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1. 发明专利

JP2012147937A Laser therapy apparatus, laser therapy system and assessment method 审中-公开
标题翻译：激光治疗装置，激光治疗系统及评估方法
公开(公告)号：JP2012147937A
公开(公告)日：2012-08-09
申请号：JP2011008733
申请日：2011-01-19
申请人： Keio Gijuku , Sony Corp , ソニー株式会社 , 学校法人慶應義塾
发明人： HAKOMORI SHIHO , ARAI TSUNENORI , ITO ARISA , TAKAHASHI MEI
IPC分类号： A61N5/067 , A61M25/01
CPC分类号： A61N5/0613 , A61B5/06 , A61B18/24 , A61B2018/00351 , A61B2018/00648 , A61B2090/065 , A61N5/0601 , A61N5/062
摘要： PROBLEM TO BE SOLVED: To provide a laser therapy apparatus, a laser therapy system and an assessment method, which assess the state of laser contact including a state in which a distal end of a laser catheter is buried in the tissue.SOLUTION: The laser therapy apparatus includes: a connection part 210 to which a second end of a laser catheter 300 is connected, the laser catheter having a first end and the second end, emitting and admitting laser beams from the distal end face of the first end, and having electrodes provided along the axial direction of the first end on the outer periphery of the first end; an emission part 110 that emits the laser beam to the second end connected to the connection part; an optical state detecting part 130 that admits returning light from the second end connected to the connection part and detects the optical state of the admitted returning light; an electrical state detecting part 135 that detects the electrical state of the electrodes via the second end connected to the connection part; and an assessing part 150 that assesses, on the basis of the detected optical state and electrical state, the contact state of the first end and the tissue to be treated using the laser catheter.
摘要翻译：解决的问题：提供一种激光治疗装置，激光治疗系统和评估方法，其评估激光接触的状态，包括激光导管的远端埋在组织中的状态。解决方案：激光治疗装置包括：激光导管300的第二端连接到的连接部210，激光导管具有第一端和第二端，从远端面发射和准许激光束并且具有沿着第一端的轴向设置在第一端的外周上的电极; 将激光束发射到连接到连接部分的第二端的发射部分110; 光学状态检测部130，承认从连接到连接部的第二端返回的光，并检测被入射的返回光的光学状态; 电状态检测部135，其经由连接到连接部的第二端检测电极的电状态; 以及评估部150，其基于检测到的光学状态和电气状态来评估使用激光导管的待处理的第一端和组织的接触状态。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2011189019A Discrimination device and discrimination method 有权
标题翻译：歧视装置和歧视方法
公开(公告)号：JP2011189019A
公开(公告)日：2011-09-29
申请号：JP2010058384
申请日：2010-03-15
申请人： Keio Gijuku , Sony Corp , ソニー株式会社 , 学校法人慶應義塾
发明人： HAKOMORI SHIHO , YAMAGUCHI KYOJI , TAMAMURA KOJI , ARAI TSUNENORI , ITO ARISA
IPC分类号： A61N5/06 , A61B5/0402 , A61B18/20 , G01N21/64
CPC分类号： A61B18/24 , A61B5/0071 , A61B5/0084 , A61B5/0402 , A61B5/1459 , A61B5/6885 , A61B5/7285 , A61N5/062
摘要： PROBLEM TO BE SOLVED: To provide a discrimination device capable of safely discriminating the contact state of the distal end part of a catheter to the tissue in real time.
