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1. 发明授权

US5750523A Pyridazinone derivatives 失效
标题翻译：哒嗪酮衍生物
公开(公告)号：US5750523A
公开(公告)日：1998-05-12
申请号：US676227
申请日：1996-07-23
申请人： Keizo Tanikawa , Takashi Matsumoto , Hiroo Matsumoto , Nobutomo Tsuruzoe , Hitoshi Nakabeppu
发明人： Keizo Tanikawa , Takashi Matsumoto , Hiroo Matsumoto , Nobutomo Tsuruzoe , Hitoshi Nakabeppu
IPC分类号： C07D237/22 , C07D401/12 , A61K31/50
CPC分类号： C07D401/12 , C07D237/22
摘要： Pyridazinone derivatives represented by the formula (I) and antiplatelet agents containing them: ##STR1## �wherein R is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, X is a hydrogen atom, a chlorine atom or a bromine atom, Ar is a pyridyl group or a phenyl group substituted with OR.sup.1 (wherein R.sup.1 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group) and A {wherein A is a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group or OR.sup.2 (wherein R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group)}, is C.sub.1 -C.sub.8 alkylene wherein one carbon atom on the straight chain is substituted with one OR.sup.1 group (wherein R.sup.1 is the same as defined above), and Z.sup.1 and Z.sup.2 are independently a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group or a OR.sup.1 group (wherein R.sup.1 is the same as defined above)!. These compounds have strong antiplatelet effects, are excellently safe, and can be used as active ingredients of prophylactic and therapeutic drugs for various thrombotic diseases.
摘要翻译： PCT No.PCT / JP95 / 00069 Sec。 371日期：1996年7月23日 102（e）日期1996年7月23日PCT提交1995年1月24日PCT公布。 WO95 / 19969 PCT公开日期：1997年7月27日由式（I）表示的哒嗪酮衍生物和含有它们的抗血小板剂：其中R是氢原子或C1-C4烷基，X是氢原子，氯原子或溴原子，Ar是吡啶基或被OR 1取代的苯基（其中R1是氢原子或C1-C4烷基）和A {其中A是氢原子，卤原子，C1-C4 烷基或OR 2（其中R 2是氢原子或C 1 -C 4烷基）}是其中一个碳原子被一个OR 1基团取代的C 1 -C 8亚烷基（其中R 1与上述定义相同），Z 1和Z 2独立地为氢原子，卤素原子，C 1 -C 4烷基或OR 1基（其中R 1与上述定义相同）]。这些化合物具有很强的抗血小板作用，非常安全，可用作各种血栓性疾病的预防和治疗药物的活性成分。

2. 发明授权

US5856327A Pyridazinone derivatives 失效
标题翻译：哒嗪酮衍生物
公开(公告)号：US5856327A
公开(公告)日：1999-01-05
申请号：US936600
申请日：1997-09-24
申请人： Keizo Tanikawa , Takashi Matsumoto , Hiroo Matsumoto , Nobutomo Tsuruzoe , Hitoshi Nakabeppu
发明人： Keizo Tanikawa , Takashi Matsumoto , Hiroo Matsumoto , Nobutomo Tsuruzoe , Hitoshi Nakabeppu
IPC分类号： C07D237/22 , C07D401/12 , A61K31/50
CPC分类号： C07D401/12 , C07D237/22
摘要： Pyridazinone derivatives represented by the formula (I) and antiplatelet agents containing them: ##STR1## �wherein R is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, X is a hydrogen atom, a chlorine atom or a bromine atom, Ar is a pyridyl group or a phenyl group substituted with OR.sup.1 (wherein R.sup.1 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group) and A {wherein A is a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group or OR.sup.2 (wherein R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group)}, Y is C.sub.1 -C.sub.8 alkylene wherein one carbon atom on the straight chain is substituted with one OR.sup.1 group (wherein R.sup.1 is the same as defined above), and Z.sup.1 and Z.sup.2 are independently a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group or a OR.sup.1 group (wherein R.sup.1 is the same as defined above)!. These compounds have strong antiplatelet effects, are excellently safe, and can be used as active ingredients of prophylactic and therapeutic drugs for various thrombotic diseases.
摘要翻译：由式（I）表示的哒嗪酮衍生物和含有它们的抗血小板剂：其中R是氢原子或C1-C4烷基，X是氢原子，氯原子或溴原子， Ar是吡啶基或被OR 1取代的苯基（其中R1是氢原子或C1-C4烷基）和A {其中A是氢原子，卤素原子，C1-C4烷基或OR2（其中R 2是氢原子或C 1 -C 4烷基），Y是直链上的一个碳原子被一个OR 1基团取代的C 1 -C 8亚烷基（其中R 1与上述相同），Z 1和 Z2独立地为氢原子，卤素原子，C1-C4烷基或OR1基团（其中R1与上述定义相同）]。这些化合物具有很强的抗血小板作用，非常安全，可用作各种血栓性疾病的预防和治疗药物的活性成分。

