会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明授权
    • Heterocycles substituted pyridine derivatives and antifungal agent containing thereof
    • 杂环取代的吡啶衍生物和含有它的抗真菌剂
    • US08153662B2
    • 2012-04-10
    • US12704643
    • 2010-02-12
    • Keigo TanakaSatoshi InoueNorio MuraiMasayuki MatsukuraKazutaka NakamotoShuji ShirotoriShinya Abe
    • Keigo TanakaSatoshi InoueNorio MuraiMasayuki MatsukuraKazutaka NakamotoShuji ShirotoriShinya Abe
    • A61K31/42A61K31/443C07D413/14
    • A01N43/56A01N43/80C07D401/04C07D401/14C07D413/04C07D413/14C07D417/14
    • An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability. According to the present invention, there is disclosed a compound represented by the following formula (I), or a salt thereof: wherein R1 represents a hydrogen atom, a halogen atom, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group or a C1-6 alkoxy C1-6 alkyl group; R2 represents a hydrogen atom, a C1-6 alkyl group, an amino group or a di C1-6 alkylamino group; one of X and Y is a nitrogen atom while the other is a nitrogen atom or an oxygen atom; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom, or 1 or 2 C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, —CH2O—, —OCH2—, —NH—, —CH2NH—, —NHCH2—, —CH2S—, or —SCH2—; R3 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-member heteroaryl group, or 5- or 6-member non-aromatic heterocyclic group which may have 1 or 2 substituents; and R4 represents a hydrogen atom or a halogen atom.
    • 本发明的目的是提供一种具有优异的抗真菌作用并且在其物理性质,安全性和代谢稳定性方面优异的抗真菌剂。 根据本发明,公开了由下式(I)表示的化合物或其盐:其中R1表示氢原子,卤素原子,氨基,C1-6烷基,C1- 6烷氧基或C 1-6烷氧基C 1-6烷基; R2表示氢原子,C1-6烷基,氨基或二C1-6烷基氨基; X和Y之一是氮原子,而另一个是氮原子或氧原子; 环A表示可以具有卤素原子或1或2个C 1-6烷基的5或6元杂芳基环或苯环; Z表示单键,亚甲基,亚乙基,氧原子,硫原子,-CH 2 O - , - OCH 2 - , - NH - , - CH 2 NH - , - NHCH 2 - , - CH 2 S-或-SCH 2 - ; R 3表示氢原子,卤素原子,C 1-6烷基,C 3-8环烷基,C 6-10芳基,5-或6-元杂芳基,或5-或6-元非 - 可以具有1或2个取代基的芳族杂环基; R4表示氢原子或卤素原子。
    • 5. 发明申请
    • PYRIDINE DERIVATIVE SUBSTITUTED BY HETEROARYL RING, AND ANTIFUNGAL AGENT COMPRISING THE SAME
    • 由异氟醚取代的吡啶衍生物和包括其的抗真菌剂
    • US20100099718A1
    • 2010-04-22
    • US12442293
    • 2007-09-20
    • Masayuki MatsukuraSatoshi InoueKeigo TanakaNorio MuraiShuji Shirotori
    • Masayuki MatsukuraSatoshi InoueKeigo TanakaNorio MuraiShuji Shirotori
    • A61K31/4439C07D401/04A61P31/10
    • C07D401/04C07D401/14C07D405/14C07D409/14C07D413/04C07D417/04
    • The present invention provides an antifungal agent that has excellent antifungal action, and is also excellent in terms of its properties, safety, and metabolic stability. The present invention discloses a compound represented by the following formula I or a salt thereof, and an antifungal agent comprising the compound or the salt: wherein R1 represents a hydrogen atom, a halogen atom, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6-alkoxy-C1-6-alkyl group; R2 represents a hydrogen atom or an amino group; X, Y, Z, and W independently represent a nitrogen atom, an oxygen atom, a sulfur atom, or —CH—, provided that at least two among X, Y, and W are nitrogen atoms; the ring A represents a 5- or 6-membered heteroaryl ring or a benzene ring; Q represents a methylene group, an oxygen atom, —CH2O—, —OCH2—, —NH—, —NHCH2—, or —CH2NH—; and R3 represents a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, or a 5- or 6-membered heteroaryl group, each of which may have one or two substituents.
