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1. 发明授权

US08906666B2 Engineering resistance to aliphatic alcohols 有权
标题翻译：工程抗脂肪醇
公开(公告)号：US08906666B2
公开(公告)日：2014-12-09
申请号：US12994100
申请日：2009-05-22
申请人： Keith Alsaker , Daniel Grenfell-Lee , Michael Hudson , Adam Lawrence , Jessica McGrath , David Young
发明人： Keith Alsaker , Daniel Grenfell-Lee , Michael Hudson , Adam Lawrence , Jessica McGrath , David Young
IPC分类号： C12N1/21 , C12N1/19 , C12P7/16 , C12N1/36 , C12N15/52
CPC分类号： C12P7/16 , C12N1/36 , C12N15/52 , Y02E50/10
摘要： The present disclosure provides improved systems for the biological production of aliphatic alcohol compounds. In particular, the present disclosure provides biological systems that show improved resistance to aliphatic alcohol toxicity; in some embodiments, such improved resistance allows for increased levels of aliphatic alcohol production. In one aspect, the present disclosure provides engineered microorganisms that both produce an aliphatic alcohol compound and show resistance to that compound as measured by an ability to grow to predetermined levels in the presence of a given concentration of the compound.
摘要翻译：本公开提供了用于脂族醇化合物的生物制备的改进的系统。特别地，本公开提供了显示改善的抗脂肪醇毒性的生物系统; 在一些实施方案中，这种改进的抗性允许增加脂族醇生产水平。在一个方面，本公开提供了工程化的微生物，其既产生脂族醇化合物，并且在给定浓度的化合物存在下通过生长至预定水平的能力来测量该化合物的抗性。

2. 发明申请

US20120040440A1 ENGINEERING RESISTANCE TO ALIPHATIC ALCOHOLS 有权
标题翻译：对酸性酒精的工程耐受性
公开(公告)号：US20120040440A1
公开(公告)日：2012-02-16
申请号：US12994100
申请日：2009-05-22
申请人： Keith Alsaker , Daniel Grenfell-Lee , Michael Hudson , Adam Lawrence , Jessica McGrath , David Young
发明人： Keith Alsaker , Daniel Grenfell-Lee , Michael Hudson , Adam Lawrence , Jessica McGrath , David Young
IPC分类号： C12N1/21 , C12N1/19
CPC分类号： C12P7/16 , C12N1/36 , C12N15/52 , Y02E50/10
摘要： The present disclosure provides improved systems for the biological production of aliphatic alcohol compounds. In particular, the present disclosure provides biological systems that show improved resistance to aliphatic alcohol toxicity; in some embodiments, such improved resistance allows for increased levels of aliphatic alcohol production. In one aspect, the present disclosure provides engineered microorganisms that both produce an aliphatic alcohol compound and show resistance to that compound as measured by an ability to grow to predetermined levels in the presence of a given concentration of the compound.
摘要翻译：本公开提供了用于脂族醇化合物的生物制备的改进的系统。特别地，本公开提供了显示改善的抗脂肪醇毒性的生物系统; 在一些实施方案中，这种改进的抗性允许增加脂族醇生产水平。在一个方面，本公开提供了工程化的微生物，其既产生脂族醇化合物，并且在给定浓度的化合物存在下通过生长至预定水平的能力来测量该化合物的抗性。

3. 发明申请

US20120058541A1 ENGINEERING RESISTANCE TO ALIPHATIC ALCOHOLS 审中-公开
标题翻译：对酸性酒精的工程耐受性
公开(公告)号：US20120058541A1
公开(公告)日：2012-03-08
申请号：US13214310
申请日：2011-08-22
申请人： Keith Alsaker , Daniel Grenfell-Lee , Michael Hudson , Adam Lawrence , Jessica McGrath , David Young
发明人： Keith Alsaker , Daniel Grenfell-Lee , Michael Hudson , Adam Lawrence , Jessica McGrath , David Young
IPC分类号： C12N1/21 , C12N1/19
CPC分类号： C12N9/52 , C12P7/16 , Y02E50/10
摘要： The present disclosure provides improved systems for the biological production of certain aliphatic alcohol compounds. In particular, the present disclosure provides biological systems that show improved resistance to aliphatic alcohol toxicity; in sonic embodiments, such improved resistance allows for increased levels of aliphatic alcohol production. Accordingly, the present disclosure provides, inter alia, engineered microorganisms that both produce an aliphatic alcohol compound and show resistance to that compound as measured by an ability to grow to predetermined levels in the presence of a given concentration of the compound.
摘要翻译：本公开提供了用于某些脂族醇化合物的生物制备的改进的系统。特别地，本公开提供了显示改善的抗脂肪醇毒性的生物系统; 在声音实施例中，这种改进的电阻允许增加脂族醇生产的水平。因此，本公开尤其提供了工程化的微生物，它们都产生脂族醇化合物，并且通过在给定浓度的化合物的存在下生长至预定水平的能力来测量该化合物的抗性。

