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1. 发明授权

US08389248B2 Deoxyketohexose isomerase and method for producing deoxyhexose and derivative thereof using same 有权
标题翻译：脱氧己糖异构酶及使用其脱氧己糖及其衍生物的方法
公开(公告)号：US08389248B2
公开(公告)日：2013-03-05
申请号：US12515605
申请日：2007-11-20
申请人： Ken Izumori , Masaaki Tokuda , George Fleet , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
发明人： Ken Izumori , Masaaki Tokuda , George Fleet , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
IPC分类号： C12P19/24 , C12N9/90
CPC分类号： C07H3/02 , C12N9/92 , C12P19/24
摘要： Providing 1- or 6-deoxy products corresponding to all of aldohexoses, ketohexoses and sugar alcohols, as based on Deoxy-Izumoring, as well as a method for systematically producing those products. A method for producing deoxyketohexose and a derivative thereof using a deoxyketohexose isomerase derived from Pseudomonas cichorii ST-24 (FERM BP-2736), comprising epimerizing 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose at position 3 to produce the individually corresponding 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose as an intended product.
摘要翻译：提供对应于所有醛脱水己酮糖，酮己立糖和糖醇的1-脱氧产物或6-脱氧产物，以脱氧消肿为基础，以及一种系统地生产这些产品的方法。使用衍生自奇异假单胞菌ST-24（FERM BP-2736）的脱氧己糖异构酶生产脱氧己糖及其衍生物的方法，其包括将1-脱氧D-酮己糖或6-脱氧D-酮己糖或1-脱氧L-酮己糖或 6-脱氧L-酮基己糖，以产生单独相应的1-脱氧D-酮己糖或6-脱氧D-酮己糖或1-脱氧L-酮己糖或6-脱氧L-酮己糖作为目标产物。

2. 发明申请

US20100105885A1 DEOXYKETOHEXOSE ISOMERASE AND METHOD FOR PRODUCING DEOXYHEXOSE AND DERIVATIVE THEREOF USING SAME 有权
标题翻译：脱乙酰壳多糖异构体及其制造方法及其衍生物
公开(公告)号：US20100105885A1
公开(公告)日：2010-04-29
申请号：US12515605
申请日：2007-11-20
申请人： Ken Izumori , Masaaki Tokuda , George Fleet , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
发明人： Ken Izumori , Masaaki Tokuda , George Fleet , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
IPC分类号： C07H3/02 , C12N9/90 , C12P19/24
CPC分类号： C07H3/02 , C12N9/92 , C12P19/24
摘要： Providing 1- or 6-deoxy products corresponding to all of aldohexoses, ketohexoses and sugar alcohols, as based on Deoxy-Izumoring, as well as a method for systematically producing those products. A method for producing deoxyketohexose and a derivative thereof using a deoxyketohexose isomerase derived from Pseudomonas cichorii ST-24 (FERM BP-2736), comprising epimerizing 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose at position 3 to produce the individually corresponding 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose as an intended product.
摘要翻译：提供对应于所有醛脱水己酮糖，酮己立糖和糖醇的1-脱氧产物或6-脱氧产物，以脱氧消肿为基础，以及一种系统地生产这些产品的方法。使用衍生自奇异假单胞菌ST-24（FERM BP-2736）的脱氧己糖异构酶生产脱氧己糖及其衍生物的方法，其包括将1-脱氧D-酮己糖或6-脱氧D-酮己糖或1-脱氧L-酮己糖或 6-脱氧L-酮基己糖，以产生单独相应的1-脱氧D-酮己糖或6-脱氧D-酮己糖或1-脱氧L-酮己糖或6-脱氧L-酮己糖作为目标产物。

