专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080090825A1 Metallo-beta-lactamase inhibitors 有权
标题翻译：金属β-内酰胺酶抑制剂
公开(公告)号：US20080090825A1
公开(公告)日：2008-04-17
申请号：US11889296
申请日：2007-08-10
申请人： Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
发明人： Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
IPC分类号： A61K31/5375 , A61K31/445 , A61P31/04 , A61K31/495
CPC分类号： A61K31/225 , A61K31/166 , A61K31/194 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/351 , A61K31/40 , A61K31/407 , A61K31/4164 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K31/546 , A61K45/06 , C07C51/00 , C07C57/13 , C07C57/145 , C07C57/26 , C07C57/42 , C07C57/50 , C07C59/52 , C07C59/64 , C07C59/70 , C07C69/593 , C07C69/60 , C07C69/608 , C07C69/618 , C07C69/732 , C07C69/734 , C07C217/22 , C07C233/65 , C07C235/20 , C07C235/84 , C07C237/22 , C07C279/08 , C07C279/14 , C07C323/54 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/12 , C07D211/46 , C07D211/60 , C07D213/55 , C07D213/80 , C07D233/60 , C07D295/15 , C07D295/16 , C07D295/192 , C07D309/06 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.
摘要翻译：公开了一种新的金属β-内酰胺酶抑制剂，其用作抑制β-内酰胺抗生素灭活和回收抗细菌活性的药物。具有通式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将通式（I）的化合物与β-内酰胺抗生素组合，可以回收β-内酰胺抗生素对产生金属β-内酰胺酶的细菌的抗菌活性。

2. 发明申请

US20120071457A1 METALLO-BETA-LACTAMASE INHIBITORS 审中-公开
标题翻译： METALLO-BETA-LACTAMASE抑制剂
公开(公告)号：US20120071457A1
公开(公告)日：2012-03-22
申请号：US13306372
申请日：2011-11-29
申请人： Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
发明人： Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
IPC分类号： A61K31/546 , A61K31/4196 , A61K31/4439 , C07C69/593 , A61P31/04 , C07C69/618 , C07D309/06 , C07D213/55 , C07D295/145 , C07D295/192 , A61K31/407 , C07C57/13
CPC分类号： A61K31/225 , A61K31/166 , A61K31/194 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/351 , A61K31/40 , A61K31/407 , A61K31/4164 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K31/546 , A61K45/06 , C07C51/00 , C07C57/13 , C07C57/145 , C07C57/26 , C07C57/42 , C07C57/50 , C07C59/52 , C07C59/64 , C07C59/70 , C07C69/593 , C07C69/60 , C07C69/608 , C07C69/618 , C07C69/732 , C07C69/734 , C07C217/22 , C07C233/65 , C07C235/20 , C07C235/84 , C07C237/22 , C07C279/08 , C07C279/14 , C07C323/54 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/12 , C07D211/46 , C07D211/60 , C07D213/55 , C07D213/80 , C07D233/60 , C07D295/15 , C07D295/16 , C07D295/192 , C07D309/06 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.
摘要翻译：公开了一种新的金属 - β-内酰胺酶抑制剂，其用作抑制β-内酰胺抗生素灭活和回收抗细菌活性的药物。具有通式（I）的马来酸衍生物具有金属 - β-内酰胺酶抑制活性。通过将通式（I）的化合物与β-内酰胺抗生素结合，可以回收抗β-生物反相抗生素对产生金属 - β-内酰胺酶的细菌的抗菌活性。

