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1. 发明授权

US4327072A Tyrosylated proinsulin C-peptide derivatives 失效
标题翻译：酪氨酸化胰岛素原C肽衍生物
公开(公告)号：US4327072A
公开(公告)日：1982-04-27
申请号：US97671
申请日：1979-11-27
申请人： Ken Inouye , Masao Kono , Nobuo Yoshida , Masuhisa Nakamura , Tadashi Okabayashi , Ken'ichi Igano
发明人： Ken Inouye , Masao Kono , Nobuo Yoshida , Masuhisa Nakamura , Tadashi Okabayashi , Ken'ichi Igano
IPC分类号： G01N33/53 , C07C67/00 , C07C231/00 , C07K14/00 , C07K14/62 , G01N33/534 , G01N33/74 , G01N33/56 , A61K43/00 , C07C103/52
CPC分类号： C07K14/62 , G01N33/534 , G01N33/74 , G01N2333/62 , Y02P20/55
摘要： The disclosed peptide derivative of the formula:Y--Tyr--Gly--RWherein, Y represents a hydrogen atom or an amino protecting group, Tyr represents a tyrosine residue wherein at least one of the hydrogen atoms on the phenyl ring may be substituted by a radioactive iodine, Gly represents a glycine residue, and R represents a peptide residue corresponding to an amino acid sequence which includes at least positions 7 through 21 of human proinsulin C-peptide proves to be useful for determining C-peptide level in human serum.
摘要翻译：所公开的下式的肽衍生物：Y-Tyr-Gly-R其中，Y表示氢原子或氨基保护基，Tyr表示酪氨酸残基，其中苯环上的至少一个氢原子可被放射性碘，Gly表示甘氨酸残基，R表示对应于氨基酸序列的肽残基，该氨基酸序列至少包含人胰岛素原C-肽的至少7至21位，可用于测定人血清中的C-肽水平。

2. 发明授权

US06677124B2 Monoclonal antibody recognizing C-terminus of hBNP 失效
标题翻译：识别hBNP的C末端的单克隆抗体
公开(公告)号：US06677124B2
公开(公告)日：2004-01-13
申请号：US09942709
申请日：2001-08-31
申请人： Tetsuo Tsuji , Ken Inouye , Akira Yamauchi , Masao Kono , Ken'ichi Igano
发明人： Tetsuo Tsuji , Ken Inouye , Akira Yamauchi , Masao Kono , Ken'ichi Igano
IPC分类号： G01N3353
CPC分类号： C07K16/26
摘要： A hybridoma producing a monoclonal antibody recognizing the C-terminus of human brain natriuretic peptide (hBNP) was cultivated in a medium or the abdominal cavity of a mouse to recover the monoclonal antibody from the medium or ascites accumulated in the abdominal cavity. An immunoassay for hBNP was established using the monoclonal antibody. The immunoassay for hBNP of the invention is so sensitive that the minimum detection limit is 1 pg/ml and can therefore determine the hBNP level in blood plasma directly, without the extraction of hBNP from blood plasma. It is useful for diagnosing diseases such as hypertension and the like, and states of the heart, kidney, and the like by using the increase/decrease of the hBNP level as an index.
摘要翻译：在小鼠的培养基或腹腔中培养产生识别人脑钠尿肽（hBNP）的C末端的单克隆抗体的杂交瘤，以从腹腔积聚的培养基或腹水中回收单克隆抗体。使用单克隆抗体建立了hBNP的免疫测定。本发明的hBNP的免疫测定非常敏感，最小检测限为1pg / ml，因此可以直接测定血浆中的hBNP水平，而不从血浆中提取hBNP。通过使用hBNP水平的增加/减少作为指标，诊断高血压等疾病，心脏和肾脏等的状态是有用的。

3. 发明授权

US5252748A Radioactive iodine compound for labeling an antibody 失效
标题翻译：用于标记抗体的放射性碘化合物
公开(公告)号：US5252748A
公开(公告)日：1993-10-12
申请号：US801810
申请日：1991-12-02
申请人： Akira Yamauchi , Akira Ueda , Masao Kono , Kenichi Igano , Ken Inouye
发明人： Akira Yamauchi , Akira Ueda , Masao Kono , Kenichi Igano , Ken Inouye
IPC分类号： C07D207/452 , C07D207/40 , G01N33/534 , C07D207/448 , C07K3/08 , C12N9/96 , C12Q1/66
CPC分类号： C07D207/40 , G01N33/534
摘要： The radioactive iodine compound of this invention or an intermediate for preparing the compound is represented by the following formula (I): ##STR1## wherein R is H or .sup.125 I. The radioactive compound can readily introduce a radioactive isotope element such as .sup.125 I into an antibody molecule without damaging the activity of the antibody molecule. Therefore, the compound can preferably be used to label an antibody of immunoradiometric assay, and allow a higher degree of measurement sensitivity.

