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1. 发明授权

US5763598A Branched cyclodextrins and method for producing them 失效
标题翻译：支链环糊精及其制备方法
公开(公告)号：US5763598A
公开(公告)日：1998-06-09
申请号：US876979
申请日：1997-06-16
申请人： Kenichi Hamayasu , Tetsuya Ito , Koki Fujita , Kozo Hara , Kyoko Koizumi , Toshiko Tanimoto , Hirofumi Nakano , Sumio Kitahata
发明人： Kenichi Hamayasu , Tetsuya Ito , Koki Fujita , Kozo Hara , Kyoko Koizumi , Toshiko Tanimoto , Hirofumi Nakano , Sumio Kitahata
IPC分类号： C12P19/26 , A61K47/48 , C08B37/16 , A01N43/04 , A61K31/715
CPC分类号： B82Y5/00 , A61K47/48969 , C08B37/0012
摘要： Disclosed are novel branched cyclodextrins having any of an N-acetylglucosamine group, a glucosaminyl group, an N-acetylgalactosaminyl group and a galactosaminyl group as bonded to the hydroxyl group of the cyclodextrin ring by .beta.-bonding therebetween, and their salts. The novel branched cyclodextrins are produced by reacting a solution containing a cyclodextrin and an N-acetylglucosamine or N-acetylgalactosamine with an N-acetylhexosaminidase, and optionally deacetylating the resulting product.
摘要翻译：公开了通过β键连接在环糊精环的羟基上的N-乙酰葡糖胺基，葡糖胺基，N-乙酰半乳糖胺基和半乳糖胺基中的任一种的新型支链环糊精及其盐。新型支链环糊精是通过使含有环糊精和N-乙酰葡糖胺或N-乙酰半乳糖胺的溶液与N-乙酰基己糖胺酶反应，并任选地将所得产物脱乙酰化来制备的。

2. 发明申请

US20090030194A1 Process for Production of Glucuronic Acid and/or Glucuronolactone 审中-公开
标题翻译：葡萄糖醛酸和/或葡糖醛酸内酯的制备方法
公开(公告)号：US20090030194A1
公开(公告)日：2009-01-29
申请号：US11913999
申请日：2006-03-30
申请人： Kenichi Hamayasu , Hiroki Tadokoro , Eriko Kishino , Tetsuya Ito , Koki Fujita , Kozo Hara
发明人： Kenichi Hamayasu , Hiroki Tadokoro , Eriko Kishino , Tetsuya Ito , Koki Fujita , Kozo Hara
IPC分类号： C07H1/06
CPC分类号： C12P19/02 , C12P7/62 , C12P17/04
摘要： Provided is a process, by which glucuronic acid and/or glucuronolactone can be produced in high yield, at low cost, in an easy manner and in safe. Also provided is a process for production of glucuronic acid and/or glucuronolactone which is characterized in that sucrose is oxidized to give sucrose carboxylic acid (and a salt thereof) (glucuronyl-fructoside, β-D-fructosyl-(2→1)-α-D-glucuronic acid and a salt thereof), yeast is added so as to hydrolyze fructose residue of the sucrose carboxylic acid and to assimilate the resulting product, and thus produced glucuronic acid and/or glucuronolactone are/is collected.
摘要翻译：提供了一种以低成本，易于且安全地以高产率生产葡糖醛酸和/或葡糖醛酸内酯的方法。还提供了用于生产葡糖醛酸和/或葡糖醛酸内酯的方法，其特征在于将蔗糖氧化得到蔗糖羧酸（及其盐）（葡糖醛酸 - 果糖苷，β-D-果糖基 - （2-> 1） -α-D-葡糖醛酸及其盐），加入酵母以水解蔗糖羧酸的果糖残基并使所得产物同化，从而收集葡萄糖醛酸和/或葡糖醛酸内酯。

