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1. 发明授权

US07915306B2 Macrocyclic compounds useful as pharmaceuticals 有权
标题翻译：用作药物的大环化合物
公开(公告)号：US07915306B2
公开(公告)日：2011-03-29
申请号：US10657910
申请日：2003-09-09
申请人： Kenichi Chiba , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Ray Wood , Satoshi Yamamoto , Naoki Yoneda
发明人： Kenichi Chiba , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Ray Wood , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： A61K31/335
CPC分类号： C07D493/04 , C07D313/00
摘要： The present invention provides compositions comprising compounds having formula (I): and additionally provides methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein. In certain embodiments, the compositions are for systemic (e.g., oral) administration. In certain embodiments, methods for the treatment of various disorders including inflammatory or autoimmune disorders comprise systemically (e.g., orally) administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I).
摘要翻译：本发明提供了包含具有式（I）的化合物的组合物：另外提供了其用于治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，X，Y， Z和n如本文所定义。在某些实施方案中，组合物用于全身（例如口服）给药。在某些实施方案中，用于治疗各种疾病（包括炎性或自身免疫性疾病）的方法包括全身（例如，口服）向有需要的受试者施用治疗有效量的式（I）化合物。

2. 发明授权

US07799827B2 Macrocyclic compounds useful as pharmaceuticals 有权
标题翻译：用作药物的大环化合物
公开(公告)号：US07799827B2
公开(公告)日：2010-09-21
申请号：US10507067
申请日：2003-03-07
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： A61K31/335 , C07D313/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.
摘要翻译：本发明提供了具有式（I）的化合物：另外提供了其合成方法及其用于治疗各种疾病（包括炎性或自身免疫性疾病以及涉及恶性肿瘤或增加血管发生的疾病）的方法，其中R1-R11， X，Y，Z和n如本文所定义。

3. 发明授权

US08329742B2 Macrocyclic compounds useful as pharmaceuticals 有权
标题翻译：用作药物的大环化合物
公开(公告)号：US08329742B2
公开(公告)日：2012-12-11
申请号：US12839873
申请日：2010-07-20
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： A61K31/355 , C07D313/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
摘要翻译：本发明提供了使用具有式（I）的化合物在治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，t，X，Y，Z和n 如本文所定义。

4. 发明申请

US20110144101A1 MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS 有权
标题翻译：大环化合物作为药物有用
公开(公告)号：US20110144101A1
公开(公告)日：2011-06-16
申请号：US12839873
申请日：2010-07-20
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： A61K31/5377 , A61K31/335 , A61K31/4184 , A61P29/00 , A61P37/00 , A61P17/06 , A61P11/06 , A61P35/00 , A61P1/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
摘要翻译：本发明提供了使用具有式（I）的化合物在治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，t，X，Y，Z和n 如本文所定义。

5. 发明申请

US20130196987A1 MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS 审中-公开
标题翻译：大环化合物作为药物有用
公开(公告)号：US20130196987A1
公开(公告)日：2013-08-01
申请号：US13663857
申请日：2012-10-30
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： C07D405/12 , C07D491/044 , C07D313/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds, methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis.
摘要翻译：本发明提供了化合物，其合成方法及其用于治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管生成的疾病的方法。

6. 发明申请

US20060247448A1 Macrocyclic compounds useful as pharmaceuticals 有权
标题翻译：用作药物的大环化合物
公开(公告)号：US20060247448A1
公开(公告)日：2006-11-02
申请号：US10507067
申请日：2003-03-07
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmanage , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmanage , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： C07D313/08
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.
摘要翻译：本发明提供具有式（I）的化合物：另外提供其合成方法及其用于治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R 1，R 11，X，Y，Z和n如本文所定义。

7. 发明授权

US09394836B2 Internal combustion engine control apparatus 有权
标题翻译：内燃机控制装置
公开(公告)号：US09394836B2
公开(公告)日：2016-07-19
申请号：US13611219
申请日：2012-09-12
申请人： Toshikatsu Saito , Takahiko Ono , Keitaro Ezumi , Tomokuni Kusunoki , Atsushi Inoue , Hiroki Morimoto
发明人： Toshikatsu Saito , Takahiko Ono , Keitaro Ezumi , Tomokuni Kusunoki , Atsushi Inoue , Hiroki Morimoto
IPC分类号： F02D35/02 , F02D41/22 , G01L23/22 , F02P5/152 , F02D41/00 , F02D41/28
CPC分类号： F02D35/027 , F02D41/0002 , F02D41/222 , F02D2041/288 , F02P5/152 , G01L23/227 , Y02T10/40
摘要： An internal combustion engine control apparatus includes a pseudo knock determination unit that determines whether or not a pseudo knock has been produced in a knock detection window, based on at least one of the frequency, a status amount indicating a rotation speed of the internal combustion engine, a status amount indicating a load of the internal combustion engine, and a status amount indicating an air-fuel ratio of the internal combustion engine; and a moving-average processing unit that sets a second period to a period that is approximately the same as a first period, in the case where it has been determined that the pseudo knock was not produced, and that does not implement moving-averaging or sets the second period to a period that is narrower than the first period, in the case where it has been determined that a pseudo knock was produced.
摘要翻译：内燃机控制装置包括：伪爆震判定单元，其基于频率，指示内燃机的转速的状态量中的至少一个，判定在爆震检测窗口中是否已经产生伪敲击，表示内燃机的负荷的状态量和表示内燃机的空燃比的状态量; 以及移动平均处理单元，其在已经确定没有产生伪敲击的情况下将第二周期设置为与第一周期大致相同的周期，并且不实现移动平均或将第二期间设定为比第一期间窄的期间，在判断为产生伪敲击的情况下。