    • 本发明提供具有优异抗真菌作用的抗真菌剂,并且在其性质,安全性和代谢稳定性方面也是优异的。 本发明公开了由下式I表示的化合物或其盐,以及包含该化合物或其盐的抗真菌剂:其中R1表示氢原子,卤素原子,氨基,C1-6烷基, C 1-6烷氧基或C 1-6 - 烷氧基-C 1-6 - 烷基; R2表示氢原子或氨基; X,Y,Z和W独立地表示氮原子,氧原子,硫原子或-CH-,条件是X,Y和W中的至少两个是氮原子; 环A表示5-或6-元杂芳基环或苯环; Q表示亚甲基,氧原子,-CH 2 O - , - OCH 2 - , - NH - , - NHCH 2 - 或-CH 2 NH-; 并且R 3表示可以具有一个或两个取代基的C 1-6烷基,C 3-8环烷基,C 6-10芳基或5或6元杂芳基。
    • 6. 发明授权
    • Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
    • 被杂芳基环取代的吡啶衍生物,及含有它们的抗真菌剂
    • US08183264B2
    • 2012-05-22
    • US12442293
    • 2007-09-20
    • Masayuki MatsukuraSatoshi InoueKeigo TanakaNorio MuraiShuji Shirotori
    • Masayuki MatsukuraSatoshi InoueKeigo TanakaNorio MuraiShuji Shirotori
    • A61K31/4439C07D401/04
    • C07D401/04C07D401/14C07D405/14C07D409/14C07D413/04C07D417/04
    • The present invention provides an antifungal agent that has excellent antifungal action, and is also excellent in terms of its properties, safety, and metabolic stability. The present invention discloses a compound represented by the following formula I or a salt thereof, and an antifungal agent comprising the compound or the salt: wherein R1 represents a hydrogen atom, a halogen atom, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6-alkoxy-C1-6-alkyl group; R2 represents a hydrogen atom or an amino group; X, Y, Z, and W independently represent a nitrogen atom, an oxygen atom, a sulfur atom, or —CH—, provided that at least two among X, Y, and W are nitrogen atoms; the ring A represents a 5- or 6-membered heteroaryl ring or a benzene ring; Q represents a methylene group, an oxygen atom, —CH2O—, —OCH2—, —NH—, —NHCH2—, or —CH2NH—; and R3 represents a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, or a 5- or 6-membered heteroaryl group, each of which may have one or two substituents.
    • 本发明提供具有优异抗真菌作用的抗真菌剂,并且在其性质,安全性和代谢稳定性方面也是优异的。 本发明公开了由下式I表示的化合物或其盐,以及包含该化合物或其盐的抗真菌剂:其中R1表示氢原子,卤素原子,氨基,C1-6烷基, C 1-6烷氧基或C 1-6 - 烷氧基-C 1-6 - 烷基; R2表示氢原子或氨基; X,Y,Z和W独立地表示氮原子,氧原子,硫原子或-CH-,条件是X,Y和W中的至少两个是氮原子; 环A表示5-或6-元杂芳基环或苯环; Q表示亚甲基,氧原子,-CH 2 O - , - OCH 2 - , - NH - , - NHCH 2 - 或-CH 2 NH-; 并且R 3表示可以具有一个或两个取代基的C 1-6烷基,C 3-8环烷基,C 6-10芳基或5或6元杂芳基。
    • 9. 发明授权
    • Heterocycles substituted pyridine derivatives and antifungal agent containing thereof
    • 杂环取代的吡啶衍生物和含有它的抗真菌剂
    • US07691882B2
    • 2010-04-06
    • US11589128
    • 2006-10-30
    • Keigo TanakaSatoshi InoueNorio MuraiMasayuki MatsukuraKazutaka NakamotoShuji ShirotoriShinya Abe
    • Keigo TanakaSatoshi InoueNorio MuraiMasayuki MatsukuraKazutaka NakamotoShuji ShirotoriShinya Abe
    • A61K31/443C07D413/14
    • A01N43/56A01N43/80C07D401/04C07D401/14C07D413/04C07D413/14C07D417/14
    • An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability. According to the present invention, there is disclosed a compound represented by the following formula (I), or a salt thereof: wherein R1 represents a hydrogen atom, a halogen atom, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group or a C1-6 alkoxy C1-6 alkyl group; R2 represents a hydrogen atom, a C1-6 alkyl group, an amino group or a di C1-6 alkylamino group; one of X and Y is a nitrogen atom while the other is a nitrogen atom or an oxygen atom; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom, or 1 or 2 C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, —CH2O—, —OCH2—, —NH—, —CH2NH—, —NHCH2—, —CH2S—, or —SCH2—; R3 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-member heteroaryl group, or 5- or 6-member non-aromatic heterocyclic group which may have 1 or 2 substituents; and R4 represents a hydrogen atom or a halogen atom.
