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1. 发明授权

US07332317B2 Phosphodiesterase and genes thereof 失效
标题翻译：磷酸二酯酶及其基因
公开(公告)号：US07332317B2
公开(公告)日：2008-02-19
申请号：US10168402
申请日：2000-12-22
申请人： Kenji Omori , Keizo Yuasa , Jun Kotera , Kotomi Oda , Hideo Michibata
发明人： Kenji Omori , Keizo Yuasa , Jun Kotera , Kotomi Oda , Hideo Michibata
IPC分类号： C12N9/16 , C07H21/04
CPC分类号： C12N9/16 , C12Q2521/119
摘要： The present invention is to provide a novel phosphodiesterase and a gene thereof, specifically, Type 11 phosphodiesterase (PDE11) and a gene thereof, more specifically, a phosphodiesterase selected from (A) a protein having an amino acid sequenced shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39, and (B) a protein having an amino acid sequence shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39 in which one or several amino acids are deleted, substituted or added, and having an activity of hydrolyzing a cyclic nucleotide, and a gene thereof, and a method of characterizing, identifying and selecting a phosphodiesterase inhibitor by using the same.
摘要翻译：本发明提供一种新的磷酸二酯酶及其基因，特别是11型磷酸二酯酶（PDE11）及其基因，更具体地，提供选自（A）具有SEQ.ID所示的氨基酸测序的蛋白质的磷酸二酯酶。 SEQ ID NO：2，SEQ ID NO：4，SEQ ID NO：6或SEQ ID NO：39，和（B）具有SEQ ID NO：2，SEQ ID NO：2所示氨基酸序列的蛋白质其中一个或几个氨基酸被缺失，取代或加入并且具有水解环状核苷酸的活性及其基因的SEQ ID NO：4，SEQ ID NO：6或SEQ ID NO：39 ，以及通过使用它们来表征，鉴定和选择磷酸二酯酶抑制剂的方法。

2. 发明授权

US08012731B2 Phosphodiesterase and gene thereof 有权
标题翻译：磷酸二酯酶及其基因
公开(公告)号：US08012731B2
公开(公告)日：2011-09-06
申请号：US11960999
申请日：2007-12-20
申请人： Kenji Omori , Keizo Yuasa , Jun Kotera , Kotomi Oda , Hideo Michibata
发明人： Kenji Omori , Keizo Yuasa , Jun Kotera , Kotomi Oda , Hideo Michibata
IPC分类号： C07H21/00 , C12N15/00 , C12Q1/68 , C12N1/21 , C12N5/10 , C12N9/16 , C12P21/00
CPC分类号： C12N9/16 , C12Q2521/119
摘要： The present invention is to provide a novel phosphodiesterase and a gene thereof, specifically, Type 11 phosphodiesterase (PDE11) and a gene thereof, more specifically, a phosphodiesterase selected from (A) a protein having an amino acid sequenced shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39, and (B) a protein having an amino acid sequence shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39 in which one or several amino acids are deleted, substituted or added, and having an activity of hydrolyzing a cyclic nucleotide, and a gene thereof, and a method of characterizing, identifying and selecting a phosphodiesterase inhibitor by using the same.
摘要翻译：本发明提供一种新的磷酸二酯酶及其基因，特别是11型磷酸二酯酶（PDE11）及其基因，更具体地，提供选自（A）具有SEQ.ID所示的氨基酸测序的蛋白质的磷酸二酯酶。 SEQ ID NO：2，SEQ ID NO：4，SEQ ID NO：6或SEQ ID NO：39，和（B）具有SEQ ID NO：2，SEQ ID NO：2所示氨基酸序列的蛋白质其中一个或几个氨基酸被缺失，取代或加入并且具有水解环状核苷酸的活性及其基因的SEQ ID NO：4，SEQ ID NO：6或SEQ ID NO：39 ，以及通过使用它们来表征，鉴定和选择磷酸二酯酶抑制剂的方法。

3. 发明申请

US20090325207A1 NOVEL PHOSPHODIESTERASE AND GENE THEREOF 有权
标题翻译：新型磷酸二酯酶及其基因
公开(公告)号：US20090325207A1
公开(公告)日：2009-12-31
申请号：US11960999
申请日：2007-12-20
申请人： Kenji OMORI , Keizo Yuasa , Jun Kotera , Kotomi Oda , Hideo Michibata
发明人： Kenji OMORI , Keizo Yuasa , Jun Kotera , Kotomi Oda , Hideo Michibata
IPC分类号： C12Q1/42 , C12N9/16 , C07H21/04 , C12N15/63 , C12N5/10
CPC分类号： C12N9/16 , C12Q2521/119
摘要： The present invention is to provide a novel phosphodiesterase and a gene thereof, specifically, Type 11 phosphodiesterase (PDE11) and a gene thereof, more specifically, a phosphodiesterase selected from (A) a protein having an amino acid sequenced shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39, and (B) a protein having an amino acid sequence shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: in which one or several amino acids are deleted, substituted or added, and having an activity of hydrolyzing a cyclic nucleotide, and a gene thereof, and a method of characterizing, identifying and selecting a phosphodiesterase inhibitor by using the same.
摘要翻译：本发明提供一种新的磷酸二酯酶及其基因，特别是11型磷酸二酯酶（PDE11）及其基因，更具体地，提供选自（A）具有SEQ.ID所示的氨基酸测序的蛋白质的磷酸二酯酶。 SEQ ID NO：2，SEQ ID NO：4，SEQ ID NO：6或SEQ ID NO：39，和（B）具有SEQ ID NO：2，SEQ ID NO：2所示氨基酸序列的蛋白质其中一个或几个氨基酸被缺失，取代或加入并具有水解环状核苷酸的活性及其基因.ID.NO:4，SEQ.ID.NO:6或SEQ.ID.NO：以及通过使用它们来表征，鉴定和选择磷酸二酯酶抑制剂的方法。

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