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1. 发明授权

US5833672A Double tube, balloon catheter produced by using double tube, and process for producing balloon catheter 失效
标题翻译：使用双管制造的双管，气囊导管，以及用于制造球囊导管的方法
公开(公告)号：US5833672A
公开(公告)日：1998-11-10
申请号：US849316
申请日：1997-06-10
申请人： Keiichi Kawata , Hidenobu Urata , Tetsuo Toyokawa , Kouichi Sakai , Masaru Uchiyama
发明人： Keiichi Kawata , Hidenobu Urata , Tetsuo Toyokawa , Kouichi Sakai , Masaru Uchiyama
IPC分类号： A61F2/958 , A61M25/00 , A61M25/14
CPC分类号： A61M25/1036 , A61M25/1027 , A61M2025/0034 , A61M2025/1061 , A61M25/0029 , A61M25/0053 , A61M25/10
摘要： A double tube from which a balloon catheter having a high rigidity and a low fluid resistance can be easily produced by means of an extruder or the like, an apparatus for producing the double tube, a balloon catheter produced by using the double tube, and a process for producing the balloon catheter are provided. The double tube comprises an outer tube having a lumen extending from the distal end to the proximal end, and an inner tube which is provided within the outer tube and has a lumen extending from the distal end to the proximal end, wherein a longitudinal member in the strip form is provided as a connecting member which continuously connects the inner surface of the outer tube to the outer surface of the inner tube in the axial direction. A balloon catheter can be easily produced by using this double tube. An apparatus for producing a double tube is also provided which comprises a first extruding means for extruding a resin for forming an outer tube portion, a second extruding means for extruding a resin for forming an inner tube portion, and a die for forming into tubes respectively from the resins extruded from the first extruding means and the second extruding means.
摘要翻译： PCT No.PCT / JP95 / 02534 Sec。 371日期：1997年6月10日 102（e）日期1997年6月10日PCT 1995年11月11日PCT PCT。公开号WO96 / 18430 日期：1996年6月20日利用挤出机等容易地制造具有高刚性和低流体阻力的球囊导管的双管，用于生产双管的装置，使用双管，以及用于制造球囊导管的方法。双管包括具有从远端延伸到近端的内腔的外管，以及设置在外管内并具有从远端延伸到近端的内腔的内管，其中纵管提供带状形式作为连接构件，其将外管的内表面沿着轴向连续地连接到内管的外表面。可以通过使用该双管容易地制造球囊导管。还提供了一种用于制造双管的装置，其包括用于挤出用于形成外管部的树脂的第一挤出装置，用于挤出用于形成内管部的树脂的第二挤出装置和分别形成管的模具从第一挤出装置和第二挤出装置挤出的树脂。

2. 发明授权

US5514073A Intra-aortic balloon catheter 失效
标题翻译：主动脉内气囊导管
公开(公告)号：US5514073A
公开(公告)日：1996-05-07
申请号：US181952
申请日：1994-01-18
申请人： Shinichi Miyata , Tetsuo Toyokawa , Kouichi Sakai , Masaru Miyahara , Takashi Tsuji , Donald R. Kirkpatrick
发明人： Shinichi Miyata , Tetsuo Toyokawa , Kouichi Sakai , Masaru Miyahara , Takashi Tsuji , Donald R. Kirkpatrick
IPC分类号： A61F2/958 , A61M1/10 , A61M25/00
CPC分类号： A61M25/1029 , A61M1/1072 , A61M25/1027 , A61M25/1038 , A61M2025/1031 , A61M2025/1059 , A61M25/1002
摘要： A balloon catheter has an inner tube communicating with a blood introduction port provided at a tip of the balloon portion. The inner tube is affixed to the inner wall of the catheter tube by adhesion, melt-bonding, or integral formation. The balloon catheter has a small channel resistance in the channel where the pressurized fluid which expands and contracts the balloon portion flows, even when the catheter tube has been bent, and enables expansion and contraction of the balloon portion with a good response. Another balloon catheter has the balloon portions at a range of the end sides of the balloon portions smaller in sectional area compared with the balloon portions at the tip sides. The catheter is able to effectively prevent side effects which occur only rarely but which are serious when they do occur. The catheter impairs as little as possible the effect of assisting the heart action inherent to the IABP method without special measurement of the diameter of the patient's blood vessels.
摘要翻译：气囊导管具有与设置在气囊部的前端的血液导入口连通的内管。内管通过粘合，熔融粘合或整体形成固定在导管管的内壁上。气囊导管在通道中具有小的通道阻力，其中膨胀和收缩气囊部分的加压流体即使当导管已被弯曲时也流动，并且能够以良好的响应使气囊部分膨胀和收缩。另一气囊导管在气囊部分的端侧范围内具有与顶端侧的球囊部分相比截面面积小的球囊部分。导管能够有效地防止副作用，这些副作用很少发生，但是发生时会严重。导管尽可能少地损害协助IABP方法固有的心脏作用而不特别测量患者血管直径的效果。

