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1. 发明授权

US6037159A Polypeptide of N-acetylglucosamine-6-O-sulfotransferase and DNA encoding the same 有权
标题翻译： N-乙酰葡糖胺-6-O-磺基转移酶的多肽和编码它们的DNA
公开(公告)号：US6037159A
公开(公告)日：2000-03-14
申请号：US263023
申请日：1999-03-05
申请人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
发明人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
IPC分类号： C12N15/09 , C07K16/28 , C07K16/44 , C12N9/10 , C12N15/54 , C12P19/04 , C12P19/26 , C12R1/91
CPC分类号： C07K16/2896 , C07K16/44 , C12N9/13 , C12P19/04
摘要： Apolypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below:(a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2; or(b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented by the formula I:GlcNAc.beta.1-3Gal.beta.1-4GlcNAc (I) wherein GlcNAc represents an N-acetylglucosamine residue, Gal represents a galactose residue, .beta.1-3 represents a .beta.1-3 glycosidic linkage, and .beta.1-4 represents a .beta.1-4 glycosidic linkage.
摘要翻译：提供N-乙酰氨基葡萄糖-6-O-磺基转移酶的多肽和编码该肽的DNA。多肽为（a）或（b）：（a）由SEQ ID NO：2所示的氨基酸序列组成的多肽; 或（b）包含在（a）的氨基酸序列中包含一个或几个氨基酸的取代，缺失，插入或转座的氨基酸序列的多肽，其具有从硫酸基团转移硫酸基团的酶活性供体位于位于由式I表示的寡糖的非还原性末端的N-乙酰葡糖胺残基的6位的羟基：GlcNAcβ1〜3Galβ1-4GlcNAc（I），其中GlcNAc表示N-乙酰氨基葡萄糖残基 Gal代表半乳糖残基，β1-3代表β1-3糖苷键，β1-4代表β1-4糖苷键。

2. 发明申请

US20100137564A1 POLYPEPTIDE OF N-ACETYLGLUCOSAMINE-6-O-SULFOTRANSFERASE AND DNA ENCODING THE SAME 有权
标题翻译： N-乙酰氨基葡萄糖-6-磷脂酰肌醇蛋白多糖和编码其的DNA
公开(公告)号：US20100137564A1
公开(公告)日：2010-06-03
申请号：US12194441
申请日：2008-08-19
申请人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
发明人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
IPC分类号： C07K16/44
CPC分类号： C07K16/2896 , C07K16/44 , C12N9/13 , C12P19/04
摘要： A polypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide having the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which includes an amino acid sequence including substitution, deletion, insertion or transposition of one or a few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented the formula I: GlcNAcβ1-3Galβ1-4GlcNAc (I) where GlcNAc represents an N-acetyl-glucosamine residue, Gal represents a galactose residue, β 1-3 represents a β 1-3 glycosidic linkage, and β 1-4 represents a β 1-4 glycosidic linkage.
摘要翻译：提供N-乙酰氨基葡萄糖-6-O-磺基转移酶的多肽和编码该肽的DNA。多肽为（a）或（b）：（a）具有SEQ ID NO：2所示氨基酸序列的多肽; 或（b）包含在（a）的氨基酸序列中包含一个或几个氨基酸的取代，缺失，插入或转座的氨基酸序列的多肽，其具有从硫酸盐转移硫酸基的酶活性给予位于寡糖的非还原末端的N-乙酰葡糖胺残基6位的羟基，代表式I：GlcNAc＆bgr; 1-3Gal＆bgr; 1-4GlcNAc（I），其中GlcNAc代表N-乙酰基 - 葡萄糖胺残基，Gal表示半乳糖残基， 1-3代表一个 1-3糖苷键，和bgr; 1-4代表一个 1-4糖苷键。

