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    • 1. 发明申请
    • ZOOM LENS SYSTEM, OPTICAL APPARATUS, AND METHOD FOR MANUFACTURING ZOOM LENS SYSTEM
    • 变焦镜头系统,光学设备和制造变焦镜头系统的方法
    • US20090086321A1
    • 2009-04-02
    • US12211900
    • 2008-09-17
    • Keiko MIZUGUCHITomoki Ito
    • Keiko MIZUGUCHITomoki Ito
    • G02B27/64G02B15/16
    • G02B27/646G02B15/173
    • Providing a zoom lens system having a vibration reduction function capable of performing quick focusing with excellent optical performance even upon vibration reduction. The system including, in order from an object, a first lens group G1 having positive refractive power, a second lens group G2 having negative refractive power, a third lens group G3 having positive refractive power, and a fourth lens group G4 having positive refractive power. Upon zooming from a wide-angle end state to a telephoto end state, a distance between the first lens group G1 and the second lens group G2 varies, and a distance between the second lens group G2 and the third lens group G3 varies. The third lens group G3 carries out focusing from an infinity object to a close object. At least a portion of the fourth lens group G4 moves in a direction perpendicular to the optical axis.
    • 提供具有减振功能的变焦透镜系统,即使在减振时也能够进行快速聚焦,具有出色的光学性能。 该系统依次包括具有正折光力的第一透镜组G1,具有负折光力的第二透镜组G2,具有正折光力的第三透镜组G3和具有正折光力的第四透镜组G4 。 在从广角端状态变焦到望远端状态时,第一透镜组G1和第二透镜组G2之间的距离变化,并且第二透镜组G2与第三透镜组G3之间的距离变化。 第三透镜组G3从无限远物体执行聚焦到近距离物体。 第四透镜组G4的至少一部分在垂直于光轴的方向上移动。
    • 2. 发明授权
    • Zoom lens system, optical apparatus, and method for manufacturing zoom lens system
    • 变焦镜头系统,光学设备及制造变焦镜头系统的方法
    • US08405906B2
    • 2013-03-26
    • US12211900
    • 2008-09-17
    • Keiko MizuguchiTomoki Ito
    • Keiko MizuguchiTomoki Ito
    • G02B27/64
    • G02B27/646G02B15/173
    • Providing a zoom lens system having a vibration reduction function capable of performing quick focusing with excellent optical performance even upon vibration reduction. The system including, in order from an object, a first lens group G1 having positive refractive power, a second lens group G2 having negative refractive power, a third lens group G3 having positive refractive power, and a fourth lens group G4 having positive refractive power. Upon zooming from a wide-angle end state to a telephoto end state, a distance between the first lens group G1 and the second lens group G2 varies, and a distance between the second lens group G2 and the third lens group G3 varies. The third lens group G3 carries out focusing from an infinity object to a close object. At least a portion of the fourth lens group G4 moves in a direction perpendicular to the optical axis.
    • 提供具有减振功能的变焦透镜系统,即使在减振时也能够进行快速聚焦,具有出色的光学性能。 该系统依次包括具有正折光力的第一透镜组G1,具有负折光力的第二透镜组G2,具有正折光力的第三透镜组G3和具有正折光力的第四透镜组G4 。 在从广角端状态变焦到望远端状态时,第一透镜组G1和第二透镜组G2之间的距离变化,并且第二透镜组G2与第三透镜组G3之间的距离变化。 第三透镜组G3从无限远物体执行聚焦到近距离物体。 第四透镜组G4的至少一部分在垂直于光轴的方向上移动。
    • 3. 发明授权
    • Zoom lens system, optical apparatus and method for manufacturing zoom lens system
    • 变焦镜头系统,光学装置及制造变焦镜头系统的方法
    • US08605362B2
    • 2013-12-10
    • US13033681
    • 2011-02-24
    • Tomoki Ito
    • Tomoki Ito
    • G02B15/14
    • G02B15/173G02B27/646
    • A zoom lens system includes, in order from an object side: a first lens group having positive refractive power; a second lens group having negative refractive power; a third lens group having positive refractive power; a fourth lens group having negative refractive power; and a fifth lens group having positive refractive power. Upon zooming from a wide-angle end state to a telephoto end state, a position of the first lens group is fixed. At least a portion of any one of the lens groups is moved in a direction including a component perpendicular to an optical axis, and a given conditional expression is satisfied, thereby providing a zoom lens system capable of excellently suppressing variation in aberrations upon zooming and upon correcting an image blur, an optical apparatus including the zoom lens system, and a method for manufacturing the zoom lens system.