3. 发明授权

US5695467A Intra aortic balloon pumping catheter 失效
标题翻译：主动脉内球囊抽吸导管
公开(公告)号：US5695467A
公开(公告)日：1997-12-09
申请号：US472774
申请日：1995-06-07
申请人： Shinichi Miyata , Tetsuo Toyokawa , Kouichi Sakai , Satoshi Morikawa
发明人： Shinichi Miyata , Tetsuo Toyokawa , Kouichi Sakai , Satoshi Morikawa
IPC分类号： A61F2/958 , A61L29/04 , A61L29/06 , A61L29/08 , A61L33/06 , A61M25/00 , A61M25/06 , A61M39/06 , A61M29/00
CPC分类号： A61M39/0613 , A61L29/041 , A61L29/06 , A61L29/085 , A61L33/068 , A61M25/0009 , A61M25/065 , A61M25/1034 , A61M25/1036 , A61M2039/062 , A61M25/0045 , A61M25/1006 , A61M25/1029
摘要： A catheter having a catheter tube. The catheter tube is comprised of a base tube comprised of a hard plastic with a linear elastic modulus of at least 100 kg/mm.sup.2 and a surface tube of an anti-thrombogenic material covering the outer circumference of the base tube. Further, The present invention provides a catheter set which is used when inserting the catheter and the like into the blood vessel of a patient. The catheter set comprises a retaining sheath whose distal end is inserted into a blood vessel and which has a hemostatic valve at its proximal end, a catheter having a catheter tube, which is inserted from the proximal end of the retaining sheath and thereby inserted into the blood vessel, and a holding ring for affixing said retaining sheath to the outer circumference of said catheter tube at any position in the axial direction.
摘要翻译：具有导管的导管。该导管由包含至少100kg / mm 2的线性弹性模量的硬塑料和覆盖基管的外圆周的抗血栓形成材料的表面管组成的基管组成。此外，本发明提供一种当将导管等插入患者的血管时使用的导管组。导管组包括一个保持护套，其远端插入血管中，其近端具有止血阀，导管具有导管，该导管从该护套的近端插入，从而插入血管，以及用于将所述保持护套固定在所述导管的外周的轴向任意位置的保持环。