3. 发明申请

US20050208631A1 Polypeptide of N-acetylglucosamine-6-O-sulfotransferase and DNA encoding the same 有权
标题翻译： N-乙酰葡糖胺-6-O-磺基转移酶的多肽和编码它们的DNA
公开(公告)号：US20050208631A1
公开(公告)日：2005-09-22
申请号：US10966849
申请日：2004-10-15
申请人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
发明人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
IPC分类号： C12N15/09 , C07K16/28 , C07K16/44 , C12N9/10 , C12N15/54 , C12P19/04 , C12P19/26 , C12R1/91 , C12P19/28
CPC分类号： C07K16/2896 , C07K16/44 , C12N9/13 , C12P19/04
摘要： A polypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented by the formula I: GlcNAcβ1-3Gal β1-4GlcNAc (I) wherein GlcNAc represents an N-acetylglucosamine residue, Gal represents a galactose residue, β1-3 represents a β1-3 glycosidic linkage, and β1-4 represents a β1-4 glycosidic linkage.
摘要翻译：提供N-乙酰氨基葡萄糖-6-O-磺基转移酶的多肽和编码该肽的DNA。多肽为（a）或（b）：（a）由SEQ ID NO：2所示的氨基酸序列组成的多肽; 或（b）包含在（a）的氨基酸序列中包含一个或几个氨基酸的取代，缺失，插入或转座的氨基酸序列的多肽，其具有从硫酸基团转移硫酸基团的酶活性供体位于位于式I表示的寡糖的非还原性末端的N-乙酰葡糖胺残基6位的羟基：<？in-line-formula description =“In-line Formulas”end =“lead” 其中GlcNAc代表N-乙酰葡糖胺残基，Gal代表半乳糖残基，β1- 3代表β1-3糖苷键，β1-4代表β1-4糖苷键。

4. 发明申请

US20050142644A1 Polypeptide of N-acetylglucosamine-6-O-sulfotransferase and DNA encoding the same 审中-公开
标题翻译： N-乙酰葡糖胺-6-O-磺基转移酶的多肽和编码它们的DNA
公开(公告)号：US20050142644A1
公开(公告)日：2005-06-30
申请号：US10966814
申请日：2004-10-15
申请人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
发明人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
IPC分类号： C12N15/09 , C07K16/28 , C07K16/44 , C12N9/10 , C12N15/54 , C12P19/04 , C12P19/26 , C12R1/91 , C07H21/04 , C08B37/00 , C12P19/28
CPC分类号： C07K16/2896 , C07K16/44 , C12N9/13 , C12P19/04
摘要： Apolypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented by the formula I: GlcNAcβ1-3Galβ1-4GlcNAc (I) wherein GlcNAc represents an N-acetylglucosamine residue, Gal represents a galactose residue, β1-3 represents a β1-3 glycosidic linkage, and β1-4 represents a β1-4 glycosidic linkage.
摘要翻译：提供N-乙酰氨基葡萄糖-6-O-磺基转移酶的多肽和编码该肽的DNA。多肽为（a）或（b）：（a）由SEQ ID NO：2所示的氨基酸序列组成的多肽; 或（b）包含在（a）的氨基酸序列中包含一个或几个氨基酸的取代，缺失，插入或转座的氨基酸序列的多肽，其具有从硫酸基团转移硫酸基团的酶活性供体位于位于式I表示的寡糖的非还原性末端的N-乙酰葡糖胺残基6位的羟基：<？in-line-formula description =“In-line Formulas”end =“lead” 其中GlcNAc代表N-乙酰氨基葡萄糖残基，Gal代表半乳糖残基，β1-3（GlcNAcbeta1-3Galbeta1-4GlcNAc（I）<？in-line-formula description =“In-line Formulas”end =“tail” 代表β1-3糖苷键，β1-4代表β1-4糖苷键。

5. 发明授权

US06455289B1 Polypeptide of N-acetylglucosamine-6-O-sulfotransferase and DNA encoding the same 有权
标题翻译： N-乙酰葡糖胺-6-O-磺基转移酶的多肽和编码它们的DNA
公开(公告)号：US06455289B1
公开(公告)日：2002-09-24
申请号：US09471867
申请日：1999-12-23
申请人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
发明人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
IPC分类号： C12N910
CPC分类号： C07K16/2896 , C07K16/44 , C12N9/13 , C12P19/04
摘要： Apolypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented by the formula I: GlcNAc&bgr;1-3Gal&bgr;1-4GlcNAc (I) wherein GlcNAc represents an N-acetylglucosamine residue, Gal represents a galactose residue, &bgr;1-3 represents a &bgr;1-3 glycosidic linkage, and &bgr;1-4 represents a &bgr;1-4 glycosidic linkage.
摘要翻译：提供N-乙酰氨基葡萄糖-6-O-磺基转移酶的多肽和编码该肽的DNA。多肽为（a）或（b）：（a）由SEQ ID NO：2所示的氨基酸序列组成的多肽; 或（b）包含在（a）的氨基酸序列中包含一个或几个氨基酸的取代，缺失，插入或转座的氨基酸序列的多肽，其具有从硫酸基团转移硫酸基团的酶活性供体位于位于由式I表示的寡糖的非还原性末端的N-乙酰葡糖胺残基的6位的羟基：其中GlcNAc表示N-乙酰葡糖胺残基，Gal表示半乳糖残基，β1-3表示 β1-糖苷键，β1-4代表β1-4糖苷键。