4. 发明授权

US08439153B2 Method and apparatus for a loudspeaker assembly 有权
标题翻译：扬声器组件的方法和装置
公开(公告)号：US08439153B2
公开(公告)日：2013-05-14
申请号：US13564947
申请日：2012-08-02
申请人： Michael Hudson , William C Stewart, Jr. , Larry Frerichs
发明人： Michael Hudson , William C Stewart, Jr. , Larry Frerichs
IPC分类号： H04R1/02
CPC分类号： H04R5/00 , H04R1/02 , H04R1/023 , H04R2201/021 , H04R2201/029 , Y10T29/4957
摘要： The present invention relates to a loudspeaker assembly and a method of assembling a loudspeaker assembly. In one or more embodiments, the invention comprises forming a front baffle comprising a first driver mounting portion, an intermediate portion, and an edge mounting portion. A first driver is installed in the first driver mounting portion proximate to a first driver aperture. A rear baffle is formed from a second material, which, in one or more embodiments, is less stiff than the first material from which the front baffle is formed. The rear baffle comprises a top portion, sidewalls, a recessed mounting portion, and an edge portion. The edge mounting portion of the front baffle is attached to the recessed mounting portion of the rear baffle such that an entirety of said front baffle is recessed within said rear baffle spaced apart from said open bottom portion.
摘要翻译：扬声器组件及组装扬声器组件的方法技术领域本发明涉及扬声器组件和组装扬声器组件的方法。在一个或多个实施例中，本发明包括形成包括第一驱动器安装部分，中间部分和边缘安装部分的前挡板。第一驱动器安装在靠近第一驱动器孔的第一驱动器安装部分中。后挡板由第二材料形成，在一个或多个实施例中，第二材料的硬度比形成前挡板的第一材料硬。后挡板包括顶部，侧壁，凹入的安装部分和边缘部分。前挡板的边缘安装部分附接到后挡板的凹入的安装部分，使得所述前挡板的整体在与所述开口底部间隔开的所述后挡板内凹入。

5. 发明授权

US08286749B2 Ceiling loudspeaker system 有权
标题翻译：吊顶扬声器系统
公开(公告)号：US08286749B2
公开(公告)日：2012-10-16
申请号：US13159801
申请日：2011-06-14
申请人： William Cameron Stewart, Jr. , Michael Hudson , Larry Frerichs , Clinton Strong , Weldon Gammon
发明人： William Cameron Stewart, Jr. , Michael Hudson , Larry Frerichs , Clinton Strong , Weldon Gammon
IPC分类号： H05K5/00
CPC分类号： H04R1/025 , H04R1/2811 , H04R31/006 , H04R2201/021
摘要： The present invention comprises a method and apparatus for installing a tile-mounted ceiling speaker that combines the ease of installation of a lay-in speaker system with the visual appearance of a tile-mounted speaker system. In one or more embodiments, the apparatus of the present invention includes a support frame and back box assembly configured for installation on top of a ceiling tile and a loudspeaker cartridge configured to be mounted to the support frame through an appropriately-sized hole in the ceiling tile. In one or more embodiments, the method of the present invention comprises forming an appropriately-sized hole in a ceiling tile, laying an integrated back box and support frame on top of the ceiling tile, connecting wires from an external audio source to terminals provided at the back box, connecting wires provided on the inside of the back box to a loudspeaker cartridge, inserting the loudspeaker cartridge into the hole in the ceiling tile from below, fastening the loudspeaker cartridge to the support frame, and fastening a grille to the loudspeaker cartridge. In one or more embodiments, a variety of interchangeable loudspeaker cartridges having differing loudspeaker configurations are provided. In one or more embodiments, the support frame and back box assembly is configured to allow installation of more than one loudspeaker cartridge. In one or more embodiments, the loudspeaker cartridges are configured for use both with a back box and without back box.
摘要翻译：本发明包括一种安装瓦片式天花板扬声器的方法和装置，其结合了将内置扬声器系统的安装的容易性与瓦片式扬声器系统的视觉外观。在一个或多个实施例中，本发明的装置包括支撑框架和后箱组件，其被配置为安装在天花板瓦片的顶部上，扬声器盒被构造成通过天花板中适当尺寸的孔安装到支撑框架瓦。在一个或多个实施例中，本发明的方法包括在天花板瓦片中形成适当尺寸的孔，在天花板瓦片的顶部铺设集成的后箱和支撑框架，将外部音频源的导线连接到后箱，将背箱内侧的连接线连接到扬声器盒，将扬声器盒从下方插入天花板瓦片中的孔中，将扬声器盒紧固到支撑框架上，并将格栅固定到扬声器盒。在一个或多个实施例中，提供了具有不同扬声器配置的各种可互换扬声器盒。在一个或多个实施例中，支撑框架和后箱组件被配置为允许安装多于一个扬声器盒。在一个或多个实施例中，扬声器盒配置成与背箱和没有后盒一起使用。

