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1. 发明申请

US20060008841A1 Aptamer capable of specifically adsorbing to verotoxin-1 and method for obtaining the aptamer 审中-公开
标题翻译：能够特异性吸附到verotoxin-1的适体和获得适体的方法
公开(公告)号：US20060008841A1
公开(公告)日：2006-01-12
申请号：US11224268
申请日：2005-09-12
申请人： Keisaku Okada , Shuji Senda , Akio Kobayashi , Eiichiro Fukusaki , Takeshi Honda , Itaru Yanagihara , Tsuyoshi Nakanishi
发明人： Keisaku Okada , Shuji Senda , Akio Kobayashi , Eiichiro Fukusaki , Takeshi Honda , Itaru Yanagihara , Tsuyoshi Nakanishi
IPC分类号： C12Q1/68
CPC分类号： C12N15/115
摘要： The present invention provides a method for obtaining an aptamer capable of specifically adsorbing to Verotoxin-1 produced by Enterohemorrhagic Escherichia coli by an in vitro selection method utilizing affinity chromatography, particularly, a method including use of an affinity column immobilizing thereon a peptide having an amino acid sequence of Verotoxin-1, for the affinity chromatography, and a single strand nucleic acid molecule, which is an aptamer capable of specifically adsorbing to Verotoxin-1.
摘要翻译：本发明提供了一种获得能够通过使用亲和层析的体外选择方法特异性吸收由肠出血性大肠杆菌产生的Verotoxin-1的适体的方法，特别是包括使用固定在其上的亲和柱的方法， Verotoxin-1的酸序列用于亲和层析，以及单链核酸分子，其是能够特异性吸附到Verotoxin-1的适体。

2. 发明申请

US20050282226A1 Aptamer capable of specifically adsorbing to bisphenol a and method for obtaining the aptamer 审中-公开
标题翻译：能够特异性吸附到双酚A的适配体和获得适体的方法
公开(公告)号：US20050282226A1
公开(公告)日：2005-12-22
申请号：US11214437
申请日：2005-08-29
申请人： Keisaku Okada , Shuji Senda , Akio Kobayashi , Eiichiro Fukusaki , Itaru Yanagihara , Tsuyoshi Nakanishi
发明人： Keisaku Okada , Shuji Senda , Akio Kobayashi , Eiichiro Fukusaki , Itaru Yanagihara , Tsuyoshi Nakanishi
IPC分类号： C12Q1/68 , C12Q1/6811 , C07H21/04
CPC分类号： C12Q1/6811
摘要： The present invention provides an aptamer capable of specifically adsorbing to bisphenol A suspected to be an endocrine disrupter as a target molecule, a method for obtaining an aptamer capable of specifically adsorbing to bisphenol A by an in vitro selection method utilizing affinity chromatography using a carrier immobilizing bisphenol A, particularly, a method including use of an antagonistic elution buffer containing an amphiprotic organic solvent for elution by the affinity chromatography, and a single-strand nucleic acid molecule which is an aptamer obtained thereby.
摘要翻译：本发明提供了能够特异性吸附到怀疑是作为内分泌干扰物的双酚A作为靶分子的适体，获得能够通过使用载体固定的亲和层析的体外选择方法获得能够特异性吸附到双酚A的适体的方法双酚A，特别是包括使用含有两亲性有机溶剂的拮抗性洗脱缓冲液用于通过亲和色谱法洗脱的方法和由其获得的适体的单链核酸分子。

