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1. 发明授权

US5602106A 16-membered macrolide derivatives 失效
标题翻译： 16元大环内酯衍生物
公开(公告)号：US5602106A
公开(公告)日：1997-02-11
申请号：US271996
申请日：1994-07-08
申请人： Keiichi Ajito , Osamu Hara , Ken-ichi Kurihara , Nobue Kikuchi , Minako Araake , Akira Shimizu , Tsuneo Okonogi , Shigeharu Inouye , Seiji Shibahara
发明人： Keiichi Ajito , Osamu Hara , Ken-ichi Kurihara , Nobue Kikuchi , Minako Araake , Akira Shimizu , Tsuneo Okonogi , Shigeharu Inouye , Seiji Shibahara
IPC分类号： C07H17/08 , A61K31/70
CPC分类号： C07H17/08
摘要： 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a substituent group which protects a hydroxyl group; R.sup.2 represents a hydrogen atom or a substituent group which protects a hydroxyl group; R.sup.3 represents a hydrogen atom or a straight-chain aliphatic acyl group having 2 to 4 carbon atoms; and R.sup.4 represents a hydrogen atom or a straight-chain aliphatic or aromatic acyl group having 1 to 10 carbon atoms;or a pharmaceutically acceptable salt thereof are disclosed.A novel process for producing these 16-membered macrolide derivatives is also disclosed.
摘要翻译：由式（I）表示的16元大环内酯衍生物：其中R 1表示氢原子或保护羟基的取代基; R2表示氢原子或保护羟基的取代基; R3表示氢原子或碳原子数2〜4的直链脂肪族酰基， R 4表示氢原子或碳原子数1〜10的直链脂肪族或芳香族酰基，或其药学上可接受的盐。还公开了一种制备这些16元大环内酯衍生物的新方法。

2. 发明授权

US5519122A 16-membered macrolide derivatives and process for producing the same 失效
公开(公告)号：US5519122A
公开(公告)日：1996-05-21
申请号：US359825
申请日：1994-12-20
申请人： Keiichi Ajito , Ken-ichi Kurihara , Akira Shimizu , Shuichi Gomi , Nobue Kikuchi , Minako Araake , Tsuneo Ishizuka , Aiko Miyata , Osamu Hara , Seiji Shibahara
发明人： Keiichi Ajito , Ken-ichi Kurihara , Akira Shimizu , Shuichi Gomi , Nobue Kikuchi , Minako Araake , Tsuneo Ishizuka , Aiko Miyata , Osamu Hara , Seiji Shibahara
IPC分类号： C07H17/08 , B01D53/047
CPC分类号： C07H17/08
摘要： 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 represents a straight-chain alkyl group having 1 to 3 carbon atoms; R.sup.2 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.3 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.4 represents a straight-chain alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted allyl group; and R.sup.5 represents a substituted or unsubstituted, straight-chain or branched alkyl, alkenyl or aralkyl group having 1 to 10 carbon atoms;and pharmaceutically acceptable salts thereof are disclosed. These compounds show excellent and long-acting antimicrobial activities. A novel process for producing these 16-membered macrolide derivatives is further disclosed.