3. 发明授权

US09260375B2 Metallo-β-lactamase inhibitors 有权
标题翻译：金属和β-内酰胺酶抑制剂
公开(公告)号：US09260375B2
公开(公告)日：2016-02-16
申请号：US13306372
申请日：2011-11-29
申请人： Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
发明人： Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
IPC分类号： C07C57/02 , A61K31/43 , A61K31/397 , A61K31/00 , C07C69/593 , A61K31/194 , C07C57/145 , A61K31/445 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C51/00 , C07C57/13 , C07C57/26 , C07C57/42 , C07C57/50 , C07C59/52 , C07C59/64 , C07C59/70 , C07C69/618 , C07C69/734 , C07C217/22 , C07C233/65 , C07C235/20 , C07C237/22 , C07C279/08 , C07C323/54 , C07D211/46 , C07D211/60 , C07D213/80 , C07D295/192 , C07D309/06 , A61K31/407 , A61K31/546
CPC分类号： A61K31/225 , A61K31/166 , A61K31/194 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/351 , A61K31/40 , A61K31/407 , A61K31/4164 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K31/546 , A61K45/06 , C07C51/00 , C07C57/13 , C07C57/145 , C07C57/26 , C07C57/42 , C07C57/50 , C07C59/52 , C07C59/64 , C07C59/70 , C07C69/593 , C07C69/60 , C07C69/608 , C07C69/618 , C07C69/732 , C07C69/734 , C07C217/22 , C07C233/65 , C07C235/20 , C07C235/84 , C07C237/22 , C07C279/08 , C07C279/14 , C07C323/54 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/12 , C07D211/46 , C07D211/60 , C07D213/55 , C07D213/80 , C07D233/60 , C07D295/15 , C07D295/16 , C07D295/192 , C07D309/06 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.
摘要翻译：公开了一种新的金属 - β-内酰胺酶抑制剂，其用作抑制β-内酰胺抗生素灭活和回收抗细菌活性的药物。具有通式（I）的马来酸衍生物具有金属 - β-内酰胺酶抑制活性。通过将通式（I）的化合物与β-内酰胺抗生素结合，可以回收抗β-生物反相抗生素对产生金属 - β-内酰胺酶的细菌的抗菌活性。

4. 发明授权

US08093294B2 Metallo-β-lactamase inhibitors 有权
标题翻译：金属和β-内酰胺酶抑制剂
公开(公告)号：US08093294B2
公开(公告)日：2012-01-10
申请号：US11889296
申请日：2007-08-10
申请人： Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
发明人： Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
IPC分类号： A61K31/19 , A61K31/43 , A61K31/545
CPC分类号： A61K31/225 , A61K31/166 , A61K31/194 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/351 , A61K31/40 , A61K31/407 , A61K31/4164 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K31/546 , A61K45/06 , C07C51/00 , C07C57/13 , C07C57/145 , C07C57/26 , C07C57/42 , C07C57/50 , C07C59/52 , C07C59/64 , C07C59/70 , C07C69/593 , C07C69/60 , C07C69/608 , C07C69/618 , C07C69/732 , C07C69/734 , C07C217/22 , C07C233/65 , C07C235/20 , C07C235/84 , C07C237/22 , C07C279/08 , C07C279/14 , C07C323/54 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/12 , C07D211/46 , C07D211/60 , C07D213/55 , C07D213/80 , C07D233/60 , C07D295/15 , C07D295/16 , C07D295/192 , C07D309/06 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.
摘要翻译：公开了一种新的金属 - β-内酰胺酶抑制剂，其用作抑制β-内酰胺抗生素灭活和回收抗细菌活性的药物。具有通式（I）的马来酸衍生物具有金属 - β-内酰胺酶抑制活性。通过将通式（I）的化合物与β-内酰胺抗生素结合，可以回收抗β-生物反相抗生素对产生金属 - β-内酰胺酶的细菌的抗菌活性。