4. 发明授权

US5460607A Balloon catheter 失效
标题翻译：气球导管
公开(公告)号：US5460607A
公开(公告)日：1995-10-24
申请号：US125843
申请日：1993-09-24
申请人： Shinichi Miyata , Takashi Kawabata , Tetsuo Toyokawa , Kouichi Sakai
发明人： Shinichi Miyata , Takashi Kawabata , Tetsuo Toyokawa , Kouichi Sakai
IPC分类号： A61M1/10 , A61M39/06 , A61M25/00
CPC分类号： A61M1/1072 , A61M39/0613 , A61M2039/062
摘要： A balloon catheter used for intra-aortic balloon pumping (IABP). In the balloon catheter, an outer diameter of a catheter tube is not made constant in the axial direction. Rather, the outer diameter of the catheter tube from a hemostatic valve to a bifurcation, the portion which is positioned outside the patient's blood vessel, is made 3 to 30 percent larger than the outer diameter of the catheter tube from the balloon portion to the hemostatic valve, which is positioned inside the patient's blood vessel. The bifurcation has a first passage and a second passage. The first passage is communicating with a shuttle gas port and is disposed straight along the direction of the axial center of the catheter tube. In the balloon catheter, improvements in a channel resistance of a shuttle gas and in the response can be expected compared with the conventional balloon catheter, where the blood pressure measurement port (the second passage) was disposed straight along the direction of the axial center of the catheter tube and the outer diameter of the catheter tube was made constant in the axial direction.
摘要翻译：用于主动脉内球囊泵送的气囊导管（IABP）。在气囊导管中，导管的外径在轴向不成一体。相反，从止血阀到分叉的导管的外径（位于患者血管外部的部分）比导管的外径从气囊部分到止血部分大3至30％阀门位于患者血管内。分叉具有第一通道和第二通道。第一通道与穿梭气体端口连通，并且沿导管的轴心方向直线设置。在气囊导管中，与传统的气囊导管相比，可以预期穿梭气体的通道阻力的改善和响应中的血压测量端口（第二通道）沿着轴向中心的方向直线设置将导管和导管的外径沿轴向保持恒定。

5. 发明授权

US06656153B1 Balloon catheter 失效
标题翻译：气球导管
公开(公告)号：US06656153B1
公开(公告)日：2003-12-02
申请号：US09508193
申请日：2000-03-08
申请人： Kouichi Sakai , Tetsuo Toyokawa , Takahiro Iida
发明人： Kouichi Sakai , Tetsuo Toyokawa , Takahiro Iida
IPC分类号： A61M2900
CPC分类号： A61M25/0075 , A61M25/10 , A61M25/1006
摘要： A balloon catheter of the present invention has an outer tube having a first lumen inside it. At the distal end of the outer tube is connected the proximal end of the balloon portion so that a balloon space is formed inside it, the distal end of the balloon portion is joined to a cylindrical front tip portion, and pressurized fluid is introduced into and released from the balloon space through the first lumen of the outer tube so as to make the balloon portion expand or contract. Inside the first lumen of the outer tube is arranged an inner tube having a second lumen freely slidable in the axial direction. The distal end of the inner tube projects out from the distal end of the outer tube and is detachably attached to the front tip portion. The balloon catheter of the present invention may have a guidewire detachably attached to the front tip portion rather than providing the inner tube.
摘要翻译：本发明的气囊导管具有在其内部具有第一腔的外管。在外管的远端与球囊部分的近端连接，从而在其内部形成球囊空间，球囊部分的远端接合到圆柱形前端部分，加压流体被引入和从气球空间通过外管的第一内腔释放，以使气囊部分膨胀或收缩。在外管的第一内腔内设置有具有沿轴向自由滑动的第二内腔的内管。内管的远端从外管的远端突出，并且可拆卸地附接到前端部。本发明的气囊导管可以具有可拆卸地附接到前端部分的导丝，而不是设置内管。

6. 发明授权

US5711754A Intra-aortic balloon catheter 失效
公开(公告)号：US5711754A
公开(公告)日：1998-01-27
申请号：US582348
申请日：1996-01-19
申请人： Shinichi Miyata , Tetsuo Toyokawa , Kouichi Sakai , Masaru Miyahara , Takashi Tsuji , Donald Robert Kirkpatrick
发明人： Shinichi Miyata , Tetsuo Toyokawa , Kouichi Sakai , Masaru Miyahara , Takashi Tsuji , Donald Robert Kirkpatrick
IPC分类号： A61F2/958 , A61M1/10 , A61M25/00 , A61N1/362
CPC分类号： A61M25/1029 , A61M1/1072 , A61M25/1027 , A61M25/1038 , A61M2025/1031 , A61M2025/1059 , A61M25/1002
摘要： A balloon catheter has an inner tube communicating with a blood introduction port provided at a tip of the balloon portion. The inner tube is affixed to the inner wall of the catheter tube by adhesion, melt-bonding, or integral formation. The balloon catheter has a small channel resistance in the channel where the pressurized fluid which expands and contracts the balloon portion flows, even when the catheter tube has been bent, and enables expansion and contraction of the balloon portion with a good response. Another balloon catheter has the balloon portions at a range of the end sides of the balloon portions smaller in sectional area compared with the balloon portions at the tip sides. The catheter is able to effectively prevent side effects which occur only rarely but which are serious when they do occur. The catheter impairs as little as possible the effect of assisting the heart action inherent to the IABP method without special measurement of the diameter of the patient's blood vessels.