3. 发明授权

US5089401A Method for the preparation of fructose-containing oligosaccharide 失效
标题翻译：含有含葡萄糖的寡糖的制备方法
公开(公告)号：US5089401A
公开(公告)日：1992-02-18
申请号：US672388
申请日：1991-03-20
申请人： Koki Fujita , Kozo Hara , Hitoshi Hashimoto , Sumio Kitahata
发明人： Koki Fujita , Kozo Hara , Hitoshi Hashimoto , Sumio Kitahata
IPC分类号： C12P19/14 , C07H3/06 , C12N9/10 , C12N9/26 , C12P19/12 , C12P19/18 , C12P19/24 , C12R1/06
CPC分类号： C12N9/2408 , C12P19/12 , C12P19/24 , Y10S435/83
摘要： An enzymatic method for the preparation of a fructose-containing oligosaccharide, in which a .beta.-fructofuranosidase obtained by culturing Arthrobacter sp. K-1 (FERM BP-3192) as an enzyme is reacted on sucrose, raffinose or stachyose as the donor in the presence of an aldose or ketose as the receptor. The enzyme is characterized by:(1) activity on sucrose for the transglycosidation of a fructosyl group to the receptor in the presence of a monosaccharide, sugar alcohol, alkyl alcohol, glycoside or oligosaccharide;(2) activity for the decomposition of sucrose, elrose, neokestose, xylsucrose, raffinose and stachyose with inactivity on a saccharide selected from the group consisting of 1-kestose, nistose, inulobiose and levan biose;(3) optimum pH of 6.5 to 6.8 at 40.degree. C. with stability at a pH of 5.5 to 10;(4) optimum temperature of 55.degree. C. at a pH of 6.5 exhibiting at least 70% of residual activity at 60.degree. C.;(5) susceptibility to inhibition by the ions of silver, mercury, zinc, copper and tin;(6) two molecular weights of 52,000.+-.2,500 and 58,000.+-.2,500; and(7) two isoelectric points of pH 4.3 and pH 4.6.

4. 发明授权

US06284510B1 &bgr;-fructofuranosidase gene 有权
标题翻译： β-呋喃果糖苷酶基因
公开(公告)号：US06284510B1
公开(公告)日：2001-09-04
申请号：US09503172
申请日：2000-02-14
申请人： Tetsuya Ito , Koki Fujita , Kozo Hara , Takashi Tonozuka , Yoshiyuki Sakano
发明人： Tetsuya Ito , Koki Fujita , Kozo Hara , Takashi Tonozuka , Yoshiyuki Sakano
IPC分类号： C12P2106
CPC分类号： C12N9/2408 , C12N9/2431 , C12Y302/01026
摘要： A &bgr;-fructofuranosidase gene coding for a protein having an amino acid sequence described in Seq. I.D. No. 1 in the Sequence Listing. The gene enables production of &bgr;-fructofuranosidase on a large scale more easily and less dependently on the productivity of microorganisms than the production by cultivation of the microorganisms. Also, the &bgr;-fructofuranosidase gene is useful for the development of variant enzymes that have increased heat resistance and transfer ratio by means of genetic engineering techniques.
摘要翻译：编码具有Seq。所述的氨基酸序列的蛋白质的β-呋喃果糖苷酶基因。 ID。序列表第1号。该基因能够比通过微生物培养的生产更容易且更不依赖于微生物的生产力而大量生产β-呋喃果糖苷酶。此外，β-呋喃果糖苷酶基因可用于通过遗传工程技术开发具有增加的耐热性和转移比的变体酶。

5. 发明申请

US20080202503A1 Crystalline Lactosucrose or Syrup Containing Crystalline Lactosucrose and Use Thereof 审中-公开
标题翻译：结晶乳糖蔗糖或含有结晶乳糖蔗糖的糖浆及其用途
公开(公告)号：US20080202503A1
公开(公告)日：2008-08-28
申请号：US11572717
申请日：2005-06-06
申请人： Kazufumi Murakami , Tetsuya Ito , Koki Fujita , Kozo Hara , Yoshiyuki Sakano , Shigehiro Kamitori
发明人： Kazufumi Murakami , Tetsuya Ito , Koki Fujita , Kozo Hara , Yoshiyuki Sakano , Shigehiro Kamitori
IPC分类号： C13F1/02 , C13K5/00
CPC分类号： A23K50/60 , A23F5/243 , A23G1/40 , A23G3/42 , A23G4/10 , A23K20/163 , A23K50/30 , A23K50/75 , A23L5/00 , A23L7/00 , A23L23/00 , A23L27/33 , A23L29/30 , A23L33/125
摘要： The present invention establishes a crystalline lactosucrose and provides a process for producing the crystalline lactosucrose or a syrup containing crystalline lactosucrose. Further, the present invention has its object to provide a composition, for example, a food or drink, a cosmetic, a drug or the like containing the crystalline lactosucrose.That is, the present invention provides the crystalline lactosucrose or the syrup containing crystalline lactosucrose, the process for producing the crystalline lactosucrose or the syrup containing crystalline lactosucrose, characterized by crystallizing a crystalline lactosucrose from a solution containing lactosucrose and collecting the crystalline lactosucrose, and the use thereof.
摘要翻译：本发明建立了结晶乳糖蔗糖并提供了生产结晶乳糖蔗糖或含有结晶乳糖的糖浆的方法。此外，本发明的目的是提供一种组合物，例如含有结晶乳糖的食品或饮料，化妆品，药物等。也就是说，本发明提供结晶乳糖蔗糖或含有结晶乳糖蔗糖的糖浆，制备结晶乳糖蔗糖的方法或含有结晶乳糖蔗糖的糖浆，其特征在于，从含有乳糖蔗糖的溶液中结晶结晶乳糖并收集结晶乳糖，使用它。