SOLUTION: A photodynamic therapy device 1 as the discrimination device irradiates the tissue incorporating a photosensitive chemical which absorbs excitation light and emits fluorescence or the tissue which absorbs the excitation light and emits the fluorescence with the excitation light from the distal end part of a laser catheter 300, and includes a connector 210, a light source 110, and a photodetection part 130. To/from the connector 210, the laser catheter 300 is attachable and detachable. The light source 110 outputs the excitation light to the laser catheter 300 through the connector 210. The photodetection part 130 detects the intensity of the fluorescence made incident from the laser catheter 300 through the connector 210 in order to discriminate the contact or non-contact of the distal end part of the laser catheter 300 to the tissue.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供能够实时地将导管的远端部分与组织的接触状态进行安全判别的鉴别装置。解决方案：作为鉴别装置的光动力治疗装置1照射包含吸收激发光并发射荧光的感光性化学物质的组织或吸收激发光的组织，并从来自远端部分的激发光发射荧光激光导管300，并且包括连接器210，光源110和光电检测部130.与连接器210相连接，从而可以安装和拆卸激光导管300。光源110通过连接器210将激发光输出到激光导管300.光电检测部130通过连接器210检测从激光导管300入射的荧光的强度，以便区分接触或非接触的激光导管300的远端部分到组织。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2011212423A Evaluation device and evaluation method 有权
标题翻译：评估设备和评估方法
公开(公告)号：JP2011212423A
公开(公告)日：2011-10-27
申请号：JP2010275511
申请日：2010-12-10
申请人： Keio Gijuku , Sony Corp , ソニー株式会社 , 学校法人慶應義塾
发明人： HAKOMORI SHIHO , UCHIYAMA JUN , YAMAGUCHI KYOJI , TAMAMURA KOJI , ARAI TSUNENORI , ITO ARISA
IPC分类号： A61B1/00 , A61B18/20 , A61B19/00 , A61N5/06
CPC分类号： A61B5/0071 , A61B5/0084 , A61B5/0402 , A61B5/4848 , A61B5/6852 , A61B5/6869 , A61B18/24 , A61B2018/00351 , A61N5/0601 , A61N5/062 , A61N2005/0602 , A61N2005/0626
摘要： PROBLEM TO BE SOLVED: To provide an evaluation device and an evaluation method that can safely evaluate the progression of treatment using a laser catheter.SOLUTION: A photodynamic treatment device 1 serving as the evaluation device is adapted to irradiate tissue, into which a light-sensitive medicine absorbing excited light and emitting fluorescent light has been taken, with excited light from the tip of the laser catheter 300. The device includes a connector 210, a light source 110 and a light detecting part 130. The laser catheter 300 is attachable to and detachable from the connector 210. The light source 110 outputs the excited light to the laser catheter 300 through the connector 210. The light detecting part 130 detects the intensity of fluorescent light incident from the laser catheter 300 through the connector 210 in order to evaluate a change of the tissue by the reaction of the excited light irradiated from the tip of the laser catheter 300 and the light-sensitive medicine taken into the tissue.
摘要翻译：要解决的问题：提供可以安全地评价使用激光导管的治疗进展的评价装置和评价方法。解决方案：作为评价装置的光动力治疗装置1适于照射组织，吸收激发光和发出荧光的敏感药物已经被采用来自激光导管300的尖端的激发光。该装置包括连接器210，光源110和光检测部分130.激光导管300可附接到并且可从连接器210拆卸。光源110通过连接器210将激发的光输出到激光导管300.光检测部分130通过连接器210检测从激光导管300入射的荧光的强度，以评估通过从激光导管300的前端照射的激发光与感光性药物t的反应来改变组织进入组织。

