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1. 发明申请

US20100145441A1 THERAPEUTIC AGENTS FOR ANGIOGENESIS-RELATED DISEASES COMPRISING CHONDROMODULIN-I AS ACTIVE INGREDIENT 审中-公开
标题翻译：含有成纤维细胞生长因子-I作为活性成分的血管发生相关疾病的治疗药物
公开(公告)号：US20100145441A1
公开(公告)日：2010-06-10
申请号：US12067593
申请日：2006-09-15
申请人： Keiichi Fukuda , Yuji Hiraki
发明人： Keiichi Fukuda , Yuji Hiraki
IPC分类号： A61F2/24 , A61K38/17 , A61K31/711 , A61K49/00 , A61P35/04 , A61P9/10 , A61P27/02 , A61P9/00 , A01K67/027 , C12Q1/02 , C12Q1/68 , C12N5/071
CPC分类号： A61K48/005 , A01K2217/075 , A01K2267/03 , A61K31/7088 , A61K38/00 , C07K14/51 , G01N33/502 , G01N2800/32
摘要： An objective of the present invention is to analyze the function of anti-angiogenic factors in cardiac valves or such to elucidate the developmental mechanism of angiogenesis-induced diseases. A more specific objective is to provide therapeutic agents for angiogenesis-induced diseases such as valvular heart disease, and methods of efficiently screening for the therapeutic agents. The present inventors discovered that chondromodulin-I was markedly expressed in cardiac valves, and plays an important role in maintaining normal functions of the valves by preventing angiogenesis, thickening, and calcification which lead to valvular heart diseases. Chondromodulin-I proteins and substances that activate the expression or function of the proteins are expected to have therapeutic effects against angiogenesis-induced diseases.
摘要翻译：本发明的目的是分析心脏瓣膜中抗血管生成因子的功能，从而阐明血管生成诱发疾病的发展机制。更具体的目的是提供血管发生诱导的疾病如瓣膜性心脏病的治疗剂和有效筛选治疗剂的方法。本发明人发现软骨调节蛋白-1在心脏瓣膜中显着表达，并且通过预防血管生成，增厚和钙化导致瓣膜性心脏病的维持正常功能起重要作用。软骨调节蛋白-1蛋白质和激活蛋白质表达或功能的物质预计具有对血管生成诱导的疾病的治疗作用。

2. 发明授权

US08841250B2 Method for promoting muscle repair comprising administering G-CSF at the site of injury 有权
标题翻译：用于促进肌肉修复的方法，包括在损伤部位施用G-CSF
公开(公告)号：US08841250B2
公开(公告)日：2014-09-23
申请号：US13942270
申请日：2013-07-15
申请人： Keiichi Fukuda
发明人： Keiichi Fukuda , Shinsuke Yuasa , Mie Hara
IPC分类号： A61P17/02 , A61K38/19 , C07K14/535
CPC分类号： A61K38/193 , Y10S930/145
摘要： The present invention relates to muscle repair promoters for local application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present invention exhibit their effect at low doses, particularly when they are administered intramuscularly.
摘要翻译：本发明涉及含有集落刺激因子（CSF）作为活性成分的局部应用的肌肉修复促进剂。本发明的肌肉修复促进剂在低剂量下表现出其作用，特别是当肌肉内给药时。

