专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100210661A1 STAT3/5 ACTIVATION INHIBITOR 失效
标题翻译： STAT3 / 5激活抑制剂
公开(公告)号：US20100210661A1
公开(公告)日：2010-08-19
申请号：US12311500
申请日：2007-10-02
申请人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
发明人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
IPC分类号： A61K31/496 , C07D401/14 , C07D405/10 , A61P3/04 , A61P25/28 , A61P3/10
CPC分类号： C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要： An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译：本发明的目的是提供一种STAT3 / 5激活抑制剂。本发明提供含有通式所示的芳香族化合物或其盐作为活性成分的STAT3 / 5活化抑制剂，其中，X1表示氮原子或-CH =，R1表示-Z-R6基，其中Z表示-CO-基团，-CH（OH） - 基等，R6表示具有1-4个氮原子的5至15元单环，二环或三环饱和或不饱和杂环基，氧原子或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基，A表示其中R 3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。

2. 发明申请

US20120322807A1 STAT3/5 ACTIVATION INHIBITOR 审中-公开
标题翻译： STAT3 / 5激活抑制剂
公开(公告)号：US20120322807A1
公开(公告)日：2012-12-20
申请号：US13526283
申请日：2012-06-18
申请人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
发明人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
IPC分类号： A61K31/496 , A61P37/08
CPC分类号： C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要： The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: Wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group
摘要翻译：本发明提供含有由通式表示的芳香族化合物或其盐作为有效成分的STAT3 / 5活化抑制剂，其中X1表示氮原子或-CH =，R1表示-Z-R6基团，其中Z表示-CO-基团，-CH（OH） - 基等，R6表示具有1-4个氮原子的5至15元单环，二环或三环饱和或不饱和杂环基，氧原子或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基，A表示基团

3. 发明授权

US08263599B2 STAT3/5 activation inhibitor 失效
标题翻译： STAT3 / 5激活抑制剂
公开(公告)号：US08263599B2
公开(公告)日：2012-09-11
申请号：US12311500
申请日：2007-10-02
申请人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
发明人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
IPC分类号： A61K31/497
CPC分类号： C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要： An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译：本发明的目的是提供一种STAT3 / 5激活抑制剂。本发明提供含有通式所示的芳香族化合物或其盐作为活性成分的STAT3 / 5活化抑制剂，其中，X1表示氮原子或-CH =，R1表示-Z-R6基，其中Z表示-CO-基团，-CH（OH） - 基等，R6表示具有1-4个氮原子的5至15元单环，二环或三环饱和或不饱和杂环基，氧原子或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基，A表示其中R 3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。

4. 发明授权

US08236826B2 Diarylether derivatives as antitumor agents 失效
标题翻译：二元醚衍生物作为抗肿瘤剂
公开(公告)号：US08236826B2
公开(公告)日：2012-08-07
申请号：US12095930
申请日：2006-12-04
申请人： Hironori Matsuyama , Kenji Ohnishi , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Kumi Higuchi , Keisuke Miyajima , Satoshi Yamada , Masaaki Motoyama , Yutaka Kojima , Koichi Yasumura , Takeshi Kodama , Shun Otsuji , Keizo Kan , Takumi Sumida
发明人： Hironori Matsuyama , Kenji Ohnishi , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Kumi Higuchi , Keisuke Miyajima , Satoshi Yamada , Masaaki Motoyama , Yutaka Kojima , Koichi Yasumura , Takeshi Kodama , Shun Otsuji , Keizo Kan , Takumi Sumida
IPC分类号： A61K31/44
CPC分类号： A61K31/496 , A61K31/495
摘要： An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译：本发明的目的在于提供一种抗肿瘤活性大大提高的安全性药物。根据本发明，提供了含有下述通式（1）表示的化合物或其盐作为有效成分的药物：[式1]其中X1表示氮原子或基团-CH =， R1表示基团-Z-R6，其中Z表示基团-CO-，基团-CH（OH） - 等，R6表示5至15元单环，二环或三环饱和或不饱和杂环基具有1至4个氮原子，氧原子或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基 A表示[式2]其中R3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。