6. 发明申请

US20070196874A1 Method of examining colon cancer and colon adenoma 失效
标题翻译：检查结肠癌和结肠腺瘤的方法
公开(公告)号：US20070196874A1
公开(公告)日：2007-08-23
申请号：US10568544
申请日：2004-07-09
申请人： Reiji Kannagi , Mineko Izawa , Takashi Muramatsu , Kenji Uchimura , Hideaki Hosokawa
发明人： Reiji Kannagi , Mineko Izawa , Takashi Muramatsu , Kenji Uchimura , Hideaki Hosokawa
IPC分类号： G01N33/574 , C07K16/30
CPC分类号： G01N33/57419 , G01N2333/91097 , G01N2400/02
摘要： The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. The present inventors discovered that there are significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, among non-cancer colorectal tissues, colorectal cancer tissues and colorectal adenoma tissues. Furthermore the inventors applied the discovery to diagnosis and found that colorectal cancers and adenomas are detected specifically by assaying a definite range of GlcNAc-6-sulfated sugar residues in tissues from patients or feces samples. MECA-79 antibody (Pharmingen, catalog No. 09961D, Distributor: Becton Dickinson), reacting with GlcNAc-6-sulfated sugar residues, which are produced specifically by the enzyme present in colorectal cancer and colorectal adenoma tissues could be used for the examination of colorectal cancers and colorectal adenomas.
摘要翻译：本发明提供一种检查结肠直肠癌和结肠直肠腺瘤的方法，其能够以高概率检测结肠直肠癌患者和结肠直肠癌风险高的患者，并且可用于诊断结肠直肠癌和结肠直肠腺瘤，并提供检查试剂其中。本发明人发现，GlcNAc-6-磺基转移酶同工酶，糖残基的硫酸化酶在非癌结肠直肠组织，结肠直肠癌组织和结肠直肠腺瘤组织中的分布存在显着差异。此外，本发明人将该发现应用于诊断，并发现通过测定来自患者或粪便样品的组织中GlcNAc-6-硫酸化糖残基的确定范围来特异性检测结肠直肠癌和腺瘤。与存在于结肠直肠癌和结肠直肠腺瘤组织中的酶特异性产生的GlcNAc-6硫酸化糖残基反应的MECA-79抗体（Pharmingen，目录号09961D，经销商：Becton Dickinson）可用于检查结肠直肠癌和结直肠腺瘤。

7. 发明授权

US07601348B2 Method of examining colon cancer and colon adenoma 失效
标题翻译：检查结肠癌和结肠腺瘤的方法
公开(公告)号：US07601348B2
公开(公告)日：2009-10-13
申请号：US10568544
申请日：2004-07-09
申请人： Reiji Kannagi , Mineko Izawa , Takashi Muramatsu , Kenji Uchimura , Hideaki Hosokawa
发明人： Reiji Kannagi , Mineko Izawa , Takashi Muramatsu , Kenji Uchimura , Hideaki Hosokawa
IPC分类号： A61K39/395
CPC分类号： G01N33/57419 , G01N2333/91097 , G01N2400/02
摘要： The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. The present inventors discovered that there are significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, among non-cancer colorectal tissues, colorectal cancer tissues and colorectal adenoma tissues. Furthermore the inventors applied the discovery to diagnosis and found that colorectal cancers and adenomas are detected specifically by assaying a definite range of GlcNAc-6-sulfated sugar residues in tissues from patients or feces samples. MECA-79 antibody (Pharmingen, catalog No. 09961D, Distributor: Becton Dickinson), reacting with GlcNAc-6-sulfated sugar residues, which are produced specifically by the enzyme present in colorectal cancer and colorectal adenoma tissues could be used for the examination of colorectal cancers and colorectal adenomas.
摘要翻译：本发明提供一种检查结肠直肠癌和结肠直肠腺瘤的方法，其能够以高概率检测结肠直肠癌患者和结肠直肠癌风险高的患者，并且可用于诊断结肠直肠癌和结肠直肠腺瘤，并提供检查试剂其中。本发明人发现，GlcNAc-6-磺基转移酶同工酶，糖残基的硫酸化酶在非癌结肠直肠组织，结肠直肠癌组织和结肠直肠腺瘤组织中的分布存在显着差异。此外，本发明人将该发现应用于诊断，并发现通过测定来自患者或粪便样品的组织中GlcNAc-6-硫酸化糖残基的确定范围来特异性检测结肠直肠癌和腺瘤。与存在于结肠直肠癌和结肠直肠腺瘤组织中的酶特异性产生的GlcNAc-6硫酸化糖残基反应的MECA-79抗体（Pharmingen，目录号09961D，经销商：Becton Dickinson）可用于检查结肠直肠癌和结直肠腺瘤。