3. 发明授权

US08735152B2 Methods for inducing cell death in pluripotent stem cells and differentiated cells other than cardiac myocytes 有权
标题翻译：在多能干细胞和心肌细胞以外的分化细胞中诱导细胞死亡的方法
公开(公告)号：US08735152B2
公开(公告)日：2014-05-27
申请号：US13260224
申请日：2010-03-29
申请人： Fumiyuki Hattori , Keiichi Fukuda
发明人： Fumiyuki Hattori , Keiichi Fukuda
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/0657 , C12N5/0081 , C12N5/0696 , C12N2501/90 , C12N2506/02
摘要： The present invention has as its object developing a method that does not involve genomic modification and which yet is capable of inducing cell death in pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells, as well as in differentiated cells other than cardiomyocytes derived from pluripotent stem cells, but not in cardiomyocytes. It has been revealed that by establishing a method capable of inducing cell death in cells other than cardiomyocytes in a very efficient manner by adding a substance having no recognized inherent toxicity or cell death inducing action to the culture conditions for pluripotent stem cells and non-cardiomyocytes, the stated problem can be solved without relying upon genomic modification.
摘要翻译：本发明的目的是开发一种不涉及基因组修饰并且能够在多能干细胞如胚胎干细胞和诱导的多能干细胞以及除了心肌细胞以外的分化细胞中诱导细胞死亡的方法来自多能干细胞，但不在心肌细胞中。已经揭示出，通过向多能干细胞和非心肌细胞的培养条件中加入不具有公认的固有毒性或细胞死亡诱导作用的物质，通过建立能够以非常有效的方式在除心肌细胞之外的细胞中诱导细胞死亡的方法所述问题可以解决而不依赖于基因组修饰。

4. 发明申请

US20130302272A1 THERAPEUTIC AGENTS FOR MUSCULAR DYSTROPHY 审中-公开
标题翻译：用于肌肉晶状体的治疗剂
公开(公告)号：US20130302272A1
公开(公告)日：2013-11-14
申请号：US13988255
申请日：2011-11-17
申请人： Keiichi Fukuda , Shinsuke Yuasa
发明人： Keiichi Fukuda , Shinsuke Yuasa
IPC分类号： A61K38/19
CPC分类号： A61K38/193
摘要： The present invention provides therapeutic agents for diseases associated with skeletal muscle degeneration comprising a granulocyte colony-stimulating factor (G-CSF) as an active ingredient. The therapeutic agents of the present invention are especially effective as therapeutic agents for muscular dystrophy.
摘要翻译：本发明提供与骨骼肌变性相关的疾病的治疗剂，其包含粒细胞集落刺激因子（G-CSF）作为活性成分。本发明的治疗剂作为肌营养不良症的治疗剂是特别有效的。

5. 发明申请

US20130189786A1 METHOD FOR PRODUCING INDUCED PLURIPOTENT STEM CELLS 有权
标题翻译：生产诱导型脑干细胞的方法
公开(公告)号：US20130189786A1
公开(公告)日：2013-07-25
申请号：US13641370
申请日：2011-04-15
申请人： Keiichi Fukuda , Shinsuke Yuasa , Tomohisa Seki , Mamoru Hasegawa
发明人： Keiichi Fukuda , Shinsuke Yuasa , Tomohisa Seki , Mamoru Hasegawa
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N5/0696 , C12N2501/2302 , C12N2501/515 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/13 , C12N2506/11 , C12N2510/00
摘要： An object of the present invention is to provide methods for producing iPS cells with low invasivity and high efficiency. The iPS cells can be produced with high efficiency using a method comprising the steps of culturing mononuclear cells derived from peripheral blood for 3 to 14 days in the presence of anti-CD3 antibody, and subjecting the cultured mononuclear cells to dedifferentiation.
摘要翻译：本发明的目的是提供用于生产低侵入性和高效率的iPS细胞的方法。可以使用包括以下步骤的方法高效率地制备iPS细胞，所述方法包括在抗CD3抗体存在下培养来自外周血的单核细胞3至14天，并对培养的单核细胞进行去分化。

6. 发明授权

US08252583B2 Method for inducing differentiation into cardiomyocytes using G-CSF 有权
标题翻译：使用G-CSF诱导分化为心肌细胞的方法
公开(公告)号：US08252583B2
公开(公告)日：2012-08-28
申请号：US12663464
申请日：2008-06-06
申请人： Keiichi Fukuda , Shinsuke Yuasa , Kenichiro Shimoji
发明人： Keiichi Fukuda , Shinsuke Yuasa , Kenichiro Shimoji
IPC分类号： C12N5/00 , C12N5/02 , C12N5/07 , C12N5/071
CPC分类号： C12N5/0657 , A61K35/12 , C12N2501/155 , C12N2501/22 , C12N2506/02
摘要： A method for inducing differentiation of ES cells into cardiomyocytes, which comprises contacting the ES cells with an agonist for G-CSF receptor.
摘要翻译：一种诱导ES细胞分化为心肌细胞的方法，其包括将ES细胞与G-CSF受体激动剂接触。

