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1. 发明授权

US4435391A Dibenzoxazepine derivative, and pharmaceutical composition comprising the same 失效
标题翻译：二苯并氮杂衍生物，以及包含其的药物组合物
公开(公告)号：US4435391A
公开(公告)日：1984-03-06
申请号：US354651
申请日：1982-03-04
申请人： Kazuo Sasahara , Masamitsu Honda , Masuo Koizumi , Yasushi Murakami , Tomohiro Neichi , Hiroshi Nakakimura , Yukifumi Noda , Hiroshi Matsushita , Shun-ichi Hata
发明人： Kazuo Sasahara , Masamitsu Honda , Masuo Koizumi , Yasushi Murakami , Tomohiro Neichi , Hiroshi Nakakimura , Yukifumi Noda , Hiroshi Matsushita , Shun-ichi Hata
IPC分类号： A61K31/55 , A61P3/06 , A61P3/08 , A61P7/02 , C07D267/20 , C07D273/06
CPC分类号： C07D267/20 , Y10S514/866
摘要： Dibenzoxazepine derivatives of the formula: ##STR1## wherein R.sub.1, n, R.sub.2 and R.sub.3 are as defined in the description, process for preparing the same, pharmaceutical composition containing the same and method of treating diseases in circulatory organs administering the composition to a patient are disclosed.The compounds of the formula have lipid lowering activity, lipid peroxide lowering activity, blood sugar lowering activity and activity to inhibit the aggregation of platelets, and hence are useful as a medicine.
摘要翻译：下式的二苯并氮杂衍生物：其中R 1，n，R 2和R 3如说明书中所定义，其制备方法，含有该化合物的药物组合物和治疗患者的该组合物的循环器官中的疾病的方法是披露该化合物具有降脂活性，脂质过氧化物降低活性，血糖降低活性和抑制血小板聚集的活性，因此可用作药物。

2. 发明授权

US4290953A Benzoxazepine derivatives and process for preparing the same 失效
标题翻译：苯并西泮衍生物及其制备方法
公开(公告)号：US4290953A
公开(公告)日：1981-09-22
申请号：US100437
申请日：1979-12-05
申请人： Masuo Koizumi , Kazuo Sasahara , Yasushi Murakami , Sakae Wada , Hiroshi Nakakimura , Noboru Kubodera , Shun-Ichi Hata
发明人： Masuo Koizumi , Kazuo Sasahara , Yasushi Murakami , Sakae Wada , Hiroshi Nakakimura , Noboru Kubodera , Shun-Ichi Hata
IPC分类号： H04Q1/45 , A61K31/55 , A61P3/06 , C07D267/20 , H04L27/26 , H04Q1/457 , C07D498/00
CPC分类号： C07D267/20
摘要： Dibenz[b,f][1,4]oxazepine derivatives represented by the formula ##STR1## [wherein R.sub.1, n, R.sub.2 and R.sub.3 are as defined in the specification], and a process for preparing the same are disclosed. The object compounds have excellent serum cholesterol lowering activity, serum lipid lowering activity, blood lipid peroxide lowering activity and anti-aggregation of platelet activity, and therefore are useful as a drug.
摘要翻译：由式[IMAGE]表示的二苯并[b，f] [1,4]氧氮杂衍生物[其中R 1，n，R 2和R 3如说明书中所定义）及其制备方法。目的化合物具有优异的血清胆固醇降低活性，血清脂质降低活性，血脂过氧化物降低活性和抗血小板活性聚集，因此可用作药物。

3. 发明授权

US5563258A Sucralfate aqueous suspension and its method of preparation 失效
标题翻译： Sucralfate水悬浮液及其制备方法
公开(公告)号：US5563258A
公开(公告)日：1996-10-08
申请号：US429512
申请日：1995-04-26
申请人： Kiyoshige Ochi , Kazuo Sasahara , Mituo Shiratori , Sakae Takaku
发明人： Kiyoshige Ochi , Kazuo Sasahara , Mituo Shiratori , Sakae Takaku
IPC分类号： A61K9/00 , A61K9/14 , A61K31/70 , C07H11/00 , A61K31/715 , C07H1/00
CPC分类号： A61K9/0095 , A61K31/70 , A61K9/14 , C07H11/00
摘要： This specification discloses a production process for an sucralfate aqueous suspension stock, the process being characterized by direct dispersement of an sucralfate aqueous stock for sucralfate preparations, which contains sucralfate particles with an average particle size of no more than 50 .mu.m in a concentration of 1-2 g/ml, in water or other aqueous medium without drying the synthesized sucralfate wet powder, followed by milling of the sucralfate particles to an average particle size of no more than 50 .mu.m. When the sucralfate aqueous suspension stock obtained directly from wet powder in accordance with this method is compared to the conventional suspension obtained from dry powder, equivalency of both stocks are obtained in terms of both properties and pharmacological activities. In comparison to the conventional process using dry powder, this wet milling method of production is economically and operationally superior and environmental pollution arising from the conventional process can be prevented.
摘要翻译：本说明书公开了硫糖铝水悬浮液的制备方法，该方法的特征在于用于硫糖铝制剂的硫糖铝水溶液的直接分散，其含有浓度为1的平均粒径不超过50μm的硫糖铝颗粒 -2g / ml，在水或其它水性介质中，不干燥合成的硫糖铝湿粉末，然后将硫糖铝粉末研磨至不超过50μm的平均粒度。当将根据该方法直接从湿粉末获得的硫糖铝水性悬浮液与从干粉获得的常规悬浮液进行比较时，可以从性质和药理活性方面获得两种原料的等效性。与使用干粉的常规方法相比，这种湿磨生产方法在经济上和操作上都是优越的，并且可以防止由常规方法引起的环境污染。

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