专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5258324A Megakaryocyte colony stimulating factor and process for its preparation 失效
标题翻译：巨核细胞集落刺激因子及其制备方法
公开(公告)号：US5258324A
公开(公告)日：1993-11-02
申请号：US668493
申请日：1991-03-20
申请人： Keita Matsunaga , Shinichiro Kuriya , Kiyoyuki Ogata , Hiroyuki Hamaguchi , Chuhei Nojiri , Osamu Makabe , Takeo Nomura , Kozo Nagaoka
发明人： Keita Matsunaga , Shinichiro Kuriya , Kiyoyuki Ogata , Hiroyuki Hamaguchi , Chuhei Nojiri , Osamu Makabe , Takeo Nomura , Kozo Nagaoka
IPC分类号： A61K38/00 , C07K14/53 , C12N5/08 , C12P21/02 , A01N37/18 , A61K37/00 , C07K3/00
CPC分类号： C07K14/53 , A61K38/00
摘要： A novel megakaryocyte colony stimulating factor has been isolated from the supernatant of the culture obtained by cultivating a cell strain of a human large cell lung cancer. When the factor is applied to human or murine bone-marrow cells in vitro, it forms a megakaryocyte colony. Also, the factor increases the number of platelets in peripheral blood in vivo.
摘要翻译： PCT No.PCT / JP89 / 00960 Sec。 371日期1991年3月20日 102（e）1991年3月20日PCT PCT 1989年9月21日PCT公布。第WO90 / 03397号公报 1990年04月5日。从通过培养人大细胞肺癌的细胞株获得的培养物的上清液中分离出新的巨核细胞集落刺激因子。当该因子在体外应用于人或鼠骨髓细胞时，其形成巨核细胞集落。此外，该因子增加了体外外周血中的血小板数量。

2. 发明授权

US5043142A Alpha-hydroperoxyisopropylphenyl compounds and process for preparing the same 失效
标题翻译： α-氢过氧异丙基苯基化合物及其制备方法
公开(公告)号：US5043142A
公开(公告)日：1991-08-27
申请号：US350707
申请日：1989-11-17
申请人： Syuji Ichikawa , Katsuya Fujii , Takeo Nomura
发明人： Syuji Ichikawa , Katsuya Fujii , Takeo Nomura
IPC分类号： C07C205/34 , C07C409/08 , C07C409/40 , C07C409/42 , C12Q1/28
CPC分类号： C07C205/34 , C07C409/08 , C07C409/40 , C07C409/42 , C12Q1/28 , Y10S436/904 , Y10T436/206664
摘要： .alpha.-Hydroperoxyisopropylphenyl compounds are useful as an organic hydroxyperoxide content in test compositions for the measurement of peroxide-active substances and are effectively utilized for detecting peroxide-active substances such as blood or hemoglobin (occult blood).Test devices for the detection of occult blood are constituted of a carrier in which organic hydroperoxide, coloration indicator, buffering agent, wetting agent, activating agent and stabilizer are impregnated. If hemoglobin is present in a specimen, the organic hydroperoxide is activated to produce nascent oxygen with which the indicator is oxidized and develops color. Although 2,5-dimethylhexane-2,5-dihydroperoxide and cumene hydroperoxide have been employed as the organic hydroperoxide, they are disadvantageous in remarkable reduction of the detective sensitivity due to lack of the stability with elapse of time, pseudonegative judgement when vitamin C is contained in urine specimen, reduction of capacity in the multi-item test pieces for the detection of urinary components caused by discoloration of the adjacent test pieces, low coloration sensitivity, etc.The compounds of the present invention are improved in the above-mentioned defects.As typical examples of the .alpha.-hydroperoxy-isopropylphenyl compounds according to the invention are mentioned 4-(2,4,7-trioxaoctyl) cumene hydroperoxide, 4-(.alpha.-operoxyisopropyl)benzyl benzyl ether, 4-octyl cumene -hydroperoxyisopropyl)benzyl benzyl ether, 4-octyl cumene hydroperoxide, bis[4-(.alpha.-hydroperoxyisopropyl)benzyl]ether, N,N-dimethyl-]4-(.alpha.-hydroperoxyisopropyl)benzene]-sulfoamide and the like.
摘要翻译： PCT No.PCT / JP87 / 00831 Sec。 371日期：一九八九年十一月十七日 102（e）日期：1989年11月17日PCT提交1987年10月29日PCT公布。出版物WO88 / 03134 日期：1988年5月5日.α-过氧异丙基苯基化合物可用作测试组合物中有机羟基过氧化物含量，用于测量过氧化物活性物质，并有效用于检测过氧化物活性物质如血液或血红蛋白（潜血）。用于检测隐血的测试装置由浸渍有机氢过氧化物，着色指示剂，缓冲剂，润湿剂，活化剂和稳定剂的载体构成。如果血红蛋白存在于样品中，有机氢过氧化物被活化以产生新生氧，指示剂被氧化并显色。虽然已经使用了2,5-二甲基己烷-2,5-二氢过氧化物和氢过氧化枯烯作为有机氢过氧化物，但由于缺乏稳定性随着时间的推移，检测灵敏度显着降低是不利的，当维生素C为尿样中含有的尿液成分的检出量降低，相邻试验片变色引起的尿成分检测能力降低，着色敏感性差等。本发明的化合物在上述缺陷中得到改善。根据本发明的α-氢过氧基 - 异丙基苯基化合物的典型实例是4-（2,4,7-三氧代辛基）氢过氧化异丙苯，4-（α-过氧异丙基）苄基苄基醚，4-辛基异丙基氢过氧异丙基）苄基苄基醚，4-辛基氢过氧化枯烯，双[4-（α-氢过氧异丙基）苄基]醚，N，N-二甲基 - ] 4-（α-氢过氧异丙基）苯] - 磺酰胺等。