8. 发明申请

US20100015632A1 METHOD FOR EXAMINING COLORECTAL CANCER AND COLORECTAL ADENOMA 审中-公开
标题翻译：检查阴道癌和色素性腺瘤的方法
公开(公告)号：US20100015632A1
公开(公告)日：2010-01-21
申请号：US12567944
申请日：2009-09-28
申请人： Reiji Kannagi , Mineko Izawa , Takashi Muramatsu , Kenji Uchimura , Hideaki Hosokawa
发明人： Reiji Kannagi , Mineko Izawa , Takashi Muramatsu , Kenji Uchimura , Hideaki Hosokawa
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57419 , G01N2333/91097 , G01N2400/02
摘要： The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. There are significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, among non-cancer colorectal tissues, colorectal cancer tissues and colorectal adenoma tissues. Furthermore, colorectal cancers and adenomas are detected specifically by assaying a definite range of GlcNAc-6-sulfated sugar residues in tissues from patients or feces samples. MECA-79 antibody (Pharmingen, catalog No. 09961D, Distributor: Becton Dickinson), reacting with GlcNAc-6-sulfated sugar residues, which are produced specifically by the enzyme present in colorectal cancer and colorectal adenoma tissues could be used for the examination of colorectal cancers and colorectal adenomas.
摘要翻译：本发明提供一种检查结肠直肠癌和结肠直肠腺瘤的方法，其能够以高概率检测结肠直肠癌患者和结肠直肠癌风险高的患者，并且可用于诊断结肠直肠癌和结肠直肠腺瘤，并提供检查试剂其中。 GlcNAc-6-磺基转移酶同工酶，糖残基硫酸化酶，非癌症结肠直肠组织，结肠直肠癌组织和结肠直肠腺瘤组织分布差异均有统计学意义。此外，通过测定来自患者或粪便样品的组织中的一定范围的GlcNAc-6-硫酸化糖残基来检测结肠直肠癌和腺瘤。与存在于结肠直肠癌和结肠直肠腺瘤组织中的酶特异性产生的GlcNAc-6硫酸化糖残基反应的MECA-79抗体（Pharmingen，目录号09961D，经销商：Becton Dickinson）可用于检查结肠直肠癌和结直肠腺瘤。

9. 发明授权

US07935792B2 Antibody reacting with N-acetylglucosamine-6-O-sulfotransferase product 有权
标题翻译：抗体与N-乙酰葡糖胺-6-O-磺基转移酶产物反应
公开(公告)号：US07935792B2
公开(公告)日：2011-05-03
申请号：US12194441
申请日：2008-08-19
申请人： Kenji Uchimura
发明人： Kenji Uchimura
IPC分类号： C07K16/00
CPC分类号： C07K16/2896 , C07K16/44 , C12N9/13 , C12P19/04
摘要： A polypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide having the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which includes an amino acid sequence including substitution, deletion, insertion or transposition of one or a few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented the formula I: GlcNAcβ1-3Galβ1-4GlcNAc (I) where GlcNAc represents an N-acetyl-glucosamine residue, Gal represents a galactose residue, β 1-3 represents a β 1-3 glycosidic linkage, and β 1-4 represents a β 1-4 glycosidic linkage.
摘要翻译：提供N-乙酰氨基葡萄糖-6-O-磺基转移酶的多肽和编码该肽的DNA。多肽为（a）或（b）：（a）具有SEQ ID NO：2所示氨基酸序列的多肽; 或（b）包含在（a）的氨基酸序列中包含一个或几个氨基酸的取代，缺失，插入或转座的氨基酸序列的多肽，其具有从硫酸盐转移硫酸基的酶活性分配给位于由式I表示的寡糖的非还原性末端的N-乙酰葡糖胺残基6位的羟基：GlcNAc＆bgr; 1-3Gal＆bgr; 1-4GlcNAc（I）其中GlcNAc代表N-乙酰基 - 葡萄糖胺残基，Gal表示半乳糖残基，＆bgr; 1-3代表一个 1-3糖苷键，和bgr; 1-4代表一个 1-4糖苷键。

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