3. 发明授权

US5407918A 16-membered macrolide derivatives and process for producing the same 失效
标题翻译： 16元大环内酯衍生物及其制备方法
公开(公告)号：US5407918A
公开(公告)日：1995-04-18
申请号：US143125
申请日：1993-10-29
申请人： Keiichi Ajito , Ken-ichi Kurihara , Akira Shimizu , Shuichi Gomi , Nobue Kikuchi , Minako Araake , Tsuneo Ishizuka , Aiko Miyata , Osamu Hara , Seiji Shibahara
发明人： Keiichi Ajito , Ken-ichi Kurihara , Akira Shimizu , Shuichi Gomi , Nobue Kikuchi , Minako Araake , Tsuneo Ishizuka , Aiko Miyata , Osamu Hara , Seiji Shibahara
IPC分类号： C07H17/08 , C12P19/62 , A61K31/70 , C12P19/60
CPC分类号： C07H17/08
摘要： 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 represents a straight-chain alkyl group having 1 to 3 carbon atoms; R.sup.2 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.3 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.4 represents a straight-chain alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted allyl group; and R.sup.5 represents a substituted or unsubstituted, straight-chain or branched alkyl, alkenyl or aralkyl group having 1 to 10 carbon atoms; and pharmaceutically acceptable salts thereof are disclosed. These compounds show excellent and long-acting antimicrobial activities. A novel process for producing these 16-membered macrolide derivatives is further disclosed.
摘要翻译：由式（I）表示的16元大环内酯衍生物：其中R 1表示氢原子或COR 6基团，其中R 6表示具有1至3个碳原子的直链烷基; R2表示氢原子或COR6基团，其中R6如上所定义; R3表示氢原子或COR6基团，其中R6如上所定义; R4表示碳原子数1〜4的直链烷基或取代或未取代的烯丙基; R 5表示具有1〜10个碳原子的取代或未取代的直链或支链烷基，烯基或芳烷基; 及其药学上可接受的盐。这些化合物显示出优异的长效抗菌活性。进一步公开了一种制备这些16元大环内酯衍生物的新方法。

4. 发明授权

US5219736A Process for producing 3-deacylated derivative of 16-membered macrolide antibiotic 失效
标题翻译：生产16-羟基磷灰石抗生素的3-脱乙酰衍生物的方法
公开(公告)号：US5219736A
公开(公告)日：1993-06-15
申请号：US925038
申请日：1992-08-05
申请人： Akira Shimizu , Shuichi Gomi , Keiichi Ajito , Takashi Yaguchi , Eriko Tanaka , Osamu Hara , Shinji Miyadoh
发明人： Akira Shimizu , Shuichi Gomi , Keiichi Ajito , Takashi Yaguchi , Eriko Tanaka , Osamu Hara , Shinji Miyadoh
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08 , C12N1/14 , C12P19/62 , C12R1/645
CPC分类号： C07H17/08 , C12P19/62
摘要： A method of producing a 3-deacylated derivative of a 16-membered macrolide antibiotic using a microorganism belonging to the genus Phialophora or Preussia which comprises incubating said microorganism with a 16-membered macrolide antibiotic in a medium containing nutritional sources commonly used for incubating microorganisms, isolating a 3-deacylated derivative from the incubation medium, a microorganism to be used for the above method and a novel macrolide antibiotic.

5. 发明授权

US4854889A Miniature electrical connector 失效
标题翻译：微型电连接器
公开(公告)号：US4854889A
公开(公告)日：1989-08-08
申请号：US197853
申请日：1988-05-24
申请人： Hiroo Ohtsuka , Osamu Hara , Akira Hori , Minoru Noda
发明人： Hiroo Ohtsuka , Osamu Hara , Akira Hori , Minoru Noda
IPC分类号： H01R4/24
CPC分类号： H01R4/2433
摘要： An electrical connector includes contacts to be connected to lead wires and a housing having apertures for receiving the contacts. The lead wires are connected to the contacts when the contacts are forced into the apertures of the housing. Each of the contacts comprises at one end a contact element to be in contact with an external terminal and at the other end a connection portion formed with a lead aperture through which a lead wire passes and with a slit continuous with the lead aperture. Edges of the slit pierce into an insulating coating of the lead wire and connect with a core of the lead wire under pressure. The housing is formed with through-apertures through each of which the contact element of each of the contacts extends and with receiving apertures each for receiving the lead wire under a condition that the edges of the slit of the connection portion of the contact pierce into the insulating coating of the lead wire and connect with the core of the lead wire under pressure and a remaining insulating coating is doubled. A doubled end of the lead wire received in each of the receiving apertures is positioned by a shoulder formed by a boundary wall between the receiving aperture and the through-aperture.
摘要翻译：电连接器包括要连接到引线的触点和具有用于接收触点的孔的壳体。当触头被迫进入外壳的孔口时，引线连接到触点。每个触点的一端包括与外部端子接触的接触元件，而另一端形成有引线孔的连接部分，引线通过该连接部分，并且与引线孔连通。狭缝的边缘刺入导线的绝缘涂层，并在压力下与引线的芯连接。壳体形成有通孔，通孔中的每一个的接触元件都延伸有接触孔，并且具有接收孔，每个接收孔用于在接触件的连接部分的狭缝的边缘刺入其中的条件下接收引线引线的绝缘涂层和压力下的引线芯连接，剩余的绝缘涂层加倍。在每个接收孔中容纳的引线的双端位于由接收孔和通孔之间的边界壁形成的肩部上。