3. 发明授权

US4536496A Polysaccharides N9GI, their preparation and therapeutic compositions containing them 失效
标题翻译：多糖N9GI，它们的制备和含有它们的治疗组合物
公开(公告)号：US4536496A
公开(公告)日：1985-08-20
申请号：US466553
申请日：1983-02-15
申请人： Masaki Shimizu , Takeo Nomura
发明人： Masaki Shimizu , Takeo Nomura
IPC分类号： A61K31/715 , C08B37/00 , C07H1/00
CPC分类号： A61K31/715 , C08B37/00
摘要： A hot-water extract of the bark of Melia azadirachta L. is treated with a gel filtrating agent with a fractionation range molecular weight from 1.times.10.sup.3 -1.times.10.sup.5 to 1.times.10.sup.3 -1.5.times.10.sup.5. There is obtained polysaccharide N9GI from the first fraction of the three divided polysaccharide fractions. Polysaccharide N9GI further treated with a gel-filtrating agent with a fractionation range molecular weight from 1.times.10.sup.3 -2.times.10.sup.5 to 1.times.10.sup.3 -8.times.10.sup.5. There are obtained polysaccharide N9GIa and polysaccharide N9GIb respectively from the first and second fractions of the two divided polysaccharide fractions.
摘要翻译： Melia azadirachta L.的树皮的热水提取物用分子量分数为1×10 3 -1×10 5至1×10 3 -1.5×10 5的凝胶过滤剂处理。从三个分离的多糖部分的第一部分获得多糖N9GI。多糖N9GI用分子量分数为1×10 3 -2×10 5〜1×10 3〜8×10 5的凝胶过滤剂进一步处理。分别从两种分离的多糖级分的第一和第二级分获得多糖N9GIa和多糖N9GIb。

