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    • 8. 发明申请
    • FIBROSIS INHIBITOR
    • 纤维蛋白酶抑制剂
    • US20110015211A1
    • 2011-01-20
    • US12919885
    • 2009-02-26
    • Koji MurakamiTakuya Toramoto
    • Koji MurakamiTakuya Toramoto
    • A61K31/4965C07D241/20A61P35/00A61P17/02A61P25/28A61P13/12A61P1/18A61P19/00
    • C07D241/20A61K31/4965
    • [Object] The main object of the present invention is to provide a fibrosis inhibitor.[Solving Means] The present invention relates to a fibrosis inhibitor containing the heterocyclic derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient; In the formula (1), R1 and R2 are the same or different and each represents an optionally substituted aryl; R3 and R4 are the same or different and each represents hydrogen atom or alkyl; R5 represents hydrogen atom, alkyl or halogen atom; Y represents N or N→O; A represents NR6, and R6 represents hydrogen atom, alkyl, etc.; D represents alkylene or alkenylene which is optionally substituted with hydroxy; E represents phenylene or a single bond; G represents O, S, etc.; and Q represents carboxy, alkoxycarbonyl, etc.
    • 本发明的主要目的在于提供纤维化抑制剂。 本发明涉及含有下述通式(1)表示的杂环衍生物或其药学上可接受的盐作为有效成分的纤维化抑制剂。 在式(1)中,R 1和R 2相同或不同,表示任选取代的芳基; R3和R4相同或不同,各自表示氢原子或烷基; R5代表氢原子,烷基或卤素原子; Y表示N或N→O; A表示NR6,R6表示氢原子,烷基等; D表示任选被羟基取代的亚烷基或亚烯基; E表示亚苯基或单键; G代表O,S等; Q表示羧基,烷氧基羰基等。