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1. 发明申请

US20100075942A1 N-PHENYL-4-PYRIDIN-2-YL-BENZAMIDE DERIVATIVES AS HISTONE DEACYLASE (HDAC) INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：作为治疗癌症的HISTONE DEACYLASE（HDAC）抑制剂的N-苯基-4-吡啶-2-基-L-苯甲酰胺衍生物
公开(公告)号：US20100075942A1
公开(公告)日：2010-03-25
申请号：US11813838
申请日：2006-01-12
申请人： Keith Hopkinson Gibson , Elaine Sophie, Elizabeth Stokes , Michael James Waring , David Michael Andrews , Zbigniew Stanley Matusiak , Mark Maybury , Craig Anthony Roberts
发明人： Keith Hopkinson Gibson , Elaine Sophie, Elizabeth Stokes , Michael James Waring , David Michael Andrews , Zbigniew Stanley Matusiak , Mark Maybury , Craig Anthony Roberts
IPC分类号： A61K31/4418 , C07D213/61 , C07D401/12 , C07D213/82 , C07D401/06 , A61K31/496 , A61K31/4523
CPC分类号： C07D213/82 , C07D213/61 , C07D213/65
摘要： The invention concerns benzamide derivatives of Formula (I) wherein R1a, R1b, R1c, R2, R3, R4, W, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of histone deacetylase (HDAC).
摘要翻译：本发明涉及式（I）的苯甲酰胺衍生物，其中R1a，R1b，R1c，R2，R3，R4，W，m和n具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对组蛋白脱乙酰酶（HDAC）的抑制敏感的肿瘤或其它增殖病症中的抗增殖剂的药物中的用途。

2. 发明申请

US20080293687A1 Benzamide Compounds 有权
标题翻译：苯甲酰胺化合物
公开(公告)号：US20080293687A1
公开(公告)日：2008-11-27
申请号：US11661498
申请日：2005-08-31
申请人： Keith Hopkinson Gibson , Elaine Sophie Elizabeth Stokes , Michael James Waring , David Michael Andrews , Zbigniew Stanley Matusiak , Mark Andrew Graham
发明人： Keith Hopkinson Gibson , Elaine Sophie Elizabeth Stokes , Michael James Waring , David Michael Andrews , Zbigniew Stanley Matusiak , Mark Andrew Graham
IPC分类号： A61K31/4427 , C07D213/85 , A61K31/44 , A61K31/496 , A61P35/00 , C07D401/14 , C07D401/06
CPC分类号： C07D417/12 , C07D213/85 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D487/08
摘要： The invention concerns benzamide compounds of Formula (I), wherein R1a, R1b, R1c, R2, R3, R4, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of histone deacetylase (HDAC).
摘要翻译：本发明涉及式（I）的苯甲酰胺化合物，其中R1a，R1b，R1c，R2，R3，R4，m和n具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对组蛋白脱乙酰酶（HDAC）的抑制敏感的肿瘤或其它增殖病症中的抗增殖剂的药物中的用途。

3. 发明授权

US07897778B2 Benzamide compounds 有权
标题翻译：苯甲酰胺化合物
公开(公告)号：US07897778B2
公开(公告)日：2011-03-01
申请号：US11661498
申请日：2005-08-31
申请人： Keith Hopkinson Gibson , Elaine Sophie Elizabeth Stokes , Michael James Waring , David Michael Andrews , Zbigniew Stanley Matusiak , Mark Andrew Graham
发明人： Keith Hopkinson Gibson , Elaine Sophie Elizabeth Stokes , Michael James Waring , David Michael Andrews , Zbigniew Stanley Matusiak , Mark Andrew Graham
IPC分类号： C07D401/00 , C07D211/78
CPC分类号： C07D417/12 , C07D213/85 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D487/08
摘要： The invention concerns benzamide compounds of Formula (I), wherein R1a, R1b, R1c, R2, R3, R4, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of histone deacetylase (HDAC).
摘要翻译：本发明涉及式（I）的苯甲酰胺化合物，其中R1a，R1b，R1c，R2，R3，R4，m和n具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对组蛋白脱乙酰酶（HDAC）的抑制敏感的肿瘤或其它增殖病症中的抗增殖剂的药物中的用途。