8. 发明申请

US20150005068A1 GAME MACHINE, AND, CONTROL METHOD OF CONTROLLING COMPUTER AND COMPUTER PROGRAM USED THEREIN 有权
标题翻译：游戏机和控制计算机控制方法及其使用的计算机程序
公开(公告)号：US20150005068A1
公开(公告)日：2015-01-01
申请号：US14376806
申请日：2012-02-08
申请人： Atsushi Inoue , Masato Okuaki , Tomoaki Hirai
发明人： Atsushi Inoue , Masato Okuaki , Tomoaki Hirai
IPC分类号： A63F13/52
CPC分类号： A63F13/52 , G07F17/3211
摘要： A game machine uses a center unit that utilizes a physical operation of a ball to select at least one pocket by a drawing, and includes: cameras that are placed to be able to take images of the pockets; a center monitor that can display a video picture taken by the camera; and, sensors that detects the pocket decided by the drawing. And, the game machine specifies a predetermined video picture range from the video picture taken by the cameras, based on a detection result of the sensors, so as to include the video picture of the selected pocket at a time when the selected pocket is selected, and, displays a predetermined video picture on the center monitor based on the video picture in the predetermined video picture range specified.
摘要翻译：游戏机使用利用球的物理操作的中心单元通过绘图来选择至少一个口袋，并且包括：放置成能够拍摄口袋图像的照相机; 可以显示摄像机拍摄的视频图像的中央监视器; 以及检测由图纸决定的口袋的传感器。并且，游戏机基于传感器的检测结果，根据摄像机所拍摄的视频图像来指定预定的视频图像范围，以便在所选择的口袋被选择时包括所选择的口袋的视频图像，并且基于指定的预定视频图像范围中的视频图像在中心监视器上显示预定的视频图像。

9. 发明授权

US08924135B2 Internal combustion engine control apparatus 有权
标题翻译：内燃机控制装置
公开(公告)号：US08924135B2
公开(公告)日：2014-12-30
申请号：US13612179
申请日：2012-09-12
申请人： Takahiko Ono , Yuhei Matsushima , Keitaro Ezumi , Tomokuni Kusunoki , Atsushi Inoue , Hiroki Morimoto
发明人： Takahiko Ono , Yuhei Matsushima , Keitaro Ezumi , Tomokuni Kusunoki , Atsushi Inoue , Hiroki Morimoto
IPC分类号： G06F19/00
CPC分类号： F02P5/152 , F02D41/222 , F02D2041/1432 , F02P5/1523 , Y02T10/46
摘要： There are provided a combustion start determination unit that determines whether or not the inner-cylinder state of an internal combustion engine has changed from a non-combustion state to a combustion state; and a filter coefficient changing demand unit that outputs a filter coefficient changing demand until a predetermined filter coefficient changing period elapses from the time instant when the combustion start determination unit determines that the inner-cylinder state of the internal combustion engine has changed from the non-combustion state to the combustion state to the time instant. Based on the filter coefficient changing demand, at least one of a background level calculation unit and a standard deviation calculation unit changes the value of a filter coefficient utilized in a filtering operation to the one with which a filtering effect is weakened.
摘要翻译：提供了一种燃烧开始确定单元，其确定内燃机的内缸状态是否已经从非燃烧状态变为燃烧状态; 以及滤波器系数变更要求单元，其从燃烧开始判定单元判断出内燃机的内侧气缸状态从非燃烧状态发生变化的时刻到期间经过了规定的过滤器系数变更期间，燃烧状态到燃烧状态到时刻。基于滤波器系数变化要求，背景等级计算单元和标准差计算单元中的至少一个将滤波操作中使用的滤波器系数的值改变为滤波效果弱化的滤波器系数的值。

10. 发明授权

US08924134B2 Knock control device of internal combustion engine 有权
标题翻译：内燃机爆震控制装置
公开(公告)号：US08924134B2
公开(公告)日：2014-12-30
申请号：US13611743
申请日：2012-09-12
申请人： Toru Tanaka , Yuhei Matsushima , Keitaro Ezumi , Tomokuni Kusunoki , Atsushi Inoue , Hiroki Morimoto
发明人： Toru Tanaka , Yuhei Matsushima , Keitaro Ezumi , Tomokuni Kusunoki , Atsushi Inoue , Hiroki Morimoto
IPC分类号： G06F19/00
CPC分类号： G01L23/225 , F02D35/027 , F02D2041/286 , F02P5/152
摘要： In a knock control device of an internal combustion engine equipped with a control unit which updates a background level based on an output signal from a knock sensor and detects the generation of a knock by comparing a variation of the background level with a knock determination value, a determination as to whether the knock is generated is performed by ((variation of first filter value of peak hold value)>((1−filter coefficient)/(1+filter coefficient)×(predetermined value larger than maximum value of variation of peak hold value in case where knock is not generated))).
摘要翻译：在配备有基于来自爆震传感器的输出信号更新背景等级的控制单元的内燃机的爆震控制装置中，通过将背景等级的变化与爆震判定值进行比较来检测爆震的产生，通过（（峰值保持值的第一滤波器值的变化）>（（1滤波器系数）/（1 +滤波器系数）×（大于最大值的变化的最大值的预定值）来进行关于是否产生爆震的判定在不产生爆震的情况下的峰值保持值）））。

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