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1. 发明申请

US20100267775A1 OXADIAZOLIDINEDIONE COMPOUND 审中-公开
标题翻译：氧化杂环化合物
公开(公告)号：US20100267775A1
公开(公告)日：2010-10-21
申请号：US12739501
申请日：2008-10-22
申请人： Kenji Negoro , Fumiyoshi Iwasaki , Kei Ohnuki , Toshio Kurosaki , Kazuyuki Tsuchiya , Kazuyuki Kuramoto , Shigeru Yoshida , Takatoshi Soga
发明人： Kenji Negoro , Fumiyoshi Iwasaki , Kei Ohnuki , Toshio Kurosaki , Kazuyuki Tsuchiya , Kazuyuki Kuramoto , Shigeru Yoshida , Takatoshi Soga
IPC分类号： A61K31/4439 , C07D271/07 , A61K31/4245 , A61P3/10 , C07D413/12
CPC分类号： C07D271/06 , C07D271/07 , C07D413/12
摘要： A pharmaceutical agent having GPR40 receptor agonistic action, particularly a compound which is useful as an insulin secretagogue or an agent for preventing and/or treating diabetes mellitus. The present inventors have examined a compound having GPR40 receptor agonistic action, confirmed that an oxadiazolidinedione compound which has a substituent such as a benzyl group, etc. linked with a substituent such as a phenyl group, etc. through a linker at the 2-position of an oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof has an excellent GPR40 agonistic activity, and thus completed the invention. The oxadiazolidinedione compound has excellent insulin secretagogue action and anti-hyperglycemic action, and therefore can be used as an insulin secretagogue or an agent for preventing and/or treating diabetes mellitus.
摘要翻译：具有GPR40受体激动作用的药剂，特别是可用作胰岛素促分泌剂的化合物或用于预防和/或治疗糖尿病的药剂。本发明人已经研究了具有GPR40受体激动作用的化合物，证实了通过2-位的连接基与诸如苯基等取代基连接的具有苄基等取代基的恶二唑烷二酮化合物等的恶二唑烷二酮环或其药学上可接受的盐具有优异的GPR40激动活性，从而完成了本发明。恶二唑烷二酮化合物具有优异的胰岛素促分泌作用和抗高血糖作用，因此可用作胰岛素促分泌素或预防和/或治疗糖尿病的药剂。

2. 发明申请

US20100152165A1 CARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：羧酸衍生物
公开(公告)号：US20100152165A1
公开(公告)日：2010-06-17
申请号：US12517033
申请日：2007-11-29
申请人： Kenji Negoro , Kei Ohnuki , Toshio Kurosaki , Fumiyoshi Iwasaki , Yasuhiro Yonetoku , Kazuyuki Tsuchiya , Norio Asai , Shigeru Yoshida , Takatoshi Soga , Daisuke Suzuki
发明人： Kenji Negoro , Kei Ohnuki , Toshio Kurosaki , Fumiyoshi Iwasaki , Yasuhiro Yonetoku , Kazuyuki Tsuchiya , Norio Asai , Shigeru Yoshida , Takatoshi Soga , Daisuke Suzuki
IPC分类号： A61K31/55 , C07D215/20 , A61K31/47 , C07D223/16 , C07D279/16 , A61K31/5415 , A61K31/4375 , C07D471/02
CPC分类号： C07D471/04 , C07D209/08 , C07D215/12 , C07D215/14 , C07D215/20 , C07D215/227 , C07D215/26 , C07D215/38 , C07D215/40 , C07D215/58 , C07D265/36 , C07D279/16 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12
摘要： [Problem] To provide a pharmaceutical, particularly a compound which can be used as an insulin secretion promoter or a preventive or therapeutic agent for diabetes mellitus and the like diseases in which GPR40 is concerned.[Means for resolution] It was found that novel carboxylic acid derivatives or salts thereof, characterized in that carboxylic acid is linked to a 6-membered monocyclic aromatic ring via two atoms and said aromatic ring is linked to a nitrogen-containing bicyclic ring via a linker, have excellent GPR40 receptor agonist action. In addition, since the carboxylic acid derivatives of the invention showed excellent insulin secretion promoting action and blood glucose reducing action, they are useful as an insulin secretion promoter and a preventive or therapeutic agent for diabetes mellitus.
摘要翻译： [问题]提供可以用作胰岛素分泌促进剂的药物，特别是涉及GPR40的糖尿病等的预防或治疗剂的化合物。 [解决方法]发现新的羧酸衍生物或其盐，其特征在于羧酸通过两个原子与6元单环芳香环连接，所述芳环经由含氮双环通过接头，具有优异的GPR40受体激动作用。此外，由于本发明的羧酸衍生物显示出优异的胰岛素分泌促进作用和降血糖作用，因此它们可用作糖尿病的胰岛素分泌促进剂和预防或治疗剂。

