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1. 发明授权

US09364755B1 Methods and apparatus for using illumination marks for spatial pointing 有权
标题翻译：用于空间指向的照明标记的方法和装置
公开(公告)号：US09364755B1
公开(公告)日：2016-06-14
申请号：US13230953
申请日：2011-09-13
申请人： Kenichiro Ashida , Junji Takamoto , Yoshitomo Goto , Fumiyoshi Suetake , Akio Ikeda , Susumu Inoue , Shin Sugiyama , Kuniaki Ito
发明人： Kenichiro Ashida , Junji Takamoto , Yoshitomo Goto , Fumiyoshi Suetake , Akio Ikeda , Susumu Inoue , Shin Sugiyama , Kuniaki Ito
IPC分类号： A63F9/24 , A63F13/00 , A63F13/20 , A63F13/219 , A63F13/213 , G06F3/03 , G06F3/0346
CPC分类号： A63F13/213 , A63F13/04 , A63F13/20 , A63F13/219 , A63F13/98 , A63F2300/1087 , G06F3/0304 , G06F3/0325 , G06F3/0346 , G06F3/03542 , G06F3/038
摘要： An elongated member such as a bar includes spaced-apart infrared light illumination ports at opposite ends thereof. Exemplary spacing between the two spaced-apart light ports may be 20 centimeters or more. Each light port comprises an array of plural light sources. The plural light sources in each array may be directionally aimed to as to provide different illumination directions. The plural light sources in each array may emit different colors or frequencies of light. Example applications include targeting or marking capabilities for a video game or other system handheld pointing device.
摘要翻译：诸如杆的细长构件在其相对端处包括间隔开的红外光照明端口。两个间隔开的光端口之间的示例性间隔可以是20厘米或更大。每个光端口包括多个光源的阵列。每个阵列中的多个光源可以定向地瞄准以提供不同的照明方向。每个阵列中的多个光源可以发射不同的颜色或频率的光。示例应用包括针对视频游戏或其他系统手持式定位设备的定位或标记功能。

2. 发明申请

US20130190223A1 NONIMMUNOSUPPRESSIVE CYCLOSPORINE ANALOGUE MOLECULES 审中-公开
标题翻译：非阻断环孢霉素类似物分子
公开(公告)号：US20130190223A1
公开(公告)日：2013-07-25
申请号：US13056616
申请日：2009-07-03
申请人： Alexander Hegmans , Bruce W. Fenske , David P. Czajkowski , Darren R. Ure , Shin Sugiyama , Dan J. Trepanier , David H. McGlade , Mark D. Abel
发明人： Alexander Hegmans , Bruce W. Fenske , David P. Czajkowski , Darren R. Ure , Shin Sugiyama , Dan J. Trepanier , David H. McGlade , Mark D. Abel
IPC分类号： C07K7/64
CPC分类号： C07K7/645 , A61K38/00 , Y02A50/463
摘要： The compounds of the present invention are non-immunosupressive cyclosporine analogue molecules that are able to bind cyclophilin. Said compounds include a modified side chain of amino acid I of cyclosporin A, consisting of an oxyalkyl having substituents R′, R1 and R2, where R′ is H or Acetyl; R1 is a saturated or unsaturated straight chain or branched aliphatic carbon chain; and R2 may be a hydrogen; a unsubstituted, N substituted or NN disubstituted amide; a N substituted or unsubstituted acyl protected amine; a carboxylic acid; a N substituted or unsubstituted amine; a nitrile; a ester; a ketone; a hydroxy, dihydroxy, trihydroxy or polyhydroxy alkyl; or a substituted or unsubstituted aryl.
摘要翻译：本发明的化合物是能够结合亲环蛋白的非免疫抑制性环孢霉素类似物分子。所述化合物包括环烷霉素A的氨基酸I的修饰侧链，其由具有取代基R'，R 1和R 2的烷氧基烷基组成，其中R'为H或乙酰基; R1是饱和或不饱和的直链或支链脂族碳链; 并且R 2可以是氢; 未取代的，N取代的或NN二取代的酰胺; N取代或未取代的酰基保护的胺; 羧酸; N取代或未取代的胺; 腈酯; 酮羟基，二羟基，三羟基或多羟基烷基; 或取代或未取代的芳基。

3. 发明申请

US20140142033A1 CYCLOSPORINE ANALOGUE MOLECULES MODIFIED AT AMINO ACID 1 AND 3 有权
标题翻译：氨基酸1和3修饰的环磷酰胺类似物分子
公开(公告)号：US20140142033A1
公开(公告)日：2014-05-22
申请号：US13994707
申请日：2011-12-14
申请人： Alexander Hegmans , Bruce W. Fenske , Dan J. Trepanier , Mark D. Abel , Daren R. Ure , Shin Sugiyama
发明人： Alexander Hegmans , Bruce W. Fenske , Dan J. Trepanier , Mark D. Abel , Daren R. Ure , Shin Sugiyama
IPC分类号： C07K7/64
CPC分类号： C07K7/645 , A61K38/00 , A61K38/13 , Y02A50/463
摘要： Analogues of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.
摘要翻译：公开了环孢菌素-A的类似物，其包含根据下式的取代基的修饰作为氨基酸1和3的位置。所公开的化合物包括对环己烯具有亲和力的化合物，包括亲环蛋白-A，与环孢菌素-A及其单独在1位修饰的类似物相比具有降低的免疫抑制性。