4. 发明授权

US4515785A Neem bark extracts 失效
标题翻译：楝树皮提取物
公开(公告)号：US4515785A
公开(公告)日：1985-05-07
申请号：US531591
申请日：1983-09-13
申请人： Masaki Shimizu , Tadashi Sudo , Takeo Nomura
发明人： Masaki Shimizu , Tadashi Sudo , Takeo Nomura
IPC分类号： A61K36/00 , A61K36/58 , F16J15/18 , A61K35/78
CPC分类号： A61K36/58
摘要： Neem bark extracts produced by pre-treating the bark of neem with an organic solvent having a dielectric constant of 10 or lower, for example, benzene or ethyl acetate and subjecting the residue obtained by the pre-treatment to extraction with a hydrophilic organic solvent having a dielectric constant from 15 to 35, for example, methanol or ethanol and recovering the neem bark extracts from the hydrophilic organic extraction solvent.
摘要翻译：通过用介电常数为10以下的有机溶剂例如苯或乙酸乙酯预处理楝树皮产生的楝树皮提取物，并将经预处理得到的残余物用亲水性有机溶剂萃取，所述亲水性有机溶剂具有介电常数为15至35，例如甲醇或乙醇，并从亲水性有机萃取溶剂回收楝树皮提取物。

5. 发明授权

US4537774A Hot-water extracts of neem bark 失效
标题翻译：楝树皮热水提取物
公开(公告)号：US4537774A
公开(公告)日：1985-08-27
申请号：US541479
申请日：1983-10-13
申请人： Masaki Shimizu , Tadashi Sudo , Takeo Nomura
发明人： Masaki Shimizu , Tadashi Sudo , Takeo Nomura
IPC分类号： A61K36/00 , A61K36/58 , A61K35/78
CPC分类号： A61K36/58
摘要： Hot-water extracts of the neem bark produced by treating the bark of neem with water at a temperature from 0.degree. to 40.degree. C. and subjecting the residue from said pre-extraction treatment to extraction treatment with hot water. Purification of the extract thus produced by means of alcohol precipitation or dialysis gives products of a higher purity. Moreover, treatments prior to the pre-extraction treatment with water at 0.degree.-40.degree. C. with a non-polar organic solvent having a dielectric constant of 10 or lower and a polar organic solvent having a dielectric constant from 15 to 35 yields neem extracts of a further higher purity. The hot-water extracts of the neem bark according to the present invention possess activity against mouse L-5178Y cells and transplanted sarcoma 180 tumors.
摘要翻译：通过在0℃至40℃的温度下用水处理楝树皮产生的楝树皮的热水提取物，并将来自所述预萃取处理的残余物用热水进行提取处理。通过醇沉淀或透析纯化由此产生的提取物，产生更高纯度的产物。此外，在用0至-40℃的水用介电常数为10或更低的非极性有机溶剂和介电常数为15至35的极性有机溶剂进行预萃取处理之前的处理产生neem 提取物具有更高的纯度。根据本发明的楝树皮的热水提取物具有针对小鼠L-5178Y细胞和移植肉瘤180肿瘤的活性。

6. 发明授权

US4355111A Microorganism culturing device 失效
标题翻译：微生物培养装置
公开(公告)号：US4355111A
公开(公告)日：1982-10-19
申请号：US153919
申请日：1980-05-28
申请人： Masaki Shimizu , Takeo Nomura
发明人： Masaki Shimizu , Takeo Nomura
IPC分类号： B01L3/14 , C12M1/24 , C12N1/00
CPC分类号： C12M23/08 , B01L3/50825 , C12M23/38 , Y10S435/801
摘要： A device for culturing microorganisms includes a vessel having a mouth for containing a culture medium and a stopper member for hermetically sealing the vessel. The stopper member is provided with a through hole on its peripheral wall for communicating with the inner atmosphere of said vessel.
摘要翻译：用于培养微生物的装置包括具有用于容纳培养基的口的容器和用于气密密封容器的止挡构件。止动构件在其周壁上设置有与所述容器的内部气氛连通的通孔。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式