3. 发明授权

US07968552B2 Oxadiazolidinedione compound 有权
标题翻译：恶二唑烷二酮化合物
公开(公告)号：US07968552B2
公开(公告)日：2011-06-28
申请号：US12298522
申请日：2007-04-23
申请人： Kenji Negoro , Fumiyoshi Iwasaki , Kei Ohnuki , Toshio Kurosaki , Yasuhiro Yonetoku , Norio Asai , Shigeru Yoshida , Takatoshi Soga
发明人： Kenji Negoro , Fumiyoshi Iwasaki , Kei Ohnuki , Toshio Kurosaki , Yasuhiro Yonetoku , Norio Asai , Shigeru Yoshida , Takatoshi Soga
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/4245 , C07D413/12 , C07D271/07
CPC分类号： C07D271/06 , C07D271/07 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided.It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.
摘要翻译：可以提供可用作药物的化合物，特别是胰岛素分泌促进剂或用于预防/治疗其中涉及GPR40的疾病如糖尿病等的化合物。已经发现，具有通过在恶二唑烷二酮环2位上的连接体与环状基团结合的苄基等取代基的恶二唑烷二酮化合物或其药学上可接受的盐具有优异的GPR40激动剂作用。此外，由于本发明的恶二唑烷二酮化合物显示出优异的胰岛素分泌促进作用和血糖降低作用，因此可用作胰岛素分泌促进剂或糖尿病的预防/治疗剂。

4. 发明申请

US20090186909A1 Oxadiazolidinedione Compound 有权
标题翻译：恶二唑烷二酮化合物
公开(公告)号：US20090186909A1
公开(公告)日：2009-07-23
申请号：US12298522
申请日：2007-04-23
申请人： Kenji Negoro , Fumiyoshi Iwasaki , Kei Ohnuki , Toshio Kurosaki , Yasuhiro Yonetoku , Norio Asai , Shigeru Yoshida , Takatoshi Soga
发明人： Kenji Negoro , Fumiyoshi Iwasaki , Kei Ohnuki , Toshio Kurosaki , Yasuhiro Yonetoku , Norio Asai , Shigeru Yoshida , Takatoshi Soga
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/4245 , C07D413/12 , C07D271/07
CPC分类号： C07D271/06 , C07D271/07 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： [Problem] A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided.[Means for resolution] It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.
摘要翻译：可以提供可用作药物的化合物，特别是胰岛素分泌促进剂或用于预防/治疗其中涉及GPR40的疾病如糖尿病等的化合物。 [解决方法]已经发现，恶二唑烷二酮化合物或其药学上可接受的盐，其特征在于具有通过在恶二唑烷二酮环的2位上的连接基与环状基团结合的苄基等取代基，具有优异的GPR40激动作用。此外，由于本发明的恶二唑烷二酮化合物显示出优异的胰岛素分泌促进作用和血糖降低作用，因此可用作胰岛素分泌促进剂或糖尿病的预防/治疗剂。

5. 发明授权

US4444039A Die forging press 失效
标题翻译：锻压机
公开(公告)号：US4444039A
公开(公告)日：1984-04-24
申请号：US371921
申请日：1982-04-26
申请人： Akira Asari , Toshio Kurosaki
发明人： Akira Asari , Toshio Kurosaki
IPC分类号： B21J9/02 , B21J9/08 , B21J13/08 , B21K29/00 , B21D37/16
CPC分类号： B21J9/08 , B21J13/085 , B21J9/02 , B21K29/00 , Y10S100/918
摘要： A die forging press which includes a press machine proper adapted to detachably mount a die set having an upper die and a lower die; an auxiliary station having a die opening mechanism for holding and moving the upper and lower dies of the die set toward and away from each other and a heater having a heating head retractably protrudable to a position between the upper and lower dies when opened by the die opening mechanism. A transfer mechanism for transferring a die set between the press machine and auxiliary station is provided.
摘要翻译：一种模锻机，包括适于可拆卸地安装具有上模和下模的模组的压力机; 具有用于保持和移动模具的上下模具朝向和远离的模具打开机构的辅助站和具有可由模具打开时可缩回地突出到上模和下模之间的位置的加热头的加热器开放机制。提供了一种用于在压机和辅助站之间传送模具组的传送机构。