3. 发明申请

US20090325231A1 THERMOSTABLE L-RIBOSE ISOMERASE AND METHOD FOR PRODUCING SAME AND USE OF SAME 有权
标题翻译：可热裂解的L-赖氨酸异构体及其生产方法及其用途
公开(公告)号：US20090325231A1
公开(公告)日：2009-12-31
申请号：US12515596
申请日：2007-03-26
申请人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
发明人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
IPC分类号： C12P21/00 , C12N9/90 , C12N1/21 , C12P19/24
CPC分类号： C12N9/90 , C12P19/24 , C12R1/01
摘要： Object: To provide a thermostable L-ribose isomerase.Means for Resolution: The thermostable L-ribose isomerase with MW. 32,000 (by SDS-PAGE), optimal temperature of 45° C., optimal pH of pH 9.0 (glycine-NaOH buffer), and stable physicochemical properties such as temperature stability up to 45° C. during thermal treatment at pH 9.0 for 10 minutes, and with an action to isomerize L-ribose to generate L-ribulose or of inversely to isomerize L-ribulose to generate L-ribose. A conversion method between an aldose and a ketose comprising allowing the thermostable L-ribose isomerase as an enzyme derived from (1) Raoultella ornithinolytica strain MB426 (NITE BP-277) to interact with an aldose selected from L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose to isomerize the aldose to generate a ketose selected from the individually corresponding L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose or to interact with a ketose selected from L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose to isomerize the ketose to generate an aldose selected from the individually corresponding L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose.
摘要翻译：目的：提供热稳定的L-核糖异构酶。解决方法：具有MW的热稳定的L-核糖异构酶。 32,000（通过SDS-PAGE），最适温度为45℃，pH 9.0的最佳pH（甘氨酸 - NaOH缓冲液），以及稳定的物理化学性质，例如在pH 9.0的热处理期间温度稳定性高达45℃，为10 分钟，并且具有异构化L-核糖以产生L-核酮糖的作用或者与L-核酮糖异构化以产生L-核糖的作用。醛糖和酮糖之间的转化方法，包括使热稳定的L-核糖异构酶作为源自（1）鸟氨酸解脂耶氏杆菌菌株MB426（NITE BP-277）的酶与选自L-核糖，D-赖索糖， D-山梨糖醇，D-甘露糖，L-丙氨酸和L-古洛糖醇以使醛糖异构化以产生选自单独对应的L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵芝蛋白和L- 山梨糖或与选自L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵敏糖和L-山梨糖的酮糖相互作用以使酮糖异构化以产生选自相应的L-核糖，D D-果糖，D-甘露糖，D-甘露糖，L-阿洛糖和L-古洛糖。

4. 发明授权

US08530222B2 Microorganism with ability to produce deoxy polyol dehydrogenase and use thereof 有权
标题翻译：具有生产脱氧多元醇脱氢酶能力的微生物及其用途
公开(公告)号：US08530222B2
公开(公告)日：2013-09-10
申请号：US12515602
申请日：2007-03-27
申请人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
发明人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
IPC分类号： C12N1/20
CPC分类号： C12R1/01 , A61K8/60 , A61K2800/86 , A61Q19/00 , C12N9/0006 , C12P19/02
摘要： Problem: To provide a microorganism with an ability to produce deoxy polyol dehydrogenase.Means for Resolution: A microorganism belonging to genus Enterobacter with an ability to produce a dehydrogenase for deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol. The bacterial cell IK7 of the genus Enterobacter (accession No. NITE P-271). A method for producing deoxy ketose comprising allowing a culture containing the deoxy polyol dehydrogenase obtained by the culturing of the microorganism of the invention or allowing the deoxy polyol dehydrogenase to react with a solution containing deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol to oxidize deoxy polyol to produce the corresponding deoxy ketose and then collecting the deoxy ketose. The deoxy polyol is 1-deoxy-D-allitol, while the corresponding deoxy ketose is 1-deoxy-L-psicose. Otherwise, the deoxy polyol is L-rhamnitol, while the corresponding deoxy ketose is 1-deoxy-L-fructose.
摘要翻译：问题：提供具有生产脱氧多元醇脱氢酶能力的微生物。解决方法：属于肠杆菌属的微生物，其在位置C2和C3处产生与核糖醇或L-阿托糖醇相同结构的脱氧多羟基化脱氢酶的能力。肠杆菌属细菌细胞IK7（登录号NITE P-271）。一种生产脱氧酮糖酮的方法，包括使含有通过培养本发明的微生物获得的脱氧多元醇脱氢酶的培养物或使脱氧多元醇脱氢酶与位置C2和C3处于相同结构的含有脱氧多羟基化合物的溶液反应，作为核糖醇或L-天冬氨酸氧化脱氧多元醇以产生相应的脱氧酮糖，然后收集脱氧酮糖酮。脱氧多元醇是1-脱氧-D-多糖，而相应的脱氧酮基是1-脱氧-L-精氨酸。否则，脱氧多元醇为L-麦芽糖醇，而相应的脱氧酮糖为1-脱氧-L-果糖。