3. 发明授权

US5318968A 5-heteroarylamino-6-oxy-substituted 3(2H)-pyridazinones 失效
标题翻译： 5-杂芳基氨基-6-氧基取代的3（2H） - 哒嗪酮
公开(公告)号：US5318968A
公开(公告)日：1994-06-07
申请号：US994413
申请日：1992-12-21
申请人： Keizo Tanikawa , Akira Saito , Takashi Matsumoto , Ryozo Sakoda , Nobutomo Tsuruzoe , Ken-ichi Shikada
发明人： Keizo Tanikawa , Akira Saito , Takashi Matsumoto , Ryozo Sakoda , Nobutomo Tsuruzoe , Ken-ichi Shikada
IPC分类号： A61K31/50 , A61K31/501 , A61P7/02 , C07D237/22 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D401/12 , C07D237/22 , C07D405/12
摘要： A compound of the formula, ##STR1## or its pharmaceutically acceptable salt, and its preparation process and pharmaceutical compositions characterized by containing these compounds as effective ingredients.These compounds have strong antithrombotic activity, cardiotonic activity, vasodilator activity and anti-SRS-A activity, and are useful as prophylactic or therapeutic agents for various thrombotic affections, congestive heart failure, hypertension, asthma, immediate type allergy diseases and the like.
摘要翻译：式（Ⅰ）化合物或其药学上可接受的盐，其制备方法和药物组合物的特征在于含有这些化合物作为有效成分。这些化合物具有强的抗血栓形成活性，强心剂活性，血管扩张剂活性和抗SRS-A活性，可用作各种血栓形成，充血性心力衰竭，高血压，哮喘，立即型过敏性疾病等的预防或治疗剂。

4. 发明授权

US5314883A 5-heteroarylamino-6-oxy-substituted 3(2H)-pyridazinones 失效
标题翻译： 5-杂芳基氨基-6-氧基取代的3（2H） - 哒嗪酮
公开(公告)号：US5314883A
公开(公告)日：1994-05-24
申请号：US994404
申请日：1992-12-21
申请人： Keizo Tanikawa , Akira Saito , Takashi Matsumoto , Ryozo Sakoda , Nobutomo Tsuruzoe , Ken-ichi Shikada
发明人： Keizo Tanikawa , Akira Saito , Takashi Matsumoto , Ryozo Sakoda , Nobutomo Tsuruzoe , Ken-ichi Shikada
IPC分类号： A61K31/50 , A61K31/501 , A61P7/02 , C07D237/22 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D401/12 , C07D237/22 , C07D405/12
摘要： A compound of the formula: ##STR1## or its pharmaceutically acceptable salt and pharmaceutical compositions containing these compounds as effective ingredients. These compounds have strong antithrombotic activity, cardiotonic activity, vasodilator activity and anti-SRS-A activity, and are useful as prophylactic or therapeutic agents for various thrombotic afflictions, congestive heart failure, hypertension, asthma, immediate-type allergy diseases and the like.
摘要翻译：下式的化合物：其含有这些化合物作为有效成分的药学上可接受的盐和药物组合物。这些化合物具有强的抗血栓活性，强心剂活性，血管扩张剂活性和抗SRS-A活性，可用作各种血栓形成疾病，充血性心力衰竭，高血压，哮喘，立即型过敏性疾病等的预防或治疗剂。

5. 发明授权

US5202323A 5-arylmethylamino-6-oxy-substituted 3(2H)-pyridazinones 失效
标题翻译： 5-氨基甲酰胺-6-氧代替3（2H） - 吡啶并[
公开(公告)号：US5202323A
公开(公告)日：1993-04-13
申请号：US768182
申请日：1991-10-16
申请人： Keizo Tanikawa , Akira Saito , Takashi Matsumoto , Ryozo Sakoda , Nobutomo Tsuruzoe , Ken-ichi Shikada
发明人： Keizo Tanikawa , Akira Saito , Takashi Matsumoto , Ryozo Sakoda , Nobutomo Tsuruzoe , Ken-ichi Shikada
IPC分类号： A61K31/50 , A61K31/501 , A61P7/02 , C07D237/22 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D401/12 , C07D237/22 , C07D405/12
摘要： A compound of the formula, ##STR1## or its pharmaceutically acceptable salt, and its preparation process and pharmaceutical compositions characterized by containing these compounds as effective ingredients.These compounds have strong antithrombotic activity, cardiotonic activity, vasodilator activity and anti-SRS-A activity, and are useful as prophylactic or therapeutic agents for various thrombotic affections, congestive heart failure, hypertension, asthma, immediate type allergy diseases and the like.

