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1. 发明授权

US07541363B2 Microcrystal 有权
标题翻译：微晶
公开(公告)号：US07541363B2
公开(公告)日：2009-06-02
申请号：US10554511
申请日：2004-05-07
申请人： Kazutoshi Kuroda , Noboru Aoki , Toshiro Ochiai , Akihiro Uchida , Yasuhiro Ishikawa , Makoto Kigoshi , Eiji Hayakawa , Kazuki Asanome
发明人： Kazutoshi Kuroda , Noboru Aoki , Toshiro Ochiai , Akihiro Uchida , Yasuhiro Ishikawa , Makoto Kigoshi , Eiji Hayakawa , Kazuki Asanome
IPC分类号： C07D473/06 , A61K31/522
CPC分类号： C07D473/06
摘要： Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.
摘要翻译：平均粒径小于50埃的（E）-8-（3,4-二甲氧基苯乙烯基）-1,3-二乙基-7-甲基-3,7-二氢-1H-嘌呤-2,6-二酮的微晶妈妈（E）-8-（3,4-二甲氧基苯乙烯基）-1,3-二乙基-7-甲基-3,7-二氢-1H-嘌呤-2,6-二酮的微晶，平均粒径小于50 具有优异的溶解性，稳定性，生物利用度，药物配方中的分散性的20％以上的结晶度等。等等。还提供了其特征在于包含其的固体药物制剂。

2. 发明申请

US20060205745A1 Microcrystal 有权
公开(公告)号：US20060205745A1
公开(公告)日：2006-09-14
申请号：US10554511
申请日：2004-05-07
申请人： Kazutoshi Kuroda , Noboru Aoki , Toshiro Ochiai , Akihiro Uchida , Yasuhiro Ishikawa , Makoto Kigoshi , Eiji Hayakawa
发明人： Kazutoshi Kuroda , Noboru Aoki , Toshiro Ochiai , Akihiro Uchida , Yasuhiro Ishikawa , Makoto Kigoshi , Eiji Hayakawa
IPC分类号： A61K31/522 , C07D473/02
CPC分类号： C07D473/06
摘要： Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.

3. 发明授权

US06254889B1 Solid dispersion dosage form of amorphous xanthine derivative and enteric-coating polymer 失效
标题翻译：固体分散剂形式的无定形黄嘌呤衍生物和肠溶衣聚合物
公开(公告)号：US06254889B1
公开(公告)日：2001-07-03
申请号：US08809651
申请日：1997-03-26
申请人： Makoto Kigoshi , Tomoaki Masada , Yasuhiko Ueno , Yasuhiro Ishikawa , Eiji Hayakawa
发明人： Makoto Kigoshi , Tomoaki Masada , Yasuhiko Ueno , Yasuhiro Ishikawa , Eiji Hayakawa
IPC分类号： A61K910
CPC分类号： C07D473/06 , A61K9/146 , C07D473/04
摘要： The present invention relates to a solid dispersion and a solid dispersion dosage form which comprise a xanthine derivative represented by the following formula (I) or a pharmacologically allowable salt thereof and a polymer. (In the above formula, R1 and R2 are the same or different, and represent substituted or unsubstituted lower alkyl groups, and Q represents a hydrogen atom or a hydroxyl group.)
摘要翻译：本发明涉及一种固体分散体和固体分散体剂型，其包含由下式（I）表示的黄嘌呤衍生物或其药理学允许的盐和聚合物（在上式中，R 1和R 2相同或不同，不同，表示取代或未取代的低级烷基，Q表示氢原子或羟基。

