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1. 发明申请

US20110231960A1 BACTERIAL TOXIN VACCINE 有权
标题翻译：细菌毒素疫苗
公开(公告)号：US20110231960A1
公开(公告)日：2011-09-22
申请号：US12990597
申请日：2009-04-28
申请人： Kazutoshi Sawada , Kazuya Yoshida , Mayumi Yoshida , Nobuo Yoshida , Kyoko Yoshida , Takeshi Matsui
发明人： Kazutoshi Sawada , Kazuya Yoshida , Mayumi Yoshida , Nobuo Yoshida , Kyoko Yoshida , Takeshi Matsui
IPC分类号： A01H5/00 , C12N15/63 , C07K19/00 , C07H21/04 , C12N5/10 , A01H5/10 , C07K7/08 , C07K14/00
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K2039/517 , C07K14/25 , C07K14/28 , C07K2319/00 , C07K2319/55 , C12N15/8258 , Y02A50/472 , Y02A50/474
摘要： A bacterial toxin protein such as a Shiga toxin protein is efficiently produced using plant cells. The plant cells are transformed using a DNA construct containing DNA encoding a hybrid protein in which the bacterial toxin proteins such as the Shiga toxin proteins are tandemly linked through a peptide having the following characteristics (A) and (B) to produce the bacterial toxin protein in the plant cells: (A) a number of amino acids is 12 to 30; and (B) a content of proline is 20 to 35%.
摘要翻译：使用植物细胞有效地产生细菌毒素蛋白如志贺毒素蛋白质。使用含有编码杂合蛋白的DNA的DNA构建体转化植物细胞，其中细菌毒素蛋白如志贺毒素蛋白通过具有以下特征（A）和（B）的肽串联连接以产生细菌毒素蛋白在植物细胞中：（A）一些氨基酸为12〜30; （B）脯氨酸含量为20〜35％。

2. 发明申请

US20110002950A1 PIG EDEMA DISEASE VACCINE 有权
标题翻译： PIG EDEMA DISEATE VACCINE
公开(公告)号：US20110002950A1
公开(公告)日：2011-01-06
申请号：US12667393
申请日：2008-03-25
申请人： Kazutoshi Sawada , Kazuya Yoshida , Mayumi Yoshida , Nobuo Yoshida , Kyoko Yoshida , Takeshi Matsui , Sou-ichi Makino , Keiko Kawamoto
发明人： Kazutoshi Sawada , Kazuya Yoshida , Mayumi Yoshida , Nobuo Yoshida , Kyoko Yoshida , Takeshi Matsui , Sou-ichi Makino , Keiko Kawamoto
IPC分类号： A61K39/00 , C07H21/04 , C12N15/63 , C12N5/10 , A01H5/00
CPC分类号： C12N15/8258 , A61K39/0258 , A61K2039/517 , A61K2039/552 , C12N15/8257 , Y02A50/474
摘要： A technology for producing a pig edema disease vaccine at low cost and at high efficiency is developed. Specifically, a gene of a pig edema disease toxin protein (Stx2e protein) is efficiently expressed in plant cells to produce a plant vaccine for pig edema disease at low cost. An Stx2e protein including a secretory signal peptide derived from a plant added at an amino terminus is expressed in cells of a plant such as Lactuca sativa using the 5′-untranslated region of an alcohol dehydrogenase gene (ADH5′UTR) derived from a plant.
摘要翻译：开发了一种以低成本，高效率生产猪水肿病疫苗的技术。具体地说，猪水肿病毒素蛋白（Stx2e蛋白）的基因在植物细胞中有效表达，以低成本生产猪水肿病植物疫苗。使用源于植物的醇脱氢酶基因（ADH5'UTR）的5'-非翻译区，在植物如莴苣植物的细胞中表达包含衍生自在氨基末端添加的植物的分泌信号肽的Stx2e蛋白质。