6. 发明申请

US20050137224A1 2-Cyanopyrrolidinecarboxamide compound 失效
标题翻译： 2-氰基吡咯烷甲酰胺化合物
公开(公告)号：US20050137224A1
公开(公告)日：2005-06-23
申请号：US10975524
申请日：2004-10-29
申请人： Ichiro Shima , Akio Kuroda , Takehiko Ohkawa , Toshio Kurosaki , Yuki Sawada , Aiko Wada
发明人： Ichiro Shima , Akio Kuroda , Takehiko Ohkawa , Toshio Kurosaki , Yuki Sawada , Aiko Wada
IPC分类号： A61K31/4025 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D451/04 , C07D453/02 , C07D471/08 , C07D487/08 , A61K31/46 , A61K31/407 , C07D43/02
CPC分类号： C07D453/02 , C07D451/04 , C07D471/08
摘要： A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X3 is ═CH2, ═CHF or ═CF2; R1 is substituent, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.]having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.
摘要翻译：式（I）化合物或其药学上可接受的盐：其中X 1和X 2各自独立地为低级亚烷基; X 3是-CH 2，-CHF或-CF 2; R 1是取代基，R 2和R 3各自独立地是H或低级烷基; n为0,1,2,3或4]具有抑制DPP-IV活性的活性。因此，它们可用于治疗DPP-IV介导的病症，例如NIDDM。

7. 发明授权

US5445508A Vulcanizing mold setting apparatus 失效
标题翻译：硫化模具设定装置
公开(公告)号：US5445508A
公开(公告)日：1995-08-29
申请号：US369331
申请日：1995-01-06
申请人： Kenji Kubo , Katsumi Ichikawa , Kashiro Ureshino , Toshio Kurosaki , Shigeru Kaneko
发明人： Kenji Kubo , Katsumi Ichikawa , Kashiro Ureshino , Toshio Kurosaki , Shigeru Kaneko
IPC分类号： B29C33/02 , B29C33/30 , B29C33/34 , B29C35/02 , B29D30/06 , B29K21/00 , B29K105/24 , B29L30/00 , B30B15/02 , H60N33/30
CPC分类号： B29C33/305 , B29D30/0606 , B30B15/028 , B29C35/02 , B29D2030/0653 , B29L2030/00
摘要： A vulcanizing mold setting apparatus for setting a vulcanizing mold assembly (21) on the platen (6) of a tire vulcanizing apparatus (1) comprises: a mold transfer mechanism (54) comprising a mold carriage (49) for horizontally moving the vulcanizing mold assembly (21) to and away from the tire vulcanizing machine (1), a pair of guide units (41) disposed respectively on the opposite sides of the platen (6), and a pair of mold supporting units (24) disposed respectively on the opposite sides of the platen (6) behind the guide units (41) to support the vulcanizing mold assembly (21) above the platen (6); a pair of lifting mechanisms (27) for vertically moving the mold supporting units (24) to place the vulcanizing mold on the platen (6); a centering mechanism (29) for centering the vulcanizing mold assembly (21) on the platen (6); and clamping members (26) for fastening the fixed mold (7) of the vulcanizing mold assembly (21 ) to the platen (6) after the vulcanizing mold assembly (21) has been centered on the platen (6).
摘要翻译：一种用于将硫化模具组件（21）设置在轮胎硫化装置（1）的台板（6）上的硫化模具固定装置包括：模具传送机构（54），包括用于水平移动硫化模具的模具托架（49）组件（21）和轮胎硫化机（1）之间的一对导向单元（41），以及分别设置在压板（6）的相对侧上的一对导向单元（41）在导向单元（41）后面的压板（6）的相对侧以支撑在压板（6）上方的硫化模具组件（21）; 一对用于垂直移动模具支撑单元（24）以将硫化模具放置在压板（6）上的提升机构（27）; 用于将硫化模具组件（21）定心在压板（6）上的定心机构（29）; 以及用于在硫化模具组件（21）已经在压板（6）上居中之后将硫化模具组件（21）的固定模具（7）紧固到压板（6）的夹紧构件（26）。