6. 发明授权

US07593006B2 Input device for moving cursor and scrolling image on screen 有权
标题翻译：用于在屏幕上移动光标和滚动图像的输入设备
公开(公告)号：US07593006B2
公开(公告)日：2009-09-22
申请号：US11345467
申请日：2006-02-01
申请人： Osamu Hara , Kouichi Ogino , Kazuhito Ooshita , Akihisa Itoh
发明人： Osamu Hara , Kouichi Ogino , Kazuhito Ooshita , Akihisa Itoh
IPC分类号： G09G5/00 , G06F3/033
CPC分类号： G06F3/016 , G06F3/03543 , G06F3/03547 , G06F2203/014
摘要： In the case where the operator is moving the cursor on the computer screen through the use of a mouse, when the cursor display moves to a position which coincides with any of the menu display, a boundary position of the menu display or a position which coincides with the icon display, pressure sensing power generating means within the mouse is actuated to give a shock force or the like to the operator. This enables the operator to recognize the grasp in the operating state by not only visual judgment but also by hand.
摘要翻译：在操作者通过使用鼠标在计算机屏幕上移动光标的情况下，当光标显示移动到与任何菜单显示相符合的位置时，菜单显示的边界位置或重合的位置利用图标显示，致动鼠标内的压力感测发生装置，向操作者施加冲击力等。这使得操作者能够通过不仅视觉判断而且手动地识别操作状态下的把握。

7. 发明授权

US5781181A Apparatus and method for changing an operation mode of a coordinate input apparatus 失效
标题翻译：用于改变坐标输入装置的操作模式的装置和方法
公开(公告)号：US5781181A
公开(公告)日：1998-07-14
申请号：US682057
申请日：1996-07-16
申请人： Akira Yanai , Osamu Hara , Tsuyoshi Ogura
发明人： Akira Yanai , Osamu Hara , Tsuyoshi Ogura
IPC分类号： G06F3/041 , G06F3/033 , G06F3/038 , G06F3/048 , G08C21/00
CPC分类号： G06F3/04883
摘要： A coordinate detection system capable of displaying relevant coordinates when operated with only one fingertip or like coordinate designator even during a repeat operation of the latter with no complicated designator manipulations required. The system comprises a coordinate detection apparatus and a coordinate output apparatus. The coordinate detection apparatus includes a sensor substrate to be operated by the coordinate designator, scan driving output units for generating a detection signal in response to the coordinate designator operation, and signal processing units for extracting tap and slide component data from the detection signal and supplying the extracted data to the coordinate output apparatus. The coordinate output apparatus includes a state detecting unit for detecting the state of the tap and slide component data, a measuring unit for measuring the tap component data, a mode changing unit for changing operation modes depending on the result of the measurement, a control unit for controlling the apparatus and a display unit for displaying various kinds of data. Operation modes are changed only if the tap component data is supplied in a predetermined state.
摘要翻译：一种坐标检测系统，即使在后者的重复操作中也只能使用一个指尖或类似的坐标指示器来显示相关坐标，而不需要复杂的指示符操作。该系统包括坐标检测装置和坐标输出装置。坐标检测装置包括由坐标指示器操作的传感器基板，响应于坐标指示器操作产生检测信号的扫描驱动输出单元和用于从检测信号中提取抽头和滑动分量数据的信号处理单元，提取的数据到坐标输出装置。坐标输出装置包括用于检测抽头和滑动部件数据的状态的状态检测单元，用于测量分接部件数据的测量单元，用于根据测量结果改变操作模式的模式改变单元，控制单元用于控制装置和用于显示各种数据的显示单元。仅当在预定状态下提供抽头分量数据时才改变操作模式。