6. 发明授权

US07491518B2 Method of elevating yield of oligosaccharides containing α-galactosyl and anti-candida compositions 失效
标题翻译：提高含有α-半乳糖基和抗念珠菌组合物的寡糖产率的方法
公开(公告)号：US07491518B2
公开(公告)日：2009-02-17
申请号：US10362483
申请日：2001-08-08
申请人： Masamichi Okada , Shigeharu Mori , Hiroyuki Hashimoto , Koki Fujita , Kozo Hara
发明人： Masamichi Okada , Shigeharu Mori , Hiroyuki Hashimoto , Koki Fujita , Kozo Hara
IPC分类号： C12P19/14 , C12P19/12 , C12P19/18
CPC分类号： C12N9/2465 , C12P19/14 , C12Y302/01022
摘要： A novel method of very efficiently elevating the yield of oligosacchrides containing α-galactosyl, compared with the conventional methods, which comprises treating galactose or a galactose-containing material with a specific α-galactosidase and thus performing a dehydrocondensation reaction at a high substrate concentration. Anti-candida compositions originating in foods, having a high safety and excellent anti-candida effect and not being restricted in the supply, which contain as the active ingredient oligosacchrides obtained by treating galactose or a galactose-containing material with an α-galactosidase and thus performing a dehydrocondensation.
摘要翻译：与常规方法相比，非常有效地提高含有α-半乳糖苷的寡糖的产率的新方法，其包括用特定的α-半乳糖苷酶处理半乳糖或含半乳糖的材料，从而以高底物浓度进行脱氢反应。起始于食物的抗念珠菌组合物，具有高安全性和优异的抗念珠菌作用，不受供体限制，其含有通过用α-半乳糖苷酶处理半乳糖或含半乳糖的物质获得的活性成分的寡糖，因此进行脱氢。

7. 发明申请

US20060234980A1 Antiinflammatory agent, agent for preventing/ameliorating allergic diseases and functional food 审中-公开
标题翻译：抗炎剂，预防/改善过敏性疾病和功能性食物的药剂
公开(公告)号：US20060234980A1
公开(公告)日：2006-10-19
申请号：US10516234
申请日：2003-05-29
申请人： Hiroyuki Hashimoto , Kei Sonoyama , Koki Fujita , Kozo Hara , Masamichi Okada , Shigeharu Mori
发明人： Hiroyuki Hashimoto , Kei Sonoyama , Koki Fujita , Kozo Hara , Masamichi Okada , Shigeharu Mori
IPC分类号： A61K31/716 , A61K31/715 , A61K47/00
CPC分类号： C07H3/06 , A23L33/10 , A61K31/702 , A61K31/715
摘要： It is intended to provide an anti-inflammatory agent made from a highly safe material which can be daily taken as a food, an agent for preventing or ameliorating allergic diseases and a functional food having the above-mentioned effects. The anti-inflammatory agent contains an α-bond galactooligosaccharide as the active ingredient. The agent for preventing or ameliorating allergic diseases contains an α-bond galactooligosaccharide as the active ingredient. The functional food contains an α-bond galactooligosaccharide as the active ingredient. As such α-bond galactooligosaccharide, use can be made of a product synthesized by the dehydration condensation reaction by α-galactosidase with the use of galactose or galactose-containing substance as a substrate.
摘要翻译：本发明提供一种由日常服用的高度安全的材料制成的抗炎剂，用于预防或改善过敏性疾病的药剂和具有上述效果的功能性食品。抗炎剂含有α-键低聚半乳糖作为活性成分。用于预防或改善过敏性疾病的药物含有α-键低聚半乳糖作为活性成分。功能性食品含有α-键低聚半乳糖作为活性成分。作为这样的α-键低聚半乳糖，可以使用通过使用半乳糖或含半乳糖的物质作为底物的α-半乳糖苷酶通过脱水缩合反应合成的产物。