3. 发明授权

US09080180B2 Transgenic plants expressing STX2EB protein for use as a pig edema disease vaccine 有权
标题翻译：表达STX2EB蛋白的转基因植物用作猪水肿病疫苗
公开(公告)号：US09080180B2
公开(公告)日：2015-07-14
申请号：US12667393
申请日：2008-03-25
申请人： Kazutoshi Sawada , Takeshi Matsui , Sou-ichi Makino , Keiko Kawamoto , Mayumi Yoshida , Nobuo Yoshida , Kyoko Yoshida
发明人： Kazutoshi Sawada , Kazuya Yoshida , Takeshi Matsui , Sou-ichi Makino , Keiko Kawamoto
IPC分类号： C12N15/82 , C12N15/30 , A61K39/112 , A61K39/108 , A61K39/00
CPC分类号： C12N15/8258 , A61K39/0258 , A61K2039/517 , A61K2039/552 , C12N15/8257 , Y02A50/474
摘要： A technology for producing a pig edema disease vaccine at low cost and at high efficiency is developed. Specifically, a gene of a pig edema disease toxin protein (Stx2e protein) is efficiently expressed in plant cells to produce a plant vaccine for pig edema disease at low cost. An Stx2e protein including a secretory signal peptide derived from a plant added at an amino terminus is expressed in cells of a plant such as Lactuca sativa using the 5′-untranslated region of an alcohol dehydrogenase gene (ADH5′UTR) derived from a plant.
摘要翻译：开发了一种以低成本，高效率生产猪水肿病疫苗的技术。具体地说，猪水肿病毒素蛋白（Stx2e蛋白）的基因在植物细胞中有效表达，以低成本生产猪水肿病植物疫苗。使用源于植物的醇脱氢酶基因（ADH5'UTR）的5'-非翻译区，在植物如莴苣植物的细胞中表达包含衍生自在氨基末端添加的植物的分泌信号肽的Stx2e蛋白质。

4. 发明授权

US08846052B2 Bacterial toxin vaccine 有权
标题翻译：细菌毒素疫苗
公开(公告)号：US08846052B2
公开(公告)日：2014-09-30
申请号：US12990597
申请日：2009-04-28
申请人： Kazutoshi Sawada , Takeshi Matsui , Mayumi Yoshida , Nobuo Yoshida , Kyoko Yoshida
发明人： Kazutoshi Sawada , Kazuya Yoshida , Takeshi Matsui
IPC分类号： A61K39/02 , C07K19/00 , A01H5/00 , C12N15/62 , C12N15/82 , C12N15/66 , A61K39/108 , C07K14/25 , C07K14/245 , A61K39/00
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K2039/517 , C07K14/25 , C07K14/28 , C07K2319/00 , C07K2319/55 , C12N15/8258 , Y02A50/472 , Y02A50/474
摘要： A bacterial toxin protein such as a Shiga toxin protein is efficiently produced using plant cells. The plant cells are transformed using a DNA construct containing DNA encoding a hybrid protein in which the bacterial toxin proteins such as the Shiga toxin proteins are tandemly linked through a peptide having the following characteristics (A) and (B) to produce the bacterial toxin protein in the plant cells: (A) a number of amino acids is 12 to 30; and (B) a content of proline is 20 to 35%.
摘要翻译：使用植物细胞有效地产生细菌毒素蛋白如志贺毒素蛋白质。使用含有编码杂合蛋白的DNA的DNA构建体转化植物细胞，其中细菌毒素蛋白如志贺毒素蛋白通过具有以下特征（A）和（B）的肽串联连接以产生细菌毒素蛋白在植物细胞中：（A）一些氨基酸为12〜30; （B）脯氨酸含量为20〜35％。