6. 发明授权

US08276706B2 Method and apparatus for a loudspeaker assembly 有权
标题翻译：扬声器组件的方法和装置
公开(公告)号：US08276706B2
公开(公告)日：2012-10-02
申请号：US13023345
申请日：2011-02-08
申请人： Michael Hudson , William C. Stewart, Jr. , Larry Frerichs
发明人： Michael Hudson , William C. Stewart, Jr. , Larry Frerichs
IPC分类号： H04R1/02
CPC分类号： H04R5/00 , H04R1/02 , H04R1/023 , H04R2201/021 , H04R2201/029 , Y10T29/4957
摘要： The present invention relates to a loudspeaker assembly and a method of assembling a loudspeaker assembly, comprising forming a front baffle, a first driver mounting portion, an intermediate portion, and an edge mounting portion. A port aperture formed in the intermediate portion, and a first driver installed in the first driver mounting portion. A rear baffle comprises a top portion, sidewalls, a recessed mounting portion, an edge portion and an electrical assembly. The edge mounting portion of the front baffle is attached to the recessed mounting portion of the rear baffle, and the rear baffle is secured to the back of the first driver. A back box is placed over the rear baffle provides thermal insulation, and a mounting plate securely attaches the first driver to a structural support. A perforated grille is crimped to the edge portion of the rear baffle and an edge portion of the back box.
摘要翻译：本发明涉及扬声器组件和组装扬声器组件的方法，包括形成前挡板，第一驱动器安装部分，中间部分和边缘安装部分。形成在中间部分中的端口孔，以及安装在第一驱动器安装部分中的第一驱动器。后挡板包括顶部，侧壁，凹入的安装部分，边缘部分和电组件。前挡板的边缘安装部分附接到后挡板的凹入安装部分，后挡板固定到第一驱动器的后部。后挡板放置在后挡板上，提供绝热，并且安装板将第一驱动器牢固地附接到结构支撑。多孔格栅被卷曲到后挡板的边缘部分和背箱的边缘部分。

7. 发明申请

US20120186902A1 METHOD AND APPARATUS FOR A LOUDSPEAKER ASSEMBLY 有权
标题翻译：扬声器装配的方法和装置
公开(公告)号：US20120186902A1
公开(公告)日：2012-07-26
申请号：US13355430
申请日：2012-01-20
申请人： William Cameron Stewart, JR. , Andrew C. Edwards , Michael Hudson , Andrew Evans
发明人： William Cameron Stewart, JR. , Andrew C. Edwards , Michael Hudson , Andrew Evans
IPC分类号： H05K5/00
CPC分类号： H04R1/2865 , H04R1/023 , H04R2201/021 , Y10T29/49005
摘要： A loudspeaker assembly is provided. In one or more embodiments the loudspeaker assembly comprises a perforated grille, a three dimensional loudspeaker frame to which a speaker driver is mounted, and a rear baffle. In one or more embodiments, the loudspeaker frame and rear baffle define a controlled volume around the speaker driver. In one or more embodiments the controlled volume comprises a driver cavity and a horn cavity in communication with the driver cavity and a port aperture.
摘要翻译：提供扬声器组件。在一个或多个实施例中，扬声器组件包括穿孔格栅，扬声器驱动器所安装的三维扬声器框架和后挡板。在一个或多个实施例中，扬声器框架和后挡板限定扬声器驱动器周围的受控体积。在一个或多个实施例中，受控体积包括与驱动器腔和端口孔连通的驱动器腔和喇叭腔。

