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1. 发明申请

US20110060123A1 CHARGE CONVERSIONAL TERNARY POLYPLEX 审中-公开
标题翻译：电荷转换三元POLYPLEX
公开(公告)号：US20110060123A1
公开(公告)日：2011-03-10
申请号：US12990386
申请日：2009-04-30
申请人： Kazunori Kataoka , Yan Lee , Nobuhiro Nishiyama , Kanjiro Miyata , Makoto Oba , Shigehiro Hiki , Mai Sanjo , HyunJin Kim
发明人： Kazunori Kataoka , Yan Lee , Nobuhiro Nishiyama , Kanjiro Miyata , Makoto Oba , Shigehiro Hiki , Mai Sanjo , HyunJin Kim
IPC分类号： C07K14/00
CPC分类号： C08G69/48 , A61K31/7084 , A61K31/785 , A61K48/0041 , C08G69/10 , C08G69/40 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要： Disclosed is a polymer composite (polyplex) that contains nucleic acid, a cationic polymer, and an anionic polymer. The anionic polymer covers the surface of the composite comprising the cationic polymer and nucleic acid, has a negative charge at neutral pH, and can change so as to have a positive charge at mildly acidic pH.
摘要翻译：公开了含有核酸，阳离子聚合物和阴离子聚合物的聚合物复合物（polyplex）。阴离子聚合物覆盖包含阳离子聚合物和核酸的复合物的表面，在中性pH下具有负电荷，并且可以改变以在弱酸性pH下具有正电荷。

2. 发明授权

US09051354B2 Protein charge regulator and protein-encapsulating polymer micelle complex 有权
标题翻译：蛋白质电荷调节剂和蛋白质包封的聚合物胶束复合物
公开(公告)号：US09051354B2
公开(公告)日：2015-06-09
申请号：US13256605
申请日：2009-09-17
申请人： Kazunori Kataoka , Nobuhiro Nishiyama , Yan Lee , Takehiko Ishii
发明人： Kazunori Kataoka , Nobuhiro Nishiyama , Yan Lee , Takehiko Ishii
IPC分类号： A61K47/48 , C07K1/113 , C07K1/13
CPC分类号： C07K1/13 , A61K47/60 , A61K47/645
摘要： The present invention provides a protein delivery means (e.g., a polyion complex) which allows efficient introduction into cells (particularly into the cytoplasm), is highly stable in serum, and is also widely applicable. The polyion complex of the present invention comprises a cationic polymer having a polycation moiety and a charge-conversional protein whose overall charge is converted from basic or neutral to acidic by a specific charge regulator.
摘要翻译：本发明提供了允许有效地引入细胞（特别是细胞质）中的蛋白质递送装置（例如，聚离子络合物），在血清中是高度稳定的，并且也可广泛应用。本发明的聚离子络合物包含具有聚阳离子部分和电荷转移蛋白质的阳离子聚合物，其电荷通过特定的电荷调节剂从碱性或中性转变为酸性。

3. 发明申请

US20120046453A1 PROTEIN CHARGE REGULATOR AND PROTEIN-ENCAPSULATING POLYMER MICELLE COMPLEX 有权
标题翻译：蛋白质电荷调节剂和蛋白质包封聚合物MICELLE复合物
公开(公告)号：US20120046453A1
公开(公告)日：2012-02-23
申请号：US13256605
申请日：2009-09-17
申请人： Kazunori Kataoka , Nobuhiro Nishiyama , Yan Lee , Takehiko Ishii
发明人： Kazunori Kataoka , Nobuhiro Nishiyama , Yan Lee , Takehiko Ishii
IPC分类号： C07K14/00 , C07D307/77 , C07D307/89 , C07D307/32
CPC分类号： C07K1/13 , A61K47/60 , A61K47/645
摘要： The present invention provides a protein delivery means (e.g., a polyion complex) which allows efficient introduction into cells (particularly into the cytoplasm), is highly stable in serum, and is also widely applicable. The polyion complex of the present invention comprises a cationic polymer having a polycation moiety and a charge-conversional protein whose overall charge is converted from basic or neutral to acidic by a specific charge regulator.
摘要翻译：本发明提供了允许有效地引入细胞（特别是细胞质）中的蛋白质递送装置（例如，聚离子络合物），在血清中是高度稳定的，并且也可广泛应用。本发明的聚离子络合物包含具有聚阳离子部分和电荷转移蛋白质的阳离子聚合物，其电荷通过特定的电荷调节剂从碱性或中性转变为酸性。