5. 发明授权

US5369513A Liquid crystal display device with biaxial birefringent plates and light shielding film 失效
标题翻译：具有双轴双折射板和遮光膜的液晶显示装置
公开(公告)号：US5369513A
公开(公告)日：1994-11-29
申请号：US987455
申请日：1992-12-07
申请人： Minoru Akatsuka , Yuji Sohda , Kazutoshi Sawada
发明人： Minoru Akatsuka , Yuji Sohda , Kazutoshi Sawada
IPC分类号： G02F1/13363 , G02F1/139 , G02F1/1335 , G02F1/137
CPC分类号： G02F1/133634 , G02F1/1397
摘要： The liquid crystal display device of the present invention comprises a liquid crystal layer of a nematic liquid crystal having positive dielectric anisotropy and including a chiral material, the liquid crystal layer being interposed between a pair of substrates with transparent electrodes each having an aligning layer which are arranged substantially in parallel to provide a twist angle of 160.degree.-300.degree., a driving means to apply a voltage across the electrodes attached to the substrates which interpose the liquid crystal layer, a pair of polarizing plates arranged outside the liquid crystal layer, and at least one birefringent plate provided between the liquid crystal layer and the polarizing plate at at least one side of the liquid crystal layer, wherein the product .DELTA.n.sub.1 .multidot.d, of the anisotropy of refractive index .DELTA.n, of liquid crystal molecules in the liquid crystal layer and the thickness d, of the liquid crystal layer is in a range of 0.4-1.5 .mu.m, and three main refractive indices n.sub.x, n.sub.y and n.sub.z of the birefringent plate are in a relation of n.sub.x .gtoreq.n.sub.z >n.sub.y where n.sub.x and n.sub.y respectively represent the refractive indices in the direction of film plane of the birefringent plate (provided n.sub.x >n.sub.y) and n.sub.z represents the refractive index in the direction of film thickness of the birefringent plate.
摘要翻译：本发明的液晶显示装置包括具有正介电各向异性的向列型液晶的液晶层，并且包括手性材料，液晶层插入在一对基板之间，每个基板具有各自具有对准层的透明电极，基本上平行布置以提供160°-300°的扭曲角;驱动装置，用于在安置在液晶层的基板上的电极上施加电压，布置在液晶层外侧的一对偏振板，以及在液晶层的至少一侧在液晶层和偏振片之间设置的至少一个双折射板，其中液晶层中的液晶分子的折射率DELTA n的各向异性的产物DELTA n1xd 并且液晶层的厚度d在0.4-1.5μm的范围内，并且三个主要折射双折射板的ve指数nx，ny和nz为nx> n = nz> ny的关系，其中nx和ny分别表示双折射板（提供nx> ny）的膜平面方向的折射率和nz 表示双折射板的膜厚方向的折射率。

6. 发明授权

US07343792B2 Method and apparatus for inspecting operation condition of pump 有权
标题翻译：检查泵运行状态的方法和装置
公开(公告)号：US07343792B2
公开(公告)日：2008-03-18
申请号：US11252620
申请日：2005-10-19
申请人： Kazutoshi Sawada
发明人： Kazutoshi Sawada
IPC分类号： G01M19/00
CPC分类号： G01M99/008
摘要： A circuit is used which includes: first and second channels having first and second input ports, respectively, and a third channel having an end where the first and second channel meet and are connected to the third channel. A first liquid to the first input port is supplied to generate a reference flow. A second liquid is supplied by the target pump to the second input port. An interface of the first and the second liquids joined in the third channel is inspected. The operation condition of the target pump is determined from a condition of the inspected interface. Pulsation in the flow supplied by the target pump is detected from waves in the interface visually inspected. The image of the interface may be magnified. Pulsation in the reference pump may be absorbed.
摘要翻译：使用电路，其包括：分别具有第一和第二输入端口的第一和第二通道，以及具有第一和第二通道相交并连接到第三通道的端部的第三通道。提供到第一输入端口的第一液体以产生参考流。目标泵将第二液体供给到第二输入口。检查在第三通道中接合的第一和第二液体的界面。目标泵的运行状态根据被检查的界面的状况确定。由目标泵提供的流量中的脉动是通过目视检查的界面中的波来检测的。可以放大界面的图像。参考泵中的脉冲可能被吸收。