6. 发明授权

US5968967A Pyrazolones derivatives 失效
标题翻译：吡唑啉酮衍生物
公开(公告)号：US5968967A
公开(公告)日：1999-10-19
申请号：US51085
申请日：1998-04-13
申请人： Keizo Tanikawa , Takashi Matsumoto , Masumi Nakamura , Yasunori Asada , Norimasa Shudo
发明人： Keizo Tanikawa , Takashi Matsumoto , Masumi Nakamura , Yasunori Asada , Norimasa Shudo
IPC分类号： A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/47 , A61K31/495 , A61P7/02 , A61P9/08 , A61P9/10 , C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06
CPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04
摘要： A pyrazolone derivative represented by general formula (I) or a salt thereof: ##STR1## [wherein one of X.sup.1 and X.sup.2 is ##STR2## (wherein A is a cyano group, a cyano C.sub.1-4 alkyl group, an amino group, an amino C.sub.1-4 alkyl group, an amidino group or a guanidino group, R.sup.1 and R.sup.2 are independently hydrogen atoms, halogen atoms, C.sub.1-6 alkyl groups or the like) or the like],the other of X.sup.1 and X.sup.2 is a C.sub.1-6 alkyl group, a C.sub.3-6 alkenyl group, an aryl C.sub.1-4 alkyl group or an aryl group,one of Y.sup.1 and Y.sup.2 is ##STR3## (wherein Q is an oxygen atom or a sulfur atom, Z.sup.1 is an oxygen atom, a --NR.sup.7 -- group or a --CHR.sup.7 -- group, Z.sup.2 is a cyclic C.sub.3-7 alkylene group, a C.sub.1-3 alkylene group, a --CH.sub.2 CO-- group or --CH.sub.2 CH.sub.2 CO-- group, Z.sup.3 is an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group or the like, Z.sup.4 is a C.sub.1-3 alkylene group, and Z.sup.5 is a carboxyl group or the like, andthe other of Y.sup.1 and Y.sup.2 is a D-E- group [wherein E is a bond, a C.sub.1-4 alkylene group or a phenylene group, and D is a hydrogen atom, a C.sub.1-6 alkyl group or the like which has an inhibitory action on platelet aggregation and is useful as a preventive or therapeutic agent for various thrombotic diseases.
摘要翻译： PCT No.PCT / JP96 / 02944 Sec。 371日期：1998年4月13日 102（e）1998年4月13日PCT PCT 1996年10月11日PCT公布。第WO97 / 13757号公报日本1997年4月17日由通式（I）表示的吡唑啉酮衍生物或其盐：其中X1和X2之一为（其中A为氰基，氰基C1-4烷基，氨基，氨基 C 1-4烷基，脒基或胍基，R 1和R 2独立地为氢原子，卤素原子，C 1-6烷基等），X 1和X 2中的另一个为C 1-6 烷基，C 3-6烯基，芳基C 1-4烷基或芳基，Y1和Y2之一为（其中Q为氧原子或硫原子，Z1为氧原子，-NR7- 基团或-CHR7-基团，Z2为环状C3-7亚烷基，C1-3亚烷基，-CH2CO-基或-CH2CH2CO-基，Z3为氧原子，硫原子，亚磺酰基，磺酰基等，Z4为C1-3亚烷基，Z5为羧基等，Y1和Y2中的另一个为DE-基[其中E为键，C1-4亚烷基基团或亚苯基，D为氢原子，C1-6烷基对血小板聚集具有抑制作用，可用作各种血栓性疾病的预防或治疗剂。

7. 发明申请

US20060065825A1 Radiological imaging apparatus and timing correction method therefor 失效
公开(公告)号：US20060065825A1
公开(公告)日：2006-03-30
申请号：US11174589
申请日：2005-07-06
申请人： Takafumi Ishitsu , Kensuke Amemiya , Yuuichirou Ueno , Takashi Matsumoto , Takashi Matsumoto
发明人： Takafumi Ishitsu , Kensuke Amemiya , Yuuichirou Ueno , Takashi Matsumoto , Takashi Matsumoto
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , A61B6/037
摘要： A processing circuit, which carries out coincidence counting, acquires calibration data so that time delays of γ-ray detection signals from radiation detectors coincide with one another. A technique for acquiring calibration data faster and easily is provided to attain high time precision and respond to multi-channeling of detectors. A signal from a test signal generator is sent to signal processing apparatuses and coincidence count events are generated as a test. The events generated are processed by a delay time control apparatus and a variable delay circuit is controlled to improve the accuracy of coincidence counting.

