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    • 8. 发明申请
    • PROCESS FOR MAKING ORGANIC COMPOUNDS AND THE ORGANIC COMPOUNDS MADE THEREFROM
    • 制造有机化合物和有机化合物的方法
    • US20100331547A1
    • 2010-12-30
    • US12492716
    • 2009-06-26
    • Yangang LiangShengxia LiuRui WangJie LiuKelly Scott Chichak
    • Yangang LiangShengxia LiuRui WangJie LiuKelly Scott Chichak
    • C07D401/14C07D401/10
    • H01L51/0067C07D213/127C07D213/26C07D213/30
    • An organic compound of formula E is made from a process comprising:reacting a compound of formula A and a compound of formula B to form a compound of formula C; and reacting one of the compound of formula C and the compound of formula D with a first boron esterification reagent to generate a boronic acid or a boronic ester to react with another of the compound of formula C and the compound of formula D to form a compound of formula E; wherein R1, R2, and R3 are, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical;X1 is chloro, bromo, trifluoromethanesulfonate, or hydroxy;X2 is chloro, bromo, iodo; and when X1 is chloro, X2 is bromo or iodo, when X1 is bromo, X2 is iodo, when X1 is hydroxy, X2 is chloro, bromo or iodo, when X1 is trifluoromethanesulfonate, X2 is bromo or iodo;X3 is a boronic acid or boronic ester;X is CH or N and when X is CH, at least one of R2 is pyridyl;X4 is chloro, bromo, trifluoromethanesulfonate, or hydroxy;X5 is chloro, bromo, iodo; and when X4 is chloro, X5 is bromo or iodo, when X4 is bromo, X5 is iodo, when X4 is hydroxy, X5 is chloro, bromo or iodo, when X4 is trifluoromethanesulfonate, X5 is bromo or iodo;a, and c are, independently at each occurrence, an integer ranging from 0-4; and b is an integer ranging from 0-3.
    • 式E的有机化合物由以下方法制得,该方法包括:使式A化合物与式B化合物反应以形成式C化合物; 并使式C化合物与式D化合物之一与第一硼酯化试剂反应,生成硼酸或硼酸酯与另一种式C化合物与式D化合物反应,形成化合物 的式E; 其中R 1,R 2和R 3在每次出现时独立地为C 1 -C 20脂族基团,C 3 -C 20芳族基团或C 3 -C 20脂环族基团; X 1是氯,溴,三氟甲磺酸酯或羟基; X2是氯,溴,碘; 当X 1为氯时,X 2为溴或碘,当X 1为溴时,X 2为碘,X 1为羟基时,X 1为氯,溴或碘时,X 1为三氟甲磺酸酯时,X 2为溴或碘; X3是硼酸或硼酸酯; X是CH或N,当X是CH时,R 2中的至少一个是吡啶基; X4是氯,溴,三氟甲磺酸酯或羟基; X5是氯,溴,碘; 当X4为氯时,X4为溴或碘,当X4为溴时,X5为碘,当X4为羟基时,X5为氯,溴或碘,当X4为三氟甲磺酸酯时,X5为溴或碘; a和c各自独立地为0-4的整数; b为0-3的整数。