5. 发明申请

US20100004438A1 DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS 失效
标题翻译：二甲苯衍生物作为抗菌剂
公开(公告)号：US20100004438A1
公开(公告)日：2010-01-07
申请号：US12095930
申请日：2006-12-04
申请人： Hironori Matsuyama , Kenji Ohnishi , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Kumi Higuchi , Keisuke Miyajima , Satoshi Yamada , Masaaki Motoyama , Yutaka Kojima , Koichi Yasumura , Takeshi Kodama , Shun Otsuji , Keizo Kan , Takumi Sumida
发明人： Hironori Matsuyama , Kenji Ohnishi , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Kumi Higuchi , Keisuke Miyajima , Satoshi Yamada , Masaaki Motoyama , Yutaka Kojima , Koichi Yasumura , Takeshi Kodama , Shun Otsuji , Keizo Kan , Takumi Sumida
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D295/155 , C07D211/56 , C07D213/72
CPC分类号： A61K31/496 , A61K31/495
摘要： An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group -Z-R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译：本发明的目的在于提供一种抗肿瘤活性大大提高的安全性药物。根据本发明，提供含有下述通式（1）表示的化合物或其盐作为有效成分的药物：[式1]其中X1表示氮原子或基团-CH-， R1表示基团-Z-R6，其中Z表示基团-CO-，基团-CH（OH） - 等，R6表示5至15元单环，二环或三环饱和或不饱和杂环基具有1至4个氮原子，氧原子或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基 A表示[式2]其中R3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。

6. 发明授权

US08074427B2 Production method for container packing filler and tubular net rolling apparatus 有权
标题翻译：集装箱包装填料和管状网轧设备的生产方法
公开(公告)号：US08074427B2
公开(公告)日：2011-12-13
申请号：US12225512
申请日：2007-03-29
申请人： Yasuyuki Shiraishi , Kenji Ohnishi , Tomoyuki Fujita , Masato Tsuji , Shinji Hiramoto
发明人： Yasuyuki Shiraishi , Kenji Ohnishi , Tomoyuki Fujita , Masato Tsuji , Shinji Hiramoto
IPC分类号： B65B63/04
CPC分类号： B31D5/0069 , B31D2205/0017 , B31D2205/0047 , B31D2205/0064
摘要： A method and an apparatus for producing a container packing filler are provided, which ensure that a net can be correctly and speedily rolled up into a bulk or ball shape. A stretchable tubular net (N) is fitted around a columnar support member (6). Then, a distal portion of the net is forcibly folded radially outward or inward by a plurality of roller belts (30) disposed circumferentially of the net (N), while the roller belts (30) are moved toward a net proximal side axially of the net (N), whereby the net (N) is rolled up radially outward or inward with the distal portion thereof being forcibly folded by circular rotation and axial movement of the roller belts (30) to form an annular roll portion (C).
摘要翻译：提供了一种用于生产容器包装填料的方法和装置，其确保网可以被正确地且快速地卷起成块状或球形。可伸缩管状网（N）围绕柱状支撑构件（6）安装。然后，通过设置在网（N）的周向上的多个辊带（30）将网的远端部分径向向外或向内强制折叠，同时，辊带（30）沿着网网（N），由此网（N）径向向外或向内卷起，其远侧部分通过滚子带（30）的圆周旋转和轴向运动而被强制折叠以形成环形辊部分（C）。

7. 发明授权

US07371506B2 Positive photosensitive resin composition 有权
标题翻译：正型感光性树脂组合物
公开(公告)号：US07371506B2
公开(公告)日：2008-05-13
申请号：US11367582
申请日：2006-03-06
申请人： Hirofumi Fujii , Makoto Saito , Kenji Ohnishi
发明人： Hirofumi Fujii , Makoto Saito , Kenji Ohnishi
IPC分类号： G03F7/00 , G03F7/004
CPC分类号： G03F7/0045 , Y10S430/114
摘要： A positive photosensitive resin composition comprising (A) a polyamic acid, (B) a 1,4-dihydropyridine derivative represented by the general formula (II): wherein R2 is a monovalent organic group; each of R3, R4, R5, and R6 is independently hydrogen or a monovalent organic group; and Ar—NO2 is an aromatic hydrocarbon group having a nitro group at ortho-position, and (C) an amine compound.
摘要翻译：一种正型光敏树脂组合物，其包含（A）聚酰胺酸，（B）由通式（II）表示的1,4-二氢吡啶衍生物：其中R 2是一价有机基团; R 3，R 4，R 5和R 6各自独立地为氢或一价有机基团 ; 和Ar-NO 2是在邻位具有硝基的芳香族烃基，（C）胺化合物。

