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1. 发明授权

US08961929B2 Targeting agent for tumor site 有权
标题翻译：肿瘤部位靶向剂
公开(公告)号：US08961929B2
公开(公告)日：2015-02-24
申请号：US13520827
申请日：2011-01-07
申请人： Kazutaka Ogiwara , Makoto Ohno , Masayoshi Kojima , Masayuki Kawakami , Chihaya Kakinuma , Tasuku Sasaki , Kiyohito Takada
发明人： Kazutaka Ogiwara , Makoto Ohno , Masayoshi Kojima , Masayuki Kawakami , Chihaya Kakinuma , Tasuku Sasaki , Kiyohito Takada
IPC分类号： A61K51/08 , A61K49/00
CPC分类号： A61K49/0034 , A61K49/0063 , A61K49/0084
摘要： It is an object of the present invention to provide a targeting agent, which enables the delivery of a drug to tumor sites or the imaging of tumor sites by utilizing its effect of accumulating to such tumor sites. The present invention provides a targeting agent for tumor site, which comprises a hydrophilic polymer-modified carrier coated with a gelatin-like protein that has repeats of a sequence represented by Gly-X-Y characteristic to collagen and has two or more sequences of cell adhesion signals in a single molecule wherein X and Y each independently represent an amino acid and a plurality of Gly-X-Y sequences may be the same or different.
摘要翻译：本发明的目的是提供一种靶向剂，其能够通过利用其累积到这种肿瘤部位的作用，将药物递送到肿瘤部位或肿瘤部位的成像。本发明提供了一种用于肿瘤部位的靶向剂，其包含涂覆有明胶样蛋白质的亲水性聚合物改性载体，其具有由Gly-XY表示的对胶原蛋白特征的序列的重复，并且具有两个或更多个细胞粘附信号序列在单分子中，其中X和Y各自独立地表示氨基酸，并且多个Gly-XY序列可以相同或不同。

2. 发明授权

US08920778B2 Targeting agent for tumor site 有权
公开(公告)号：US08920778B2
公开(公告)日：2014-12-30
申请号：US13520827
申请日：2011-01-07
申请人： Kazutaka Ogiwara , Makoto Ohno , Masayoshi Kojima , Masayuki Kawakami , Chihaya Kakinuma , Tasuku Sasaki , Kiyohito Takada
发明人： Kazutaka Ogiwara , Makoto Ohno , Masayoshi Kojima , Masayuki Kawakami , Chihaya Kakinuma , Tasuku Sasaki , Kiyohito Takada
IPC分类号： A61K51/08 , A61K49/00
摘要： It is an object of the present invention to provide a targeting agent, which enables the delivery of a drug to tumor sites or the imaging of tumor sites by utilizing its effect of accumulating to such tumor sites. The present invention provides a targeting agent for tumor site, which comprises a hydrophilic polymer-modified carrier coated with a gelatin-like protein that has repeats of a sequence represented by Gly-X-Y characteristic to collagen and has two or more sequences of cell adhesion signals in a single molecule wherein X and Y each independently represent an amino acid and a plurality of Gly-X-Y sequences may be the same or different.

3. 发明申请

US20130017147A1 TARGETING AGENT FOR TUMOR SITE 有权
标题翻译： TUMOR SITE的目标代理
公开(公告)号：US20130017147A1
公开(公告)日：2013-01-17
申请号：US13520827
申请日：2011-01-07
申请人： Kazutaka Ogiwara , Makoto Ohno , Masayoshi Kojima , Masayuki Kawakami , Chihaya Kakinuma , Tasuku Sasaki , Kiyohito Takada
发明人： Kazutaka Ogiwara , Makoto Ohno , Masayoshi Kojima , Masayuki Kawakami , Chihaya Kakinuma , Tasuku Sasaki , Kiyohito Takada
IPC分类号： A61K49/00 , A61P35/00 , A61K51/12 , A61K49/18 , A61K9/00 , A61K9/127
CPC分类号： A61K49/0034 , A61K49/0063 , A61K49/0084
摘要： It is an object of the present invention to provide a targeting agent, which enables the delivery of a drug to tumor sites or the imaging of tumor sites by utilizing its effect of accumulating to such tumor sites. The present invention provides a targeting agent for tumor site, which comprises a hydrophilic polymer-modified carrier coated with a gelatin-like protein that has repeats of a sequence represented by Gly-X—Y characteristic to collagen and has two or more sequences of cell adhesion signals in a single molecule wherein X and Y each independently represent an amino acid and a plurality of Gly-X—Y sequences may be the same or different.
摘要翻译：本发明的目的是提供一种靶向剂，其能够通过利用其累积到这种肿瘤部位的作用，将药物递送到肿瘤部位或肿瘤部位成像。本发明提供了一种用于肿瘤部位的靶向剂，其包含涂覆有明胶样蛋白质的亲水性聚合物改性载体，其具有由胶原特征的Gly-X-Y表示的序列的重复并具有两个或更多个细胞序列单分子中的粘合信号，其中X和Y各自独立地表示氨基酸，并且多个Gly-X-Y序列可以相同或不同。