3. 发明授权

US06391652B2 Immunoassay method and immunoassay kit 失效
标题翻译：免疫测定法和免疫测定试剂盒
公开(公告)号：US06391652B2
公开(公告)日：2002-05-21
申请号：US09120192
申请日：1998-07-22
申请人： Keisaku Okada , Kenjiro Mori , Shuji Senda
发明人： Keisaku Okada , Kenjiro Mori , Shuji Senda
IPC分类号： G01N3353
CPC分类号： G01N33/558 , Y10S436/81
摘要： An immunoassay method comprising bringing an immobilized phase comprising, at different positions on a water-absorbable base material, at least two first immunity substances capable of specifically binding with at least two kinds of assay target substances selected from the group consisting of verotoxin-producing Escherichia coli, verotoxin and human hemoglobin contained in a test sample, into contact with a test sample and a liquid containing labeled immunity substances each comprising a second immunity substance that is labeled with colored particles and capable of binding with said assay target substance, thereby to form an assay target substance-labeled immunity substance complex and to bind said complex with respective first immunity substances at the immobilized phase. The immunoassay method, the immunoassay device and the immunoassay kit of the present invention enable easy and simultaneous analysis of O157 (VTEC), VT and Hb in a test sample, by adsorption of the assay target substances on an immobilized phase and evaluation of the developed color.
摘要翻译：一种免疫测定方法，其特征在于，使含有能够吸水性基材的不同位置的固定相含有至少两种能够与选自产生毒力素的大肠杆菌的至少两种检测对象物质特异性结合的第一免疫物质包含在测试样品中的大肠杆菌，藜芦毒素和人血红蛋白与测试样品和含有标记免疫物质的液体接触，每个液体包含用有色颗粒标记并能够与所述测定目标物质结合的第二免疫物质，从而形成测定目标物质标记的免疫物质复合物，并在固定化阶段将所述复合物与各自的第一免疫物质结合。本发明的免疫测定方法，免疫测定装置和免疫测定试剂盒能够容易地并同时分析试验样品中的O157（VTEC），VT和Hb，通过将测定目标物质吸附在固定相上，颜色。

4. 发明授权

US06753190B1 Immunologic test method and immunologic test kit 失效
标题翻译：免疫试验方法和免疫试剂盒
公开(公告)号：US06753190B1
公开(公告)日：2004-06-22
申请号：US09486640
申请日：2000-02-29
申请人： Keisaku Okada , Takeshi Saika , Shuji Senda , Kenjiro Mori , Ken Sato
发明人： Keisaku Okada , Takeshi Saika , Shuji Senda , Kenjiro Mori , Ken Sato
IPC分类号： G01N35533
CPC分类号： G01N33/558 , G01N33/543 , G01N33/54306 , Y10S436/808
摘要： The present invention relates to an immunological detection method capable of performing detection of an analyte in a test sample, and a kit used therefor. There is provided an immunological detection method for detecting an analyte by using a water-absorbent substrate in which a capture region is positioned in a given region on a surface thereof, the capture region being immobilized with a first immunochemical component capable of specifically binding to the analyte, wherein the detection signal is amplified and a kit used therefor.
摘要翻译：本发明涉及能够检测测试样品中的分析物的免疫检测方法及其用途。提供了一种用于通过使用捕获区域位于其表面上的给定区域中的吸水性基底来检测分析物的免疫学检测方法，所述捕获区域被固定有能够特异性结合至所述捕获区域的第一免疫化学成分分析物，其中检测信号被扩增和用于其的试剂盒。

5. 发明授权

US07442682B2 Transepithelial delivery of peptides with incretin hormone activities 有权
标题翻译：多肽与肠上皮素激素活性的上皮递送
公开(公告)号：US07442682B2
公开(公告)日：2008-10-28
申请号：US11219145
申请日：2005-09-02
申请人： Chieko Kitaura , Kenjiro Minomi , Katsuyuki Okubo , Keisaku Okada , Natsuko Kagehisa , Masashi Kamiyama , Zheng Hou , Jian Liu , Yucheng Song , Lei Yu
发明人： Chieko Kitaura , Kenjiro Minomi , Katsuyuki Okubo , Keisaku Okada , Natsuko Kagehisa , Masashi Kamiyama , Zheng Hou , Jian Liu , Yucheng Song , Lei Yu
IPC分类号： A61K9/00 , A61K9/06 , A61K38/22 , A61K38/28 , A61K47/42 , C07K14/00
CPC分类号： C07K14/605 , A61K9/0014 , A61K38/00 , A61K47/62 , A61K47/645 , C07K14/57563
摘要： Compositions and methods are disclosed for the treatment of diabetes and related diseases using peptides with incretin hormone activity. Preferably, the peptide with incretin hormone activity is GLP-1, exendin or an analog of GLP-1 or exendin. The peptides with incretin hormone activity are administered transepithelially using a transepithelial carrier peptide. The transepithelial peptide contains sufficient amino, guanidine or amidino groups to stimulate transepithelial delivery. In some embodiments, the transepithelial carrier and the peptide with incretin hormone activity are embedded in a pressure sensitive adhesive layer of a plaster or patch.
摘要翻译：公开了使用具有肠降血糖素激素活性的肽治疗糖尿病和相关疾病的组合物和方法。优选地，具有肠降血糖素激素活性的肽是GLP-1，毒蜥外泌肽或GLP-1或毒蜥外泌肽类似物。具有肠过氧化物激素活性的肽通过经上皮载体肽经由上皮下给药。跨上皮肽含有足够的氨基，胍或脒基以刺激跨上皮递送。在一些实施方案中，将经上皮载体和具有肠降血糖素激素活性的肽嵌入石膏或贴片的压敏粘合剂层中。