7. 发明授权

US5683347A Balloon catheter 失效
标题翻译：气球导管
公开(公告)号：US5683347A
公开(公告)日：1997-11-04
申请号：US508885
申请日：1995-07-28
申请人： Shinichi Miyata , Takashi Kawabata , Tetsuo Toyokawa , Kouichi Sakai
发明人： Shinichi Miyata , Takashi Kawabata , Tetsuo Toyokawa , Kouichi Sakai
IPC分类号： A61M1/10 , A61M39/06 , A61N1/362
CPC分类号： A61M1/1072 , A61M39/0613 , A61M2039/062
摘要： A balloon catheter used for intra-aortic balloon pumping (IABP). In the balloon catheter, an outer diameter of a catheter tube is not made constant in the axial direction. Rather, the outer diameter of the catheter tube from a hemostatic valve to a bifurcation, the portion which is positioned outside the patient's blood vessel, is made 3 to 30 percent larger than the outer diameter of the catheter tube from the balloon portion to the hemostatic valve, which is positioned inside the patient's blood vessel. The bifurcation has a first passage and a second passage. The first passage is communicating with a shuttle gas port and is disposed straight along the direction of the axial center of the catheter tube. In the balloon catheter, improvements in a channel resistance of a shuttle gas and in the response can be expected compared with the conventional balloon catheter, where the blood pressure measurement port (the second passage) was disposed straight along the direction of the axial center of the catheter tube and the outer diameter of the catheter tube was made constant in the axial direction.
摘要翻译：用于主动脉内球囊泵送的气囊导管（IABP）。在气囊导管中，导管的外径在轴向不成一体。相反，从止血阀到分叉的导管的外径（位于患者血管外部的部分）比导管的外径从气囊部分到止血部分大3至30％阀门位于患者血管内。分叉具有第一通道和第二通道。第一通道与穿梭气体端口连通，并且沿导管的轴心方向直线设置。在气囊导管中，与传统的气囊导管相比，可以预期穿梭气体的通道阻力的改善和响应中的血压测量端口（第二通道）沿着轴向中心的方向直线设置将导管和导管的外径沿轴向保持恒定。

8. 发明授权

US5298015A Wound dressing having a porous structure 失效
标题翻译：伤口敷料具有多孔结构
公开(公告)号：US5298015A
公开(公告)日：1994-03-29
申请号：US854765
申请日：1992-03-20
申请人： Shigeru Komatsuzaki , Toshinobu Hirayama , Tetsuo Toyokawa
发明人： Shigeru Komatsuzaki , Toshinobu Hirayama , Tetsuo Toyokawa
IPC分类号： A61F13/02 , A61F13/00 , A61F13/15 , A61L15/44 , A61F15/00
CPC分类号： A61F13/00063 , A61F13/00021 , A61F13/00995 , A61F13/8405 , A61F2013/00157 , A61F2013/00225 , A61F2013/00234 , A61F2013/00255 , A61F2013/00472 , A61F2013/00519 , A61F2013/00608 , A61F2013/00612 , A61F2013/00863 , A61F2013/00906 , A61F2013/0091 , A61F2013/00927 , A61F2013/53081 , Y10S514/944 , Y10S516/926 , Y10S602/90
摘要： A dressing for a wound having a porous structure of continuous pores throughout the dressing made of minute filaments arranged in three dimensions and filmy links (viewed at a magnification of about 35 to 350) connecting the filaments. The porous structure has pores defined by the filmy interconnections. In other words, the wound dressing has a continuous open-celled structure in an expanded foam. The wound dressing can advantageously be made of a highly biocompatible material, such as poly-.alpha.-amino acid.
摘要翻译：一种用于伤口的敷料，其具有连续孔的多孔结构，整个敷料由三维布置的细丝构成，并连接长丝的胶片连接（以约35至350的倍率观察）。多孔结构具有由薄膜互连限定的孔。换句话说，伤口敷料在膨胀泡沫中具有连续的开孔结构。伤口敷料可以有利地由高度生物相容的材料制成，例如聚（α） - 氨基酸。