7. 发明申请

US20090195960A1 Electronic Device and Production Method Thereof 有权
标题翻译：电子设备及其制作方法
公开(公告)号：US20090195960A1
公开(公告)日：2009-08-06
申请号：US11922697
申请日：2006-06-23
申请人： Shigeki Sato , Keiichi Fukuda
发明人： Shigeki Sato , Keiichi Fukuda
IPC分类号： H01G4/30 , C04B35/468 , C03C3/04
CPC分类号： H01G4/1227 , B82Y30/00 , C04B35/4686 , C04B35/6264 , C04B35/63424 , C04B35/638 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3224 , C04B2235/3225 , C04B2235/3241 , C04B2235/3262 , C04B2235/3272 , C04B2235/3275 , C04B2235/3279 , C04B2235/3418 , C04B2235/3436 , C04B2235/36 , C04B2235/5445 , C04B2235/5454 , C04B2235/6025 , C04B2235/656 , C04B2235/6562 , C04B2235/6567 , C04B2235/6582 , C04B2235/6584 , C04B2235/663 , C04B2235/79 , H01B3/12 , H01G4/30
摘要： Electronic device 1 comprises an element body 10, comprising a dielectric layer 2 constituted by a dielectric ceramic composition, and a terminal electrode 4, formed outside of the element body 10. The dielectric ceramic composition comprised a main component including barium titanate; a first subcomponent including at least one oxide of Mg and Ca; a second subcomponent including SiO2; a third subcomponent including at least one oxide of Mn and Cr; and a fourth subcomponent including an oxide of rare earth elements, wherein the net valence of Mn and/or Cr in the third subcomponent is 2.2 to 2.4. According to the electronic device 1, both high temperature accelerated lifetime characteristics and capacity stress aging characteristics can be improved in a balanced manner.
摘要翻译：电子设备1包括元件体10，其包括由电介质陶瓷组合物构成的电介质层2和形成在元件主体10的外部的端子电极4.该介电陶瓷组合物包括包含钛酸钡的主要成分; 包含Mg和Ca的至少一种氧化物的第一副成分; 第二个次要组分包括SiO2; 包含至少一种Mn和Cr的氧化物的第三副成分; 以及包含稀土元素氧化物的第四副成分，其中第三副成分中Mn和/或Cr的净价为2.2〜2.4。根据电子装置1，能够以均衡的方式提高高温加速寿命特性和容量应力老化特性。

8. 发明授权

US07531510B2 Methods of recruiting fibroblasts by administering G-CSF 有权
标题翻译：通过给予G-CSF募集成纤维细胞的方法
公开(公告)号：US07531510B2
公开(公告)日：2009-05-12
申请号：US10577241
申请日：2004-10-27
申请人： Keiichi Fukuda , Jun Fujita
发明人： Keiichi Fukuda , Jun Fujita
IPC分类号： A61K38/00 , A61K45/00
CPC分类号： A61K38/193
摘要： The object of the present invention is to achieve simple recruitment of fibroblasts into wounded tissues and engraftment of the fibroblasts in the wounded tissues, thereby healing the wounds without requiring fibroblast transplantation. Upon G-CSF administration, fibroblasts migrate into myocardial infarct lesions and prevent a reduction in cardiac function, thus alleviating cardiac remodeling.
摘要翻译：本发明的目的是实现将伤口组织中的成纤维细胞简单地募集到受伤组织中的成纤维细胞，从而使伤口愈合而不需要成纤维细胞移植。在G-CSF施用后，成纤维细胞迁移到心肌梗塞病变中并防止心脏功能的降低，从而减轻心脏重塑。

