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1. 发明授权

US4642812A Sound field enlarging device and method 失效
标题翻译：声场放大装置及方法
公开(公告)号：US4642812A
公开(公告)日：1987-02-10
申请号：US726267
申请日：1985-04-23
申请人： Junichi Yoshio , Toshio Hirano , Kenichiro Yasukawa , Masayuki Yoshida
发明人： Junichi Yoshio , Toshio Hirano , Kenichiro Yasukawa , Masayuki Yoshida
IPC分类号： G11B20/10 , H04S1/00 , H04R5/00
CPC分类号： H04S1/007
摘要： A method for performing sound field enlargement in a digital audio reproducing apparatus such as a compact disc player. A sum is calculated between each received pair of right-channel and left-channel data read from the disc, and the resulting sum data is stored in a random access memory. After a predetermined delay time, the sum data are read from the memory and multiplexed with the then-incoming right-channel and left-channel data. The resulting data stream is converted to respective right-channel, left-channel, and delayed-sum analog signals, which are then subjected to low-pass filtering. The filtered signals are processed in a conventional manner to yield outputs signals which, when reproduced, produce a perception of an enlarged sound field.
摘要翻译：一种用于在诸如光盘播放器的数字音频再现装置中执行声场放大的方法。在从盘读取的每个接收的右声道和左声道数据对之间计算和，并将所得到的和数据存储在随机存取存储器中。在预定的延迟时间之后，从存储器中读取和数据，并与随后的右声道和左声道数据进行多路复用。所得到的数据流被转换成相应的右声道，左声道和延迟和模拟信号，然后进行低通滤波。滤波后的信号以常规方式进行处理，以产生输出信号，当再现时产生放大声场的感知。

2. 发明授权

US4616271A Digital audio system with automatic fade in and fade out operations 失效
标题翻译：数字音频系统具有自动淡入和淡出操作
公开(公告)号：US4616271A
公开(公告)日：1986-10-07
申请号：US674667
申请日：1984-11-26
申请人： Kenichiro Yasukawa , Toshio Hirano , Masayuki Yoshida , Junichi Yoshio
发明人： Kenichiro Yasukawa , Toshio Hirano , Masayuki Yoshida , Junichi Yoshio
IPC分类号： H03F3/217 , G11B20/10 , H03F3/20 , H03G3/00 , H03G3/02 , H03M1/08 , H04B1/10 , H04B14/02 , G11B5/02 , G11B5/09
CPC分类号： G11B20/10527
摘要： A digital audio system constructed to reproduce an audio signal by separating low frequency components of a PAM (Pulse Amplitude Modulation) signal made up of pulses being produced at predetermined time intervals and representing a predetermined audio signal, the digital audio system including a pulse width control means for varying the pulse width of each of the pulses of the PAM signal in accordance with a predetermined command signal, whereby an automatic fade in and fade out operation is performed.
摘要翻译：一种数字音频系统，被构造为通过分离由预定时间间隔产生的脉冲组成的PAM（脉冲幅度调制）信号的低频分量并且表示预定音频信号来再现音频信号，该数字音频系统包括脉冲宽度控制用于根据预定的命令信号改变PAM信号的每个脉冲的脉冲宽度的装置，从而执行自动淡入和淡出操作。

3. 发明授权

US5186931A Composition and method for supporting bone marrow transplantation 失效
标题翻译：支持骨髓移植的组成和方法
公开(公告)号：US5186931A
公开(公告)日：1993-02-16
申请号：US366866
申请日：1989-06-15
申请人： Tadamitsu Kishimoto , Toshio Hirano , Yukio Akiyama , Akira Okano , Hiroshi Matsui , Yoshiyuki Takahara
发明人： Tadamitsu Kishimoto , Toshio Hirano , Yukio Akiyama , Akira Okano , Hiroshi Matsui , Yoshiyuki Takahara
IPC分类号： A61K38/00 , A61K38/20 , C07K14/54
CPC分类号： A61K38/204 , C07K14/54
摘要： A composition and a method for supporting bone marrow transplantation are disclosed. The composition comprises a therapeutically acceptable amount of human B cell differentiation factor, or its biological equivalent, optionally in combination with an auxiliary agent selected from IL-1, IL-3, IL-4, IL-5, G-CSF, GM-CSF, and M-CSF. The composition also promotes the proliferation of hematopoietic cells in vitro.
摘要翻译：公开了一种用于支持骨髓移植的组合物和方法。组合物包含治疗上可接受量的人B细胞分化因子或其生物学等同物，任选与选自IL-1，IL-3，IL-4，IL-5，G-CSF，GM- CSF和M-CSF。该组合物还促进体外造血细胞的增殖。