4. 发明授权

US4018753A Polypeptides with ACTH-like activities 失效
标题翻译：具有ACTH样活性的多肽
公开(公告)号：US4018753A
公开(公告)日：1977-04-19
申请号：US596245
申请日：1975-07-16
申请人： Ken Inouye , Masaru Shin , Kunio Watanabe
发明人： Ken Inouye , Masaru Shin , Kunio Watanabe
IPC分类号： C07K14/575 , A61K38/00 , C07K1/113 , C07K14/695 , C07C103/52 , A61K37/40
CPC分类号： C07K14/695 , C07K14/6955 , A61K38/00 , Y10S514/805 , Y10S930/29
摘要： A polypeptide of the formula:X.sub.1 -Tyr-Ser-X.sub.2 -X.sub.3 -His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-(Lys).sub.n -Ywherein X.sub.1 is .alpha.-aminoisobutyric acid, .beta.-alanine, L-serine, glycine, D-serine, D-alanine, .gamma.-aminobutyric acid or sarcosine residue; X.sub.2 is L-methionine, L-norleucine, L-isoleucine or L-norvaline residue; X.sub.3 is L-glutamic acid or L-glutamine residue; n is an integer of 1-4 and Y is a group of ##STR1## which is linked to the carbonyl group of the C-terminal lysine residue, wherein R.sub.1 and R.sub.2 are each hydrogen or the same or different lower alkyl having 1-5 carbon atoms, and R.sub.1 and R.sub.2, when taken together with or without another hetero atom, form a substituted or unsubstituted nitrogen containing heterocyclic ring, with the proviso that a peptide when X.sub.1 is a .alpha.-aminoisobutyric acid or D-serine, R.sub.1 and R.sub.2 are each hydrogen and n is 4 is excluded; non-toxic acid addition salts thereof and complexes thereof; being useful as a medicament owing to their strong adrenal-stimulating activity with protracted action and little side effects. They can be prepared by condensing the amino acids together one by one or by condensing the small peptide fragments together in a per se conventional manner.
摘要翻译：一种下式的多肽：

5. 发明授权

US4018754A Novel polypeptides having ACTH-like action 失效
标题翻译：具有ACTH样作用的新型多肽
公开(公告)号：US4018754A
公开(公告)日：1977-04-19
申请号：US596246
申请日：1975-07-16
申请人： Ken Inouye , Masaru Shin , Kunio Watanabe
发明人： Ken Inouye , Masaru Shin , Kunio Watanabe
IPC分类号： C07K14/575 , A61K38/00 , A61K38/22 , C07K1/113 , C07K14/695 , C07C103/52 , A61K37/40
CPC分类号： C07K14/695 , C07K14/6955 , A61K38/00 , Y02P20/55 , Y10S930/29
摘要： A polypeptide of the formula:X.sub.1 --Tyr--Ser--X.sub.2 --X.sub.3 --His--Phe--Arg--Trp--Gly--Lys--Pro--Val--Gly--(Lys).sub.n --Ywherein X.sub.1 is .alpha.-aminoisobutyric acid, .beta.-alanine, L-serine, D-serine, glycine, D-alanine, .gamma.-aminobutyric acid or sarcosine residue; X.sub.2 is L-methionine, L-norleucine, L-isoleucine or L-norvaline residue; X.sub.3 is L-glutamic acid or L-glutamine residue; n is an integer of 5-10; and Y is --R.sub.1, ##STR1## wherein R.sub.1 is hydroxy or lower alkoxy having 1-5 carbon atoms; R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each hydrogen or lower alkyl having 1-5 carbon atoms; m is an integer of 1-10 and Y is a group bound to the carbonyl group of the C-terminal lysine residue; non-toxic acid addition salts thereof; and complexes thereof; being useful as a medicament owing to their strong adrenal-stimulating activity with protracted action and little side effects. They can be prepared by condensing the amino acids together one by one or by condensing the small peptide fragments together in a per se conventional manner.
摘要翻译：一种下式的多肽：

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