4. 发明授权

US06964779B1 Tablet manufacturing method and tablet 有权
标题翻译：平板电脑制造方法和平板电脑
公开(公告)号：US06964779B1
公开(公告)日：2005-11-15
申请号：US09647786
申请日：1999-04-07
申请人： Eiji Hayakawa , Yasuhiro Ishikawa , Tomohiko Goto , Kiyoshi Morimoto , Kunio Ito
发明人： Eiji Hayakawa , Yasuhiro Ishikawa , Tomohiko Goto , Kiyoshi Morimoto , Kunio Ito
IPC分类号： A61J3/10 , B30B15/00 , A61K9/20
CPC分类号： A61J3/10 , B30B15/0011
摘要： According to the tablet production method of the present invention, tablet is produced by compressing molding material by means of punches and dies comprising the steps of using powdered or granular material including compound which is denaturalized or inactivated when tabletted at high pressure is used as the molding material, housing the punches and the dies in a spraying chamber, generating pulsating vibration air and spraying lubricant mixed in air in the spraying chamber, applying the lubricant on the surfaces of the punches and the dies while the lubricant sprayed in the spraying chamber is mixed with the pulsating vibration air, and tabletting the molding material by means of the punches applied with the lubricant on the surface thereof and the dies applied with the lubricant on the surface thereof.
摘要翻译：根据本发明的片剂生产方法，通过冲压和冲模压缩成型材料制成片剂，该方法包括以下步骤：使用粉末或颗粒状材料，包括在高压下压片时被变性或失活的化合物作为模塑材料，在喷雾室中容纳冲头和模具，产生脉动振动空气并喷洒混合在喷雾室中的空气中的润滑剂，同时将喷射在喷雾室中的润滑剂混合在冲头和模具的表面上的润滑剂用脉动的振动空气，并通过在其表面上施加有润滑剂的冲头和在其表面上施加润滑剂的模具对成型材料进行压片。

5. 发明授权

US08318201B2 Method of stabilizing diarylvinylene compound 有权
标题翻译：稳定二芳基亚乙烯基化合物的方法
公开(公告)号：US08318201B2
公开(公告)日：2012-11-27
申请号：US10528451
申请日：2004-09-29
申请人： Akihiro Uchida , Yasuhiro Ishikawa , Yasuhiko Ueno , Kiichiro Kaji , Masaharu Aimoto , Naoki Kaneko
发明人： Akihiro Uchida , Yasuhiro Ishikawa , Yasuhiko Ueno , Kiichiro Kaji , Masaharu Aimoto , Naoki Kaneko
IPC分类号： A61K31/522 , A61K9/20
CPC分类号： A61K9/2018 , A61K9/2813 , A61K9/2866 , A61K31/522 , C07D473/06
摘要： (wherein Y1 and Y2 may be the same or different and each represents a hydrogen atom, halogen or lower alkyl; and Z and A may be the same or different and each represents substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl) The present invention provides, for example, a method for stabilization of a diarylvinylene compound such as a compound represented by the above formula (I) or the like, or a pharmaceutically acceptable salt thereof in a solid formulation containing the diarylvinylene compound or the pharmaceutically acceptable salt thereof, which comprises allowing an inorganic substance and/or a colorant to exist in the solid formulation, and the like.
摘要翻译：（其中Y1和Y2可以相同或不同，并且各自表示氢原子，卤素或低级烷基; Z和A可以相同或不同，各自表示取代或未取代的芳基或取代或未取代的杂芳基）本发明提供了例如在含有二芳基亚乙烯基化合物或其药学上可接受的盐的固体制剂中稳定二芳基亚乙烯基化合物，例如由上式（I）表示的化合物或其药学上可接受的盐的方法，其包括使无机物质和/或着色剂存在于固体制剂中等。