5. 发明授权

US09115079B2 NDM inhibitor 有权
标题翻译： NDM抑制剂
公开(公告)号：US09115079B2
公开(公告)日：2015-08-25
申请号：US14234456
申请日：2012-07-26
申请人： Akihiro Morinaka , Kazunori Maebashi , Takashi Ida , Muneo Hikida , Mototsugu Yamada , Takao Abe
发明人： Akihiro Morinaka , Kazunori Maebashi , Takashi Ida , Muneo Hikida , Mototsugu Yamada , Takao Abe
IPC分类号： C07C69/593 , A61K45/06 , A61K31/194 , A61K31/351 , A61K31/40 , A61K31/407 , A61K31/4164 , C07D309/06 , C07C279/08 , C07C217/18 , C07C233/65 , C07C235/20 , C07C237/22 , A61K31/216 , A61K31/225 , A61K31/4015 , A61K31/4174 , A61K31/4406 , A61K31/45 , A61K31/5375 , C07C69/608 , C07C69/612 , C07C69/618 , C07C69/732 , C07D207/12 , C07D211/46 , C07D213/55 , C07D233/64 , C07D295/108 , C07C63/66 , C07C57/13 , C07C57/26 , C07C57/30 , C07C57/42 , C07C57/48 , C07C57/50 , C07C59/46 , C07C59/64
CPC分类号： C07C69/593 , A61K31/194 , A61K31/216 , A61K31/225 , A61K31/351 , A61K31/40 , A61K31/4015 , A61K31/407 , A61K31/4164 , A61K31/4174 , A61K31/4406 , A61K31/45 , A61K31/5375 , A61K45/06 , C07C57/13 , C07C57/26 , C07C57/30 , C07C57/42 , C07C57/48 , C07C57/50 , C07C59/46 , C07C59/64 , C07C63/66 , C07C69/608 , C07C69/612 , C07C69/618 , C07C69/732 , C07C217/18 , C07C233/65 , C07C235/20 , C07C237/22 , C07C279/08 , C07D207/12 , C07D211/46 , C07D213/55 , C07D233/64 , C07D295/108 , C07D309/06 , Y02A50/473 , A61K2300/00
摘要： An objective of the present invention is to provide a novel NDM (New Delhi metallo-β-lactamase) inhibitor that functions as a drug for restoring the antibacterial activity of β-lactam antibiotics that have been inactivated as a result of decomposition by NDM. According to the present invention, there is provided an NDM inhibitor contains a compound represented by general formula (I):
摘要翻译：本发明的目的是提供一种新型的NDM（新德里金属 - β-内酰胺酶）抑制剂，其作为恢复由NDM分解而灭活的β-内酰胺抗生素的抗菌活性的药物。根据本发明，提供了含有通式（I）表示的化合物的NDM抑制剂：

6. 发明申请

US20140221330A1 NDM INHIBITOR 有权
标题翻译： NDM抑制剂
公开(公告)号：US20140221330A1
公开(公告)日：2014-08-07
申请号：US14234456
申请日：2012-07-26
申请人： Akihiro Morinaka , Kazunori Maebashi , Takashi Ida , Muneo Hikida , Mototsugu Yamada , Takao Abe
发明人： Akihiro Morinaka , Kazunori Maebashi , Takashi Ida , Muneo Hikida , Mototsugu Yamada , Takao Abe
IPC分类号： C07C69/593 , A61K45/06 , C07C69/612 , A61K31/216 , C07C69/618 , C07C69/732 , C07D309/06 , A61K31/351 , C07C69/608 , C07D213/55 , A61K31/4406 , C07D295/108 , A61K31/5375 , C07D211/46 , A61K31/45 , C07D233/64 , A61K31/4174 , C07D207/12 , A61K31/4015 , A61K31/225
CPC分类号： C07C69/593 , A61K31/194 , A61K31/216 , A61K31/225 , A61K31/351 , A61K31/40 , A61K31/4015 , A61K31/407 , A61K31/4164 , A61K31/4174 , A61K31/4406 , A61K31/45 , A61K31/5375 , A61K45/06 , C07C57/13 , C07C57/26 , C07C57/30 , C07C57/42 , C07C57/48 , C07C57/50 , C07C59/46 , C07C59/64 , C07C63/66 , C07C69/608 , C07C69/612 , C07C69/618 , C07C69/732 , C07C217/18 , C07C233/65 , C07C235/20 , C07C237/22 , C07C279/08 , C07D207/12 , C07D211/46 , C07D213/55 , C07D233/64 , C07D295/108 , C07D309/06 , Y02A50/473 , A61K2300/00
摘要： An objective of the present invention is to provide a novel NDM (New Delhi metallo-β-lactamase) inhibitor that functions as a drug for restoring the antibacterial activity of β-lactam antibiotics that have been inactivated as a result of decomposition by NDM. According to the present invention, there is provided an NDM inhibitor contains a compound represented by general formula (I):
摘要翻译：本发明的目的是提供一种新型的NDM（新德里金属 - β-内酰胺酶）抑制剂，其作为恢复由NDM分解而灭活的β-内酰胺抗生素的抗菌活性的药物。根据本发明，提供了含有通式（I）表示的化合物的NDM抑制剂：