    • 变焦透镜系统从物体侧依次包括具有正折射光焦度的第一透镜组; 具有负屈光力的第二透镜组; 具有正折射力的第三透镜组; 具有负屈光力的第四透镜组; 以及具有正屈光力的第五透镜组。 当从广角端状态变焦到长焦端状态时,第一透镜组的位置是固定的。 任何一个透镜组的至少一部分在包括垂直于光轴的分量的方向上移动,并且满足给定的条件表达式,从而提供能够极好地抑制变焦和随后的像差变化的变焦透镜系统 校正图像模糊,包括变焦透镜系统的光学装置以及用于制造变焦透镜系统的方法。
    • 5. 发明申请
    • Methods to Treat Disease States by Influencing the Signaling of Ox-40-Receptors and High Throughput Screening Methods for Identifying Substances Therefor
    • 通过影响Ox-40受体信号治疗疾病状态的方法和高通量筛选方法鉴定其物质
    • US20080286286A1
    • 2008-11-20
    • US11659266
    • 2007-01-16
    • Yong-Jun LiuTomoki Ito
    • Yong-Jun LiuTomoki Ito
    • A61K39/395G01N33/535A61P37/02
    • A61K38/177C07K16/2878G01N33/505G01N33/56972G01N2333/5428
    • OX40L inhibits the generation of IL-10-producing Tr1 cells from naïve and memory CD4+ T cells induced by the immunuosuppressive drugs dexamethasone and vitamin D3. This unique function of OX40L is not shared by two other costimulatory TNF-family members, GITR-ligand and 4-1BB-ligand. OX40L also strongly inhibits the generation of IL-10-producing Tr1 cells induced by two physiological stimuli provided by inducible costimulatory ligand and immature DCs and inhibits the production of IL-10 by regulatory T cells. It has thus been shown that signaling the OX40-receptor on human T cells by monoclonal antibodies, small molecules, or OX40L regulates the generation and function of IL-10 producing immunosuppressive T cells. Also provided are high throughput methods for identifying substances that promote or inhibit the generation and function of IL-10 producing T cells. Numerous disease states, such as human allergic, autoimmune, and autoimmune diseases, and cancer, may be treated by targeting OX40/OX40L.
    • OX40L抑制由免疫抑制药物地塞米松和维生素D3诱导的初始和记忆的CD4 + T细胞产生产生IL-10的Tr1细胞。 OX40L的这种独特功能不是由另外两种共刺激的TNF-家族成员,GITR-配体和4-1BB-配体共享。 OX40L还强烈地抑制由诱导性共刺激配体和未成熟DC提供的两种生理刺激诱导的产生IL-10的Tr1细胞的产生,并通过调节性T细胞抑制IL-10的产生。 因此,已经表明,通过单克隆抗体,小分子或OX40L信号传导人T细胞上的OX40-受体调节产生IL-10的免疫抑制性T细胞的产生和功能。 还提供了用于鉴定促进或抑制产生IL-10和产生T细胞的功能的物质的高通量方法。 可以通过靶向OX40 / OX40L来治疗许多疾病状态,例如人类过敏,自身免疫和自身免疫性疾病和癌症。
    • 7. 发明申请
    • ZOOMING OPTICAL SYSTEM, OPTICAL APPARATUS HAVING THE ZOOMING OPTICAL SYSTEM, AND METHOD FOR MANUFACTURING ZOOMING OPTICAL SYSTEM
    • 变焦光学系统,具有变焦光学系统的光学装置及其制造光学系统的方法
    • US20130258495A1
    • 2013-10-03
    • US13994730
    • 2011-12-14
    • Tomoki Ito
    • Tomoki Ito
    • G02B15/16
    • G02B15/16G02B15/173G02B27/646Y10T29/49826
    • A zoom optical system ZL to be mounted on an optical apparatus such as a single lens reflex camera 1, comprising, in order from an object side, a first lens group G1 having positive refractive power, a second lens group G2 having negative refractive power, a third lens group G3 having positive refractive power, a fourth lens group G4 having negative refractive power, a fifth lens group G5 having positive refractive power, and a sixth lens group G6 having negative refractive power. The zoom optical system is configured such that at least a portion of any one lens group among these lens group G1 to G6 may be moved such that a component in a direction perpendicular to the optical axis may be included. Thus, there are provided a zoom optical system that can suppress well variation in aberrations upon zooming, an optical apparatus equipped therewith and a method for manufacturing the zoom optical system.
    • 安装在诸如单个透镜反射照相机1的光学装置上的变焦光学系统ZL包括从物体侧开始具有正折光力的第一透镜组G1,具有负折光力的第二透镜组G2, 具有正折光力的第三透镜组G3,具有负折光力的第四透镜组G4,具有正折光力的第五透镜组G5和具有负折光力的第六透镜组G6。 变焦光学系统被配置为使得这些透镜组G1至G6中的任何一个透镜组的至少一部分可以移动,使得可以包括在垂直于光轴的方向上的分量。 因此,提供了可以抑制变焦时的像差的良好变化的变焦光学系统,配备有其的光学装置以及用于制造变焦光学系统的方法。