6. 发明申请

US20060134192A1 Method of stabilizing diarylvinylene compound 有权
标题翻译：稳定二芳基亚乙烯基化合物的方法
公开(公告)号：US20060134192A1
公开(公告)日：2006-06-22
申请号：US10528451
申请日：2004-09-29
申请人： Akihiro Uchida , Yasuhiro Ishikawa , Yasuhiko Ueno , Kiichiro Kaji , Masaharu Aimoto , Naoki Kaneko
发明人： Akihiro Uchida , Yasuhiro Ishikawa , Yasuhiko Ueno , Kiichiro Kaji , Masaharu Aimoto , Naoki Kaneko
IPC分类号： A61K31/522 , A61K9/20
CPC分类号： A61K9/2018 , A61K9/2813 , A61K9/2866 , A61K31/522 , C07D473/06
摘要： (wherein Y1 and Y2 may be the same or different and each represents a hydrogen atom, halogen or lower alkyl; and Z and A may be the same or different and each represents substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl) The present invention provides, for example, a method for stabilization of a diarylvinylene compound such as a compound represented by the above formula (I) or the like, or a pharmaceutically acceptable salt thereof in a solid formulation containing the diarylvinylene compound or the pharmaceutically acceptable salt thereof, which comprises allowing an inorganic substance and/or a colorant to exist in the solid formulation, and the like.
摘要翻译：（其中Y 1和Y 2可以相同或不同，各自表示氢原子，卤素或低级烷基; Z和A可以相同或不同，各自表示取代或未取代的芳基或取代或未取代的杂芳基）本发明提供例如稳定二芳基亚乙烯基化合物如上式（I）等表示的化合物或其药学上可接受的盐其包含含有二芳基亚乙烯基化合物或其药学上可接受的盐的固体制剂，其包括使无机物质和/或着色剂存在于固体制剂中等。

7. 发明申请

US20060029663A1 Solid formulation 审中-公开
标题翻译：固体制剂
公开(公告)号：US20060029663A1
公开(公告)日：2006-02-09
申请号：US10515204
申请日：2004-07-16
申请人： Akihiro Uchida , Yasuhiro Ishikawa , Yasuhiko Ueno , Kiichiro Kaji , Tsuneaki Tottori
发明人： Akihiro Uchida , Yasuhiro Ishikawa , Yasuhiko Ueno , Kiichiro Kaji , Tsuneaki Tottori
IPC分类号： A61K31/522 , A61K9/20
CPC分类号： A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2866 , A61K31/522 , C07D473/04
摘要： (wherein R1, R2 and R3 may be the same or different and each represents a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; and R4 represents cycloalkyl, —(CH2)n—R5 or the above formula (II)) The present invention provides a solid formulation comprising a xanthine derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof, and microcrystalline cellulose, which possesses excellent pharmaceutical properties, for example, in hardness, disintegration property, dissolution property, stability or the like.
摘要翻译：（其中R 1，R 2和R 3）可以相同或不同，并且各自表示氢原子，低级烷基，低级烯基或低级炔基; R 4表示环烷基， - （CH 2）n - R 5 - 或上式（II））本发明提供包含由上述式（I）表示的黄嘌呤衍生物或其药学上可接受的盐和微晶纤维素的固体制剂，其具有优异的药物性质，例如硬度，崩解性，溶解性财产，稳定性等。

8. 发明授权

US09608449B2 Power system and control method of the power system 有权
公开(公告)号：US09608449B2
公开(公告)日：2017-03-28
申请号：US14361426
申请日：2012-11-14
申请人： Shingo Takahashi , Yasuhiro Ishikawa , Kazuaki Honda
发明人： Shingo Takahashi , Yasuhiro Ishikawa , Kazuaki Honda
IPC分类号： H02J1/00 , H02J3/00 , H02J3/46 , H01M10/44 , H01M10/48 , H02J7/00 , H02M7/493 , H01M10/42
CPC分类号： H02J3/46 , H01M10/425 , H01M10/441 , H01M10/482 , H02J7/0016 , H02J7/0021 , H02M7/493 , Y10T307/707
摘要： Provided is a power system that can arbitrarily set output power while stabilizing output voltages. Connection terminals 13 and 23 of lower power sources 1 and 2 are connected to external connection terminals 41 in parallel. Voltage measurement section 31 measures voltage values of external connection terminals 41 as measured voltage values. Power converters 12 and 22 measure power supply capacities of lower power sources 1 and 2, respectively. Output instruction section 32 adjusts power or currents flowing through connection terminals 13 and 23 based on the measured voltage values and the power supply capacities so that the measured voltage values are included in a predetermined voltage range.