4. 发明授权

US4400808A Rotary recording medium reproducing apparatus 失效
公开(公告)号：US4400808A
公开(公告)日：1983-08-23
申请号：US294360
申请日：1981-08-19
申请人： Takashi Saito , Toshio Hirano , Takashi Kumaki
发明人： Takashi Saito , Toshio Hirano , Takashi Kumaki
IPC分类号： G11B17/032 , G11B17/04 , G11B25/04
CPC分类号： G11B17/049 , G11B17/032
摘要： A rotary recording medium reproducing apparatus reproduces a rotary recording medium accommodated within a case, where the case comprises a jacket provided with a space for accommodating the rotary recording medium and an opening for allowing the rotary recording medium to go in and out of the jacket, and a lid member inserted through the opening of the jacket for closing the opening of the jacket. The rotary recording medium reproducing apparatus comprises an inserting opening through which the case is inserted, a turntable for rotating the rotary recording medium, a lid member locking mechanism and rotary recording medium clamping mechanism respectively provided at an innermost part of the reproducing apparatus opposite to the inserting opening with respect to the turntable, a jacket opening enlarging mechanism provided in the vicinity of the inserting opening, capable of moving over the turntable between a position in the vicinity of the inserting opening and the innermost part of the reproducing apparatus, in response to an operation in which the case is inserted into and pulled out from the reproducing apparatus, an elevator mechanism for raising and lowering a rotary recording medium supporting member for supporting the rotary recording medium, independently from the turntable, an elevator motor for operating the elevator mechanism, when the elevator motor operates so that the support member is at a raised position due to the operation of the elevator mechanism upon insertion of the case into the reproducing apparatus, and an elevator lever member provided respective of the elevator mechanism, for operating the elevator mechanism by operating independently from the elevator motor. The elevator lever member is positioned within a moving passage of a locking guiding part which is a part of the jacket opening enlarging means. Further, the elevator lever member is locked and guided by the locking guiding part and displaced towards a direction so as to operate the elevator means to lower the supporting member so that the supporting member retreats from a case inserting path upon insertion of the case into the reproducing apparatus, and is released of the locking operation by the locking guiding part and displaced towards an opposite direction so as to operate the elevator means to raise the supporting member upon extraction of the case from the reproducing apparatus.

5. 发明申请

US20130247671A1 BLADE VIBRATION MEASURING APPARATUS 有权
标题翻译：叶片振动测量装置
公开(公告)号：US20130247671A1
公开(公告)日：2013-09-26
申请号：US13613398
申请日：2012-09-13
申请人： Kohichi Nakayama , Kenji Osaki , Hisashi Matsuda , Hitoshi Sakakida , Toshio Hirano , Toshiaki Hirate , Sueyoshi Mizuno , Ikuo Saito
发明人： Kohichi Nakayama , Kenji Osaki , Hisashi Matsuda , Hitoshi Sakakida , Toshio Hirano , Toshiaki Hirate , Sueyoshi Mizuno , Ikuo Saito
IPC分类号： G01N29/12
CPC分类号： G01N29/12 , F01D5/16 , F01D21/003 , F05D2220/31 , G01H3/04 , G01H3/10
摘要： According to the embodiment, there is provided a blade vibration measuring apparatus, having, a contactless displacement 5 sensor which outputs a displacement measurement signal as measuring a displacement of a turbine moving blade in a rotation axis direction, a blade top position identifying device which outputs a blade top position identification signal to identify a top position based on a distance between the contactless displacement sensor 10 and the top position of the turbine moving blade as receiving the displacement measurement signal output from the contactless displacement sensor, and a blade vibration calculating device which calculates vibration amplitude and a vibration frequency of the turbine moving blade based on temporal variation of the distance 15 between the contactless displacement sensor and the top position of the turbine moving blade as receiving the blade top position identification signal output from the blade top position identifying device.
摘要翻译：根据本实施方式，提供一种叶片振动测定装置，具有：非旋转位移传感器，其输出作为测量涡轮机动叶片在旋转轴方向上的位移的位移测量信号;叶片顶部位置识别装置，其输出叶片顶部位置识别信号，用于在接收从非接触位移传感器输出的位移测量信号时基于非接触位移传感器10与涡轮机动叶片的顶部位置之间的距离来识别顶部位置;以及叶片振动计算装置，基于从叶片顶部位置识别装置输出的叶片顶部位置识别信号，基于非接触位移传感器和涡轮机动叶片的顶部位置之间的距离15的时间变化来计算涡轮机动叶片的振动振幅和振动频率。