8. 发明授权

US08960847B2 Liquid ejecting apparatus having a light sensor for detecting when a recording medium is raised from a support unit 有权
标题翻译：液体喷射装置具有用于检测记录介质何时从支撑单元升起的光传感器
公开(公告)号：US08960847B2
公开(公告)日：2015-02-24
申请号：US13567885
申请日：2012-08-06
申请人： Osamu Hara , Tsuneyuki Sasaki
发明人： Osamu Hara , Tsuneyuki Sasaki
IPC分类号： B41J29/393 , B41J11/00
CPC分类号： B41J11/006 , B41J11/0095
摘要： A liquid ejecting apparatus including: a liquid ejecting head configured to eject liquid to a target; a supporting unit configured to support the target; a light-detecting unit arranged so that a transporting route is located between the supporting unit and the light-detecting unit in a prescribed direction in which the supporting unit and the target supported by the supporting unit are arranged when the supporting unit supports the target, and including a light-emitting portion configured to emit light and a light-receiving portion configured to receive the light from the light-emitting portion; and a determining unit configured to determine whether or not at least part of a supported portion of the target supported by the supporting unit is separated from the supporting unit on the basis of the light-receiving quantity at the light-receiving portion.
摘要翻译：一种液体喷射装置，包括：液体喷射头，其配置成将液体喷射到目标上; 配置为支撑所述目标的支撑单元; 光检测单元，其布置成使得当所述支撑单元支撑所述目标时，所述输送路径沿着规定的方向位于所述支撑单元和所述光检测单元之间，其中所述支撑单元和由所述支撑单元支撑的所述目标被支撑，并且包括被配置为发光的发光部分和被配置为接收来自发光部分的光的光接收部分; 以及确定单元，被配置为基于所述光接收部分的光接收量来确定由所述支撑单元支撑的所述目标的支撑部分的至少一部分是否与所述支撑单元分离。

9. 发明申请

US20060125788A1 Input device for moving cursor and scrolling image on screen 有权
公开(公告)号：US20060125788A1
公开(公告)日：2006-06-15
申请号：US11345467
申请日：2006-02-01
申请人： Osamu Hara , Kouichi Ogino , Kazuhito Ooshita , Akihisa Itoh
发明人： Osamu Hara , Kouichi Ogino , Kazuhito Ooshita , Akihisa Itoh
IPC分类号： G09G5/08
CPC分类号： G06F3/016 , G06F3/03543 , G06F3/03547 , G06F2203/014
摘要： In the case where the operator is moving the cursor on the computer screen through the use of a mouse, when the cursor display moves to a position which coincides with any of the menu display, a boundary position of the menu display or a position which coincides with the icon display, pressure sensing power generating means within the mouse is actuated to give a shock force or the like to the operator. This enables the operator to recognize the grasp in the operating state by not only visual judgment but also by hand.

10. 发明授权

US4144413A Rotary telephone dial 失效
标题翻译：旋转电话拨号
公开(公告)号：US4144413A
公开(公告)日：1979-03-13
申请号：US816219
申请日：1977-07-15
申请人： Tadashi Kodama , Masayuki Murakami , Tsuneji Kimeda , Tadahiko Matsuoka , Osamu Hara , Satoru Tsukiyama
发明人： Tadashi Kodama , Masayuki Murakami , Tsuneji Kimeda , Tadahiko Matsuoka , Osamu Hara , Satoru Tsukiyama
IPC分类号： H04M1/31 , H04M1/30 , H04M1/34
CPC分类号： H04M1/31
摘要： A rotary telephone dial, in which at least one shaft is fixedly planted on a base plate. A rotary member is rotatably mounted on the shaft. Another base plate is engaged with the free end of the shaft to support the shaft. One direction assembling can be performed as a result of the above structure. A finger moving compensation mechanism is provided to obtain a sufficent allowable range of finger moving. The spring retaining structure and the governor mechanism are improved to effectively reduce the number of parts and to realize simplification of the manufacturing process.
摘要翻译：旋转电话表盘，其中至少一个轴固定地植在基板上。旋转构件可旋转地安装在轴上。另一个底板与轴的自由端接合以支撑轴。作为上述结构的结果，可以进行单向组装。提供手指移动补偿机构以获得足够的手指移动的允许范围。改进了弹簧保持结构和调速器机构，以有效地减少零件数量并实现制造过程的简化。

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