    • 本发明的目的是提供一种具有优异的抗真菌作用并且在其物理性质,安全性和代谢稳定性方面优异的抗真菌剂。 根据本发明,公开了由下式(I)表示的化合物或其盐:其中R1表示氢原子,卤素原子,氨基,C1-6烷基,C1- 6烷氧基或C 1-6烷氧基C 1-6烷基; R2表示氢原子,C1-6烷基,氨基或二C1-6烷基氨基; X和Y之一是氮原子,而另一个是氮原子或氧原子; 环A表示可以具有卤素原子或1或2个C 1-6烷基的5或6元杂芳基环或苯环; Z表示单键,亚甲基,亚乙基,氧原子,硫原子,-CH 2 O - , - OCH 2 - , - NH - , - CH 2 NH - , - NHCH 2 - , - CH 2 S-或-SCH 2 - ; R 3表示氢原子,卤素原子,C 1-6烷基,C 3-8环烷基,C 6-10芳基,5-或6-元杂芳基,或5-或6-元非 - 可以具有1或2个取代基的芳族杂环基; R4表示氢原子或卤素原子。
    • 10. 发明申请
    • Heterocycles substituted pyridine derivatives and antifungal agent containing thereof
    • 杂环取代的吡啶衍生物和含有它的抗真菌剂
    • US20070105904A1
    • 2007-05-10
    • US11589128
    • 2006-10-30
    • Keigo TanakaSatoshi InoueNorio MuraiMasayuki MatsukuraKazutaka NakamotoShuji ShirotoriShinya Abe
    • Keigo TanakaSatoshi InoueNorio MuraiMasayuki MatsukuraKazutaka NakamotoShuji ShirotoriShinya Abe
    • A61K31/444A61K31/4439C07D413/14C07D403/14
    • A01N43/56A01N43/80C07D401/04C07D401/14C07D413/04C07D413/14C07D417/14
    • An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability. According to the present invention, there is disclosed a compound represented by the following formula (I), or a salt thereof: wherein R1 represents a hydrogen atom, a halogen atom, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group or a C1-6 alkoxy C1-6 alkyl group; R2 represents a hydrogen atom, a C1-6 alkyl group, an amino group or a di C1-6 alkylamino group; one of X and Y is a nitrogen atom while the other is a nitrogen atom or an oxygen atom; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom, or 1 or 2 C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, —CH2O—, —OCH2—, —NH—, —CH2NH—, —NHCH2—, —CH2S—, or —SCH2—; R3 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-member heteroaryl group, or 5- or 6-member non-aromatic heterocyclic group which may have 1 or 2 substituents; and R4 represents a hydrogen atom or a halogen atom.
    • 本发明的目的是提供一种具有优异的抗真菌作用并且在其物理性质,安全性和代谢稳定性方面优异的抗真菌剂。 根据本发明,公开了由下式(I)表示的化合物或其盐:其中R 1表示氢原子,卤素原子,氨基,C C 1-6烷基,C 1-6烷氧基或C 1-6烷氧基C 1-6烷基, 烷基; R 2表示氢原子,C 1-6烷基,氨基或二C 1-6烷基氨基; X和Y之一是氮原子,而另一个是氮原子或氧原子; 环A表示可以具有卤素原子或1或2个C 1-6烷基的5或6元杂芳基环或苯环; Z表示单键,亚甲基,亚乙基,氧原子,硫原子,-CH 2 O,-OCH 2 - , - NH- ,-CH 2 NH-,-NHCH 2 - , - CH 2 S - 或-SCH 2 - - ; R 3表示氢原子,卤素原子,C 1-6烷基,C 3-8环烷基,C 可以具有1或2个取代基的5-或6-元芳基,5-或6-元杂芳基或5-或6-元非芳族杂环基; R 4表示氢原子或卤素原子。