4. 发明授权

US09550728B2 Thermo-responsive draw solute for forward osmosis and method for water desalination and purification using the same 有权
标题翻译：用于正向渗透的热敏吸引溶质和使用其的水脱盐和纯化方法
公开(公告)号：US09550728B2
公开(公告)日：2017-01-24
申请号：US14235192
申请日：2012-07-27
申请人： Yan Lee , Minwoo Noh , Yeongbong Mok , Heejin Kim , Seonju Lee , Daichi Nakayama
发明人： Yan Lee , Minwoo Noh , Yeongbong Mok , Heejin Kim , Seonju Lee , Daichi Nakayama
IPC分类号： B01D11/00 , C02F1/44 , B01D61/00 , B01D61/24 , C07C233/05 , C07C233/36 , C07C309/14 , C02F103/08
CPC分类号： C07C233/05 , B01D61/002 , B01D61/005 , C02F1/445 , C02F2103/08 , C02F2303/18 , C07C233/36 , C07C309/14 , Y02A20/131 , Y02W10/37
摘要： The present invention relates to a thermo-responsive draw solute that can be applied to water desalination and purification based on forward osmosis. The thermo-responsive draw solute has a molar mass of 50 to 3000 g/mol and undergoes a phase transition at a temperature of 0° C. to 70° C. The thermo-responsive draw solute creates optimum conditions for the desalination of seawater and the purification of contaminated water based on forward osmosis. The present invention also relates to a method for water desalination and purification using the thermo-responsive draw solute. The method consumes little energy for water desalination or purification, is simple to apply to water desalination or purification, and enables separation of the draw solute in a very easy manner.
摘要翻译：本发明涉及可应用于基于正向渗透的水脱盐和净化的热响应性拉伸溶质。热响应拉伸溶质的摩尔质量为50-3000g / mol，并在0℃至70℃的温度下进行相变。热响应拉伸溶质为海水淡化提供了最佳条件，基于正向渗透的污染水净化。本发明还涉及使用热敏吸引溶质的水脱盐和净化方法。该方法消耗少量用于水脱盐或净化的能量，易于应用于海水淡化或净化，并且能够以非常容易的方式分离吸附溶质。

5. 发明授权

US07683671B2 Method, apparatus, and system providing power supply independent imager output driver having a constant slew rate 有权
标题翻译：提供具有恒定压摆率的电源独立成像器输出驱动器的方法，装置和系统
公开(公告)号：US07683671B2
公开(公告)日：2010-03-23
申请号：US11512301
申请日：2006-08-30
申请人： Yan Lee
发明人： Yan Lee
IPC分类号： H03K19/094 , H03K19/0175 , H03K5/12
CPC分类号： H03K19/018521 , H03K19/00384
摘要： An output driver having an output that is not dependant on the variation of the voltage level of a variable supply voltage. The output driver, having at least two power supply voltages and which is not influenced by the variation of the voltage level of a variable power supply, leads to a constant output slew rate.
摘要翻译：具有不依赖于可变电源电压的电压电平的变化的输出的输出驱动器。具有至少两个电源电压并且不受可变电源的电压电平的变化的影响的输出驱动器导致恒定的输出转换速率。

6. 发明申请

US20060164277A1 Programmable integrating ramp generator and method of operating the same 有权
标题翻译：可编程积分斜坡发生器及其运行方法
公开(公告)号：US20060164277A1
公开(公告)日：2006-07-27
申请号：US11044532
申请日：2005-01-27
申请人： Yan Lee
发明人： Yan Lee
IPC分类号： H03M1/12
CPC分类号： G06J1/00 , H03K4/066 , H03K4/50 , H03K4/502 , H03M1/123 , H03M1/58
摘要： A ramp generator for an analog-to-digital converter comprises an array of capacitors each controlled by a switch responsive to one or more control signals and operable to connect/disconnect one or more of the capacitors relative to the array and a current source operable to charge at least one of the capacitors. A method for operating a ramp generator having an array of capacitors comprises resetting the ramp generator, enabling a current generator to charge at least one capacitor in the switched capacitor array, and controlling the state of one or more switches, wherein the switches are operable to connect and disconnect one or more of the capacitors relative to the array. The output of the ramp generator having a plurality of programmable breakpoints. Because of the rules governing abstracts, this abstract should not be used to construe the claims.
摘要翻译：用于模数转换器的斜坡发生器包括电容器阵列，每个电容器由响应于一个或多个控制信号的开关控制，并且可操作以相对于阵列连接/断开一个或多个电容器，电流源可操作以对至少一个电容器充电。用于操作具有电容器阵列的斜坡发生器的方法包括复位斜坡发生器，使得电流发生器能够对开关电容器阵列中的至少一个电容器进行充电，并且控制一个或多个开关的状态，其中开关可操作为连接和断开相对于阵列的一个或多个电容器。具有多个可编程断点的斜坡发生器的输出。由于管理摘要的规则，本摘要不应用于解释索赔。