4. 发明申请

US20080119451A1 Novel Benzamide Derivatives 审中-公开
标题翻译：新型苯甲酰胺衍生物
公开(公告)号：US20080119451A1
公开(公告)日：2008-05-22
申请号：US11814340
申请日：2006-01-17
申请人： Keith Hopkinson Gibson , Elaine Sophie Elizabeth Stokes , Michael James Waring , David Michael Andrews , Zbigniew Stanley Matusiak
发明人： Keith Hopkinson Gibson , Elaine Sophie Elizabeth Stokes , Michael James Waring , David Michael Andrews , Zbigniew Stanley Matusiak
IPC分类号： A61K31/496 , A61K31/4439 , C07D403/02 , C07D211/84 , C07D213/56
CPC分类号： C07D213/73 , C07D213/38 , C07D213/56 , C07D213/75 , C07D213/82 , C07D401/06 , C07D401/12
摘要： The invention concerns benzamide derivatives of Formula (I) wherein R1a, R1b, R1c, R2, R3, R4, integer m, integer n and W have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of histone deacetylase (HDAC).
摘要翻译：本发明涉及式（I）的苯甲酰胺衍生物，其中R 1a，R 1b，R 1c，R 2， R 3，R 4，整数m，整数n和W具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对组蛋白脱乙酰酶（HDAC）的抑制敏感的肿瘤或其它增殖病症中的抗增殖剂的药物中的用途。

5. 发明授权

US07402583B2 Substituted quinolines as antitumor agents 失效
标题翻译：取代的喹啉作为抗肿瘤剂
公开(公告)号：US07402583B2
公开(公告)日：2008-07-22
申请号：US11374423
申请日：2006-03-14
申请人： Francis Thomas Boyle , Keith Hopkinson Gibson , Kevin Michael Foote
发明人： Francis Thomas Boyle , Keith Hopkinson Gibson , Kevin Michael Foote
IPC分类号： A61K31/4965 , A61K31/47 , C07D401/00
CPC分类号： C07D215/56 , C07D215/54 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention provides a compound of Formula (Ia), or a pharmaceutically acceptable salt thereof, a process for t he preparation of a compound of Formula (1a) and pharmaceutical compositions of a compound of Formula (1a).
摘要翻译：本发明提供式（Ia）化合物或其药学上可接受的盐，制备式（1a）化合物的方法和式（1a）化合物的药物组合物。

6. 发明授权

US07504408B2 Quinzoline derivatives for use in the treatment of cancer 失效
标题翻译：喹唑啉衍生物用于治疗癌症
公开(公告)号：US07504408B2
公开(公告)日：2009-03-17
申请号：US10520266
申请日：2003-07-04
申请人： Laurent Francois Andre Hennequin , Keith Hopkinson Gibson , Kevin Michael Foote
发明人： Laurent Francois Andre Hennequin , Keith Hopkinson Gibson , Kevin Michael Foote
IPC分类号： A61K31/517 , C07D239/88 , C07D239/94 , C07D239/93
CPC分类号： C07D405/12 , C07D405/14
摘要： The invention concerns quinazoline derivatives of Formula (I) wherein each of Z, m, R1, n, R3, Z2 and R14 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease.
摘要翻译：本发明涉及式（I）的喹唑啉衍生物，其中Z，m，R 1，n，R 3，Z 2和R 14中的每一个具有上文在描述中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于在实体瘤疾病的遏制和/或治疗中作为抗侵袭性或抗增殖剂的药物的用途。

7. 发明授权

US07253184B2 4-Substituted quinolines as antitumor agents 失效
标题翻译： 4-取代的喹啉作为抗肿瘤剂
公开(公告)号：US07253184B2
公开(公告)日：2007-08-07
申请号：US10415813
申请日：2001-10-25
申请人： Francis Thomas Boyle , Keith Hopkinson Gibson
发明人： Francis Thomas Boyle , Keith Hopkinson Gibson
IPC分类号： A61K31/4706 , C07D215/42
CPC分类号： C07D215/56 , C07D215/54 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention concerns compounds of formula (I), wherein each of R1, R2, R3, R4, R5, R6, R8, R9, R10 m, n, p, X, Y and Z have any meanings defined in the description, processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-proliferative agent in the treatment of solid tumour disease.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 8，R 9，R 10， SUP，m，n，p，X，Y和Z具有本说明书中定义的任何含义，其制备方法，含有它们的药物组合物及其在制备用于治疗中的抗增殖剂的药物中的用途的实体瘤病。