5. 发明授权

US08227232B2 Thermostable L-ribose isomerase and method for producing same and use of same 有权
标题翻译：热稳定性L-核糖异构酶及其制备方法及用途
公开(公告)号：US08227232B2
公开(公告)日：2012-07-24
申请号：US12515596
申请日：2007-03-26
申请人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
发明人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
IPC分类号： C12N9/90 , C12N1/00 , C12P19/24 , C07H1/00 , C07H1/06
CPC分类号： C12N9/90 , C12P19/24 , C12R1/01
摘要： Object: To provide a thermostable L-ribose isomerase.Means for Resolution: The thermostable L-ribose isomerase with MW. 32,000 (by SDS-PAGE), optimal temperature of 45° C., optimal pH of pH 9.0 (glycine-NaOH buffer), and stable physicochemical properties such as temperature stability up to 45° C. during thermal treatment at pH 9.0 for 10 minutes, and with an action to isomerize L-ribose to generate L-ribulose or of inversely to isomerize L-ribulose to generate L-ribose. A conversion method between an aldose and a ketose comprising allowing the thermostable L-ribose isomerase as an enzyme derived from (1) Raoultella ornithinolytica strain MB426 (NITE BP-277) to interact with an aldose selected from L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose to isomerize the aldose to generate a ketose selected from the individually corresponding L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose or to interact with a ketose selected from L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose to isomerize the ketose to generate an aldose selected from the individually corresponding L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose.
摘要翻译：目的：提供热稳定的L-核糖异构酶。解决方法：具有MW的热稳定性L-核糖异构酶。 32,000（通过SDS-PAGE），最适温度为45℃，pH 9.0的最佳pH（甘氨酸 - NaOH缓冲液），以及稳定的物理化学性质，例如在pH 9.0的热处理期间温度稳定性高达45℃，为10 分钟，并且具有异构化L-核糖以产生L-核酮糖的作用或者与L-核酮糖异构化以产生L-核糖的作用。醛糖和酮糖之间的转化方法，包括使热稳定的L-核糖异构酶作为源自（1）鸟氨酸解脂耶氏杆菌菌株MB426（NITE BP-277）的酶与选自L-核糖，D-赖索糖， D-山梨糖醇，D-甘露糖，L-丙氨酸和L-古洛糖醇以使醛糖异构化以产生选自单独对应的L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵芝蛋白和L- 山梨糖或与选自L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵敏糖和L-山梨糖的酮糖相互作用以使酮糖异构化以产生选自相应的L-核糖，D D-果糖，D-甘露糖，D-甘露糖，L-阿洛糖和L-古洛糖。

6. 发明申请

US20100167350A1 MICROORGANISM WITH ABILITY TO PRODUCE DEOXY POLYOL DEHYDROGENASE AND USE THEREOF 有权
标题翻译：具有生产脱氧多糖脱氢酶能力的微生物及其用途
公开(公告)号：US20100167350A1
公开(公告)日：2010-07-01
申请号：US12515602
申请日：2007-03-27
申请人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
发明人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
IPC分类号： C12P19/00 , C07H3/08 , C12N1/20
CPC分类号： C12R1/01 , A61K8/60 , A61K2800/86 , A61Q19/00 , C12N9/0006 , C12P19/02
摘要： Problem: To provide a microorganism with an ability to produce deoxy polyol dehydrogenase.Means for Resolution: A microorganism belonging to genus Enterobacter with an ability to produce a dehydrogenase for deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol. The bacterial cell IK7 of the genus Enterobacter (accession No. NITE P-271). A method for producing deoxy ketose comprising allowing a culture containing the deoxy polyol dehydrogenase obtained by the culturing of the microorganism of the invention or allowing the deoxy polyol dehydrogenase to react with a solution containing deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol to oxidize deoxy polyol to produce the corresponding deoxy ketose and then collecting the deoxy ketose. The deoxy polyol is 1-deoxy-D-allitol, while the corresponding deoxy ketose is 1-deoxy-L-psicose. Otherwise, the deoxy polyol is L-rhamnitol, while the corresponding deoxy ketose is 1-deoxy-L-fructose.
摘要翻译：问题：提供具有生产脱氧多元醇脱氢酶能力的微生物。解决方法：属于肠杆菌属的微生物，其在位置C2和C3处产生与核糖醇或L-阿托糖醇相同结构的脱氧多羟基化脱氢酶的能力。肠杆菌属细菌细胞IK7（登录号NITE P-271）。一种生产脱氧酮糖酮的方法，包括使含有通过培养本发明的微生物获得的脱氧多元醇脱氢酶的培养物或使脱氧多元醇脱氢酶与位置C2和C3处于相同结构的含有脱氧多羟基化合物的溶液反应，作为核糖醇或L-天冬氨酸氧化脱氧多元醇以产生相应的脱氧酮糖，然后收集脱氧酮糖酮。脱氧多元醇是1-脱氧-D-多糖，而相应的脱氧酮基是1-脱氧-L-精氨酸。否则，脱氧多元醇为L-麦芽糖醇，而相应的脱氧酮糖为1-脱氧-L-果糖。