8. 发明授权

US07129476B2 Radiological imaging apparatus and timing correction method therefor 失效
公开(公告)号：US07129476B2
公开(公告)日：2006-10-31
申请号：US11174589
申请日：2005-07-06
申请人： Takafumi Ishitsu , Kensuke Amemiya , Yuuichirou Ueno , Takashi Matsumoto , Takashi Matsumoto
发明人： Takafumi Ishitsu , Kensuke Amemiya , Yuuichirou Ueno , Takashi Matsumoto , Takashi Matsumoto
IPC分类号： G01D18/00
CPC分类号： G01T1/2985 , A61B6/037
摘要： A processing circuit, which carries out coincidence counting, acquires calibration data so that time delays of γ-ray detection signals from radiation detectors coincide with one another. A technique for acquiring calibration data faster and easily is provided to attain high time precision and respond to multi-channeling of detectors. A signal from a test signal generator is sent to signal processing apparatuses and coincidence count events are generated as a test. The events generated are processed by a delay time control apparatus and a variable delay circuit is controlled to improve the accuracy of coincidence counting.

9. 发明授权

US07312438B2 Radiological imaging apparatus and timing correction method therefor 失效
标题翻译：放射成像装置及其定时校正方法
公开(公告)号：US07312438B2
公开(公告)日：2007-12-25
申请号：US11503170
申请日：2006-08-14
申请人： Takafumi Ishitsu , Kensuke Amemiya , Yuuichirou Ueno , Takashi Matsumoto , Takashi Matsumoto
发明人： Takafumi Ishitsu , Kensuke Amemiya , Yuuichirou Ueno , Takashi Matsumoto , Takashi Matsumoto
IPC分类号： G12B13/00
CPC分类号： G01T1/2985 , A61B6/037
摘要： A processing circuit, which carries out coincidence counting, acquires calibration data so that time delays of γ-ray detection signals from radiation detectors coincide with one another. A technique for acquiring calibration data faster and easily is provided to attain high time precision and respond to multi-channeling of detectors. A signal from a test signal generator is sent to signal processing apparatuses and coincidence count events are generated as a test. The events generated are processed by a delay time control apparatus and a variable delay circuit is controlled to improve the accuracy of coincidence counting.
摘要翻译：执行符合计数的处理电路获取校准数据，使得来自辐射检测器的伽马射线检测信号的时间延迟彼此一致。提供了更快更容易地获取校准数据的技术，以获得高时间精度并响应检测器的多通道。来自测试信号发生器的信号被发送到信号处理设备，并且产生符合计数事件作为测试。所产生的事件由延迟时间控制装置处理，并且可变延迟电路被控制以提高重合计数的准确性。

10. 发明申请

US20060273250A1 Radiological imaging apparatus and timing correction method therefor 失效
标题翻译：放射成像装置及其定时校正方法
公开(公告)号：US20060273250A1
公开(公告)日：2006-12-07
申请号：US11503170
申请日：2006-08-14
申请人： Takafumi Ishitsu , Kensuke Amemiya , Yuuichirou Ueno , Takashi Matsumoto , Takashi Matsumoto
发明人： Takafumi Ishitsu , Kensuke Amemiya , Yuuichirou Ueno , Takashi Matsumoto , Takashi Matsumoto
IPC分类号： G01T1/166
CPC分类号： G01T1/2985 , A61B6/037
摘要： A processing circuit, which carries out coincidence counting, acquires calibration data so that time delays of γ-ray detection signals from radiation detectors coincide with one another. A technique for acquiring calibration data faster and easily is provided to attain high time precision and respond to multi-channeling of detectors. A signal from a test signal generator is sent to signal processing apparatuses and coincidence count events are generated as a test. The events generated are processed by a delay time control apparatus and a variable delay circuit is controlled to improve the accuracy of coincidence counting.
摘要翻译：执行符合计数的处理电路获取校准数据，使得来自辐射检测器的伽马射线检测信号的时间延迟彼此一致。提供了更快更容易地获取校准数据的技术，以获得高时间精度并响应检测器的多通道。来自测试信号发生器的信号被发送到信号处理设备，并且产生符合计数事件作为测试。所产生的事件由延迟时间控制装置处理，并且可变延迟电路被控制以提高重合计数的准确性。

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