7. 发明授权

US5523867A Liquid crystal display device having light shielding film and birefringent films with N.sub.x =N.sub.z >N.sub.y 失效
标题翻译：具有遮光膜和Nx = Nz> Ny的双折射膜的液晶显示装置
公开(公告)号：US5523867A
公开(公告)日：1996-06-04
申请号：US358942
申请日：1994-12-19
申请人： Minoru Akatsuka , Yuji Sohda , Kazutoshi Sawada
发明人： Minoru Akatsuka , Yuji Sohda , Kazutoshi Sawada
IPC分类号： G02F1/13363 , G02F1/139 , G02F1/1335
CPC分类号： G02F1/133634 , G02F1/1397
摘要： The liquid crystal display device of the present invention comprises a liquid crystal layer of a nematic liquid crystal having positive dielectric anisotropy and including a chiral material, the liquid crystal layer being interposed between a pair of substrates with transparent electrodes each having an aligning layer which are arranged substantially in parallel to provide a twist angle of 160.degree.-300.degree., a driving means to apply a voltage across the electrodes attached to the substrates which interpose the liquid crystal layer, a pair of polarizing plates arranged outside the liquid crystal layer, and at least one birefringent plate provided between the liquid crystal layer and the polarizing plate at at least one side of the liquid crystal layer, wherein the product .DELTA.n.sub.1 .multidot.d, of the anisotropy of refractive index .DELTA.n, of liquid crystal molecules in the liquid crystal layer and the thickness d, of the liquid crystal layer is in a range of 0.4-1.5 .mu.m, and three main refractive indices n.sub.x, n.sub.y and n.sub.z of the birefringent plate are in a relation of n.sub.x .gtoreq.n.sub.z >n.sub.y where n.sub.x and n.sub.y respectively represent the refractive indices in the direction of film plane of the birefringent plate (provided n.sub.x >n.sub.y) and n.sub.z represents the refractive index in the direction of film thickness of the birefringent plate.
摘要翻译：本发明的液晶显示装置包括具有正介电各向异性的向列型液晶的液晶层，并且包括手性材料，液晶层插入在一对基板之间，每个基板具有各自具有对准层的透明电极，基本上平行布置以提供160°-300°的扭曲角;驱动装置，用于在安置在液晶层的基板上的电极上施加电压，布置在液晶层外侧的一对偏振板，以及在液晶层的至少一侧在液晶层和偏振片之间设置的至少一个双折射板，其中液晶层中的液晶分子的折射率DELTA n的各向异性的产物DELTA n1xd 并且液晶层的厚度d在0.4-1.5μm的范围内，并且三个主要折射双折射板的ve指数nx，ny和nz为nx> n = nz> ny的关系，其中nx和ny分别表示双折射板（提供nx> ny）的膜平面方向的折射率和nz 表示双折射板的膜厚方向的折射率。

8. 发明授权

US5136406A Plural layer liquid crystal display device for a high density display 失效
标题翻译：多层液晶显示器件，用于高密度显示
公开(公告)号：US5136406A
公开(公告)日：1992-08-04
申请号：US364439
申请日：1989-06-06
申请人： Kazunori Kato , Yukiio Endo , Minoru Akatsuka , Masao Ohgawara , Kazutoshi Sawada
发明人： Kazunori Kato , Yukiio Endo , Minoru Akatsuka , Masao Ohgawara , Kazutoshi Sawada
IPC分类号： G02F1/133 , G02F1/1335 , G02F1/13363 , G02F1/1347 , G02F1/137 , G02F1/139
CPC分类号： G02F1/13475 , G02F1/133636 , G02F1/13471 , G02F1/1397
摘要： A plural layer liquid crystal display device for a high density display has a second liquid crystal layer containing dye and a dirst layer constructed such that the product .DELTA.n.sub.1 .multidot.d.sub.1 of the anisotropy of refractive index .DELTA.n.sub.1 of liquid molecules in the first liquid crystal layer and the thickness of the first liquid crystal layer d.sub.1 is in a range of 0.7-2.0 .mu.m. The foregoing arrangement provides a display close to a monochrome display with excellent viewing angle characteristics and a high contrast ratio.
摘要翻译： PCT No.PCT / JP88 / 01000 Sec。 371日期：1989年6月6日 102（e）日期1989年6月6日PCT提交1988年9月30日PCT公开号出版物WO89 / 03542 日本1989年4月20日。用于高密度显示器的多层液晶显示装置具有包含染料和第一层的第二液晶层，其构造为使得液体分子的折射率DELTA n1的各向异性的乘积DELTA n1xd1 第一液晶层和第一液晶层d1的厚度在0.7-2.0μm的范围内。上述布置提供了接近具有优异的视角特性和高对比度的单色显示的显示。