4. 发明专利

JP2011189020A Computing device and computing method 有权
标题翻译：计算设备和计算方法
公开(公告)号：JP2011189020A
公开(公告)日：2011-09-29
申请号：JP2010058386
申请日：2010-03-15
申请人： Keio Gijuku , Sony Corp , ソニー株式会社 , 学校法人慶應義塾
发明人： TAMAMURA KOJI , HAKOMORI SHIHO , YAMAGUCHI KYOJI , ARAI TSUNENORI , ITO ARISA
IPC分类号： A61N5/06 , A61B1/00 , A61B19/00
CPC分类号： A61B5/1459 , A61B5/0071 , A61B5/0084 , A61B5/0402 , A61N5/0601 , A61N5/062 , A61N2005/0602
摘要： PROBLEM TO BE SOLVED: To provide a computing device and a computing method for computing the concentration of medicine in a tissue in real time. SOLUTION: A photodynamic therapy apparatus 1 as a computing device is an apparatus for applying an excitation light from the distal end of a laser catheter 300 to a tissue incorporating a photosensitive medicine which absorbs the excitation light to emit fluorescence, wherein the photodynamic therapy apparatus 1 includes a connector 210, a light source 110, and a photodetection section 130. The connector 210 allows the attachment/detachment of the laser catheter 300. The light source 110 outputs the excitation light to the laser catheter 300 via the connector 210. The photodetection section 130 detects the intensity of the fluorescence entering from the laser catheter 300 via the connector 210 for computing the concentration of the photosensitive medicine in the tissue with which the distal end of the laser catheter 300 comes into contact. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于计算实时中的组织中药物浓度的计算装置和计算方法。解决方案：作为计算装置的光动力治疗装置1是一种用于将激发光从激光导管300的远端施加到包含吸收激发光以发射荧光的感光药物的组织的装置，其中光动力治疗装置1包括连接器210，光源110和光电检测部130.连接器210允许激光导管300的附接/分离。光源110经由连接器210将激发光输出到激光导管300 光检测部130经由连接器210检测从激光导管300进入的荧光的强度，以计算激光导管300的远端与其接触的组织中的感光药物的浓度。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2013208331A Photodynamic therapy system accompanying temperature adjustment 审中-公开
标题翻译：伴随温度调节的光电疗法系统
公开(公告)号：JP2013208331A
公开(公告)日：2013-10-10
申请号：JP2012081173
申请日：2012-03-30
申请人： Keio Gijuku , 学校法人慶應義塾 , Arai Medphoton Research Laboratories Corp , 株式会社アライ・メッドフォトン研究所
发明人： ARAI TSUNENORI , ITO ARISA , TAKAHASHI MEI , OGAWA EMIYU , FUTAMI KIYOHIKO
IPC分类号： A61N5/06 , A61F7/00 , A61N5/067
摘要： PROBLEM TO BE SOLVED: To provide a system capable of controlling the depth of therapy on a tissue surface layer by adjusting the binding rate of a photosensitive substance and a protein such as serum protein by adjusting the temperature of a target tissue for therapy, and varying the reaction efficiency of the photodynamic therapy.SOLUTION: A system for controlling the depth of therapy of the photodynamic therapy by temperature adjustment includes: (i) a light beam irradiation device for irradiating a target tissue for therapy with a light beam; and (ii) a cooling device for cooling the target tissue for therapy. The photodynamic therapy is performed on the surface layer of the target tissue for therapy by: having the cooling device cool the surface of the target tissue for therapy in which a photodynamic therapeutic agent is present; reducing the binding rate of the photodynamic therapeutic agent present in the surface layer of the target tissue for therapy and serum protein by cooling; increasing the ratio of the free photodynamic therapeutic agent on the surface of the target tissue for therapy; and having the light beam irradiation device irradiate the target tissue for therapy with the light beam.
摘要翻译：要解决的问题：提供一种能够通过调节用于治疗的靶组织的温度来调节感光物质和蛋白质如血清蛋白的结合速率来控制组织表面层上的治疗深度的系统，并且变化光动力疗法的反应效率。解决方案：通过温度调节控制光动力治疗深度的系统包括：（i）用于用光束照射靶组织进行治疗的光束照射装置; 和（ii）用于冷却目标组织进行治疗的冷却装置。通过以下方式对目标组织的表层进行光动力学治疗：使冷却装置冷却目标组织的表面以进行光动力治疗剂的治疗; 通过冷却降低目标组织表层中存在的光动力治疗剂的治疗和血清蛋白的结合率; 增加游离光动力治疗剂对靶组织表面的比例用于治疗; 并且使光束照射装置用光束照射目标组织进行治疗。

6. 发明专利

SG183946A1 ESTIMATING APPARATUS AND ESTIMATING METHOD 未知
公开(公告)号：SG183946A1
公开(公告)日：2012-10-30
申请号：SG2012066239
申请日：2011-03-07
申请人： SONY CORP , UNIV KEIO
发明人： YAMAGUCHI TAKASHI , HAKOMORI SHIHO , TAMAMURA KOSHI , ARAI TSUNENORI , ITO ARISA , UCHIYAMA JUN
摘要： ESTIMATING APPARATUS AND ESTIMATING METHOD Abstract[Abstract][Object] To provide an estimating apparatus and anestimating method capable of estimating process of therapy using a laser the catheter 300 accurately in real time.[Solving Means]A photodynamic therapy apparatus 1 as an estimating apparatus is an apparatus for irradiating atissue having absorbed photo-sensitive pharmaceutical,the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser the catheter 300, including a connector 210, a lightsource 110, and a light detection unit 130. The laser the catheter 300 is capable of being attached/detached to/from the connector 210. The light source 110 outputs the excitation light to the laser the catheter 300 via the connector 210. The light detection unit 130 detectsintensity or a spectrum of the fluorescence, the fluorescence being entered from the laser the catheter 300 via the connector 210, to estimate whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of thelaser the catheter 300 and the photo-sensitive pharmaceutical absorbed in the tissue.Fig. 3