6. 发明申请

US20130236473A1 THERAPEUTIC AGENTS AND PROPHYLACTIC AGENTS FOR SYMPTOMS ACCOMPANYING AUTOIMMUNE DISEASES, INFLAMMATORY DISEASES, ALLERGY DISEASES AND ORGAN TRANSPLANTS 审中-公开
标题翻译：治疗药物和预防药物，用于伴有自身免疫性疾病，炎性疾病，过敏性疾病和机构运输的症状
公开(公告)号：US20130236473A1
公开(公告)日：2013-09-12
申请号：US13823325
申请日：2011-09-14
申请人： Toshio Hirano , Masaaki Murakami
发明人： Toshio Hirano , Masaaki Murakami
IPC分类号： A61K39/395 , A61K38/18 , A61K31/5377 , A61K31/517
CPC分类号： A61K39/3955 , A61K31/517 , A61K31/5377 , A61K31/7105 , A61K38/1808 , C07D239/94 , C12N15/113 , C12N2310/14
摘要： A major object of the present invention is to provide a novel therapeutic or prophylactic agent for at least one disease or symptom selected from the group consisting of autoimmune diseases, inflammatory diseases, allergic diseases, and symptoms accompanying organ transplants; the therapeutic or prophylactic agent artificially controls the activity of IL-6 amplifier, thus controlling immune reactions in living organisms. Another object of the present invention is to provide an immunosuppressant, an inflammatory cytokine production inhibitor, and an IL-6 amplifier inhibitor.The compound that inhibits expression of the function of a protein belonging to ErbB1 pathway provided as means for achieving the object is capable of suppressing the activity of IL-6 amplifier, thereby reducing production of inflammatory cytokine such as IL-6. Therefore, the compound that inhibits the function of a protein belonging to ErbB1 pathway can be used as an active ingredient of the therapeutic agent or the prophylactic agent for at least one disease or symptom selected from the group consisting of autoimmune diseases, inflammatory diseases, allergic diseases, and symptoms accompanying organ transplants.
摘要翻译：本发明的主要目的是提供一种用于至少一种疾病或症状的新型治疗或预防剂，所述疾病或症状选自自身免疫疾病，炎性疾病，过敏性疾病和伴随器官移植的症状; 治疗或预防剂人为地控制IL-6放大器的活性，从而控制活生物体中的免疫反应。本发明的另一个目的是提供免疫抑制剂，炎性细胞因子产生抑制剂和IL-6放大抑制剂。抑制属于ErbB1途径的蛋白质的功能表达的化合物作为实现该目标的手段能够抑制IL-6放大器的活性，从而减少炎症细胞因子如IL-6的产生。因此，抑制属于ErbB1途径的蛋白质的功能的化合物可以用作治疗剂或预防剂的活性成分，所述至少一种疾病或症状选自自身免疫性疾病，炎性疾病，过敏性疾病和伴随器官移植的症状。

7. 发明授权

US06627740B2 Monoclonol antibody which binds to a polypeptide having pre-B cell growth supporting ability 失效
标题翻译：结合具有前B细胞生长支持能力的多肽的单克隆醇抗体
公开(公告)号：US06627740B2
公开(公告)日：2003-09-30
申请号：US09935720
申请日：2001-08-24
申请人： Toshio Hirano , Tsuneyasu Kaisho
发明人： Toshio Hirano , Tsuneyasu Kaisho
IPC分类号： C07K1628
CPC分类号： C07K14/52 , A61K38/00
摘要： The present invention provides a monoclonal antibody which binds to a polypeptide as set forth in SEQ ID NO: 1 as described herein.
摘要翻译：本发明提供了结合如本文所述的SEQ ID NO：1所示的多肽的单克隆抗体。

8. 发明授权

US5753464A DNA encoding a polypeptide having pre-B cell growth-supporting ability 失效
标题翻译：编码具有前B细胞生长支持能力的多肽的DNA
公开(公告)号：US5753464A
公开(公告)日：1998-05-19
申请号：US537942
申请日：1995-11-21
申请人： Toshio Hirano , Tsuneyasu Kaisho
发明人： Toshio Hirano , Tsuneyasu Kaisho
IPC分类号： A61K38/00 , C07K14/52 , C12N15/12 , C12N15/16 , C12N15/36
CPC分类号： C07K14/52 , A61K38/00
摘要： This invention relates to a gene encoding a polypeptide having pre-B cell growth-supporting ability, and an adhesion molecule of the polypeptide consisting of 318 amino acid residues having pre-B cell growth-supporting ability, or a part of it. Said adhesion molecule is produced by preparing transformants such as microorganism or cells by transforming a host cell with a vector containing said gene and culturing said transformants. The above gene encodes the novel adhesion molecule enhancing the pre-B cell growth-supporting ability on the bone marrow cell and the synovial cell derived from patients with rheumatoid arthritis (RA) and multiple myeloma (MM). The homogeneous and purified adhesion molecule having pre-B cell growth-supporting ability can be produced in large quantities, and therefore it is possible to identify multiple myeloma (MM) and rheumatoid arthritis (RA), and also prepare reagents for the clinical diagnosis thereof.
摘要翻译： PCT No.PCT / JP94 / 00819 Sec。 371日期：1995年11月21日 102（e）1995年11月21日日期PCT 1994年5月20日PCT PCT。出版物WO94 / 28130 PCT 日期1994年12月8日本发明涉及编码具有前B细胞生长支持能力的多肽的基因和由具有前B细胞生长支持能力的318个氨基酸残基组成的多肽的粘附分子，或部分的。所述粘附分子通过用含有所述基因的载体转化宿主细胞并培养所述转化体来制备转化体如微生物或细胞。上述基因编码新型粘附分子增强骨髓细胞和来自类风湿性关节炎（RA）和多发性骨髓瘤（MM）患者的滑膜细胞的B细胞前生长支持能力。具有前B细胞生长支持能力的均相和纯化的粘附分子可以大量生产，因此可以鉴定多发性骨髓瘤（MM）和类风湿性关节炎（RA），并且还可以制备用于临床诊断的试剂。