7. 发明授权

US08420606B2 Method of utilizing physiological activity of rare saccharide and composition containing rare saccharide 有权
标题翻译：利用稀有糖类生物活性的方法和含有稀有糖类的组合物
公开(公告)号：US08420606B2
公开(公告)日：2013-04-16
申请号：US13007058
申请日：2011-01-14
申请人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad A. Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
发明人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad A. Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
IPC分类号： A61K31/7004 , A61K31/70
CPC分类号： A61Q19/00 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A61K8/60 , A61K31/7004
摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.
摘要翻译：利用稀有糖类的生理活性的方法，其中用稀有糖类处理生理活性敏感性细胞以改变细胞的功能。作为活性成分含有引入生理活性敏感性细胞的稀有糖类并具有改变细胞功能的作用的组合物。细胞是人细胞。组合物是功能性食品，药物或化妆品。罕见的糖是属于醛糖和/或酮糖的稀有糖。醛糖是D-丙氨酸，细胞选自癌细胞增殖抑制活性敏感细胞和活性氧生成抑制活性敏感细胞。酮糖是D-psicose，细胞选自趋化因子分泌抑制活性敏感细胞，小胶质细胞迁移抑制活性敏感细胞和低血糖活性敏感细胞。

8. 发明申请

US20110112043A1 METHOD OF UTILIZING PHYSIOLOGICAL ACTIVITY OF RARE SACCHARIDE AND COMPOSITION CONTAINING RARE SACCHARIDE 有权
标题翻译：利用稀有酸的生理活性和含有稀土的组合物的方法
公开(公告)号：US20110112043A1
公开(公告)日：2011-05-12
申请号：US13007058
申请日：2011-01-14
申请人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad Akram Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
发明人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad Akram Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
IPC分类号： A61K31/7004 , A61P35/04 , A61P25/00
CPC分类号： A61Q19/00 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A61K8/60 , A61K31/7004
摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.
摘要翻译：利用稀有糖类的生理活性的方法，其中用稀有糖类处理生理活性敏感性细胞以改变细胞的功能。作为活性成分含有引入生理活性敏感性细胞的稀有糖类并具有改变细胞功能的作用的组合物。细胞是人细胞。组合物是功能性食品，药物或化妆品。罕见的糖是属于醛糖和/或酮糖的稀有糖。醛糖是D-丙氨酸，细胞选自癌细胞增殖抑制活性敏感细胞和活性氧生成抑制活性敏感细胞。酮糖是D-psicose，细胞选自趋化因子分泌抑制活性敏感细胞，小胶质细胞迁移抑制活性敏感细胞和低血糖活性敏感细胞。

9. 发明授权

US07906487B2 Method of utilizing physiological activity of rare saccharide and composition containing rare saccharide 有权
标题翻译：利用稀有糖类生物活性的方法和含有稀有糖类的组合物
公开(公告)号：US07906487B2
公开(公告)日：2011-03-15
申请号：US10515018
申请日：2003-05-22
申请人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad Akram Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
发明人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad Akram Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
IPC分类号： A61K31/70004 , A61K31/70
CPC分类号： A61Q19/00 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A61K8/60 , A61K31/7004
摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.
摘要翻译：利用稀有糖类的生理活性的方法，其中用稀有糖类处理生理活性敏感性细胞以改变细胞的功能。作为活性成分含有引入生理活性敏感性细胞的稀有糖类并具有改变细胞功能的作用的组合物。细胞是人细胞。组合物是功能性食品，药物或化妆品。罕见的糖是属于醛糖和/或酮糖的稀有糖。醛糖是D-丙氨酸，细胞选自癌细胞增殖抑制活性敏感细胞和活性氧生成抑制活性敏感细胞。酮糖是D-psicose，细胞选自趋化因子分泌抑制活性敏感细胞，小胶质细胞迁移抑制活性敏感细胞和低血糖活性敏感细胞。

10. 发明申请

US20050245459A1 Method of utilizing physiological activity of rare saccharide and composition containing rare saccharide 有权
标题翻译：利用稀有糖类生物活性的方法和含有稀有糖类的组合物
公开(公告)号：US20050245459A1
公开(公告)日：2005-11-03
申请号：US10515018
申请日：2003-05-22
申请人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
发明人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
IPC分类号： A23L1/09 , A23L1/30 , A61K8/60 , A61K31/7004 , A61Q19/00 , C12N5/08 , A61K31/70 , A61K31/715
CPC分类号： A61Q19/00 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A61K8/60 , A61K31/7004
摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.
摘要翻译：利用稀有糖类的生理活性的方法，其中用稀有糖类处理生理活性敏感性细胞以改变细胞的功能。作为活性成分含有引入生理活性敏感性细胞的稀有糖类并具有改变细胞功能的作用的组合物。细胞是人细胞。组合物是功能性食品，药物或化妆品。罕见的糖是属于醛糖和/或酮糖的稀有糖。醛糖是D-丙氨酸，细胞选自癌细胞增殖抑制活性敏感细胞和活性氧生成抑制活性敏感细胞。酮糖是D-psicose，细胞选自趋化因子分泌抑制活性敏感细胞，小胶质细胞迁移抑制活性敏感细胞和低血糖活性敏感细胞。

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