9. 发明申请

US20140106208A1 POLYCARBONATE RESIN COMPOSITION FOR BATTERY PACK, AND BATTERY PACK 审中-公开
标题翻译：用于电池组的聚碳酸酯树脂组合物和电池组
公开(公告)号：US20140106208A1
公开(公告)日：2014-04-17
申请号：US14123179
申请日：2012-05-28
申请人： Yasuhiro Ishikawa , Yusuke Aoki , Takayoshi Tanaka
发明人： Yasuhiro Ishikawa , Yusuke Aoki , Takayoshi Tanaka
IPC分类号： H01M2/02 , C08L83/04 , C08K5/52
CPC分类号： H01M2/026 , C08G77/448 , C08K3/04 , C08K5/42 , C08K5/52 , C08K5/526 , C08K2201/011 , C08L27/18 , C08L69/00 , C08L83/10 , H01M2/0262 , H01M2/1094
摘要： A polycarbonate resin composition for a battery pack, which comprises: 100 parts by mass of (A) a polycarbonate-based resin composed of 5 to 100 mass % of a polycarbonate-polyorganosiloxane copolymer (A-1) whose main chain is formed of a structural unit represented by the general formula (I) and a structural unit represented by the general formula (II), and that contains 2 to 10 mass % of a polyorganosiloxane block, and 0 to 95 mass % of an aromatic polycarbonate (A-2) except the copolymer (A-1); and 0.01 to 1 parts by mass of (B) a phosphorus-based antioxidant; and a battery pack formed by using the resin composition.
摘要翻译：一种电池组用聚碳酸酯树脂组合物，其包含：（A）由5〜100质量％的聚碳酸酯 - 聚有机硅氧烷共聚物（A-1）构成的聚碳酸酯类树脂100质量份，其主链由由通式（I）表示的结构单元和由通式（II）表示的结构单元，含有2〜10质量％的聚有机硅氧烷嵌段和0〜95质量％的芳香族聚碳酸酯（A-2））除了共聚物（A-1）外; 和（B）磷系抗氧化剂0.01〜1质量份; 以及通过使用该树脂组合物形成的电池组。

10. 发明申请

US20130064492A1 OPTICAL WAVEGUIDE DEVICE 有权
标题翻译：光波器件
公开(公告)号：US20130064492A1
公开(公告)日：2013-03-14
申请号：US13583593
申请日：2011-03-09
申请人： Yasuhiro Ishikawa , Katsutoshi Kondou , Norikazu Miyazaki , Satoshi Oikawa
发明人： Yasuhiro Ishikawa , Katsutoshi Kondou , Norikazu Miyazaki , Satoshi Oikawa
IPC分类号： G02F1/035
CPC分类号： G02B6/29352 , G02B6/12007 , G02B6/122 , G02B6/29355 , G02F2001/212 , G02F2001/217 , G02F2201/05 , G02F2201/06 , G02F2202/20
摘要： An optical waveguide device having a Mach-Zehnder type waveguide formed on a substrate is provided in which a slope of two waveguides input to an optical coupler on an output side of the Mach-Zehnder type waveguide is 0 degrees, a waveguide of the optical coupler after being coupled by the optical coupler is a multi-mode waveguide, and the waveguide which is output from the optical coupler is a three-branched waveguide including an output main waveguide and two output sub waveguides interposing the output main waveguide therebetween.
摘要翻译：提供了一种在基板上形成有马赫 - 曾德尔型波导的光波导器件，其中输入到马赫 - 策德尔型波导输出侧的光耦合器的两个波导的斜率为0度，光耦合器的波导在由光耦合器耦合之后是多模波导，并且从光耦合器输出的波导是包括输出主波导的三分支波导和插入其中的输出主波导的两个输出子波导。

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