9. 发明授权

US4796251A Dual-sized disk player 失效
标题翻译：双尺寸磁盘播放器
公开(公告)号：US4796251A
公开(公告)日：1989-01-03
申请号：US2468
申请日：1987-01-12
申请人： Toshio Hirano
发明人： Toshio Hirano
IPC分类号： G11B17/04 , G11B17/056 , G11B19/10 , G11B19/20 , G11B25/04 , G11B15/30 , G11B15/44
CPC分类号： G11B17/0565 , G11B17/0283 , G11B19/10 , G11B19/2009 , G11B25/043
摘要： A disk player for both optical and compact disk having two spindle motors for the two types of disk. One of the spindle motors is located far enough from the other spindle motors to receive its own smaller disk and is movable to allow the other spindle motor to receive the larger disk. The disks are carried on a tray to the respective spindle motor and are clamped thereagainst. The tray comprises two carriers for two disk sizes which are separable from each other inside the disk player.
摘要翻译：用于光盘和光盘的盘播放器，具有用于两种类型的盘的两个主轴电机。其中一个主轴电机距离其他主轴电机足够远，以接收其自己的较小的磁盘，并且可移动以允许另一主轴电机接收较大的磁盘。盘被托盘托在相应的主轴马达上，并被夹在其上。托盘包括两个托盘，两个托盘可以在盘播放器内彼此分离。

10. 发明授权

US4395744A Disc-shaped recording medium reproducing apparatus 失效
标题翻译：碟形记录介质再现装置
公开(公告)号：US4395744A
公开(公告)日：1983-07-26
申请号：US288292
申请日：1981-07-30
申请人： Takashi Saito , Toshio Hirano , Takashi Kumaki
发明人： Takashi Saito , Toshio Hirano , Takashi Kumaki
IPC分类号： G11B17/032 , G11B17/04 , G11B23/03 , G11B23/04 , G11B25/04
CPC分类号： G11B17/049 , G11B17/032 , G11B23/0328
摘要： A reproducing apparatus reproduces a disc-shaped recording medium which is accommodated within a case. The case comprises a jacket which has a space for accommodating the disc-shaped recording medium and an opening for allowing the disc-shaped recording medium to go in and out of the jacket, and a lid member inserted through the opening of the jacket for closing the opening of the jacket. The reproducing apparatus comprises an inserting opening part through which the case is inserted into the reproducing apparatus, a turntable for rotating the disc-shaped recording medium, lid member locking mechanism and disc-shaped recording medium clamping mechanism respectively provided at the innermost part of the reproducing apparatus opposite to the inserting opening with respect to the turntable, jacket opening enlarging mechanism provided in the vicinity of the inserting opening, moving over the turntable between the position in the vicinity of the inserting opening and the innermost part of the reproducing apparatus, accompanied by operation of inserting the case into and pulling the same from the reproducing apparatus, and an elevating mechanism for moving a member for supporting the disc-shaped recording medium upwards and downwards independent of the turntable.
摘要翻译：再现装置再现容纳在壳体内的盘状记录介质。壳体包括具有用于容纳盘形记录介质的空间和用于允许盘形记录介质进出外壳的开口的外壳，以及插入穿过外壳的开口以关闭的盖构件外套的开口。再现装置包括插入开口部分，壳体通过该插入孔插入到再现装置中，转盘用于旋转盘形记录介质，盖构件锁定机构和盘形记录介质夹紧机构，分别设置在最内部伴随着插入口相对于转盘相对的再现装置，设置在插入孔附近的护套开口扩大机构，在转盘的移动位置之间，在插入口附近的位置和再现装置的最内部之间，伴随着通过将盒子从再现装置插入并将其拉出的操作，以及用于独立于转盘而将用于支撑盘形记录介质的构件向上和向下移动的升降机构。

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