9. 发明申请

US20060096363A1 Method and apparatus for inspecting operation condition of pump 有权
标题翻译：检查泵运行状态的方法和装置
公开(公告)号：US20060096363A1
公开(公告)日：2006-05-11
申请号：US11252620
申请日：2005-10-19
申请人： Kazutoshi Sawada
发明人： Kazutoshi Sawada
IPC分类号： G01M19/00
CPC分类号： G01M99/008
摘要： A circuit is used which includes: first and second channels having first and second input ports, respectively, and a third channel having an end where the first and second channel meet and are connected to the third channel. A first liquid to the first input port is supplied to generate a reference flow. A second liquid is supplied by the target pump to the second input port. An interface of the first and the second liquids joined in the third channel is inspected. The operation condition of the target pump is determined from a condition of the inspected interface. Pulsation in the flow supplied by the target pump is detected from waves in the interface visually inspected. The image of the interface may be magnified. Pulsation in the reference pump may be absorbed.
摘要翻译：使用电路，其包括：分别具有第一和第二输入端口的第一和第二通道，以及具有第一和第二通道相交并连接到第三通道的端部的第三通道。提供到第一输入端口的第一液体以产生参考流。目标泵将第二液体供给到第二输入口。检查在第三通道中连接的第一和第二液体的界面。目标泵的运行状态根据被检查的界面的状况确定。由目标泵提供的流量中的脉动是通过目视检查的界面中的波来检测的。可以放大界面的图像。参考泵中的脉冲可能被吸收。

10. 发明授权

US5923392A Liquid crystal display device 失效
标题翻译：液晶显示装置
公开(公告)号：US5923392A
公开(公告)日：1999-07-13
申请号：US805500
申请日：1997-02-26
申请人： Minoru Akatsuka , Yuji Sohda , Kazutoshi Sawada
发明人： Minoru Akatsuka , Yuji Sohda , Kazutoshi Sawada
IPC分类号： G02F1/13363 , G02F1/139 , G02F1/1335
CPC分类号： G02F1/133634 , G02F1/1397
摘要： The liquid crystal display device of the present invention comprises a liquid crystal layer of a nematic liquid crystal having positive dielectric anisotropy and including a chiral material, the liquid crystal layer being interposed between a pair of substrates with transparent electrodes each having an aligning layer which are arranged substantially in parallel to provide a twist angle of 160-300.degree., a driving means to apply a voltage across the electrodes attached to the substrates which interpose the liquid crystal layer, a pair of polarizing plates arranged outside the liquid crystal layer, and at least one birefringent plate provided between the liquid crystal layer and the polarizing plate at at least one side of the liquid crystal layer, wherein the product .DELTA.n.sub.1 .multidot.d, of the anisotropy of refractive index .DELTA.n, of liquid crystal molecules in the liquid crystal layer and the thickness d, of the liquid crystal layer is in a range of 0.4-1.5 .mu.m, and three main refractive indices n.sub.x, n.sub.y and n.sub.z of the birefringent plate are in a relation of n.sub.x .gtoreq.n.sub.z >n.sub.y where n.sub.x and n.sub.y respectively represent the refractive indices in the direction of film plane of the birefringent plate (provided n.sub.x >n.sub.y) and n.sub.z represents the refractive index in the direction of film thickness of the birefringent plate.
摘要翻译：本发明的液晶显示装置包括具有正介电各向异性的向列型液晶的液晶层，并且包括手性材料，液晶层插入在一对基板之间，每个基板具有各自具有对准层的透明电极，基本上平行布置以提供160-300°的扭曲角;驱动装置，用于施加电极，所述驱动装置在安置在液晶层的基板上的电极和布置在液晶层外侧的一对偏振板在液晶层的至少一侧在液晶层和偏振片之间设置有至少一个双折射板，其中液晶层中的液晶分子的折射率DELTA n的各向异性的产物DELTA n1xd和液晶层的厚度d在0.4-1.5μm的范围内，并且三个主折射率双折射板的骰子nx，ny和nz是nx> n = nz> ny的关系，其中nx和ny分别表示双折射板（提供nx> ny）的膜平面方向上的折射率，nz表示双折射板的膜厚方向的折射率。

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