4. 发明申请

US20080009045A1 MICROORGANISM HAVING AN ABILITY OF PRODUCING DOCOSAHEXAENOIC ACID AND USE THEREOF 有权
标题翻译：具有生产DOCOSAHEXAENOIC酸的能力的微生物及其使用
公开(公告)号：US20080009045A1
公开(公告)日：2008-01-10
申请号：US11774261
申请日：2007-07-06
申请人： Hiroyuki Komazawa , Masayoshi Kojima , Tsunehiro Aki , Kazuhisa Ono , Masayuki Kawakami
发明人： Hiroyuki Komazawa , Masayoshi Kojima , Tsunehiro Aki , Kazuhisa Ono , Masayuki Kawakami
IPC分类号： C12P7/64
CPC分类号： C12P7/6427 , A23D9/00 , A23K20/158 , A23L33/12 , C11C1/025 , C11C1/045 , C11C3/123 , C12P7/6472 , C12R1/90
摘要： An object of the present invention is to provide a microorganism which has a high ability of producing docosahexaenoic acid. The present invention provides a Thraustochytrium strain which has an ability of producing docosahexaenoic acid, and use thereof.
摘要翻译：本发明的目的是提供一种具有高生产二十二碳六烯酸能力的微生物。本发明提供了具有生产二十二碳六烯酸的能力的破囊壶菌菌株及其应用。

5. 发明授权

US07259006B2 Microorganism having an ability of producing docosahexaenoic acid and use thereof 有权
标题翻译：具有生产二十二碳六烯酸的能力的微生物及其用途
公开(公告)号：US07259006B2
公开(公告)日：2007-08-21
申请号：US10743832
申请日：2003-12-24
申请人： Hiroyuki Komazawa , Masayoshi Kojima , Tsunehiro Aki , Kazuhisa Ono , Masayuki Kawakami
发明人： Hiroyuki Komazawa , Masayoshi Kojima , Tsunehiro Aki , Kazuhisa Ono , Masayuki Kawakami
IPC分类号： C12N1/14 , A01N63/04
CPC分类号： C12P7/6427 , A23D9/00 , A23K20/158 , A23L33/12 , C11C1/025 , C11C1/045 , C11C3/123 , C12P7/6472 , C12R1/90
摘要： An object of the present invention is to provide a microorganism which has a high ability of producing docosahexaenoic acid. The present invention provides a Thraustochytrium strain which has an ability of producing docosahexaenoic acid, and use thereof.
摘要翻译：本发明的目的是提供一种具有高生产二十二碳六烯酸能力的微生物。本发明提供了具有生产二十二碳六烯酸的能力的破囊壶菌菌株及其应用。

6. 发明授权

US07863026B2 Microorganism having an ability of producing docosahexaenoic acid and use thereof 有权
标题翻译：具有生产二十二碳六烯酸的能力的微生物及其用途
公开(公告)号：US07863026B2
公开(公告)日：2011-01-04
申请号：US11774261
申请日：2007-07-06
申请人： Hiroyuki Komazawa , Masayoshi Kojima , Tsunehiro Aki , Kazuhisa Ono , Masayuki Kawakami
发明人： Hiroyuki Komazawa , Masayoshi Kojima , Tsunehiro Aki , Kazuhisa Ono , Masayuki Kawakami
IPC分类号： C12P7/64
CPC分类号： C12P7/6427 , A23D9/00 , A23K20/158 , A23L33/12 , C11C1/025 , C11C1/045 , C11C3/123 , C12P7/6472 , C12R1/90
摘要： An object of the present invention is to provide a microorganism which has a high ability of producing docosahexaenoic acid. The present invention provides a Thraustochytrium strain which has an ability of producing docosahexaenoic acid, and use thereof.
摘要翻译：本发明的目的是提供一种具有高生产二十二碳六烯酸能力的微生物。本发明提供了具有生产二十二碳六烯酸的能力的破囊壶菌菌株及其应用。

7. 发明申请

US20150237973A1 Slider Cover for Slide Fastener and Slide Fastener with Slide Cover 有权
标题翻译：带滑盖的滑轨紧固件和滑轨紧固件滑块盖
公开(公告)号：US20150237973A1
公开(公告)日：2015-08-27
申请号：US14424492
申请日：2012-08-31
申请人： Masayoshi Kojima , Wataru Izumi , Takanori Fujisawa
发明人： Masayoshi Kojima , Wataru Izumi , Takanori Fujisawa
IPC分类号： A44B19/26
CPC分类号： A44B19/26 , A44B19/262 , A44B19/265 , Y10T24/2586 , Y10T24/2588
摘要： There is provided a slider cover for a slide fastener. An upper member and a lower member are spaced apart from each other in an upward and downward direction and arranged in parallel to each other. A connecting post connects the upper member with the lower member. The upper member includes a receiving portion configured to receive at least a part of an upper blade of a slider.
摘要翻译：提供了一种用于拉链的滑块盖。上部构件和下部构件在上下方向上彼此间隔开并且彼此平行地布置。连接柱将上部构件与下部构件连接。上部构件包括构造成容纳滑块的上部刀片的至少一部分的容纳部分。

