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1. 发明申请

US20060172413A1 Transgenic mice containing melanocyte stimulating hormone receptor gene disruptions 审中-公开
公开(公告)号：US20060172413A1
公开(公告)日：2006-08-03
申请号：US11376438
申请日：2006-03-14
申请人： Keith Allen , William Matthews , Mark Moore , Russell Phillips
发明人： Keith Allen , William Matthews , Mark Moore , Russell Phillips
IPC分类号： C12N15/63
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K14/705 , C07K14/70567 , C07K14/7158 , C07K14/72 , C07K14/723 , C12N9/13 , C12N9/16 , C12N2800/30
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in melanocyte stimulating hormone receptor genes. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

2. 发明申请

US20060174361A1 Transgenic mice containing adrenocorticotropin hormone receptor gene disruptions 审中-公开
公开(公告)号：US20060174361A1
公开(公告)日：2006-08-03
申请号：US11400159
申请日：2006-04-06
申请人： Keith Allen , William Matthews , Mark Moore
发明人： Keith Allen , William Matthews , Mark Moore
IPC分类号： A01K67/027 , C12N15/63
CPC分类号： A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , A01K2267/0393 , A61K38/00 , C07K14/72 , C12N15/8509 , C12N2800/30
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an ACTHR gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

3. 发明授权

US06909031B2 Transgenic mice containing glucagon receptor gene disruptions 失效
标题翻译：含有胰高血糖素受体基因破坏的转基因小鼠
公开(公告)号：US06909031B2
公开(公告)日：2005-06-21
申请号：US10010065
申请日：2001-12-05
申请人： Keith D. Allen , Mark Moore , William Matthews
发明人： Keith D. Allen , Mark Moore , William Matthews
IPC分类号： A61K38/00 , C07K14/705 , C12N15/85 , A01K67/027 , C12N5/00 , C12N5/02 , C12N5/06 , C12N15/00
CPC分类号： C07K14/705 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0362 , A01K2267/0393 , A61K38/00 , C12N15/8509 , C12N2800/30
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a glucagon receptor gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions. The present invention also relates to diabetes and diabetic condition, as it demonstrates the role of the glucagon receptor in diabetes and diabetic conditions. The present invention further relates to weight gain and weight related conditions, such as obesity, and demonstrates the role of the glucagon receptor in weight gain and weight related conditions, such as obesity. In accordance with these aspects, the present invention provides methods and compositions useful in identifying, testing, and providing treatments for diabetes and diabetic conditions, weight gain and weight related conditions such as obesity.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供包含胰高血糖素受体基因突变的转基因小鼠。这样的转基因小鼠可用作疾病的模型并用于鉴定调节基因表达和基因功能的试剂，以及作为各种疾病状态和疾病状况的潜在治疗。本发明还涉及糖尿病和糖尿病病症，因为它证明了胰高血糖素受体在糖尿病和糖尿病病症中的作用。本发明进一步涉及体重增加和体重相关的条件，例如肥胖，并且证明了胰高血糖素受体在体重增加和体重相关条件如肥胖中的作用。根据这些方面，本发明提供了可用于鉴定，测试和提供糖尿病和糖尿病状况的治疗方法和组合物，体重增加和体重相关条件如肥胖症。

4. 发明申请

US20060075512A1 Transgenic mice containing PAFR gene disruptions 审中-公开
公开(公告)号：US20060075512A1
公开(公告)日：2006-04-06
申请号：US11284710
申请日：2005-11-21
申请人： Thomas Brennan , William Matthews , Mark Moore
发明人： Thomas Brennan , William Matthews , Mark Moore
IPC分类号： A01K67/027 , C12N5/06
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C12N2800/30
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a platelet-activating factor receptor gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

5. 发明申请

US20070074299A1 Transgenic Mice Containing GPCR5-1 Gene Disruptions 审中-公开
标题翻译：含有GPCR5-1基因中断的转基因小鼠
公开(公告)号：US20070074299A1
公开(公告)日：2007-03-29
申请号：US11463266
申请日：2006-08-08
申请人： Thomas Brennan , William Matthews , Mark Moore
发明人： Thomas Brennan , William Matthews , Mark Moore
IPC分类号： A01K67/027 , C12N5/06 , C12N15/09
CPC分类号： A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C12N15/8509 , C12N2800/30
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a GPCR5-1 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供了包含GPCR5-1基因突变的转基因小鼠。这样的转基因小鼠可用作疾病的模型并用于鉴定调节基因表达和基因功能的试剂，以及作为各种疾病状态和疾病状况的潜在治疗。