8. 发明授权

US07186731B2 2-cyanopyrrolidinecarboxamide compound 失效
标题翻译： 2-氰基吡咯烷甲酰胺化合物
公开(公告)号：US07186731B2
公开(公告)日：2007-03-06
申请号：US10975524
申请日：2004-10-29
申请人： Ichiro Shima , Akio Kuroda , Takehiko Ohkawa , Toshio Kurosaki , Yuki Sawada , Aiko Wada
发明人： Ichiro Shima , Akio Kuroda , Takehiko Ohkawa , Toshio Kurosaki , Yuki Sawada , Aiko Wada
IPC分类号： A61K31/4439 , C07D451/00
CPC分类号： C07D453/02 , C07D451/04 , C07D471/08
摘要： A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X3 is ═CH2, ═CHF or ═CF2; R1 is substituent, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.] having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.
摘要翻译：式（I）化合物或其药学上可接受的盐：其中X 1和X 2各自独立地为低级亚烷基; X 3是-CH 2，-CHF或-CF 2; R 1是取代基，R 2和R 3各自独立地是H或低级烷基; n为0,1,2,3或4]具有抑制DPP-IV活性的活性。因此，它们可用于治疗DPP-IV介导的病症，例如NIDDM。

9. 发明授权

US5196990A Metal printed circuit board 失效
标题翻译：金属印刷电路板
公开(公告)号：US5196990A
公开(公告)日：1993-03-23
申请号：US857125
申请日：1992-03-25
申请人： Toshio Kurosaki
发明人： Toshio Kurosaki
IPC分类号： H05K1/02 , H05K3/00
CPC分类号： H05K1/0216 , H05K1/0203 , H05K1/0272 , H05K2201/09745 , H05K3/0061
摘要： A metal printed board having circuit conductors on the surface of an insulating plate layered on a metal plate, wherein grooves formed in the portions of the metal plate which face the circuit conductor. The electronic parts mounted conducts into the metal plate through the solder portions and the insulating plate just thereunder. Accordingly, the presence of the grooves little impairs the thermal conduction. The stray capacitance between the conductor circuit and the metal plate because of the formed grooves, is considerably reduced, so that the signal leakage and noise sneaking are minimized.
摘要翻译：一种金属印刷电路板，其在位于金属板上的绝缘板的表面上具有电路导体，其中形成在金属板的与电路导体相对的部分中的沟槽。安装的电子部件通过焊接部分和绝缘板正下方进入金属板。因此，凹槽的存在几乎不会损害热传导。导体电路和金属板之间的杂散电容由于形成的沟槽而大大减小，从而使信号泄漏和噪声潜流最小化。

10. 发明授权

US4744236A Method of and apparatus for indirect extrusion 失效
标题翻译：间接挤出的方法和装置
公开(公告)号：US4744236A
公开(公告)日：1988-05-17
申请号：US811960
申请日：1985-12-10
申请人： Akira Asari , Masakazu Ueda , Takahisa Tabuchi , Munenori Soejima , Toshio Kurosaki , Masaru Sugamoto
发明人： Akira Asari , Masakazu Ueda , Takahisa Tabuchi , Munenori Soejima , Toshio Kurosaki , Masaru Sugamoto
IPC分类号： B21C23/20 , B21C23/21 , B21C27/04 , B21C23/00 , B21C26/00 , B21C35/04
CPC分类号： B21C27/04 , B21C23/205 , B21C23/218
摘要： Double-stem type extrusion method and apparatus used for extrusion-molding rod-like and tubular products. In order to upset a solid or hollow billet (5, 5A) supplied to a container (1), the end of the container (1) which is on the side of a press stem (6) is closed with a blistering-preventing cover (11) which is not moved relatively to the container (1). A pressure is then applied to the billet (5, 5A) from the side of a die (8) to start the yield deformation thereof from the same side thereof. As the yield deformation movement of the billet (5, 5A) progresses, the air existing between the inner surface of the container and billet (5, 5A) is discharged from the portion of the container (1) which is on the side of the cover (11).
摘要翻译： PCT No.PCT / JP85 / 00215 Sec。 371 1985年12月10日第 102（e）1985年12月10日日期PCT提交1985年4月18日PCT公布。出版物WO85 / 0482500 日期：1985年11月7日。双杆式挤压成型方法和装置用于挤出成型棒状和管状产品。为了扰乱供应到容器（1）的固体或中空坯料（5,5A），容器（1）的位于压力杆（6）侧的端部用防起泡罩盖（11），其不相对于所述容器（1）移动。然后从模具（8）侧向坯料（5A）施加压力，以从其同一侧开始屈服变形。当坯料（5A）的屈服变形运动进行时，存在于容器的内表面和坯料（5,5A）之间的空气从容器（1）的位于盖（11）。

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