6. 发明授权

US08808879B2 Phototherapy devices and methods comprising substituted carbazole compounds 有权
标题翻译：光疗装置和方法包括取代的咔唑化合物
公开(公告)号：US08808879B2
公开(公告)日：2014-08-19
申请号：US13183981
申请日：2011-07-15
申请人： Amane Mochizuki , Sazzadur Rahman Khan , Shijun Zheng , Keisaku Okada
发明人： Amane Mochizuki , Sazzadur Rahman Khan , Shijun Zheng , Keisaku Okada
IPC分类号： H01L51/54
CPC分类号： A61N5/062 , A61N2005/0653 , C07D403/14 , H01L51/0072 , H01L51/0085 , H01L51/5016
摘要： Methods and devices related to the treatment of diseases using phototherapy are described. Some embodiments provide an organic light-emitting diode device, such as a light-emitting device for phototherapy, comprising a compound of Formula 1. Methods of treating disease diseases with phototherapy are also described.
摘要翻译：描述了使用光疗治疗疾病的方法和装置。一些实施方案提供有机发光二极管装置，例如用于光疗的发光装置，其包含式1的化合物。还描述了用光疗法治疗疾病疾病的方法。

7. 发明申请

US20120016449A1 PHOTOTHERAPY DEVICES AND METHODS COMPRISING SUBSTITUTED CARBAZOLE COMPOUNDS 有权
标题翻译：包含取代的羧甲基化合物的照相装置和方法
公开(公告)号：US20120016449A1
公开(公告)日：2012-01-19
申请号：US13183981
申请日：2011-07-15
申请人： Amane Mochizuki , Sazzadur Rahman Khan , Shijun Zheng , Keisaku Okada
发明人： Amane Mochizuki , Sazzadur Rahman Khan , Shijun Zheng , Keisaku Okada
IPC分类号： A61N5/06 , C07D413/10 , C07D403/10 , C07D403/14 , C07D413/14
CPC分类号： A61N5/062 , A61N2005/0653 , C07D403/14 , H01L51/0072 , H01L51/0085 , H01L51/5016
摘要： Methods and devices related to the treatment of diseases using phototherapy are described. Some embodiments provide an organic light-emitting diode device, such as a light-emitting device for phototherapy, comprising a compound of Formula 1. Methods of treating disease diseases with phototherapy are also described.
摘要翻译：描述了使用光疗治疗疾病的方法和装置。一些实施方案提供有机发光二极管装置，例如用于光疗的发光装置，其包含式1的化合物。还描述了用光疗法治疗疾病疾病的方法。