7. 发明申请

US20120064557A1 METHOD OF IDENTIFYING METALLO-BETA-LACTAMASE-PRODUCING BACTERIA 失效
标题翻译：鉴定生产金属 - β-谷氨酸酶的细菌的方法
公开(公告)号：US20120064557A1
公开(公告)日：2012-03-15
申请号：US13260965
申请日：2010-03-31
申请人： Akihiro Morinaka
发明人： Akihiro Morinaka
IPC分类号： C12Q1/34
CPC分类号： C12Q1/04 , C12Q1/045 , C12Q1/34 , G01N2333/986
摘要： An object of the present invention is to provide a method of identifying metallo-β-lactamase-producing bacteria, particularly, a method of conveniently identifying an IMP or VIM type. According to the present invention, there is provided a method of detecting metallo-β-lactamase-producing bacteria, comprising spotting a compound (I) onto a surface of a solid medium coated with the bacteria to be tested, spotting 3 types of β-lactam agents at 3 respective positions different from the spot of the compound (I), culturing the solid medium, and then detecting the metallo-β-lactamase-producing bacteria based on the shape of an inhibition zone formed around the spot of each of the β-lactam agents. There is further provided a method of identifying an IMP or VIM type of the metallo-β-lactamase-producing bacteria.
摘要翻译：本发明的目的是提供一种识别产生金属 - β-内酰胺酶的细菌的方法，特别是方便地鉴定IMP或VIM型的方法。根据本发明，提供了一种检测产生金属 - β-内酰胺酶的细菌的方法，其包括将化合物（I）放在涂覆有待测试细菌的固体培养基的表面上，发现3种类型的 ;在与化合物（I）的斑点不同的3个位置处的内酰胺试剂，培养固体培养基，然后基于形成在所述化合物（I）的斑点周围的抑制区的形状来检测产生金属和β-内酰胺酶的细菌每个＆bgr。 - 内酰胺代理。还提供了鉴定产生金属 - β-内酰胺酶的细菌的IMP或VIM类型的方法。

8. 发明授权

US08697382B2 Method of identifying metallo-β-lactamase-producing bacteria 失效
标题翻译：鉴定金属 - β-内酰胺酶生产细菌的方法
公开(公告)号：US08697382B2
公开(公告)日：2014-04-15
申请号：US13260965
申请日：2010-03-31
申请人： Akihiro Morinaka
发明人： Akihiro Morinaka
IPC分类号： C12Q1/34 , A61K31/19
CPC分类号： C12Q1/04 , C12Q1/045 , C12Q1/34 , G01N2333/986
摘要： An object of the present invention is to provide a method of identifying metallo-β-lactamase-producing bacteria, particularly, a method of conveniently identifying an IMP or VIM type. According to the present invention, there is provided a method of detecting metallo-β-lactamase-producing bacteria, comprising spotting a compound (I) onto a surface of a solid medium coated with the bacteria to be tested, spotting 3 types of β-lactam agents at 3 respective positions different from the spot of the compound (I), culturing the solid medium, and then detecting the metallo-β-lactamase-producing bacteria based on the shape of an inhibition zone formed around the spot of each of the β-lactam agents. There is further provided a method of identifying an IMP or VIM type of the metallo-β-lactamase-producing bacteria.
摘要翻译：本发明的目的是提供一种识别产生金属 - β-内酰胺酶的细菌的方法，特别是方便地鉴定IMP或VIM型的方法。根据本发明，提供了一种检测产生金属 - β-内酰胺酶的细菌的方法，其包括将化合物（I）放在涂覆有待测试细菌的固体培养基的表面上，发现3种类型的 ;在与化合物（I）的斑点不同的3个位置处的内酰胺试剂，培养固体培养基，然后基于形成在所述化合物（I）的斑点周围的抑制区的形状来检测产生金属和β-内酰胺酶的细菌每个＆bgr。 - 内酰胺代理。还提供了鉴定产生金属 - β-内酰胺酶的细菌的IMP或VIM类型的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式