7. 发明专利

SG183959A1 DETERMINING APPARATUS AND DETERMINING METHOD 未知
公开(公告)号：SG183959A1
公开(公告)日：2012-10-30
申请号：SG2012066445
申请日：2011-03-07
申请人： SONY CORP , UNIV KEIO
发明人： HAKOMORI SHIHO , YAMAGUCHI TAKASHI , TAMAMURA KOSHI , ARAI TSUNENORI , ITO ARISA
摘要： 81DETERMINING APPARATUS AND DETERMINING METHOD Abstract[Abstract][Object] To provide a determining apparatus capable of5 safely determining a contact state of the tip portion of a catheter with respect to a tissue in real time.[Solving Means] A photodynamic therapy apparatus 1 as a determining apparatus is the photodynamic therapy apparatus 1 for irradiating a tissue having absorbed10 photo-sensitive pharmaceutical, the photo-sensitivepharmaceutical absorbing an excitation light and emitting fluorescence, or a tissue absorbing the excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser15 catheter 300, including a connector 210, a light source 110, and a light detection unit 130. The laser catheter 300 is capable of being attached/detached to/from the connector 210. The light source 110 outputs the excitation light to the laser catheter 300 via the20 connector 210. The light detection unit 130 detectsintensity or a spectrum of the fluorescence, the fluorescence being entered from the laser catheter 300 via the connector 210, to determine whether the tip portion of the laser catheter 300 contacts the tissue25 or not.Fig. 3

8. 发明公开

EP2548615A4 DETERMINATION DEVICE AND DETERMINATION METHOD 审中-公开
标题翻译：确定设备和确定过程
公开(公告)号：EP2548615A4
公开(公告)日：2013-08-28
申请号：EP11755845
申请日：2011-03-07
申请人： SONY CORP , UNIV KEIO
发明人： HAKOMORI SHIHO , YAMAGUCHI TAKASHI , TAMAMURA KOSHI , ARAI TSUNENORI , ITO ARISA
IPC分类号： A61N5/06 , A61B5/0402 , A61B19/00 , G01N21/64
CPC分类号： A61B18/24 , A61B5/0071 , A61B5/0084 , A61B5/0402 , A61B5/1459 , A61B5/6885 , A61B5/7285 , A61N5/062

9. 发明专利

SG191947A1 LASER THERAPY APPRATUS, LASER THERAPY SYSTEM, AND DETERMINATION METHOD 未知
公开(公告)号：SG191947A1
公开(公告)日：2013-08-30
申请号：SG2013053483
申请日：2011-12-22
申请人： SONY CORP , UNIV KEIO
发明人： HAKOMORI SHIHO , ARAI TSUNENORI , ITO ARISA , TAKAHASHI MEI
摘要： 37 LASER THERAPY APPARATUS, LASER THERAPY SYSTEM, AND DETERMINATION METHODAbstract 5 [Abstract][Object] To provide a laser therapy apparatus that is capable of determining a contact state between a tipportion of a laser catheter and a tissue, which includes a buried state of the tip portion in the 10 tissue, a laser therapy system, and a determination method.[Solving Means] It includes a connection portion210 to which a second end portion of a laser catheter 300 is connected, the laser catheter 300 including a 15 first end portion, the second end portion, and an electrode, a laser beam entering and exiting from an apical surface of the first end portion, the electrode being provided at outer periphery of the first endportion along an axial direction of the first end 20 portion, an emission unit 110 configured to emit a laser beam to the second end portion connected to the connection portion 210, an optical state detection unit 130 configured to cause light reflected from the second end portion connected to the connection portion 210 to 25 enter, and to detect an optical state of the entered reflected light, an electrical state detection unit 135 configured to detect an electrical state of the electrode via the second end portion connected to the connection portion 210, and a determination unit 150 30 configured to determine, based on the detected optical state and electrical state, a contact state between the first end portion and a therapy-target tissue treated by using the laser catheter.

10. 发明专利

SG183935A1 CALCULATION APPARATUS AND CALCULATION METHOD 未知
公开(公告)号：SG183935A1
公开(公告)日：2012-10-30
申请号：SG2012065967
申请日：2011-03-07
申请人： SONY CORP , UNIV KEIO
发明人： TAMAMURA KOSHI , HAKOMORI SHIHO , YAMAGUCHI TAKASHI , ARAI TSUNENORI , ITO ARISA
摘要： CALCULATION APPARATUS AND CALCULATION METHODAbstract[Abstract][Object] To provide a calculation apparatus and acalculation method capable of calculatingpharmaceutical concentration in a tissue in real time. [Solving Means] A photodynamic therapy apparatus 1 as a calculation apparatus is an apparatus forirradiating a tissue having absorbed photo-sensitivepharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion ofa laser catheter 300, including a connector 210, alight source 110, and a light detection unit 130. The laser catheter 300 is capable of beingattached/detached to/from the connector 210. The light source 110 outputs the excitation light to the laser catheter 300 via the connector 210. The light detectionunit 130 detects intensity of the fluorescence, the fluorescence being entered from the laser catheter 300 via the connector 210, to calculate concentration of the photo-sensitive pharmaceutical in a tissue, the tipportion of the laser catheter 300 contacting the tissue.Fig. 3

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