6. 发明申请

US20060143724A1 Transgenic mice containing anaphylatoxin C3a gene disruptions 审中-公开
公开(公告)号：US20060143724A1
公开(公告)日：2006-06-29
申请号：US11363579
申请日：2006-02-27
申请人： Thomas Brennan , William Matthews , Mark Moore
发明人： Thomas Brennan , William Matthews , Mark Moore
IPC分类号： A01K67/027 , C12N15/87
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K14/705 , C12N2800/30 , G01N33/564 , G01N2333/4716 , G01N2500/00
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an anaphylatoxin C3a receptor gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

7. 发明申请

US20060156426A1 Transgenic mice containing ABC transporter-like ATPase gene disruptions 审中-公开
标题翻译：含ABC转运蛋白的ATPase基因破坏的转基因小鼠
公开(公告)号：US20060156426A1
公开(公告)日：2006-07-13
申请号：US11369694
申请日：2006-03-06
申请人： Keith Allen , Mark Moore
发明人： Keith Allen , Mark Moore
IPC分类号： A01K67/027
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an ABC transporter-like ATPase gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供了包含ABC转运蛋白样ATP酶基因突变的转基因小鼠。这样的转基因小鼠可用作疾病的模型并用于鉴定调节基因表达和基因功能的试剂，以及作为各种疾病状态和疾病状况的潜在治疗。

8. 发明申请

US20060143722A1 OGR1 gene disruptions, compositions and methods relating thereto 审中-公开
公开(公告)号：US20060143722A1
公开(公告)日：2006-06-29
申请号：US11360239
申请日：2006-02-22
申请人： Thomas Brennan , William Matthews , Mark Moore
发明人： Thomas Brennan , William Matthews , Mark Moore
IPC分类号： A01K67/027
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0356 , A01K2267/0393 , C12N2800/30
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an OGR1 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

9. 发明申请

US20060185028A1 Transgenic mice containing SOCS-5 cytokine signalling suppressor gene disruptions 审中-公开
公开(公告)号：US20060185028A1
公开(公告)日：2006-08-17
申请号：US11366316
申请日：2006-03-02
申请人： Keith Allen , Mark Moore , Qin Zhang , Christopher Kirk
发明人： Keith Allen , Mark Moore , Qin Zhang , Christopher Kirk
IPC分类号： A01K67/027
CPC分类号： A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0356 , A01K2267/0393 , C07K14/4703 , C07K14/715 , C12N15/8509 , C12N2800/30
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a SOCS-5 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

10. 发明申请

US20070233199A1 Communicating Medical Event Information 审中-公开
标题翻译：沟通医疗事件信息
公开(公告)号：US20070233199A1
公开(公告)日：2007-10-04
申请号：US11758533
申请日：2007-06-05
申请人： Mark Moore , Ward Silver
发明人： Mark Moore , Ward Silver
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61B5/002 , G06F19/3418 , G06F19/3481 , G16H40/63 , Y10S128/903
摘要： In general, the invention provides techniques for wireless communication of medical event information between medical devices that treat a particular patient. In general, medical event information describes the condition and treatment of a patient. A medical device may detect another medical device via a wireless communications medium, and establish a local wireless communication session the other device in order to receive medical event information stored by the other device for a patient. The wireless communications medium may be a radio frequency communications medium, and the medical devices may establish a local wireless communication session according to any of a number of local wireless data communication standards. The medical event information received from the other medical device may be used to select a therapy, or to generate a report or patient chart detailing the condition and treatment of the patient.
摘要翻译：通常，本发明提供了用于在治疗特定患者的医疗装置之间进行医疗事件信息的无线通信的技术。一般来说，医疗事件信息描述患者的状况和治疗。医疗设备可以经由无线通信介质检测另一医疗设备，并且建立另一设备的本地无线通信会话，以便接收另一设备为患者存储的医疗事件信息。无线通信介质可以是射频通信介质，并且医疗设备可以根据多个本地无线数据通信标准中的任何一个建立本地无线通信会话。从其他医疗装置接收到的医疗事件信息可以用于选择治疗，或者生成详细描述病人的状况和治疗的报告或患者图。

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