状构件和硬质金属尖端的每个表面在垂直于轴向方向的平面中延伸并且可以容易地制造,并且可以传输从土壤通气器提供的驱动力而不会损失。
    • 7. 发明申请
    • AERATION TINE DEVICE
    • 电气设备
    • US20050167126A1
    • 2005-08-04
    • US10760578
    • 2004-01-20
    • Kenji Uehara
    • Kenji Uehara
    • A01B45/02
    • A01B45/023
    • A highly durable aeration tine device attached to a soil aerator has a tubular tine member extending cylindrically and a hard metal tip made of a hard metal material and typically made in a frustum shape of a cone, which is in an area contact with the tubular tine member between the surfaces of the tubular tine member and the hard metal tip. Each surface of the tubular tine member and the hard metal tip is extending in a plane perpendicular to the axial direction and can be fabricated easily, and the drive force provided from the soil aerator can be transmitted without loss.
    • 连接到土壤充气器的高度耐用的曝气装置具有圆柱形延伸的管状构件和由硬质金属材料制成的硬质金属尖端,并且通常制成锥形的锥体形状,其与管状尖端接触 管状构件的表面和硬质金属尖端之间的构件。 管状构件和硬质金属尖端的每个表面在垂直于轴向方向的平面中延伸并且可以容易地制造,并且可以传输从土壤通气器提供的驱动力而不会损失。