9. 发明申请

US20080090266A1 Method of Selecting a Cardiomyoctye Using Intracellular Mitochondria as an Indicator 有权
标题翻译：使用细胞内线粒体作为指标选择心肌细胞的方法
公开(公告)号：US20080090266A1
公开(公告)日：2008-04-17
申请号：US11660581
申请日：2005-08-26
申请人： Fumiyuki Hattori , Keiichi Fukuda
发明人： Fumiyuki Hattori , Keiichi Fukuda
IPC分类号： C12Q1/02 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0657 , C12N2506/02 , G01N33/56966
摘要： The invention relates to methods of selecting a cardiomyocyte from a cell population derived from a whole heart or a differentiated cell population derived from a stem cell without genetic alteration. Specifically, the invention relates to a method of selecting a cardiomyocyte from a cardiomyocyte-containing cell mixture without genetic alteration of a cardiomyocyte, on the basis of a relative content of cellular mitochondria and/or a relative mitochondrial transmembrane potential of the cell. The invention also relates to methods of enriching a cardiomyocyte from a cardiomyocyte-containing cell mixture without genetic alteration of a cardiomyocyte, producing a cardiomyocyte without genetic alteration of a cardiomyocyte, and evaluating the ratio of a cardiomyocyte in a cardiomyocyte-containing cell mixture.
摘要翻译：本发明涉及从源自全部心脏的细胞群体或源自干细胞的分化细胞群体中选择心肌细胞而不进行遗传改变的方法。具体地说，本发明涉及一种基于细胞线粒体的相对含量和/或细胞的相对线粒体跨膜电位从含有心肌细胞的细胞混合物中选择心肌细胞而不对心肌细胞进行遗传改变的方法。本发明还涉及从含有心肌细胞的细胞混合物中丰富心肌细胞的方法，而没有心肌细胞的遗传改变，产生心肌细胞而没有心肌细胞的遗传改变，以及评估心肌细胞含有心肌细胞的细胞混合物中的比例。

10. 发明授权

US07213156B2 Contents data transmission/reception system, contents data transmitter, contents data receiver and contents data transmission/reception method 有权
标题翻译：内容数据发送/接收系统，内容数据发送器，内容数据接收器和内容数据发送/接收方法
公开(公告)号：US07213156B2
公开(公告)日：2007-05-01
申请号：US10400491
申请日：2003-03-28
申请人： Keiichi Fukuda
发明人： Keiichi Fukuda
IPC分类号： H04L9/32
CPC分类号： H04N21/4367 , H04N7/163 , H04N7/1675 , H04N21/4405 , H04N21/4408
摘要： An object of the invention is to prevent original high quality contents data from being illegally obtained by extracting encryption breaking information from data transmitted through a single signal line for connecting two apparatuses and by using the encryption breaking information to decrypt encrypted contents data. In a contents data transmission/reception system, a contents data transmitter encrypts contents data by using key information, transmits the key information through plural signal lines to a contents data receiver, and then, transmits the encrypted contents data through the plural signal lines to the contents data receiver. The contents data receiver acquires the key information from data transmitted from the contents data transmitter through the plural signal lines, receives the encrypted contents data transmitted from the contents data transmitter through the plural signal lines, and decrypts the encrypted contents data by using the key information.
摘要翻译：本发明的目的是通过从通过用于连接两个装置的单个信号线发送的数据提取加密分解信息，并且通过使用加密分解信息来解密加密的内容数据来防止原始的高质量内容数据被非法获得。在内容数据发送/接收系统中，内容数据发送器通过使用密钥信息来加密内容数据，通过多个信号线将密钥信息发送到内容数据接收机，然后通过多个信号线将加密的内容数据发送到内容数据接收器。内容数据接收器从通过多条信号线从内容数据发送机发送的数据中获取密钥信息，通过多条信号线接收从内容数据发送机发送的加密内容数据，并通过使用密钥信息对加密的内容数据进行解密。

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