9. 发明授权

US5439443A Balloon catheter 失效
标题翻译：气球导管
公开(公告)号：US5439443A
公开(公告)日：1995-08-08
申请号：US951951
申请日：1992-09-28
申请人： Shin'ichi Miyata , Tetsuo Toyokawa , Koichi Sakai , Hiroshi Hisaki
发明人： Shin'ichi Miyata , Tetsuo Toyokawa , Koichi Sakai , Hiroshi Hisaki
IPC分类号： A61L29/06 , A61M25/00 , A61M29/00
CPC分类号： A61M25/1027 , A61L29/06
摘要： A balloon catheter having a balloon part composed of a film which is formed from a polymer having a number average molecular weight of at least 50,000, and has an initial modulus at 100% of at least 95 kg/cm.sup.2 is provided. The balloon part is far excellent in preventive effect against its destruction is provided. The balloon catheter is suitable for use as a balloon catheter for intraaortic balloon pumping because the balloon part is prevented from being worn due to the rubbing of the balloon part against a calcified deposit on a blood vessel upon its practical operation.
摘要翻译：提供了一种气球导管，其具有由数均分子量为至少50,000的聚合物形成的膜构成的气囊部分，并且具有100％的初始模量为至少95kg / cm 2。气球部分是非常优秀的预防效果，以防止其破坏。气球导管适用于用于主动脉内气囊泵送的球囊导管，因为在其实际操作时，由于气囊部分抵抗血管上的钙化沉积物而被阻止气囊部分被磨损。

10. 发明授权

US5149469A Method of manufacturing a wound dressing 失效
标题翻译：一种创造性的连接方法
公开(公告)号：US5149469A
公开(公告)日：1992-09-22
申请号：US665203
申请日：1991-03-26
申请人： Shigeru Komatsuzaki , Toshinobu Hirayama , Tetsuo Toyokawa
发明人： Shigeru Komatsuzaki , Toshinobu Hirayama , Tetsuo Toyokawa
IPC分类号： A61F13/02 , A61F13/00 , A61F13/15 , A61L15/44
CPC分类号： A61F13/00063 , A61F13/00021 , A61F13/00995 , A61F13/8405 , A61F2013/00157 , A61F2013/00225 , A61F2013/00234 , A61F2013/00255 , A61F2013/00472 , A61F2013/00519 , A61F2013/00608 , A61F2013/00612 , A61F2013/00863 , A61F2013/00906 , A61F2013/0091 , A61F2013/00927 , A61F2013/53081 , Y10S514/944 , Y10S516/926 , Y10S602/90
摘要： A method of manufacturing a wound dressing having microscopic web-like interconnections and a porous structure of continuous pores throughout the wound dressing. In the first embodiment of the method, the dressing is produced by the steps of heating while simultaneously stirring a biocompatible material and solvent to form a homogenous solution; cooling while simultaneously stirring the homogenous solution to form a gel made of a dispersion of gel particles of the biocompatible material and freeze-drying the gel. In a second embodiment of the method, the wound dressing is produced by heating while simultaneously stirring a biocompatible material and the solvent to form a homogenous solution, cooling while simultaneously stirring the homogenous solution to form a gel made of a dispersion of gel particles of the biocompatible material; warming while simultaneously stirring the gel, allowing the warm gel to cool to form a soft gel and freeze-drying the soft gel. Finally, in a third embodiment of the method, the steps of heating while simultaneously stirring a biocompatible material and the solvent to form a homogenous solution, adding a liquid which inhibits the freezing of the homogenous solution, cooling while simultaneously stirring the homogenous solution to form a gel comprising a dispersion of gel particles of the biocompatible material and freeze-drying the gel.

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