4. 发明申请

US20060223743A1 Metabolites of cyclosporin analogs 审中-公开
标题翻译：环孢菌素类似物的代谢物
公开(公告)号：US20060223743A1
公开(公告)日：2006-10-05
申请号：US11313239
申请日：2005-12-19
申请人： Mark Abel , Robert Foster , Derrick Freitag , Daniel Trepanier , Shin Sugiyama , Seetharaman Jayaraman , Randall Yatscoff
发明人： Mark Abel , Robert Foster , Derrick Freitag , Daniel Trepanier , Shin Sugiyama , Seetharaman Jayaraman , Randall Yatscoff
IPC分类号： A61K38/13 , C07K7/64
CPC分类号： A61K38/13 , C07K7/64 , C07K7/645
摘要： Isolated metabolites of the cyclosporine analog ISA247 are disclosed, including in vitro methods for their preparation. The metabolites comprise a chemical modification of ISA247, wherein the modification is at least one reaction selected from the group consisting of hydroxylation, N-demethylation, diol formation, epoxide formation, and intramolecular cyclization phosphorylation, sulfation, glucuronide formation and glycosylation. Methods of preparation include semi-synthetic methods, wherein metabolites of ISA247 are produced from the microsomal extracts of animal liver cells, or from cultures using microorganisms, and completely synthetic methods, such as chemically modifying the parent compound or isolated metabolites using organic synthetic methods.
摘要翻译：公开了环孢菌素类似物ISA247的分离的代谢物，包括其制备方法。代谢物包括ISA247的化学修饰，其中所述修饰是选自羟基化，N-去甲基化，二醇形成，环氧化物形成和分子内环化磷酸化，硫酸化，葡糖苷酸形成和糖基化中的至少一种反应。制备方法包括半合成方法，其中ISA247的代谢物由动物肝细胞的微粒体提取物或使用微生物的培养物产生，以及完全合成的方法，例如使用有机合成方法化学改性母体化合物或分离的代谢物。

5. 发明授权

US6049425A Multiple-stage optical isolator 失效
标题翻译：多级光隔离器
公开(公告)号：US6049425A
公开(公告)日：2000-04-11
申请号：US884346
申请日：1997-06-27
申请人： Toshiaki Watanabe , Shin Sugiyama , Toshihiko Ryuo
发明人： Toshiaki Watanabe , Shin Sugiyama , Toshihiko Ryuo
IPC分类号： G02F1/09 , G02B5/30
CPC分类号： G02F1/093 , Y10S372/703
摘要： The present multiple-stage optical isolator has low polarization-dependency and low polarization-mode dispersion but does not require a long time for the assembly. It is constructed of a first unit having a first Faraday rotator placed within a magnetic field and at least one birefringent crystal sandwiching the Faraday rotator, these components being arranged in order from the light incident side; and a second unit having a second Faraday rotator placed within a magnetic field and at least one birefringent crystal sandwiching the Faraday rotator, these components being arranged in order from the light incident side, wherein the first and second units are arranged in order along the direction of the light transmission.
摘要翻译：本发明的多级光隔离器具有低偏振相关性和低偏振模色散，但不需要较长的组装时间。它由具有放置在磁场内的第一法拉第旋转器和夹着法拉第转子的至少一个双折射晶体的第一单元构成，这些部件从光入射侧依次布置; 以及第二单元，其具有放置在磁场内的第二法拉第旋转器和夹着所述法拉第旋转器的至少一个双折射晶体，这些部件从光入射侧依次布置，其中所述第一和第二单元沿着所述方向依次布置的光传输。

6. 发明授权

US09200038B2 Cyclosporine analogue molecules modified at amino acid 1 and 3 有权
标题翻译：在氨基酸1和3修饰的环孢霉素类似物分子
公开(公告)号：US09200038B2
公开(公告)日：2015-12-01
申请号：US13994707
申请日：2011-12-14
申请人： Alexander Hegmans , Bruce W. Fenske , Dan J. Trepanier , Mark D. Abel , Daren R. Ure , Shin Sugiyama
发明人： Alexander Hegmans , Bruce W. Fenske , Dan J. Trepanier , Mark D. Abel , Daren R. Ure , Shin Sugiyama
IPC分类号： A61K38/13 , C07K7/64 , A61K38/00
CPC分类号： C07K7/645 , A61K38/00 , A61K38/13 , Y02A50/463
摘要： Analogs of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.
摘要翻译：公开了环孢菌素-A的类似物，其包含根据下式的取代基的修饰作为氨基酸1和3的位置。所公开的化合物包括对环己烯具有亲和力的化合物，包括亲环蛋白-A，与环孢菌素-A及其单独在1位修饰的类似物相比具有降低的免疫抑制性。

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