8. 发明授权

US08048952B2 Silicone oil-in-water emulsions formulation, production and use 有权
标题翻译：硅油水包油乳液 - 配方，生产和使用
公开(公告)号：US08048952B2
公开(公告)日：2011-11-01
申请号：US11763609
申请日：2007-06-15
申请人： Neil Wynne , Michael Hudson
发明人： Neil Wynne , Michael Hudson
IPC分类号： C08L83/04
CPC分类号： B01F3/0807 , B01F7/164 , B01F15/065 , B01F2015/061 , C03C17/30 , C09D5/022 , Y10T428/31663
摘要： The present invention provides a stable silicone oil-in-water emulsion substantially free of any additives. The emulsions of the invention can be stable for at least about fifteen (15) and preferably for at least about thirty (30) minutes. The emulsions of the invention are useful for the siliconization of glass container surfaces.
摘要翻译：本发明提供基本上不含任何添加剂的稳定的硅油水包油乳液。本发明的乳液可稳定至少约十五（15），优选至少约三十（30）分钟。本发明的乳液可用于玻璃容器表面的硅化。

9. 发明申请

US20060229777A1 System and methods of performing real-time on-board automotive telemetry analysis and reporting 审中-公开
标题翻译：执行实时车载汽车遥测分析和报告的系统和方法
公开(公告)号：US20060229777A1
公开(公告)日：2006-10-12
申请号：US11401831
申请日：2006-04-11
申请人： Michael Hudson , Kelly McArthur
发明人： Michael Hudson , Kelly McArthur
IPC分类号： G01M17/00
CPC分类号： G07C5/008 , G01M15/05 , G05B23/021 , G06F11/0739 , G07C5/085
摘要： Active diagnosis of current operating and potential fault conditions in the operation of the vehicle is implemented using a diagnostic controller interoperating with an on-board vehicle control system as installed within a vehicle. The diagnostic controller supports autonomous execution of diagnostic tests initiated dependent on the operational state of the vehicle. The control system includes a diagnostics control manager that autonomously selects test routines for execution at defined operational states, including in-service operational states, a monitor, responsive to sensor data retrieved in real-time from the on-board vehicle control system, operative to detect a current instance of the in-service operational state of the vehicle, and a diagnostic test scheduler operative to initiate execution of the diagnostic test routine upon detection of the current instance of the in-service operational state of the vehicle.
摘要翻译：使用与安装在车辆内的车载车辆控制系统互操作的诊断控制器来实现车辆操作中的当前操作和潜在故障状况的主动诊断。诊断控制器支持根据车辆的运行状态启动的诊断测试的自主执行。控制系统包括诊断控制管理器，其自动选择用于在所定义的操作状态（包括在役操作状态）执行的测试例程，响应于从车载车辆控制系统实时检索的传感器数据的监视器，操作到检测车辆的在役操作状态的当前实例，以及诊断测试调度器，用于在检测到车辆的在役操作状态的当前实例时启动诊断测试例程的执行。

10. 发明申请

US20050169943A1 Neisserial vaccine compositions and methods 审中-公开
标题翻译：奈瑟氏球菌疫苗组合物和方法
公开(公告)号：US20050169943A1
公开(公告)日：2005-08-04
申请号：US11056199
申请日：2005-02-14
申请人： Andrew Robinson , Andrew Gorringe , Michael Hudson , Philippa Bracegirdle , John Kroll , Paul Langford , Steven Webb , Keith Cartwright , Cliona O'Dwyer
发明人： Andrew Robinson , Andrew Gorringe , Michael Hudson , Philippa Bracegirdle , John Kroll , Paul Langford , Steven Webb , Keith Cartwright , Cliona O'Dwyer
IPC分类号： A61K39/095 , A61K39/165 , A61P31/04 , C07K14/22 , C12N1/21 , C12N15/31
CPC分类号： A61K39/165 , A61K39/095 , A61K39/12 , A61K2039/505 , A61K2039/521 , A61K2039/523 , C07K14/22 , Y10S530/825
摘要： Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria. Further methods and compositions comprise commensal Neisseria which express genes from virulent strains of Neisseria and/or heterologous gene products from non-Neisserial sources. Such compositions are used in vaccine preparations for the treatment of microbial infection.
摘要翻译：用于治疗微生物感染，特别是脑膜炎球菌疾病的方法和组合物包含共生奈瑟氏球菌或共生的奈瑟氏球菌的提取物。其他方法和组合物包含共表达的奈瑟氏球菌，其表达来自奈奈瑟氏球菌的毒性菌株的基因和/或来自非奈瑟氏菌来源的异源基因产物。这种组合物用于治疗微生物感染的疫苗制剂中。

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