8. 发明申请

US20120015998A1 PHOTOTHERAPY METHODS AND DEVICES COMPRISING EMISSIVE ARYL-HETEROARYL COMPOUNDS 审中-公开
标题翻译：曝光方法和包含发射性芳香族化合物的装置
公开(公告)号：US20120015998A1
公开(公告)日：2012-01-19
申请号：US13179826
申请日：2011-07-11
申请人： Amane Mochizuki , Sazzadur Rahman Khan , Sheng Li , Shijun Zheng , Jensen Cayas , Keisaku Okada , Brett T. Harding
发明人： Amane Mochizuki , Sazzadur Rahman Khan , Sheng Li , Shijun Zheng , Jensen Cayas , Keisaku Okada , Brett T. Harding
IPC分类号： A61K31/409 , C07D403/12 , C07D263/57 , A61K31/221 , A61K31/197 , A61P33/02 , A61P17/00 , A61P35/00 , A61P27/02 , A61P29/00 , A61P3/04 , A61P9/00 , C07D235/18 , A61P31/00
CPC分类号： C09K11/06 , A61N5/0613 , A61N2005/0653 , H01L51/0059 , H01L51/0078 , H01L51/0089 , H01L51/5012 , H05B33/20
摘要： Disclosed herein are compounds represented by a formula: R1—Ar1—X—Ar2—Ar3-Het, wherein R1, Ar1, X, Ar2, Ar3, and Het are described herein. Compositions and light-emitting devices related thereto are also disclosed.
摘要翻译：本文公开的是由下式表示的化合物：R1-Ar1-X-Ar2-Ar3-Het，其中R1，Ar1，X，Ar2，Ar3和Het如本文所述。还公开了与其相关的组合物和发光器件。

9. 发明申请

US20060084604A1 Transepithelial delivery of peptides with incretin hormone activities 有权
标题翻译：多肽与肠上皮素激素活性的上皮递送
公开(公告)号：US20060084604A1
公开(公告)日：2006-04-20
申请号：US11219145
申请日：2005-09-02
申请人： Chieko Kitaura , Kenjiro Minomi , Katsuyuki Okubo , Keisaku Okada , Natsuko Kagehisa , Masashi Kamiyama , Zheng Hou , Jian Liu , Yucheng Song , Lei Yu
发明人： Chieko Kitaura , Kenjiro Minomi , Katsuyuki Okubo , Keisaku Okada , Natsuko Kagehisa , Masashi Kamiyama , Zheng Hou , Jian Liu , Yucheng Song , Lei Yu
IPC分类号： A61K38/22
CPC分类号： C07K14/605 , A61K9/0014 , A61K38/00 , A61K47/62 , A61K47/645 , C07K14/57563
摘要： Compositions and methods are disclosed for the treatment of diabetes and related diseases using peptides with incretin hormone activity. Preferably, the peptide with incretin hormone activity is GLP-1, exendin or an analog of GLP-1 or exendin. The peptides with incretin hormone activity are administered transepithelially using a transepithelial carrier peptide. The transepithelial peptide contains sufficient amino, guanidine or amidino groups to stimulate transepithelial delivery. In some embodiments, the transepithelial carrier and the peptide with incretin hormone activity are embedded in a pressure sensitive adhesive layer of a plaster or patch.
摘要翻译：公开了使用具有肠降血糖素激素活性的肽治疗糖尿病和相关疾病的组合物和方法。优选地，具有肠降血糖素激素活性的肽是GLP-1，毒蜥外泌肽或GLP-1或毒蜥外泌肽类似物。具有肠过氧化物激素活性的肽通过经上皮载体肽经由上皮下给药。跨上皮肽含有足够的氨基，胍或脒基以刺激跨上皮递送。在一些实施方案中，将经上皮载体和具有肠降血糖素激素活性的肽嵌入石膏或贴片的压敏粘合剂层中。

10. 发明申请

US20120107264A1 NUCLEIC ACID DELIVERY COMPOUNDS 审中-公开
标题翻译：核酸递送化合物
公开(公告)号：US20120107264A1
公开(公告)日：2012-05-03
申请号：US13273106
申请日：2011-10-13
申请人： Padmanabh Chivukula , Jian Liu , Akinobu Soma , Keisaku Okada , Sang Van , Julia Zhu , Nianchun Ma , Chen-Chang Lee , Fu Chen , Lei Yu
发明人： Padmanabh Chivukula , Jian Liu , Akinobu Soma , Keisaku Okada , Sang Van , Julia Zhu , Nianchun Ma , Chen-Chang Lee , Fu Chen , Lei Yu
IPC分类号： A61K47/48 , C08F220/60 , A61P35/00 , A61K47/32 , C12N5/071 , C08F120/60 , C08G65/333
CPC分类号： C12N15/87 , C08F293/005 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell.
摘要翻译：包括两种或更多种不同重复单元的聚合物在本文中公开。本文还公开了使用这种聚合物将核酸递送至细胞的方法。

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