8. 发明授权

US5738448A Ribbon cassette for printer 失效
标题翻译：打印机色带盒
公开(公告)号：US5738448A
公开(公告)日：1998-04-14
申请号：US652415
申请日：1996-05-23
申请人： Kozo Hara , Hajime Yamamoto
发明人： Kozo Hara , Hajime Yamamoto
IPC分类号： B41J33/14 , F16D1/06 , F16D9/00
CPC分类号： B41J33/14 , F16D1/06 , F16D9/00 , F16D2001/062
摘要： Disclosed herein is a ribbon cassette for use with a printer, including a cassette case detachably mounted in the printer and an ink ribbon stored in the cassette case and partially exposed to face a print head provided in the printer. The ribbon cassette further includes a ribbon take-up member rotatably supported in the cassette case, a driven member rotatably supported in the cassette case and meshing with the ribbon take-up member through the ink ribbon, and a power transmitting member provided in the ribbon take-up member to connect the ribbon take-up member to a ribbon driving shaft provided in the printer. A breaking strength of the power transmitting member against a load from the ink ribbon is set smaller than that of the ribbon driving shaft. Accordingly, in the event that ribbon jam occurs, the power transmitting member breaks to thereby prevent fracture of the ribbon driving shaft in the printer.
摘要翻译：本文公开了一种用于打印机的色带盒，包括可拆卸地安装在打印机中的盒壳体和存储在盒壳体中并部分地暴露于面对设置在打印机中的打印头的色带。色带盒还包括可旋转地支撑在盒壳体中的色带卷取构件，可旋转地支撑在盒壳体中并通过色带与色带卷取构件啮合的从动构件，以及设置在色带中的动力传递构件卷取构件将色带卷绕构件连接到设置在打印机中的色带驱动轴。动力传递部件相对于来自墨带的负载的断裂强度被设定为小于色带驱动轴的断裂强度。因此，在发生带状卡纸的情况下，动力传递部件断裂，从而防止打印机中的色带驱动轴断裂。

9. 发明授权

US5302036A Multi-color ribbon cassette position adjusting apparatus 失效
标题翻译：多色色带盒位置调节装置
公开(公告)号：US5302036A
公开(公告)日：1994-04-12
申请号：US930849
申请日：1992-08-14
申请人： Masahiro Akiyama , Hidekazu Ishii , Kozo Hara
发明人： Masahiro Akiyama , Hidekazu Ishii , Kozo Hara
IPC分类号： B41J32/00 , B41J35/22 , B41J33/14
CPC分类号： B41J35/22 , B41J32/00
摘要： A multi-color ribbon cassette position adjusting apparatus comprises a carrier having a print head, a cassette mounting member rockably supported on the carrier, and a fine adjustment mechanism attached to the cassette mounting member, for finely rocking the mounting member. The fine adjustment mechanism includes a guide member fixed to the cassette mounting member, a follower piece guided by the guide member to engage a helical cam for shifting the position of the cassette mounting member, and a position adjusting member for relatively moving the guide member and the follower piece.
摘要翻译：多色带盒位置调整装置包括具有打印头的托架，可滑动地支撑在托架上的盒安装构件以及安装在盒安装构件上的精细调节机构，用于使安装构件微调。微调机构包括固定在盒安装部件上的引导部件，由引导部件引导的从动部件与用于移动盒安装部件的位置的螺旋凸轮接合;以及位置调节部件，用于相对移动引导部件，随从片。

10. 发明授权

US06306893B1 Taxoid derivatives and process for producing the same 有权
标题翻译：紫杉烷衍生物及其生产方法
公开(公告)号：US06306893B1
公开(公告)日：2001-10-23
申请号：US09529208
申请日：2000-04-07
申请人： Tadakatsu Mandai , Hiroshi Okumoto , Koji Hara , Katsuhiko Mikuni , Kozo Hara , Yoshinori Tsuchiya , Kosho Nakamura , Teruhiko Umetsu
发明人： Tadakatsu Mandai , Hiroshi Okumoto , Koji Hara , Katsuhiko Mikuni , Kozo Hara , Yoshinori Tsuchiya , Kosho Nakamura , Teruhiko Umetsu
IPC分类号： A61K3335
CPC分类号： C07H15/04 , C07H15/26
摘要： An object of the invention is to develop galactose or mannose derivatives of docetaxel, etc. having improved solubility and physiological activity, to alleviate burden imposed on patients and to provide effective therapeutic drug for tumors. The present invention provides taxoid derivatives comprising any of paclitaxel, docetaxel and 10-deacetyl-baccatin III to which galactose or mannose is linked through a spacer, and methods for producing taxoid derivatives comprising reacting paclitaxel, docetaxel or 10-deacetyl-baccatin III with tetrabenzyl acetyloxygalactoside or tetrabenzyl acetyloxymannoside, subjecting the product to debenzylation reaction, and optionally to detriethylsilylation reaction.
摘要翻译：本发明的目的是开发具有改善的溶解性和生理活性的多西紫杉醇等的半乳糖或甘露糖衍生物，以减轻施加于患者的负担并为肿瘤提供有效的治疗药物。本发明提供了包含紫杉醇，多西紫杉醇和通过间隔基连接的10-脱乙酰基 - 浆果赤霉素III，以及用于制备紫杉醇，多西紫杉醇或10-脱乙酰基浆果赤霉素III与四苄基乙酰氧基半乳糖苷或四苄基乙酰氧基甘露糖苷的方法，所述方法包括使产物脱苄基反应，并任选地进行脱乙烯基硅烷化反应。

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