7. 发明申请

US20080061830A1 Method, apparatus, and system providing power supply independent imager output driver having a constant slew rate 有权
标题翻译：提供具有恒定压摆率的电源独立成像器输出驱动器的方法，装置和系统
公开(公告)号：US20080061830A1
公开(公告)日：2008-03-13
申请号：US11512301
申请日：2006-08-30
申请人： Yan Lee
发明人： Yan Lee
IPC分类号： H03K19/094
CPC分类号： H03K19/018521 , H03K19/00384
摘要： An output driver having an output that is not dependant on the variation of the voltage level of a variable supply voltage. The output driver, having at least two power supply voltages and which is not influenced by the variation of the voltage level of a variable power supply, leads to a constant output slew rate.
摘要翻译：具有不依赖于可变电源电压的电压电平的变化的输出的输出驱动器。具有至少两个电源电压并且不受可变电源的电压电平的变化的影响的输出驱动器导致恒定的输出转换速率。

8. 发明申请

US20060220941A1 Ramp generators for imager analog-to-digital converters 有权
标题翻译：用于成像器模数转换器的斜坡发生器
公开(公告)号：US20060220941A1
公开(公告)日：2006-10-05
申请号：US11440096
申请日：2006-05-25
申请人： Yan Lee
发明人： Yan Lee
IPC分类号： H03M1/12
CPC分类号： H03K4/50 , H03M1/56 , H04N5/335 , H04N5/378
摘要： An imager with an analog-to-digital converter having at least one ramp generator that precisely and efficiently produces the desired ramp voltages required by the analog-to-digital converter. The analog-to-digital converter can use differential or two ramp generators. The analog-to-digital converter can also use ramp generators operated in linear or compressed ramp modes.
摘要翻译：具有模拟 - 数字转换器的成像器具有至少一个斜坡发生器，其精确且有效地产生模数转换器所需的期望斜坡电压。模数转换器可以使用差分或两个斜坡发生器。模数转换器还可以使用以线性或压缩斜坡模式运行的斜坡发生器。

9. 发明授权

US07274319B2 Ramp generators for imager analog-to-digital converters 有权
标题翻译：用于成像器模数转换器的斜坡发生器
公开(公告)号：US07274319B2
公开(公告)日：2007-09-25
申请号：US11440096
申请日：2006-05-25
申请人： Yan Lee
发明人： Yan Lee
IPC分类号： H03M1/12
CPC分类号： H03K4/50 , H03M1/56 , H04N5/335 , H04N5/378
摘要： An imager with an analog-to-digital converter having at least one ramp generator that precisely and efficiently produces the desired ramp voltages required by the analog-to-digital converter. The analog-to-digital converter can use differential or two ramp generators. The analog-to-digital converter can also use ramp generators operated in linear or compressed ramp modes.
摘要翻译：具有模拟 - 数字转换器的成像器具有至少一个斜坡发生器，其精确且有效地产生模数转换器所需的期望斜坡电压。模数转换器可以使用差分或两个斜坡发生器。模数转换器还可以使用以线性或压缩斜坡模式运行的斜坡发生器。

10. 发明授权

US07782091B2 Apparatus, system, and method for driver circuits 有权
标题翻译：用于驱动电路的装置，系统和方法
公开(公告)号：US07782091B2
公开(公告)日：2010-08-24
申请号：US11598945
申请日：2006-11-14
申请人： Yan Lee
发明人： Yan Lee
IPC分类号： H03K19/0175 , H03K19/094 , H03K19/003
CPC分类号： H03K19/00346
摘要： Some embodiments include an output driver having a first circuit to provide a plurality of first parallel circuit paths between an output node and a first supply node, a second circuit to provide a plurality of second parallel circuit paths between the output node and a second supply node, and a control circuit responsive to a voltage at the output node to vary a value of a current in the plurality of first parallel circuit paths and a value of a second current in the plurality of second parallel circuit paths to control a signal shape of the output signal. Additional apparatus, systems, and methods are disclosed.
摘要翻译：一些实施例包括具有第一电路以在输出节点和第一供电节点之间提供多个第一并联电路路径的输出驱动器，第二电路，用于在输出节点和第二供电节点之间提供多个第二并联电路路径以及响应于输出节点处的电压以改变多个第一并联电路路径中的电流值和多个第二并联电路路径中的第二电流的值的控制电路，以控制多个第二并联电路路径的信号形状输出信号。公开了附加装置，系统和方法。

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