8. 发明申请

US20130097819A1 Fastening Member and Slide Fastener 有权
标题翻译：紧固件和滑轨紧固件
公开(公告)号：US20130097819A1
公开(公告)日：2013-04-25
申请号：US13808662
申请日：2010-07-07
申请人： Masayoshi Kojima
发明人： Masayoshi Kojima
IPC分类号： A44B19/26 , B32B5/16
CPC分类号： A44B19/06 , A44B19/14 , A44B19/26 , B29C45/0013 , B29D5/02 , B29K2505/02 , B32B5/16 , Y10T24/2543 , Y10T24/2561 , Y10T428/256
摘要： A fastening member contains a synthetic resin, in which flat metal foil containing aluminum is mixed with the synthetic resin and an average particle diameter of the metal foil is set to be equal to or more than 3 μm and equal to or less than 8 μm. Accordingly, the fastening member has both an advantage of a synthetic resin of being inexpensive and light and an advantage of a metal of having strength and gloss having a high-grade sense, and an outer appearance or a texture thereof can be viewed like the metallic member. In the fastening member, a weld mark can be restrained from being generated, and even if the weld mark is generated, the weld mark can be made difficult to be visually recognized relatively and the weld mark can be mixed with the gloss.
摘要翻译：紧固构件包含合成树脂，其中含有铝的扁平金属箔与合成树脂混合，并且金属箔的平均粒径设定为等于或大于3μm且等于或小于8μm。因此，紧固构件具有廉价且轻的合成树脂的优点，并且具有高等级感的强度和光泽的金属的优点，外观或其外观可以看作是金属会员。在紧固构件中，可以抑制焊接痕迹的产生，即使产生了焊接痕迹，也可以使焊接痕迹难以相对于视觉上识别，并且能够将焊接痕迹与光泽混合。

9. 发明授权

US08084275B2 Magnetic composite body, production method thereof, method for removing substance with mannose on its surface, and method for concentrating substance with mannose on its surface 有权
标题翻译：磁性复合体及其制造方法，其表面用甘露糖除去物质的方法及其表面上甘露糖浓缩物质的方法
公开(公告)号：US08084275B2
公开(公告)日：2011-12-27
申请号：US11883742
申请日：2006-02-08
申请人： Hiroyuki Hirai , Masayoshi Kojima
发明人： Hiroyuki Hirai , Masayoshi Kojima
IPC分类号： G01N33/553 , B01D35/06 , G01N25/18
CPC分类号： B03C1/01 , B82Y25/00 , H01F1/0054
摘要： A magnetic composite body comprising magnetic nanoparticles having a number average particle diameter of 1 to 50 nm and having a compound represented by formula (I) fixed on their surfaces, and a method comprising bringing the magnetic composite body into contact with a test piece followed by magnetic separation: R1O—(CH(R2)CH2O)n-L-X Formula (I) wherein R1 represents a hydrogen atom, an alkyl or alkenyl group having a carbon chain length of 1 to 20, or a substituted or unsubstituted, aryl or heterocyclic group; R2 represents a hydrogen atom or a methyl group; L may be present or not present, and, when L is present, L represents an alkylene or alkenylene group having a carbon chain length of 1 to 10 which may have a branched chain or a substituent; X represents a hydrogen atom, a carboxylic acid group, a phosphoric acid group, or a sulfonic acid group; and n represents an integer of 1 to 10.
摘要翻译：一种磁性复合体，其包含数均粒径为1〜50nm的磁性纳米颗粒，并且具有固定在其表面上的式（I）表示的化合物，以及包括使磁性复合体与试验片接触的方法，磁性分离：R1O-（CH（R2）CH2O）nLX其中R1表示氢原子，碳链长度为1-20的烷基或烯基或取代或未取代的芳基或杂环基的式（I） R2表示氢原子或甲基; L可以存在或不存在，并且当存在L时，L表示碳链长度为1至10的亚烷基或亚烯基，其可以具有支链或取代基; X表示氢原子，羧酸基，磷酸基或磺酸基; n表示1〜10的整数。

10. 外观设计

USD644564S1 Chain for slide fastener 有权
公开(公告)号：USD644564S1
公开(公告)日：2011-09-06
申请号：US29383620
申请日：2011-01-20
申请人： Masayoshi Kojima , Aya Shigematsu
设计人： Masayoshi Kojima , Aya Shigematsu

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