8. 发明授权

US5301586A Vibration prevention device for bandsaw machines 失效
标题翻译：带锯机防振装置
公开(公告)号：US5301586A
公开(公告)日：1994-04-12
申请号：US105688
申请日：1993-08-13
申请人： Kenji Ohnishi , Isomi Washio , Koji Nakano
发明人： Kenji Ohnishi , Isomi Washio , Koji Nakano
IPC分类号： B23D55/00 , B23D55/08
CPC分类号： B23D55/082 , B23D55/005 , Y10T83/7264 , Y10T83/888 , Y10T83/8886
摘要： A bandsaw machine which has a sawhead assembly in which a flexible endless bandsaw blade is trained around a pair of bandsaw blade wheels to cut a workpiece, with the blade being guided by a guide arm, includes a guide member on the guide arm, for holding the bandsaw blade in a vertical orientation by pushing the bandsaw blade from both sides. A rolling member is mounted on the sawhead assembly and is free to push a side surface of the bandsaw blade with a predetermined force so as to prevent vibration of the blade.
摘要翻译：一种带锯机，其具有锯片组件，其中柔性环形带锯刀片围绕一对带锯叶轮轮廓进行训练，以切割工件，其中刀片由引导臂引导，包括在引导臂上的引导构件，用于保持通过从两侧推动带状锯片，垂直方向的带锯刀片。滚动构件安装在锯片组件上，并以预定的力自由地推动带锯刀片的侧表面，以防止刀片的振动。

9. 发明授权

US5271306A Vibration prevention device for bandsaw machines 失效
标题翻译：带锯机防振装置
公开(公告)号：US5271306A
公开(公告)日：1993-12-21
申请号：US884943
申请日：1992-05-18
申请人： Kenji Ohnishi , Isomi Washio , Koji Nakano
发明人： Kenji Ohnishi , Isomi Washio , Koji Nakano
IPC分类号： B23D55/00 , B23D55/08
CPC分类号： B23D55/082 , B23D55/005 , Y10T83/7264 , Y10T83/888
摘要： A bandsaw machine which has a sawhead assembly in which a flexible endless bandsaw blade is trained around a pair of bandsaw blade wheels to cut a workpiece, with the blade being guided by a guide arm, includes a guide member on the guide arm, for holding the bandsaw blade in a vertical orientation by pushing the bandsaw blade from both sides. A rolling member is mounted on the sawhead assembly and is free to push a side surface of the bandsaw blade with a predetermined force so as to prevent vibration of the blade.
摘要翻译：一种带锯机，其具有锯片组件，其中柔性环形带锯刀片围绕一对带锯叶轮轮廓进行训练，以切割工件，其中刀片由引导臂引导，包括在引导臂上的引导构件，用于保持通过从两侧推动带状锯片，垂直方向的带锯刀片。滚动构件安装在锯片组件上，并以预定的力自由地推动带锯刀片的侧表面，以防止刀片的振动。

10. 发明申请

US20090078608A1 Packing Filler For Container 有权
标题翻译：集装箱包装填料
公开(公告)号：US20090078608A1
公开(公告)日：2009-03-26
申请号：US12087828
申请日：2007-01-19
申请人： Shinji Hiramoto , Yasuyuki Shiraishi , Kenji Ohnishi , Kouichi Yoshimi
发明人： Shinji Hiramoto , Yasuyuki Shiraishi , Kenji Ohnishi , Kouichi Yoshimi
IPC分类号： B65D81/02
CPC分类号： B65D51/26 , B65D81/02 , Y10S206/814
摘要： A container packing filler (1) includes an annular roll portion (3) formed by folding one of axially opposite end portions of a stretchable tubular net (2) radially outward and rolling the net (2) toward the other end portion of the net (2), and a rigid holder portion (4) provided at the other end portion of the net (2). The holder portion (4) has a necessary and sufficient axial length and a maximum width (W) greater than the diameter (R) of a center hole (5) of the annular roll portion (3) so that, when the holder portion (4) of the packing filler (1) is squeezed into the center hole (5) of the annular roll portion (3), the annular roll portion (3) is expanded from the inside thereof by the holder portion (4) and layers of the annular roll portion (3) are unitarily rolled inward. Therefore, the bulging of only the outermost layer of the annular roll portion is prevented which may otherwise occur when the holder portion is squeezed. Thus, the packing filler provides a sufficient cushioning effect, and prevents inadvertent scattering of tablets or the like.
摘要翻译：容器填充填料（1）包括通过径向向外折叠可拉伸管状网（2）的轴向相对端部之一并且将网（2）向网的另一端部折叠而形成的环形辊部（3）以及设置在网（2）的另一端部的刚性保持器部分（4）。保持器部分（4）具有必要且足够的轴向长度和大于环形辊部分（3）的中心孔（5）的直径（R）的最大宽度（W），使得当保持器部分包装填料（1）的第一部分（4）被挤压到环形辊部分（3）的中心孔（5）中，环形辊部分（3）从其内侧通过保持器部分（4）膨胀，并且环状辊部（3）向内一体地卷起。因此，仅当保持器部分被挤压时可以防止环形辊部分的最外层的膨胀。因此，包装填料提供足够的缓冲效果，并防止片剂等的无意散射。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式