8. 发明授权

US07067532B2 Substituted quinolines as antitumor agents 失效
标题翻译：取代的喹啉作为抗肿瘤剂
公开(公告)号：US07067532B2
公开(公告)日：2006-06-27
申请号：US10415812
申请日：2001-10-26
申请人： Francis Thomas Boyle , Keith Hopkinson Gibson , Kevin Michael Foote
发明人： Francis Thomas Boyle , Keith Hopkinson Gibson , Kevin Michael Foote
IPC分类号： A61K31/47 , C07D215/38 , C07D413/00 , C07D417/00 , C07D205/08 , C07D401/00 , C07D279/10
CPC分类号： C07D215/56 , C07D215/54 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention provides a compound of Formula (Ia), or a pharmaceutically acceptable salt pro-drug or solvate thereof. The invention also provides a process for the preparation of a compound of Formula (Ia), pharmaceutical compositions of a compound of Formula (Ia) and methods for the treatment or prevention of cancer comprising administering an effective amount of a compound of Formula (Ia).
摘要翻译：本发明提供式（Ia）化合物或其药学上可接受的盐前体药物或其溶剂合物。本发明还提供了制备式（Ia）化合物，式（Ia）化合物的药物组合物和治疗或预防癌症的方法的方法，包括给予有效量的式（Ia）化合物，。

9. 发明授权

US5770603A Quinazoline derivatives 失效
标题翻译：喹唑啉衍生物
公开(公告)号：US5770603A
公开(公告)日：1998-06-23
申请号：US871989
申请日：1997-04-10
申请人： Keith Hopkinson Gibson
发明人： Keith Hopkinson Gibson
IPC分类号： C07D405/12 , A61K31/495 , A61K31/50 , C07D403/02 , C07D403/14
CPC分类号： C07D405/12
摘要： The invention concerns quinazoline derivatives of the formula I ##STR1## wherein n is 1,2 or 3 and each R.sup.2 is independently halogeno, trifluoromethyl or (1-4C)alkyl; R.sup.1 is (1-4C)alkoxy; A is (1-4C)alkylene; and Q is a saturated, monocyclic 4-, 5-, 6- or 7-membered heterocyclic ring containing one or two oxygen heteroatoms, which ring optionally bears up to four (1-4C)alkyl substituents; or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and the use of their receptor tyrosine kinase inhibitory properties in the treatment of proliferative disease such as cancer.
摘要翻译：本发明涉及式I的喹唑啉衍生物，其中n为1,2或3，各R 2独立地为卤代，三氟甲基或（1-4C）烷基; R1是（1-4C）烷氧基; A是（1-4C）亚烷基; 并且Q是含有一个或两个氧杂原子的饱和的单环4-，5-，6-或7-元杂环，其任选地带有多达四个（1-4C）烷基取代基; 或其药学上可接受的盐; 其制备方法，含有它们的药物组合物及其受体酪氨酸激酶抑制性质在治疗增殖性疾病如癌症中的用途。

10. 发明授权

US07504416B2 4-substituted quinolines as antitumor agents 失效
标题翻译： 4-取代喹啉作为抗肿瘤剂
公开(公告)号：US07504416B2
公开(公告)日：2009-03-17
申请号：US11826507
申请日：2007-07-16
申请人： Francis Thomas Boyle , Keith Hopkinson Gibson
发明人： Francis Thomas Boyle , Keith Hopkinson Gibson
IPC分类号： A61K31/4706 , C07D215/42
CPC分类号： C07D215/56 , C07D215/54 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention concerns compounds of formula (I), wherein each of R1, R2, R3, R4, R5, R6, R8, R9, R10 m, n, p, X, Y and Z have any meanings defined in the description, processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-proliferative agent in the treatment of solid tumor disease.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 8，R 9，R 10 m，n，p，X，Y和Z各自具有在说明书中定义的任何含义，用于其制备，含有它们的药物组合物及其在制备用作治疗实体瘤疾病中的抗增殖剂的药物中的用途。

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